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Blood Pressure Volume 32, 2023 - Issue 1
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Editorial

TIME to face the reality about evening dosing of antihypertensive drugs in hypertension

Sverre E. Kjeldsena Departments of Cardiology and Nephrology, Ullevaal Hospital, University of Oslo, Oslo, NorwayCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-2389-0272View further author information
ORCID Icon,
Brent M. Eganb American Medical Association, University of South Carolina, Greenville, SC, USAORCID Iconhttps://orcid.org/0000-0002-1470-5875View further author information
ORCID Icon,
Krzysztof Narkiewiczc Department of Hypertension and Diabetology, Krzysztof Narkiewicz, Medical University of Gdansk, Gdansk, PolandORCID Iconhttps://orcid.org/0000-0001-5949-5018View further author information
ORCID Icon,
Reinhold Kreutzd Charité – Universitätsmedizin Berlin, Institute of Clinical Pharmacology and Toxicology, Berlin, GermanyORCID Iconhttps://orcid.org/0000-0002-4818-211XView further author information
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Michel Burniere University of Lausanne, Lausanne, SwitzerlandORCID Iconhttps://orcid.org/0000-0003-1283-8487View further author information
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Suzanne Oparilf Vascular Biology and Hypertension Program, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USAORCID Iconhttps://orcid.org/0000-0002-7505-2599View further author information
ORCID Icon &
Giuseppe Manciag University of Milan-Bicocca, Milan, ItalyORCID Iconhttps://orcid.org/0000-0003-0942-3176View further author information
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Pages 1-3 | Received 24 Oct 2022, Accepted 27 Oct 2022, Published online: 12 Nov 2022

References

  • Mackenzie IS, Rogers A, Poulter NR, et al. Cardiovascular outcomes in adults with hypertension allocated to evening or morning dosing of usual antihypertensives: a prospective, randomised, open-label, blinded-endpoint clinical trial. The TIME study. Lancet. 2022;400(10361):1417–1425.
  • Mancia G, Verdecchia P. Clinical value of ambulatory blood pressure: evidence and limits. Circ Res. 2015;116(6):1034–1045.
  • Hermida RC, Crespo JJ, Domínguez-Sardiña M, et al. Bedtime hypertension treatment improves cardiovascular risk reduction: the HYGIA chronotherapy trial. Eur Heart J. 2020;41(48):4565–4576.
  • Kreutz R, Kjeldsen SE, Burnier M, et al. Blood pressure medication should not be routinely dosed at bedtime. We must disregard the data from the HYGIA project. Blood Press. 2020;29(3):135–136.
  • Brunström M, Kjeldsen SE, Kreutz R, et al. Missing verification of source data in hypertension research: the HYGIA project in perspective. Hypertension. 2021;78(2):555–558.
  • Stergiou G, Brunström M, MacDonald TM, et al. Bedtime dosing of antihypertensive medications: systematic review and consensus statement. An international society of hypertension position paper. J Hypertens. 2022;40(10):1847–1858.
  • Vrijens B, Vincze G, Kristanto P, et al. Adherence to prescribed antihypertensive drug treatments: longitudinal study of electronically compiled dosing histories. BMJ. 2008;336(7653):1114–1117.
  • Parati G, Schumacher H, Bilo G, et al. Evaluating 24-h antihypertensive efficacy by the smoothness index: a meta-analysis of an ambulatory blood pressure monitoring database. J Hypertens. 2010;28(11):2177–2183.

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