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Blood Pressure Volume 32, 2023 - Issue 1
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Letter to the Editor

Lessons learned from conducting a randomized controlled trial to improve non-adherence to antihypertensive drug treatment

L.E.J. Peetersa Erasmus MC, University Medical Center Rotterdam, Department of Hospital Pharmacy, the Netherlands;b Erasmus MC, University Medical Center Rotterdam, Department of Internal Medicine, the NetherlandsCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-6148-9714View further author information
, PharmDORCID Icon,
T. van Geldera Erasmus MC, University Medical Center Rotterdam, Department of Hospital Pharmacy, the Netherlands;b Erasmus MC, University Medical Center Rotterdam, Department of Internal Medicine, the NetherlandsView further author information
, MD, PhD,
L. van Dijkc Nivel, Netherlands Institute for Health Services Research, Department Healthcare from the Perspective of Patients, Clients and Citizens, Utrecht, the Netherlands;d University of Groningen, Department of PharmacoTherapy, -Epidemiology & -Economics (PTEE), Groningen Research Institute of Pharmacy, Faculty of Science and Engineering, University of Groningen, Groningen, the NetherlandsView further author information
, PhD,
B.C.P. Kochb Erasmus MC, University Medical Center Rotterdam, Department of Internal Medicine, the NetherlandsView further author information
, PharmD, PhD &
J. Versmissena Erasmus MC, University Medical Center Rotterdam, Department of Hospital Pharmacy, the Netherlands;b Erasmus MC, University Medical Center Rotterdam, Department of Internal Medicine, the NetherlandsORCID Iconhttps://orcid.org/0000-0003-0674-7765View further author information
, MD, PhDORCID Icon
Article: 2281316 | Received 18 Oct 2023, Accepted 03 Nov 2023, Published online: 27 Nov 2023

References

  • Burnier M. Drug adherence in hypertension. Pharmacological Research. 2017;125:1–3. doi: 10.1016/j.phrs.2017.08.015.
  • Peeters LEJ, Feyz L, Boersma E, Daemen J, van Gelder T, Koch BCP, et al. Clinical Applicability of Monitoring Antihypertensive Drug Levels in Blood. Hypertension. 2020;76(1):80–6.
  • Peeters LEJ, Kappers MHW, Boersma E, Massey EK, van Dijk L, van Gelder T, et al. The effect of combining therapeutic drug monitoring of antihypertensive drugs with personalised feedback on adherence and resistant hypertension: the (RHYME-RCT) trial protocol of a multi-centre randomised controlled trial. BMC Cardiovasc Disord. 2023;23(1):87.
  • Peeters LEJ, Kappers MHW, Hesselink DA, van der Net JB, Hartong SCC, van de Laar R, et al. Antihypertensive drug concentration measurement combined with personalized feedback in resistant hypertension: a randomized controlled trial. J Hypertens. 2023.
  • Peeters LEJ, van der Net JB, Schoenmakers-Buis K, van der Meer IM, Massey EK, van Dijk L, et al. Introducing the importance and difficulties of a three-step approach to improve nonadherence to antihypertensive drugs: a case series. J Hypertens. 2022;40(1):189–93.
  • Shemesh E, Mitchell J, Neighbors K, Feist S, Hawkins A, Brown A, et al. Recruiting a representative sample in adherence research—The MALT multisite prospective cohort study experience. Pediatric Transplantation. 2017;21(8):e13067. doi: 10.1111/petr.13067.
  • Guillemin M, McDougall R, Martin D, Hallowell N, Brookes A, Gillam L. Primary care physicians’ views about gatekeeping in clinical research recruitment: A qualitative study. AJOB Empir Bioeth. 2017;8(2):99–105.
  • Rohla M, Nahler A, Lambert T, Reiter C, Gammer V, Grund M, et al. Predictors of response to renal denervation for resistant arterial hypertension: a single center experience. Journal of Hypertension. 2016;34(1):123–9. doi: 10.1097/hjh.0000000000000764.
  • Peeters LEJ, Hesselink DA, Lafeber M, Severs D, van den Hoogen MWF, Sonneveld MAH, et al. Monitoring antihypertensive drug concentrations to determine nonadherence in hypertensive patients with or ­without a kidney transplant. J Hypertens. 2023;41(8):1239–44.
  • Torgerson DJ. Contamination in trials: is cluster randomisation the answer? Bmj. 2001;322(7282):355–7.

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