139
Views
35
CrossRef citations to date
0
Altmetric
ORIGINAL ARTICLE

Cerebrospinal fluid from amyotrophic lateral sclerosis patients causes fragmentation of the Golgi apparatus in the neonatal rat spinal cord

, , , , , & show all
Pages 79-82 | Received 23 Aug 2006, Accepted 25 Nov 2006, Published online: 10 Jul 2009

References

  • Fujita Y., Okamoto K. Golgi apparatus of the motor neurons in patients with amyotrophic lateral sclerosis and in mice models of amyotrophic lateral sclerosis. Neuropathology 2005; 25: 388–94
  • Gonatas N. K., Stieber A., Gonatas J. O. Fragmentation of the Golgi apparatus in neurodegenerative diseases and cell death. J Neurol Sci 2006; 246: 21–30
  • Stieber A., Gonatas J. O., Collard J., Meier J., Julien J., Schweitzer P., et al. The neuronal Golgi apparatus is fragmented in transgenic mice expressing a mutant human SOD1, but not in mice expressing the human NF‐H gene. J Neurol Sci 2000; 173: 63–72
  • Stieber A., Gonatas J. O., Moore J. S., Bantly A., Yim H. S., Yim M. B., et al. Disruption of the structure of the Golgi apparatus and the function of the secretory pathway by mutants G93A and G85R of Cu/Zn superoxide dismutase (SOD1) of familial amyotrophic lateral sclerosis. J Neurol Sci 2004; 219: 45–53
  • Nagaraja T. N., Gourie‐Devi M., Nalini A., Raju T. R. Neurofilament phosphorylation is enhanced in cultured chick spinal cord neurons exposed to cerebrospinal fluid from amyotrophic lateral sclerosis patients. Acta Neuropathol (Berl) 1994; 88: 349–352
  • Rao M. S., Devi M. G., Nalini A., Shahani N., Raju T. R. Neurofilament phosphorylation is increased in ventral horn neurons of neonatal rat spinal cord exposed to cerebrospinal fluid from patients with amyotrophic lateral sclerosis. Neurodegeneration 1995; 4: 397–401
  • Shahani N., Nalini A., Gourie‐Devi M., Raju T. R. Reactive astrogliosis in neonatal rat spinal cord after exposure to cerebrospinal fluid from patients with amyotrophic lateral sclerosis. Exp Neurol 1998; 149: 295–8
  • Shahani N., Gourie‐Devi M., Nalini A., Raju T. R. Cyclophosphamide attenuates the degenerative changes induced by CSF from patients with amyotrophic lateral sclerosis in the neonatal rat spinal cord. J Neurol Sci 2001; 185: 109–18
  • Shahani N., Gourie‐Devi M., Nalini A., Rammohan P., Shobha K., Harsha H. N., et al. (‐)‐Deprenyl alleviates the degenerative changes induced in the neonatal rat spinal cord by CSF from amyotrophic lateral sclerosis patients. Amyotroph Lateral Scler Other Motor Neuron Disord 2004; 5: 172–9
  • Cole N. B., Sciaky N., Marotta A., Song J., Lippincott‐Schwartz J. Golgi dispersal during microtubule disruption: regeneration of Golgi stacks at peripheral endoplasmic reticulum exit sites. Mol Biol Cell 1996; 7: 631–50
  • Hafezparast M., Klocke R., Ruhrberg C., Marquardt A., Ahmad‐Annuar A., Bowen S., et al. Mutations in dynein link motor neuron degeneration to defects in retrograde transport. Science 2003; 300: 808–12
  • Farah C. A., Nguyen M. D., Julien J. P., Leclerc N. Altered levels and distribution of microtubule‐associated proteins before disease onset in a mouse model of amyotrophic lateral sclerosis. J Neurochem 2003; 84: 77–86
  • Strey C. W., Spellman D., Stieber A., Gonatas J. O., Wang X., Lambris J. D., et al. Dysregulation of stathmin, a microtubule‐destabilizing protein, and up‐regulation of Hsp25, Hsp27, and the antioxidant peroxiredoxin 6 in a mouse model of familial amyotrophic lateral sclerosis. Am J Pathol 2004; 165: 1701–18
  • Picklo M. J., Amarnath V., McIntyre J. O., Graham D. G., Montine T. J. 4‐hydroxy‐2(E)‐nonenal inhibits CNS mitochondrial respiration at multiple sites. J Neurochem 1999; 72: 1617–24
  • Ligon L. A., LaMonte B. H., Wallace K. E., Weber N., Kalb R. G., Holzbaur E. L. Mutant superoxide dismutase disrupts cytoplasmic dynein in motor neurons. Neuroreport 2005; 16: 533–6

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.