285
Views
8
CrossRef citations to date
0
Altmetric
Original Article

Public health value of fixed‐dose combinations in hypertension

, , , , , & show all
Pages 5-14 | Published online: 08 Jul 2009

References

  • Corren J. Evaluation and treatment of asthma: An overview. Am J Manag Care 2005; 11((14 Suppl))S408–S415
  • Leichter S. B., Thomas S. Combination medications in diabetes care: An opportunity that merits more attention. Clin Diabetes 2003; 21: 175–178
  • Lewington S., Clarke R., Qizilbash N., Peto R., Collins R. Age‐specific relevance of usual blood pressure to vascular mortality: A meta‐analysis of individual data for one million adults in 61 prospective studies. Lancet 2002; 360: 1903–1913
  • Wolf‐Maier K., Cooper R. S., Kramer H., Banegas J. R., Giampaoli S., Joffres M. R., et al. Hypertension treatment and control in five European countries, Canada, and the United States. Hypertension 2004; 43: 10–17
  • Kearney P. M., Whelton M., Reynolds K., Muntner P., Whelton P. K., He J. Global burden of hypertension: Analysis of worldwide data. Lancet 2005; 365: 217–223
  • Wolf‐Maier K., Cooper R. S., Banegas J. R., Giampaoli S., Hense H‐W., Joffres M., et al. Hypertension prevalence and blood pressure levels in 6 European countries, Canada, and the United States. JAMA 2003; 289: 2363–2369
  • Ezzati M., Lopez A. D., Rodgers A., Vander Hoom S., Murray C. J. L., the Comparative Risk Assessment Collaborating Group. Selected major risk factors and global and regional burden of disease. Lancet 2002; 360: 1347–1360
  • World Health Organization. The World Health Report 2002 – Reducing risks, promoting healthy life. 83, Chapter 4
  • Mullins C. D., Sikirica M., Seneviratne V., Ahn J., Akras K. S. Comparisons of hypertension‐related costs from multinational clinical studies. Pharmacoeconomics 2004; 22: 1001–1014
  • Chockalingam A., Campbell N. R., Fodor J. G. Worldwide epidemic of hypertension. Can J Cardiol 2006; 22: 553–555
  • Neal B., MacMahon S., Chapman N., Blood Pressure Lowering Treatment Trialists' Collaboration. Effects of ACE inhibitors, calcium antagonists, and other blood‐pressure‐lowering drugs: Results of prospectively designed overviews of randomised trials. Blood Pressure Lowering Treatment Trialists' Collaboration. Lancet 2000; 356: 1955–1964
  • Klungel O. H., Kaplan R. C., Heckbert S. R., Smith N. L., Lemaitre R. N., Longstreth W. T., Jr., et al. Control of BP and risk of stroke among pharmacologically treated hypertensive patients. Stroke 2000; 31: 420–424
  • Hansson L., Zanchetti A., Carruthers S. G., Dahlöf B., Elmfeldt D., Julius S., et al. Effects of intensive blood‐pressure lowering and low‐dose aspirin in patients with hypertension: Principal results of the Hypertension Optimal Treatment (HOT) randomised trial. Lancet 1998; 351: 1755–1762
  • ESH–ESC Guidelines Committee. 2003 European Society of Hypertension‐European Society of Cardiology guidelines for the management of arterial hypertension (ESH 2003). J Hypertens 2003; 21: 1011–1053
  • Chobanian A. V., Bakris G. L., Black H. R., Cushman W. C., Green L. A., Izzo J. I., Jr., et al. Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. National Heart, Lung, and Blood Institute; National High Blood Pressure Education Program Coordinating Committee. The seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. JAMA 2003; 289: 2560–2572
  • Jamerson K. A., Nwose O., Jean‐Louis L., Schofield L., Purkayastha D., Baron M. Initial angiotensin‐converting enzyme inhibitor/calcium channel blocker combination therapy achieves superior blood pressure control compared with calcium channel blocker monotherapy in patients with stage 2 hypertension. Am J Hypertens 2004; 17: 495–501
  • Cushman W. C., Ford C. E., Cutler J. A., Margolis K. L., Davis B. R., Grimm R. H., et al. Success and predictors of blood pressure control in diverse North American settings: The antihypertensive and lipid‐lowering treatment to prevent heart attack trial (ALLHAT). J Clin Hypertens (Greenwich) 2002; 4: 393–404
  • Julius S., Kjeldsen S. E., Brunner H., Hansson L., Platt F., Ekman S., et al. VALUE trial: Long‐term blood pressure trends in 13,449 patients with hypertension and high cardiovascular risk. Am J Hypertens 2003; 16: 544–548
  • Walley T., Duggan A. K., Haycox A. R., Niziol C. J. Treatment for newly diagnosed hypertension: Patterns of prescribing and antihypertensive effectiveness in the UK. J Royal Soc Med 2003; 96: 525–531
  • Lloyd A., Schmieder C., Marchant N. Financial and health costs of uncontrolled blood pressure in the United Kingdom. Pharmacoeconomics 2003; 21(Suppl 1)33–41
  • Flack J. M., Casciano R., Casciano J., Doyle J., Arikian S., Tang S., et al. Cardiovascular disease costs associated with uncontrolled hypertension. Manag Care Interface 2002; 15: 28–36
  • Degli Esposti L., Valpiani G. Pharmacoeconomic burden of undertreating hypertension. Pharmacoeconomics 2004; 22: 907–928
  • Black H. R., Elliott W. J., Grandits G., Grambsch P., Lucente T., White W. B., et al. Principal results of the Controlled Onset Verapamil Investigation of Cardiovascular End Points (CONVINCE) trial. JAMA 2003; 289: 2073–2082
  • Burnier M. Medication adherence and persistence as the cornerstone of effective antihypertensive therapy. Am J Hypertens 2006; 19: 1190–1196
  • World Health Organization (WHO). Adherence to long term therapies: Evidence for action. 2003, WHO
  • International Society for Pharmacoeconomics and Outcomes Research (ISPOR), Pharmacoeconomic guidelines around the word. http://www.ispor.org/PEguidelines/index.asp (accessed on 25 August 2006).
  • Berger M. L., Bingefors K., Hedblom E. C., , editors, et al. Health care cost, quality and outcomes: ISPOR book of terms. 2003, ISPOR
  • Sturkenboom M. C. J. M., Picelli G., Dieleman J. P., Mozaffari E., Pompen M., van der Lei J. Patient adherence and persistence with antihypertensive therapy: One‐versus two‐pill combinations. J Hypertens 2005; 23(Suppl 2)S326
  • DiMatteo M. R., Giordani P. J., Lepper H. S., Croghan T. W. Patient adherence and medical treatment outcomes: A meta‐analysis. Med Care 2002; 40: 794–811
  • Dezii C. M. Medication noncompliance: What is the problem?. Manag Care 2000; 9((9 Suppl))S7–S12
  • Taylor A. A., Shoheiber O. Adherence to antihypertensive therapy with fixed‐dose amlodipine besylate/benazepril HCl versus comparable component‐based therapy. Congest Heart Fail 2003; 9: 324–332
  • Davis T. C., Wolf M. S. Health literacy: Implications for family medicine. Fam Med 2004; 36: 595–598
  • Caro J. J., Speckman J. L., Salas M., Raggio G., Jackson J. D. Effect of initial drug choice on persistence with antihypertensive therapy: The importance of actual practice data. CMAJ 1999; 160: 41–46
  • Hughes D., McGuire A. The direct costs to the NHS of discontinuing and switching prescriptions for hypertension. J Hum Hypertens 1998; 12: 533–537
  • Osterberg L., Blaschke T. Adherence to medication. N Engl J Med 2005; 353: 487–497
  • Halpern M. T., Vincze G., Stewart W. F., Khan Z. M. Persistence with hypertension therapy and long‐term cardiovascular outcomes. J Hypertens 2006; 24(Suppl 4)S182–S183, (P11.86)
  • Breekveldt‐Postma N. S., Siiskonen S. J., Penning‐Van Beest F. J. A., et al. Non‐persistent use of antihypertensive drugs leads to increased risk of hospitalizations for acute myocardial infarction or stroke. Value Health 2006; 9(Suppl)A339
  • Granger B. B., Swedberg K., Ekman I., Granger C. B., Olofsson B., McMurray J. J., et al. Adherence to candesartan and placebo and outcomes in chronic heart failure in the CHARM programme: Double‐blind, randomised, controlled trial. Lancet 2005; 366: 2005–2011
  • Cleemput I., Kesteloot K., DeGeest S. A review of the literature on the economics of non‐complicance. Room for methodological improvement. Health Policy 2002; 59: 65–94
  • McCombs J. S., Nichol M. B., Newman C. M., Sclar D. A. The costs of interrupting antihypertensive drug therapy in a Medicaid population. Med Care 1994; 32: 214–226
  • Sokol M. C., McGuigan K. A., Verbrugge R. R., Epstein R. S. Impact of medication adherence on hospitalization risk and healthcare cost. Med Care 2005; 43: 521–530
  • Levy G., Zamacona M. K., Jusko W. J. Developing compliance instructions for drug labeling. Clin Pharmacol Ther 2000; 68: 586–591
  • Rizzo J. A., Abbott T. A., 3rd., Pashko S. Labour productivity effects of prescribed medicines for chronically ill workers. Health Econ 1996; 5: 249–265
  • Jamerson K. A., Bakris G. L., Wun C. C., Dahlöf B., Lefkowitz M., Manfreda S., et al. Rationale and design of the avoiding cardiovascular events through combination therapy in patients living with systolic hypertension (ACCOMPLISH) trial: The first randomized controlled trial to compare the clinical outcome effects of first‐line combination therapies in hypertension. Am J Hypertens 2004; 17: 793–801
  • Jamerson K., Bakris G. L., Dahlöf B., Pitt B., Velazquez E., Gupte J., et al. ACCOMPLISH Investigators. Exceptional early blood pressure control rates: The ACCOMPLISH trial. Blood Press 2007; 16: 80–86
  • Ruilope L. M., Malacco E., Khder Y., Kandra A., Bönner G., Heintz D. Efficacy and tolerability of combination therapy with valsartan plus hydrochlorothiazide compared with amlodipine monotherapy in hypertensive patients with other cardiovascular risk factors: The VAST study. Clin Ther 2005; 27: 578–587
  • Andreadis E. A., Tsourous G. I., Marakomichelakis G. E., Katsanou P. M., Fotia M. E., Vassilopoulos C. V., Diamantopoulos E. J. High‐dose monotherapy vs low‐dose combination therapy of calcium channel blockers and angiotensin receptor blockers in mild to moderate hypertension. J Hum Hypertens 2005; 19: 491–496
  • Neutel J., Smith D. H. Evaluation of angiotensin II receptor blockers for 24‐hour blood pressure control: Meta‐analysis of a clinical database. J Clin Hypertens (Greenwich) 2003; 5: 58–63
  • Wanovich R., Kerrish P., Gerbino, Shoheiber O. Compliance patterns of patients treated with two separate antihypertensive agents versus fixed‐dose combination therapy. Am J Hypertens 2004; 17: 223A
  • Dickson M., Plauschinat C. A. Antihypertensive therapy compliance and total cost of care in a Medicaid population: Fixed‐dose combination vs free‐combination treatment. Am J Health Syst Pharm 2005; 62: P71E
  • Hilleman D. E., Reyes A. P., Wurdeman R. L., Faulkner M. Efficacy and safety of a therapeutic interchange from high‐dose calcium channel blockers to a fixed‐dose comfobination of amlodipine/benazepril in patients with moderate‐to‐severe hypertension. J Hum Hypertens 2001; 15: 559–565
  • Kountz D. S. Cost containment for treating hypertension in African Americans: Impact of a combined ACE inhibitor‐calcium channel blocker. J Natl Med Assoc 1997; 89: 457–460
  • Dezii C. M. A retrospective study of persistence with single‐pill combination therapy vs. concurrent two‐pill therapy in patients with hypertension. Manag Care 2000b; 9(Suppl)S2–S6
  • Jackson K., Brixner D., Oderda G., et al. Persistence of fixed versus free combination therapy with valsartan and HCTZ for patients with hypertension. Value Health 2006; 9(Suppl)A363
  • Drummond M., Jonsson B. Moving beyond the drug budget silo mentality in Europe. Value Health 2003; 6(Suppl 1)S74–S77
  • Wertheimer A., Santella T. M., Finestone A. J., Levy R. Clinical and economic advantages of modern dosage forms: Improving medication adherence. 2006, Center for Pharmaceutical Health Services Research
  • Kalo Z., Muszbek N., Bodrogi J., Bidlo J. Does therapeutic reference pricing always result in cost‐containment? The Hungarian evidence. Health Policy 2006; 89: 401–412
  • Lopez‐Casasnovas G., Puig‐Junoy J. Review of the literature on reference pricing. Health Policy 2000; 54: 87–123
  • Atella V., Peracchi F., Depalo D., Rossetti C. Drug compliance, co‐payment and health outcomes: Evidence from a panel of Italian patients. Health Economics 2006; 15: 875–892
  • Andersson K., Petzold M. G., Sonesson C., Lonnroth K., Caristen A. Do policy changes in the pharmaceutical reimbursement schedule affect drug expenditures? Interrupted time series analysis of cost, volume and cost per volume trends in Sweden 1986–2002. Health Policy 2006; 79: 231–243
  • Kanavos P., Reinhardt U. Reference pricing for drugs: Is it compatible with US health care?. Health Affairs (Millwood) 2003; 22: 16–30
  • Koopmanschap M. A., Rutten F. F. H. The drug budget silo mentality: The Dutch case. Value Health 2003; 6(Suppl 1)S46–S51
  • Puig‐Junoy J. Incentives and pharmaceutical reimbursement reforms in Spain. Health Policy 2004; 67: 149–165
  • World Health Organization Collaborating Centre for Drug Statistics Methodology (WHO), About the ATC/DDD system: http://www.whocc.no/atcddd/6 (Last accessed 25 August 2006).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.