IFNGR2 genetic polymorphism associated with sex-specific paranoid schizophrenia risk

References

• Owen MJ, Sawa A, Mortensen PB. Schizophrenia. Lancet 2016;388:86--97.
   PubMed Web of Science ®Google Scholar
• Gejman PV, Sanders AR, Duan J. The role of genetics in the etiology of schizophrenia. Psychiatr Clin North Am 2010;33:35–66.
   PubMed Web of Science ®Google Scholar
• Kronfol Z, Remick DG. Cytokines and the brain: Implications for clinical psychiatry. Am J Psychiatry 2000;157:683–94.
   PubMed Web of Science ®Google Scholar
• Elenkov I. Neuroendocrine effects on immune system. In: De Groot LJ, Beck-Peccoz P, Chrousos G, Dungan K, Grossman A, Hershman JM, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc; 2000–2009.
   Google Scholar
• Maes M, Bosmans E, Meltzer HY, Scharpé S, Suy E. Interleukin-1 beta: A putative mediator of HPA axis hyperactivity in major depression? Am J Psychiatry 1993;150:1189–93.
   PubMed Web of Science ®Google Scholar
• Ganguli R, Brar JS, Chengappa KR, Deleo M, Yang ZW. Mitogen stimulated interleukin 2 production in never-medicated first episode schizophrenics-the influence of age of onset and negative symptoms. Arch Gen Psychiatry 1995;52:668–72.
   PubMed Web of Science ®Google Scholar
• Watanabe Y, Someya T, Nawa H. Cytokine hypothesis of schizophrenia pathogenesis: evidence from human studies and animal models. Psychiatry Clin Neurosci 2010;64:217–30.
   PubMed Web of Science ®Google Scholar
• Ho-Kyoung Y, Yong-Ku K. The T allele of the interferon-gamma +874A/T polymorphism is associated with bipolar disorder. Nord J Psychiatry 2012;66:14–18.
   Web of Science ®Google Scholar
• Hanisch UK. Microglia as a source and target of cytokines. Glia 2002;40:140–55.
   PubMed Web of Science ®Google Scholar
• Neumann H, Schmidt H, Wilharm E, Behrens L, Wekerle H. Interferon gamma gene expression in sensory neurons: Evidence for autocrine gene regulation. J Exp Med 2008;186:2023–31.
   Web of Science ®Google Scholar
• Taylor MW, Feng GS. Relationship between interferon gamma, indoleamine 2,3-dioxygenase, and tryptophan catabolism. FASEB J 1991;5:2516–22.
   PubMed Web of Science ®Google Scholar
• Huh GS, Boulanger LM, Du H, Riquelme PA, Brotz TM, Shatz CJ. Functional requirement for class I MHC in CNS development and plasticity. Science 2000;290:2155–9.
   PubMed Web of Science ®Google Scholar
• Lee J, Kim SJ, Son TG, Chan SL, Mattson MP. Interferon-gamma is upregulated in the hippocampus in response to intermittent fasting and protects hippocampal neurons against excitotoxicity. J Neurosci Res 2006;83:1552–7.
   PubMed Web of Science ®Google Scholar
• Ottum PA, Arellano G, Reyes LI, Iruretagoyena M, Naves R. Opposing roles of interferon-gamma on cells of the central nervous system in autoimmune neuroinflammation. Front Immunol 2015;30:539.
   Google Scholar
• Mogensen KE, Lewerenz M, Reboul J, Lutfalla G, Uze G. The type I interferon receptor: Structure, function, and evolution of a family business. J Interferon Cytokine Res 1999;19:1069–98.
   PubMed Web of Science ®Google Scholar
• Larkin JIII, Johnson HM, Subramaniam PS. Differential nuclear localization of the IFNGR-1 and IFNGR-2 subunits of the IFN-γ receptor complex following activation by IFN-γ. J Interferon Cytokine Res 2000;20:565–76.
   PubMed Web of Science ®Google Scholar
• DePaus RA, Kilic SS, Van Dissel JT, Van de Vosse E. Effect of amino acid substitutions in the human IFN-γR2 on IFN-γ responsiveness. Genes Immun 2011;12:136–44.
   PubMed Web of Science ®Google Scholar
• Nakashima H, Inoue H, Akahoshi M, Tanaka Y, Yamaoka K, Ogami E, et al. The combination of polymorphisms within interferon-gamma receptor 1 and receptor 2 associated with the risk of systemic lupus erythematosus. FEBS Lett 1999;453:187–90.
   PubMed Web of Science ®Google Scholar
• Schrijver HM, Hooper-van Veen T, Van Belzen MJ, Crusius JB, Pena AS, Barkhof F, et al. Polymorphisms in the genes encoding interferon-gamma and interferon-gamma receptors in multiple sclerosis. Eur J Immunogenet 2004;31:133–40.
   PubMedGoogle Scholar
• Gao P-S, Mao X-Q, Jouanguy E, Pallier A, Doffinger R, Tanaka Y, et al. Nonpathogenic common variants of IFNGR1 and IFNGR2 in association with total serum IgE levels. Biochem Biophys Res Comm 1999;263:425–9.
   PubMed Web of Science ®Google Scholar
• Kay SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 1987;13:261–76.
   PubMed Web of Science ®Google Scholar
• Overall JE, Gorham DR. The brief psychiatric rating scale. Psychol Rep 1962;10:799–812.
   Web of Science ®Google Scholar
• American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washington (DC): American Psychiatric Association; 1994–2000.
   Google Scholar
• Girgis RR, Kumar SS, Brown AS. The cytokine model of schizophrenia: Emerging therapeutic strategies. Biol Psychiatry 2014;75:292–9.
   PubMed Web of Science ®Google Scholar
• Turhan L, Batmaz S, Kocbiyik S, Soygur AH. The role of tumour necrosis factor alpha and soluble tumour necrosis factor alpha receptors in the symptomatology of schizophrenia. Nord J Psychiatry 2016;70:342–50.
   PubMed Web of Science ®Google Scholar
• Dasdemir S, Kucukali CI, Bireller ES, Tuzun E, Cakmakoglu B. Chemokine gene variants in schizophrenia. Nord J Psychiatry 2016;70:407–12.
   PubMed Web of Science ®Google Scholar
• Miller BJ, Buckley P, Seabolt W, Mellor A, Kirkpatrick B. Meta-analysis of cytokine alterations in schizophrenia: Clinical status and antipsychotic effects. Biol Psychiatry 2011;70:663–71.
   PubMed Web of Science ®Google Scholar
• Drzyzga L, Obuchowicz E, Marcinowska A, Herman ZS. Cytokines in schizophrenia and the effects of antipsychotic drugs. Brain Behav Immun 2006;20:532–45.
   PubMed Web of Science ®Google Scholar
• Kamińska T, Wysocka A, Marmurowska-Michalowska H, Dubas-Slemp H, Kandefer-Szerszeń M. Investigation of serum cytokine levels and cytokine production in whole blood cultures of paranoid schizophrenic patients. Arch Immunol Ther Exp (Warsz) 2001;496:439–45.
   Google Scholar
• Kim YK, Myint AM, Lee BH, Han CS, Lee HJ, Kim DJ, et al. Th1, Th2 and Th3 cytokine alteration in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 2004;28:1129–34.
   PubMed Web of Science ®Google Scholar
• Becker D, Kritschmann E, Floru S, Shlomo-David Y, Gotlieb-Stematsky T. Serum interferon in first psychotic attack. Br J Psychiatry 1990;157:136–8.
   PubMed Web of Science ®Google Scholar
• Gattaz WF, Dalgalarrondo P, Schröder HC. Abnormalities in serum concentrations of interleukin-2, interferon-alpha and interferon-gamma in schizophrenia not detected. Schizophr Res 1992;6:237–41.
   PubMed Web of Science ®Google Scholar
• Guo J, Liu C, Wang Y, Feng B, Zhang X. Role of T helper lymphokines in the immune-inflammatory pathophysiology of schizophrenia: Systematic review and meta-analysis. Nord J Psychiatry 2015;69:364–72.
   PubMed Web of Science ®Google Scholar
• Wysokiński A, Margulska A, Strzelecki D, Kłoszewska I. Levels of C-reactive protein (CRP) in patients with schizophrenia, unipolar depression and bipolar disorder. Nord J Psychiatry 2015;69:346–53.
   PubMed Web of Science ®Google Scholar
• Thabet S, Ben Nejma M, Zaafrane F, Gaha L, Ben Salem K, Romdhane A, et al. Association of the Met-196-Arg variation of human tumor necrosis factor receptor2 (TNFR2) with paranoid schizophrenia. J Mol Neurosci 2011;43:358–63.
   PubMed Web of Science ®Google Scholar
• Paul-Samojedny M, Kowalczyk M, Suchanek R, Owczarek A, Fila-Danilow A, Szczygiel A, et al. Functional polymorphism in the interleukin-6 and interleukin-10 genes in patients with paranoid schizophrenia-a case-control study. J Mol Neurosci 2010;42:112–19.
   PubMed Web of Science ®Google Scholar
• Dimitrov DH, Lee S, Yantis J, Honaker C, Braida N, Walss-Bass C. Elevated serum levels of high-sensitivity C-reactive proteins are associated with severe delusional symptoms in a subgroup of patients with schizophrenia. J Clin Psychiatry 2016;77:131–2.
   PubMed Web of Science ®Google Scholar
• Pusic AD, Pusic KM, Clayton BL, Kraig RP. IFNγ-stimulated dendritic cell exosomes as a potential therapeutic for remyelination. J Neuroimmunol 2014;266:12–23.
   PubMed Web of Science ®Google Scholar
• Grüber L, Bunse T, Weidinger E, Reichard H, Müller N. Adjunctive recombinant human interferon gamma-1b for treatment-resistant schizophrenia in 2 patients. J Clin Psychiatry 2014;75:1266–7.
   PubMed Web of Science ®Google Scholar
• Müller N, Myint M, Schwarz MJ. Kynurenine pathway in schizophrenia: Pathophysiological and therapeutic aspects. Curr Pharm Des 2011;17:130–6.
   PubMed Web of Science ®Google Scholar
• Kim IJ, Beck HN, Lein PJ, Higgins D. Interferon γ induces retrograde dendritic retraction and inhibits synapse formation. J Neurosci 2002;22:4530–9.
   PubMed Web of Science ®Google Scholar
• Goddard CA, Butts DA, Shatz CJ. Regulation of CNS synapses by neuronal MHC class I. Proc Natl Acad Sci U S A 2007;104:6828–33.
   PubMed Web of Science ®Google Scholar
• Bae HR, Leung PS, Tsuneyama K, Valencia JC, Hodge DL, Kim S, et al. Chronic expression of interferon gamma leads to murine autoimmune cholangitis with a female predominance. Hepatology 2016. [Epub ahead of print]. doi: 10.1002/hep.28641.
   Web of Science ®Google Scholar
• Loisel DA, Tan Z, Tisler CJ, Evans MD, Gangnon RE, Jackson DJ, et al. IFNG genotype and sex interact to influence the risk of childhood asthma. J Allergy Clin Immunol 2011;128:524–31.
   PubMed Web of Science ®Google Scholar
• Morrison BA, Ucisik-Akkaya E, Flores H, Alaez C, Gorodezky C, Dorak MT. Multiple sclerosis risk markers in HLA-DRA, HLA-C, and IFNG genes are associated with sex-specific childhood leukemia risk. Autoimmunity 2010;43:690–7.
   PubMed Web of Science ®Google Scholar
• Goetzl EJ, Huang MC, Kon J, Patel K, Schwartz JB, Fast K, et al. Gender specificity of altered human immune cytokine profiles in Aging. FASEB J 2010;24:3580–9.
   PubMed Web of Science ®Google Scholar
• Booth M, Mwatha JK, Joseph S, Jones FM, Kadzo H, Ireri E, et al. Periportal fibrosis in human Schistosoma mansoni infection is associated with low IL-10, low IFN-gamma, high TNF-alpha, or low RANTES, depending on age and gender. J Immunol 2004;172:1295–303.
   PubMed Web of Science ®Google Scholar
• Bao M, Yang Y, Jun HS, Yoon JW. Molecular mechanisms for gender differences in susceptibility to T cell-mediated autoimmune diabetes in nonobese diabetic mice. J Immunol 2002;168:5369–75.
   PubMed Web of Science ®Google Scholar
• McFarland HI, Bigley NJ. Sex-dependent, early cytokine production by NK-like spleen cells following infection with the D variant of encephalomyocarditis virus (EMCV-D). Viral Immunol Fall 1989;2:205–14.
   PubMedGoogle Scholar
• Disshon KA, Dluzen DE. Estrogen reduces acute striatal dopamine responses in vivo to the neurotoxin MPP + in female, but not male rats. Brain Res 2000;868:95–104.
   PubMed Web of Science ®Google Scholar
• Da Silva JA. Sex hormones and glucocorticoids: interactions with the immune system. Ann N Y Acad Sci 1999;876:102–17.
   PubMed Web of Science ®Google Scholar
• Ben Nejma M, Zaabar I, Zaafrane F, Thabet S, Mechri A, Gaha L, et al. A gender-specific association of interleukin 1 receptor antagonist polymorphism with schizophrenia susceptibility. Acta Neuropsychiatr 2013;25:349–55.
   PubMed Web of Science ®Google Scholar
• Xiang L, Rehm KE, Sunesara I, Griswold M, Marshall GD. Gene polymorphisms of stress hormone and cytokine receptors associate with immunomodulatory profile and psychological measurement. J Psychosom Res 2015;78:438–44.
   PubMed Web of Science ®Google Scholar
• Müller N, Weidinger E, Leitner B, Schwarz MJ. The role of inflammation in schizophrenia. Front Neurosci 2015;9:372.
   PubMed Web of Science ®Google Scholar