Elevated serum S100B levels in medication naïve children and adolescents with obsessive-compulsive disorder

References

• American Psychiatric Association, 2013. Diagnostic and statistical manual of mental disorders. 5th ed. Washington, DC: American Psychiatric Publishing, Inc.
   Google Scholar
• Douglass H, Moffitt T, Dar R, et al. Obsessive-compulsive disorder in a birth cohort of 18-year-olds: prevalence and predictors. J Am Acad Child Adolesc Psychiatry. 1995;34(11):1424–1431.
   PubMed Web of Science ®Google Scholar
• Heyman I, Fombonne E, Simmons H, et al. Prevalence of obsessive-compulsive disorder in the British nationwide survey of child mental health. Br J Psychiatry. 2001;179:324–329.
   PubMed Web of Science ®Google Scholar
• Kessler RC, Berglund P, Demler O, et al. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the national comorbidity survey replication. Arch Gen Psychiatry. 2005;62(6):593–602.
   PubMed Web of Science ®Google Scholar
• Micali N, Heyman I, Perez M, et al. Long-term outcomes of obsessive-compulsive disorder: follow-up of 142 children and adolescents . Br J Psychiatry. 2010;197(2):128–134.
   PubMed Web of Science ®Google Scholar
• Schwartzman CM, Boisseau CL, Sibrava NJ, et al. Symptom subtype and quality of life in obsessive-compulsive disorder. Psychiatry Res. 2017;249:307–310.
   PubMed Web of Science ®Google Scholar
• Skoog G, Skoog I. A 40-year follow-up of patients with obsessive-compulsive disorder. Arch Gen Psychiatry. 1999;56(2):121–127.
   PubMed Web of Science ®Google Scholar
• Stewart SE, Geller DA, Jenike M, et al. Long-term outcome of pediatric obsessive-compulsive disorder: a meta-analysis and qualitative review of the literature. Acta Psychiatr Scand. 2004;110(1):4–13.
   PubMed Web of Science ®Google Scholar
• Storch EA, Larson MJ, Muroff J, et al. Predictors of functional impairment in pediatric obsessive-compulsive disorder. J Anxiety Disord. 2010;24(2):275–283.
   PubMed Web of Science ®Google Scholar
• Wewetzer C, Jans T, Müller B, et al. Long-term outcome and prognosis of obsessive-compulsive disorder with onset in childhood or adolescence. Eur Child Adolesc Psychiatry. 2001;10(1):37–46.
   PubMed Web of Science ®Google Scholar
• Hirschtritt ME, Bloch MH, Mathews CA. Obsessive-compulsive disorder: advances in diagnosis and treatment. J Am Med Assoc. 2017;317(13):1358–1367.
   PubMed Web of Science ®Google Scholar
• Taylor S, Asmundson GJG, Jang KL. Etiology of obsessions and compulsions: general and specific genetic and environmental factors. Psychiatry Res. 2016;237:17–21.
   PubMed Web of Science ®Google Scholar
• Hazari N, Narayanaswamy JC, Venkatasubramanian G. Neuroimaging findings in obsessive–compulsive disorder: a narrative review to elucidate neurobiological underpinnings. Indian J Psychiatry. 2019;61(7):9–29.
   Web of Science ®Google Scholar
• Ozcan H, Ozer S, Yagcioglu S. Neuropsychological, electrophysiological and neurological impairments in patients with obsessive compulsive disorder, their healthy siblings and healthy controls: identifying potential endophenotype(s). Psychiatry Res. 2016;240:110–117.
   PubMed Web of Science ®Google Scholar
• Taylor S. Disorder-specific genetic factors in obsessive-compulsive disorder: a comprehensive meta-analysis. Am J Med Genet B Neuropsychiatr Genet. 2016;171B(3):325–332.
   PubMedGoogle Scholar
• Gerentes M, Pelissolo A, Rajagopal K, et al. Obsessive-compulsive disorder: autoimmunity and neuroinflammation. Curr Psychiatry Rep. 2019;21(8):78.
   PubMed Web of Science ®Google Scholar
• Frick L, Pittenger C. Microglial dysregulation in OCD, tourette syndrome, and PANDAS. J Immunol Res. 2016;2016:8606057–8606058.
   PubMed Web of Science ®Google Scholar
• Bachiller S, Jiménez-Ferrer I, Paulus A, et al. Microglia in neurological diseases: a road map to brain-disease dependent-inflammatory response. Front Cell Neurosci. 2018;12:488–417.
   PubMed Web of Science ®Google Scholar
• Ramirez K, Fornaguera-Trìas J, Sheridan JF. 2017. Stress-induced microglia activation and monocyte trafficking to the brain underlie the development of anxiety and depression. In Current topics in behavioral neurosciences.  Berlin, Germany: Springer Cham. p. 155–172.
   Google Scholar
• Stein DJ, Vasconcelos MF, Albrechet-Souza L, et al. Microglial over-activation by social defeat stress contributes to anxiety-and depressive-like behaviors. Front Behav Neurosci. 2017;11:207.
   PubMed Web of Science ®Google Scholar
• Donato R. S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. Int J Biochem Cell Biol. 2001;33(7):637–668.
   PubMed Web of Science ®Google Scholar
• Donato R, Cannon R, Sorci B, et al. Functions of S100 proteins. CMM. 2012;13(1):24–57.
   Web of Science ®Google Scholar
• Donato R, Sorci G, Riuzzi F, et al. S100B's double life: intracellular regulator and extracellular signal. Biochim Biophys Acta. 2009;1793(6):1008–1022.
   PubMed Web of Science ®Google Scholar
• Alexanian AR, Bamburg JR. Neuronal survival activity of s100betabeta is enhanced by calcineurin inhibitors and requires activation of NF-kappaB. Faseb J. 1999;13(12):1611–1620.
   PubMed Web of Science ®Google Scholar
• Mariggió MA, Fulle S, Calissano P, et al. The brain protein S-100ab induces apoptosis in PC12 cells. Neuroscience. 1994;60(1):29–35.
   PubMed Web of Science ®Google Scholar
• Michetti F, D'Ambrosi N, Toesca A, et al. The S100B story: from biomarker to active factor in neural injury. J Neurochem. 2019;148(2):168–187.
   PubMed Web of Science ®Google Scholar
• Kroksmark H, Vinberg M. Does S100B have a potential role in affective disorders? A literature review. Nord J Psychiatry. 2018;72(7):462–470.
   PubMed Web of Science ®Google Scholar
• Schümberg K, Polyakova M, Steiner J, et al. Serum s100b is related to illness duration and clinical symptoms in Schizophrenia-A meta-regression analysis. Front Cell Neurosci. 2016;10:46.
   PubMed Web of Science ®Google Scholar
• Tomova A, Keményová P, Filčíková D, et al. Plasma levels of glial cell marker S100B in children with autism. Physiol Res. 2019;68:315–323.
   Web of Science ®Google Scholar
• Foa EB, Coles M, Huppert JD, et al. Development and validation of a child version of the obsessive compulsive inventory. Behav Ther. 2010;41(1):121–132.
   PubMed Web of Science ®Google Scholar
• Seçer I. Adapting the child version of obsessive-compulsive inventory into Turkish: the study of reliability and validity. Educ Sci. 2014;39(176):355–367.
   Web of Science ®Google Scholar
• Liu L, Li Y, Van Eldik LJ, et al. S100B-induced microglial and neuronal IL-1 expression is mediated by cell type-specific transcription factors. J Neurochem. 2005;92(3):546–553.
   PubMed Web of Science ®Google Scholar
• Ponath G, Schettler C, Kaestner F, et al. Autocrine S100B effects on astrocytes are mediated via RAGE. J Neuroimmunol. 2007;184(1–2):214–222.
   PubMed Web of Science ®Google Scholar
• Sheng JG, Ito K, Skinner RD, et al. In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis. Neurobiol Aging. 1996;17(5):761–766.
   PubMed Web of Science ®Google Scholar
• Çolak Sivri R, Bilgiç A, Kılınç İ. Cytokine, chemokine and BDNF levels in medication-free pediatric patients with obsessive–compulsive disorder. Eur Child Adolesc Psychiatry. 2018;27(8):977–984.
   PubMed Web of Science ®Google Scholar
• Şimşek Ş, Yüksel T, Çim A, et al. Serum cytokine profiles of children with obsessive-compulsive disorder shows the evidence of autoimmunity. IJNPPY. 2016;19(8):pyw027.
   Google Scholar
• Attwells S, Setiawan E, Wilson AA, et al. Inflammation in the neurocircuitry of obsessive-compulsive disorder. JAMA Psychiatry. 2017;74(8):833–840.
   PubMed Web of Science ®Google Scholar
• Behl A, Swami G, Sircar SS, et al. Relationship of possible stress-related biochemical markers to oxidative/antioxidative status in obsessive-compulsive disorder. Neuropsychobiology. 2010;61(4):210–214.
   PubMed Web of Science ®Google Scholar
• Kandemir H, Abuhandan M, Aksoy N, et al. Oxidative imbalance in child and adolescent patients with obsessive compulsive disorder. J Psychiatr Res. 2013;47(11):1831–1834.
   PubMed Web of Science ®Google Scholar
• Shrivastava A, Kar SK, Sharma E, et al. A study of oxidative stress biomarkers in obsessive compulsive disorder. J Obsessive Compuls Relat Disord. 2017;15:52–56.
   Web of Science ®Google Scholar
• Bilgiç A, Çolak Sivri R, Kılınç İ. 8-F2-isoprostane, thioredoxin and thioredoxin reductase levels in children with obsessive-compulsive disorder. Nord J Psychiatry. 2018;72(7):484–488.
   PubMed Web of Science ®Google Scholar
• Maia A, Oliveira J, Lajnef M, et al. Oxidative and nitrosative stress markers in obsessive-compulsive disorder: a systematic review and meta-analysis. Acta Psychiatr Scand. 2019;139(5):420–433.
   PubMed Web of Science ®Google Scholar
• Tsai MC, Huang TL. Decreased S100B serum levels after treatment in bipolar patients in a manic phase. Compr Psychiatry. 2017;74:27–34.
   PubMed Web of Science ®Google Scholar
• Shapiro LA, Bialowas-McGoey LA, Whitaker-Azmitia PM. Effects of S100B on serotonergic plasticity and neuroinflammation in the hippocampus in down syndrome and Alzheimer’s disease: studies in an S100B overexpressing mouse model. Cardiovasc Psychiatry Neurol. 2010;2010:1–13.
   Google Scholar
• Ramos AJ, Rubio MD, Defagot C, et al. The 5HT1A receptor agonist, 8-OH-DPAT, protects neurons and reduces astroglial reaction after ischemic damage caused by cortical devascularization. Brain Res. 2004;1030(2):201–220.
   PubMed Web of Science ®Google Scholar
• Yoon YJ, McKenna MC, Rollins DA, et al. Anxiety-associated alternative polyadenylation of the serotonin transporter mRNA confers translational regulation by hnRNPK. Proc Natl Acad Sci USA. 2013;110(28):11624–11629.
   PubMed Web of Science ®Google Scholar
• Stroth N, Svenningsson P. S100B interacts with the serotonin 5-HT7 receptor to regulate a depressive-like behavior. Eur Neuropsychopharmacol. 2015;25(12):2372–2380.
   PubMed Web of Science ®Google Scholar
• Derksen M, Feenstra M, Willuhn I, et al. 2020. The serotonergic system in obsessive-compulsive disorder. In: Muller C, Cunningham KA, editors. Handbook of behavioral neuroscience. London: Elsevier (Academic Press Inc). p. 865–891.
   Google Scholar
• Sinopoli VM, Burton CL, Kronenberg S, et al. A review of the role of serotonin system genes in obsessive-compulsive disorder. Neurosci Biobehav Rev. 2017;80:372–381.
   PubMed Web of Science ®Google Scholar
• Hedlund PB, Sutcliffe JG. The 5-HT7 receptor influences stereotypic behavior in a model of obsessive-compulsive disorder. Neurosci Lett. 2007;414(3):247–251.
   PubMed Web of Science ®Google Scholar
• Lin SH, Lee LT, Yang YK. Serotonin and mental disorders: a concise review on molecular neuroimaging evidence. Clin Psychopharmacol Neurosci. 2014;12(3):196–202.
   PubMed Web of Science ®Google Scholar
• Schroeter ML, Sacher J, Steiner J, et al. Serum S100B represents a new biomarker for mood disorders. Curr Drug Targets. 2013;14(11):1237–1248.
   PubMed Web of Science ®Google Scholar
• Schroeter ML, Abdul-Khaliq H, Krebs M, et al. Neuron-specific enolase is unaltered whereas S100B is elevated in serum of patients with schizophrenia-original research and meta-analysis. Psychiatry Res. 2009;167(1–2):66–72.
   PubMed Web of Science ®Google Scholar
• Steiner J, Schiltz K, Walter M, et al. S100B serum levels are closely correlated with body mass index: an important caveat in neuropsychiatric research. Psychoneuroendocrinology. 2010;35(2):321–324.
   PubMed Web of Science ®Google Scholar
• Ferri GL, Probert L, Cocchia D, et al. Evidence for the presence of S-100 protein in the glial component of the human enteric nervous system. Nature. 1982;297(5865):409–410.
   PubMed Web of Science ®Google Scholar
• Hofmann MA, Drury S, Fu C, et al. RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. Cell. 1999;97(7):889–901.
   PubMed Web of Science ®Google Scholar
• Turco F, Sarnelli G, Cirillo C, et al. Enteroglial-derived S100B protein integrates bacteria-induced Toll-like receptor signalling in human enteric glial cells. Gut. 2014;63(1):105–115.
   PubMed Web of Science ®Google Scholar
• Jung TD, Jung PS, Raveendran L, et al. Changes in gut microbiota during development of compulsive checking and locomotor sensitization induced by chronic treatment with the dopamine agonist quinpirole. Behav Pharmacol. 2018;29(2 and 3-Spec Issue):211–224.
   PubMed Web of Science ®Google Scholar
• Macphail EC, Reimer R, Arnold PD. A314 A characterization of nutrition status and gut microbiota in obsessive-compulsive disorder (OCD) in youth. J Can Assoc Gastroenterol. 2018;1(suppl_2):451–452.
   Google Scholar
• Scheepers IM, Cryan JF, Bastiaanssen TFS, et al. Natural compulsive-like behaviour in the deer mouse (Peromyscus maniculatus bairdii) is associated with altered gut microbiota composition. Eur J Neurosci. 2020;51(6):1419–1427.
   PubMed Web of Science ®Google Scholar