School performance and genetic propensities for educational attainment and depression in the etiology of self-harm: a Danish population-based study

References

• Morthorst B, Soegaard B, Nordentoft M, et al. Incidence rates of deliberate self-harm in Denmark 1994-2011. Crisis. 2016;37(4):256–264.
   PubMedGoogle Scholar
• Carroll R, Metcalfe C, Gunnell D. Hospital presenting self-harm and risk of fatal and non-fatal repetition: systematic review and meta-analysis. PLOS One. 2014;9(2):e89944.
   PubMed Web of Science ®Google Scholar
• Kendler KS, Ohlsson H, Sundquist J, et al. The sources of parent-child transmission of risk for suicide attempt and deaths by suicide in Swedish National Samples. Am J Psychiatry. 2020;177(10):928–935.
   PubMed Web of Science ®Google Scholar
• Erlangsen A, Appadurai V, Wang Y, et al. Genetics of suicide attempts in individuals with and without mental disorders: a population-based genome-wide association study. Mol Psychiatry. 2020;25(10):2410–2421.
   PubMed Web of Science ®Google Scholar
• Hawton K, Saunders KE, O'Connor RC. Self-harm and suicide in adolescents. Lancet. 2012;379(9834):2373–2382.
   PubMed Web of Science ®Google Scholar
• Jablonska B, Lindberg L, Lindblad F, et al. School performance and hospital admissions due to self-inflicted injury: a Swedish National Cohort Study. Int J Epidemiol. 2009;38(5):1334–1341.
   PubMed Web of Science ®Google Scholar
• Kosidou K, Dalman C, Fredlund P, et al. School performance and the risk of suicide attempts in young adults: a longitudinal population-based study. Psychol Med. 2014;44(6):1235–1243.
   PubMed Web of Science ®Google Scholar
• Sörberg Wallin A, Zeebari Z, Lager A, et al. Suicide attempt predicted by academic performance and childhood IQ: a cohort study of 26 000 children. Acta Psychiatr Scand. 2018;137(4):277–286.
   PubMed Web of Science ®Google Scholar
• Björkenstam C, Weitoft GR, Hjern A, et al. School grades, parental education and suicide—a national register-based cohort study. J Epidemiol Community Health. 2011;65(11):993–998.
   PubMed Web of Science ®Google Scholar
• Jablonska B, Lindblad F, Östberg V, et al. A national cohort study of parental socioeconomic status and non-fatal suicidal behaviour-the mediating role of school performance. BMC Public Health. 2012;12:17.
   PubMed Web of Science ®Google Scholar
• Brunner R, Parzer P, Haffner J, et al. Prevalence and psychological correlates of occasional and repetitive deliberate self-harm in adolescents. Arch Pediatr Adolesc Med. 2007;161(7):641–649.
   PubMed Web of Science ®Google Scholar
• Levey DF, Polimanti R, Cheng Z, et al. Genetic associations with suicide attempt severity and genetic overlap with major depression. Transl Psychiatry. 2019;9(1):22.
   PubMedGoogle Scholar
• Mullins N, Bigdeli TB, Børglum AD, et al. GWAS of suicide attempt in psychiatric disorders and association with major depression polygenic risk scores. Am J Psychiatry. 2019;176(8):651–660.
   PubMed Web of Science ®Google Scholar
• Ruderfer DM, Walsh CG, Aguirre MW, et al. Significant shared heritability underlies suicide attempt and clinically predicted probability of attempting suicide. Mol Psychiatry. 2020;25(10):2422–2430.
   PubMed Web of Science ®Google Scholar
• Strawbridge RJ, Ward J, Ferguson A, et al. Identification of novel genome-wide associations for suicidality in UK biobank, genetic correlation with psychiatric disorders and polygenic association with completed suicide. EBioMedicine. 2019;41:517–525.
   PubMed Web of Science ®Google Scholar
• Laursen TM, Trabjerg BB, Mors O, et al. Association of the polygenic risk score for schizophrenia with mortality and suicidal behavior – a Danish population-based study. Schizophr Res. 2017;184:122–127.
   PubMed Web of Science ®Google Scholar
• Taquet M, Smith SM, Prohl AK, et al. A structural brain network of genetic vulnerability to psychiatric illness. Mol Psychiatry. 2021;26(6):2089–2100.
   PubMed Web of Science ®Google Scholar
• Selzam S, Krapohl E, Von Stumm S, et al. Predicting educational achievement from DNA. Mol Psychiatry. 2017;22(2):267–272.
   PubMed Web of Science ®Google Scholar
• Sørensen HJ, Debost JC, Agerbo E, et al. Polygenic risk scores, school achievement, and risk for schizophrenia: a Danish Population-Based Study. Biol Psychiatry,. 2018;84(9):684–691.
   PubMed Web of Science ®Google Scholar
• Pedersen CB. The Danish civil registration system. Scand J Public Health. 2011;39(7 Suppl):22–25.
   PubMed Web of Science ®Google Scholar
• Nørgaard-Pedersen B, Hougaard DM. Storage policies and use of the Danish newborn screening biobank. J Inherit Metab Dis. 2007;30(4):530–536.
   PubMed Web of Science ®Google Scholar
• Mors O, Perto GP, Mortensen PB. The Danish psychiatric central research register. Scand J Public Health. 2011;39(7 Suppl):54–57.
   PubMedGoogle Scholar
• World Health, O. ICD-10 classification of mental and behavioural disorders: diagnostic criteria for research. Albany, Switzerland: World Health Organization; 1993.
   Google Scholar
• Pedersen CB, Bybjerg-Grauholm J, Pedersen MG, et al. The iPSYCH2012 case-cohort sample: new directions for unravelling genetic and environmental architectures of severe mental disorders. Mol Psychiatry. 2018;23(1):6–14.
   PubMed Web of Science ®Google Scholar
• Grove J, Ripke S, Als TD, et al. Identification of common genetic risk variants for autism spectrum disorder. Nat Genet. 2019;51(3):431–444.
   PubMed Web of Science ®Google Scholar
• Wray NR, Lee SH, Mehta D, et al. Research review: polygenic methods and their application to psychiatric traits. J Child Psychol Psychiatry. 2014;55(10):1068–1087.
   PubMed Web of Science ®Google Scholar
• Lee JJ, Wedow R, Okbay A, et al. Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. Nat Genet. 2018;50(8):1112–1121.
   PubMed Web of Science ®Google Scholar
• Howard DM, Adams MJ, Clarke TK, et al. Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions. Nat Neurosci. 2019;22(3):343–352.
   PubMed Web of Science ®Google Scholar
• Jensen VM, Rasmussen AW. Danish education registers. Scand J Public Health. 2011;39(7 Suppl):91–94.
   PubMed Web of Science ®Google Scholar
• Lynge E, Sandegaard JL, Rebolj M. The Danish national patient register. Scand J Public Health. 2011;39(7 Suppl):30–33.
   PubMed Web of Science ®Google Scholar
• Nordentoft M, Mortensen PB, Pedersen CB. Absolute risk of suicide after first hospital contact in mental disorder. Arch Gen Psychiatry. 2011;68(10):1058–1064.
   PubMed Web of Science ®Google Scholar
• Petersson F, Baadsgaard M, Thygesen LC. Danish registers on personal labour market affiliation. Scand J Public Health. 2011;39(7 Suppl):95–98.
   PubMed Web of Science ®Google Scholar
• Searle SR, Speed FM, Milliken GA. Population marginal means in the linear model: an alternative to least squares means. Am Statistician. 1980;34:216–221.
   Web of Science ®Google Scholar
• Demontis D, Walters RK, Martin J, et al. Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder. Nat Genet. 2019;51(1):63–75.
   PubMed Web of Science ®Google Scholar
• O’Connor LJ, Price AL. Distinguishing genetic correlation from causation across 52 diseases and complex traits. Nat Genet. 2018;50(12):1728–1734.
   PubMed Web of Science ®Google Scholar
• Zhu Z, Zheng Z, Zhang F, et al. Causal associations between risk factors and common diseases inferred from GWAS summary data. Nat Commun. 2018;9(1):224.
   PubMedGoogle Scholar
• Peyrot WJ, Lee SH, Milaneschi Y, et al. The association between lower educational attainment and depression owing to shared genetic effects? Results in ∼25,000 subjects. Mol Psychiatry. 2015;20(6):735–743.
   PubMed Web of Science ®Google Scholar
• Belsky DW, Moffitt TE, Corcoran DL, et al. The genetics of success: how single-nucleotide polymorphisms associated with educational attainment relate to Life-Course development. Psychol Sci. 2016;27(7):957–972.
   PubMed Web of Science ®Google Scholar
• Salvatore JE, Barr PB, Stephenson M, et al. Sibling comparisons elucidate the associations between educational attainment polygenic scores and alcohol, nicotine and cannabis. Addiction. 2020;115(2):337–346.
   PubMed Web of Science ®Google Scholar
• Orri M, Séguin JR, Castellanos-Ryan N, et al. A genetically informed study on the association of cannabis, alcohol, and tobacco smoking with suicide attempt. Mol Psychiatry. 2021;26(9):5061–5070.
   PubMed Web of Science ®Google Scholar
• Martin AR, Daly MJ, Robinson EB, et al. Predicting polygenic risk of psychiatric disorders. Biol Psychiatry. 2019;86(2):97–109.
   PubMed Web of Science ®Google Scholar
• Visscher PM, Wray NR, Zhang Q, et al. 10 Years of GWAS discovery: biology, function, and translation. Am J Hum Genet. 2017;101(1):5–22.
   PubMed Web of Science ®Google Scholar
• Agerbo E, Trabjerg BB, Borglum AD, et al. Risk of early-onset depression associated with polygenic liability, parental psychiatric history, and socioeconomic status. JAMA Psychiatry. 2021;78(4):387.
   PubMed Web of Science ®Google Scholar
• Torkamani A, Wineinger NE, Topol EJ. The personal and clinical utility of polygenic risk scores. Nat Rev Genet. 2018;19(9):581–590.
   PubMed Web of Science ®Google Scholar
• Murray GK, Lin T, Austin J, et al. Could polygenic risk scores be useful in psychiatry?: a review. JAMA Psychiatry. 2021;78(2):210–219.
   PubMed Web of Science ®Google Scholar
• Wray NR, Lin, T, Austin J, et al. From basic science to clinical application of polygenic risk scores: a primer. JAMA Psychiatry. 2021;78(1):101–109.
   PubMed Web of Science ®Google Scholar