596
Views
4
CrossRef citations to date
0
Altmetric
Review

Keeping an ‘eye’ on ocular GVHD

, &
Pages 135-142 | Received 22 Apr 2021, Accepted 20 Jun 2021, Published online: 19 Sep 2021

References

  • Hill GR, Betts BC, Tkachev V, et al. Current concepts and advances in graft-versus-host disease immunology. Annu Rev Immunol. 2021;39:19–49.
  • Styczyński J, Tridello G, Koster L, et al. Death after hematopoietic stem cell transplantation: changes over calendar year time, infections and associated factors. Bone Marrow Transplant. 2020;55:126–136.
  • Filipovich AH, Weisdorf D, Pavletic S, et al. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: i. Diagnosis and staging working group report. Biol Blood Marrow Transplant. 2005;11:945–956.
  • Flowers ME, Inamoto Y, Carpenter PA, et al. Comparative analysis of risk factors for acute graft-versus-host disease and for chronic graft-versus-host disease according to National Institutes of Health consensus criteria. Blood. 2011;117:3214–3219.
  • Jagasia MH, Greinix HT, Arora M, et al. National institutes of health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: i. The 2014 diagnosis and staging working group report. Biol Blood Marrow Transplant. 2015;21:389–401.e381.
  • Kollman C, Howe CW, Anasetti C, et al. Donor characteristics as risk factors in recipients after transplantation of bone marrow from unrelated donors: the effect of donor age. Blood. 2001;98:2043–2051.
  • Petersdorf EW. Which factors influence the development of GVHD in HLA-matched or mismatched transplants? Best Pract Res Clin Haematol. 2017;30:333–335.
  • Fürst D, Neuchel C, Tsamadou C, et al. HLA matching in unrelated stem cell transplantation up to date. Transfus Med Hemother. 2019;46:326–336.
  • Inamoto Y, Valdés-Sanz N, Ogawa Y, et al. ocular graft-versus-host disease after hematopoietic cell transplantation: expert review from the late effects and quality of life working committee of the center for international blood and marrow transplant research and transplant complications working party of the european society of blood and marrow transplantation. Biol Blood Marrow Transplant. 2019;25:e46–e54.
  • Munir SZ, Aylward J. A review of ocular graft-versus-host disease. Optom Vis Sci. 2017;94:545–555.
  • Anderson NG, Regillo C. Ocular manifestations of graft versus host disease. Curr Opin Ophthalmol. 2004;15:503–507.
  • Jacobs R, Tran U, Chen H, et al. Prevalence and risk factors associated with development of ocular GVHD defined by NIH consensus criteria. Bone Marrow Transplant. 2012;47:1470–1473.
  • Na KS, Yoo YS, Mok JW, et al. Incidence and risk factors for ocular GVHD after allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant. 2015;50:1459–1464.
  • Uchino M, Ogawa Y, Uchino Y, et al. Comparison of stem cell sources in the severity of dry eye after allogeneic haematopoietic stem cell transplantation. Br J Ophthalmol. 2012;96:34–37.
  • Kamoi M, Ogawa Y, Uchino M, et al. Donor-recipient gender difference affects severity of dry eye after hematopoietic stem cell transplantation. Eye (Lond). 2011;25:860–865.
  • Wang JC, Teichman JC, Mustafa M, et al. Risk factors for the development of ocular graft-versus-host disease (GVHD) dry eye syndrome in patients with chronic GVHD. Br J Ophthalmol. 2015;99:1514–1518.
  • Balaram M, Dana MR. Phacoemulsification in patients after allogeneic bone marrow transplantation. Ophthalmology. 2001;108:1682–1687.
  • Qiu Y, Hong J, Peng R. Manifestation of clinical categories of ocular graft-versus-host disease. J Ophthalmol. 2018;2018:6430953.
  • Dietrich-Ntoukas T, Cursiefen C, Westekemper H, et al. Diagnosis and treatment of ocular chronic graft-versus-host disease: report from the German-Austrian-Swiss Consensus Conference on Clinical Practice in chronic GVHD. Cornea. 2012;31:299–310.
  • Rojas B, Cuhna R, Zafirakis P, et al. Cell populations and adhesion molecules expression in conjunctiva before and after bone marrow transplantation. Exp Eye Res. 2005;81:313–325.
  • Allan EJ, Flowers ME, Lin MP, et al. Visual acuity and anterior segment findings in chronic graft-versus-host disease. Cornea. 2011;30:1392–1397.
  • Giannaccare G, Pellegrini M, Bernabei F, et al. Ocular surface system alterations in ocular graft-versus-host disease: all the pieces of the complex puzzle. Graefes Arch Clin Exp Ophthalmol. 2019;257:1341–1351.
  • Hwang HS, Ha M, Kim HS, et al. Longitudinal analysis of meibomian gland dropout in patients with ocular graft-versus-host disease. Ocul Surf. 2019;17:464–469.
  • Dikmetas O, Kocabeyoglu S, Mocan MC. The association between meibomian gland atrophy and corneal subbasal nerve loss in patients with chronic ocular graft-versus-host disease. Curr Eye Res. 2021;46(6):796–801.
  • Hassan AS, Clouthier SG, Ferrara JL, et al. Lacrimal gland involvement in graft-versus-host disease: a murine model. Invest Ophthalmol Vis Sci. 2005;46:2692–2697.
  • Kim S, Yoo YS, Kim HS, et al. Changes of meibomian glands in the early stage of post hematopoietic stem cell transplantation. Exp Eye Res. 2017;163:85–90.
  • Kusne Y, Temkit M, Khera N, et al. Conjunctival subepithelial fibrosis and meibomian gland atrophy in ocular graft-versus-host disease. Ocul Surf. 2017;15:784–788.
  • Ogawa Y, Kim SK, Dana R, et al. International chronic ocular graft-vs-host-disease (GVHD) consensus group: proposed diagnostic criteria for chronic GVHD (Part I). Sci Rep. 2013;3:3419.
  • Rapoport Y, Freeman T, Koyama T, et al. Validation of International chronic ocular graft-versus-host disease (GVHD) group diagnostic criteria as a chronic ocular GVHD-specific metric. Cornea. 2017;36:258–263.
  • Schargus M, Meyer-ter-vehn T, Menrath J, et al. correlation between tear film osmolarity and the disease score of the international chronic ocular graft-versus-host-disease consensus group in hematopoietic stem cell transplantation patients. Cornea. 2015;34:911–916.
  • Shikari H, Antin JH, Dana R. Ocular graft-versus-host disease: a review. Surv Ophthalmol. 2013;58:233–251.
  • Hosseini H, Kumar PV, Geramizadeh B, et al. Conjunctival scrape cytology findings in patients with chronic graft-versus-host disease following allogeneic bone marrow transplantation. Acta Cytol. 2010;54:272–276.
  • Nassiri N, Eslani M, Panahi N, et al. Ocular graft versus host disease following allogeneic stem cell transplantation: a review of current knowledge and recommendations. J Ophthalmic Vis Res. 2013;8:351–358.
  • Hu B, Qiu Y, Hong J. Tear cytokine levels in the diagnosis and severity assessment of ocular chronic graft-versus-host disease(GVHD). Ocul Surf. 2020;18:298–304.
  • Nair S, Vanathi M, Mahapatra M, et al. Tear inflammatory mediators and protein in eyes of post allogenic hematopoeitic stem cell transplant patients. Ocul Surf. 2018;16:352–367.
  • de Almeida Borges D, Alborghetti MR. Franco Paes Leme A et al. Tear proteomic profile in three distinct ocular surface diseases: keratoconus, pterygium, and dry eye related to graft-versus-host disease. Clin Proteomics. 2020;17:42.
  • Berchicci L, Iuliano L, Miserocchi E, et al. Tear osmolarity in ocular graft-versus-host disease. Cornea. 2014;33:1252–1256.
  • West RH, Szer J, Pedersen JS. Ocular surface and lacrimal disturbances in chronic graft-versus-host disease: the role of conjunctival biopsy. Aust N Z J Ophthalmol. 1991;19:187–191.
  • Wang Y, Ogawa Y, Dogru M, et al. Baseline profiles of ocular surface and tear dynamics after allogeneic hematopoietic stem cell transplantation in patients with or without chronic GVHD-related dry eye. Bone Marrow Transplant. 2010;45:1077–1083.
  • Giannaccare G, Bonifazi F, Sessa M, et al. Ocular surface analysis in hematological patients before and after allogeneic hematopoietic stem cell transplantation: implication for daily clinical practice. Eye (Lond). 2017;31:1417–1426.
  • Giannaccare G, Bonifazi F, Sebastiani S, et al. meibomian gland dropout in hematological patients before hematopoietic stem cell transplantation. Cornea. 2018;37:1264–1269.
  • Jeppesen H, Sengeløv H, Eriksson F, et al. Chronic ocular graft-versus-host disease after allogeneic haematopoietic stem cell transplantation in Denmark - factors associated with risks and rates in adults according to conditioning regimen. Bone Marrow Transplant. 2021;56:144–154.
  • Pellegrini M, Giannaccare G, Bernabei F, et al. Longitudinal corneal endothelial cell changes in patients undergoing hematopoietic stem cell transplantation. In: Cornea; 2021;40(4):462–466.
  • Schmid KE, Kornek GV, Scheithauer W, et al. Update on ocular complications of systemic cancer chemotherapy. Surv Ophthalmol. 2006;51:19–40.
  • Vishnevskia-Dai V, Rozner L, Berger R, et al. Ocular side effects of novel anti-cancer biological therapies. Sci Rep. 2021;11:787.
  • Kheirkhah A, Saboo US, Abud TB, et al. Reduced corneal endothelial cell density in patients with dry eye disease. Am J Ophthalmol. 2015;159:1022–1026.e1022.
  • Kheirkhah A, Satitpitakul V, Hamrah P, et al. Patients with dry eye disease and low subbasal nerve density are at high risk for accelerated corneal endothelial cell loss. Cornea. 2017;36:196–201.
  • Amparo F, Shikari H, Saboo U, et al. Corneal fluorescein staining and ocular symptoms but not Schirmer test are useful as indicators of response to treatment in chronic ocular GVHD. Ocul Surf. 2018;16:377–381.
  • Saboo US, Amparo F, Shikari H, et al. Prevalence of ocular hypertension and glaucoma in patients with chronic ocular graft-versus-host disease. Graefes Arch Clin Exp Ophthalmol. 2016;254:923–928.
  • Yu Q, Wang H, Zhang L, et al. Advances in the treatment of graft-versus-host disease with immunomodulatory cells. Int Immunopharmacol. 2021;92:107349.
  • Phulke S, Kaushik S, Kaur S, et al. Steroid-induced Glaucoma: an Avoidable Irreversible Blindness. J Curr Glaucoma Pract. 2017;11:67–72.
  • Tahmaz V, Wiesen MHJ, Gehlsen U, et al. Detection of systemic immunosuppressants in autologous serum eye drops (ASED) in patients with severe chronic ocular graft versus host disease. Graefes Arch Clin Exp Ophthalmol. 2021;259:121–128.
  • Zeiser R, Blazar BR. Preclinical models of acute and chronic graft-versus-host disease: how predictive are they for a successful clinical translation? Blood. 2016;127:3117–3126.
  • Negrin RS. Immune regulation in hematopoietic cell transplantation. Bone Marrow Transplant. 2019;54:765–768.
  • Azari AA, Karadag R, Kanavi MR, et al. Safety and efficacy of autologous serum eye drop for treatment of dry eyes in graft-versus-host disease. Cutan Ocul Toxicol. 2017;36:152–156.
  • Anitua E, Muruzabal F, Tayebba A, et al. Autologous serum and plasma rich in growth factors in ophthalmology: preclinical and clinical studies. Acta Ophthalmol. 2015;93:e605–614.
  • Sanchez-Avila RM, Merayo-Lloves J, Muruzabal F, et al. Plasma rich in growth factors for the treatment of dry eye from patients with graft versus host diseases. Eur J Ophthalmol. 2020;30:94–103.
  • Xu M, Randleman JB, Chiu GB. Long-term descemetocele management with prosthetic replacement of the ocular surface ecosystem (PROSE) treatment. Eye Contact Lens. 2020;46:e7–e10.
  • Chiu GB, Theophanous C, Irvine JA. PROSE treatment in atypical ocular graft-versus-host disease. Optom Vis Sci. 2016;93:1444–1448.
  • Markey KA, MacDonald KP, Hill GR. The biology of graft-versus-host disease: experimental systems instructing clinical practice. Blood. 2014;124:354–362.
  • Reddy P, Ferrara JLM. Mouse models of graft-versus-host disease. In: StemBook. Cambridge (MA): Harvard Stem Cell Institute; 2008. Copyright: © 2009 Pavan Reddy and James L.M. Ferrara., 2008–2009;Feb 28.
  • Perez VL, Barsam A, Duffort S, et al. Novel scoring criteria for the evaluation of ocular graft-versus-host disease in a preclinical allogeneic hematopoietic stem cell transplantation animal model. Biol Blood Marrow Transplant. 2016;22:1765–1772.
  • Cooke KR, Kobzik L, Martin TR, et al. An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: i. The roles of minor H antigens and endotoxin. Blood. 1996;88:3230–3239.
  • Magone MT, Chan CC, Rizzo LV, et al. A novel murine model of allergic conjunctivitis. Clin Immunol Immunopathol. 1998;87:75–84.
  • Poe JC, Jia W, Di Paolo JA, et al. SYK inhibitor entospletinib prevents ocular and skin GVHD in mice. In: JCI Insight. 2018;3(19):e122430.
  • Pérez RL, Pérez-Simón JA, Caballero-Velazquez T, et al. Limbus damage in ocular graft-versus-host disease. Biol Blood Marrow Transplant. 2011;17:270–273.
  • Sánchez-Abarca LI, Hernández-Galilea E, Lorenzo R, et al. Human bone marrow stromal cells differentiate into corneal tissue and prevent ocular graft-versus-host disease in mice. Cell Transplant. 2015;24:2423–2433.
  • Martínez-Carrasco R, Sánchez-Abarca LI, Nieto-Gómez C, et al. Assessment of dry eye in a GVHD murine model: approximation through tear osmolarity measurement. Exp Eye Res. 2017;154:64–69.
  • Zhang Z, Yang WZ, Zhu ZZ, et al. Therapeutic effects of topical doxycycline in a benzalkonium chloride-induced mouse dry eye model. Invest Ophthalmol Vis Sci. 2014;55:2963–2974.
  • Shamloo K, Barbarino A, Alfuraih S, et al. Graft versus host disease-associated dry eye: role of ocular surface mucins and the effect of rebamipide, a mucin secretagogue. Invest Ophthalmol Vis Sci. 2019;60:4511–4519.
  • Herretes S, Ross DB, Duffort S, et al. Recruitment of donor t cells to the eyes during ocular GVHD in recipients of MHC-matched allogeneic hematopoietic stem cell transplants. Invest Ophthalmol Vis Sci. 2015;56:2348–2357.
  • Ogawa Y, He H, Mukai S, et al. Heavy chain-hyaluronan/pentraxin 3 from amniotic membrane suppresses inflammation and scarring in murine lacrimal gland and conjunctiva of chronic graft-versus-host disease. Sci Rep. 2017;7:42195.
  • Martínez-Carrasco R, Sánchez-Abarca LI, Nieto-Gómez C, et al. Subconjunctival injection of mesenchymal stromal cells protects the cornea in an experimental model of GVHD. Ocul Surf. 2019;17:285–294.
  • Yaguchi S, Ogawa Y, Shimmura S, et al. Angiotensin II type 1 receptor antagonist attenuates lacrimal gland, lung, and liver fibrosis in a murine model of chronic graft-versus-host disease. PLoS One. 2013;8:e64724.
  • Mukai S, Ogawa Y, Urano F, et al. Novel treatment of chronic graft-versus-host disease in mice using the ER stress reducer 4-phenylbutyric acid. Sci Rep. 2017;7:41939.
  • Yamane M, Ogawa Y, Mukai S, et al. Functional role of lacrimal gland fibroblasts in a mouse model of chronic graft-versus-host disease. Cornea. 2018;37:102–108.
  • Li W, Cao T, Luo C, et al. Crosstalk between ER stress, NLRP3 inflammasome, and inflammation. Appl Microbiol Biotechnol. 2020;104:6129–6140.
  • Sprenkle NT, Sims SG, Sánchez CL, et al. Endoplasmic reticulum stress and inflammation in the central nervous system. Mol Neurodegener. 2017;12:42.
  • Ohigashi H, Hashimoto D, Hayase E, et al. Ocular instillation of vitamin A-coupled liposomes containing HSP47 siRNA ameliorates dry eye syndrome in chronic GVHD. Blood Adv. 2019;3:1003–1010.
  • Royer DJ, Echegaray-Mendez J, Lin L, et al. Complement and CD4(+) T cells drive context-specific corneal sensory neuropathy. In: Elife. 2019;15(8):e48378.
  • He J, Ogawa Y, Mukai S, et al. In vivo confocal microscopy evaluation of ocular surface with graft-versus-host disease-related dry eye disease. Sci Rep. 2017;7:10720.
  • Stephens DN, McNamara NA. Altered mucin and glycoprotein expression in dry eye disease. Optom Vis Sci. 2015;92:931–938.
  • Zeiser R, Blazar BR. Acute graft-versus-host disease - biologic process, prevention, and therapy. N Engl J Med. 2017;377:2167–2179.
  • Zeiser R, Blazar BR. Pathophysiology of chronic graft-versus-host disease and therapeutic targets. N Engl J Med. 2017;377:2565–2579.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.