Modulation of Immune Response by B7 Family Molecules in Tumor Microenvironments

REFERENCES

• Anichini A., Vegetti C., Mortarini R. The paradox of T-cell-mediated antitumor immunity in spite of poor clinical outcome in human melanoma. Cancer Immunol. Immunother 2004; 53(10)855–864, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Ara G., Baher A., Storm N., Horan T., Baikalov C., Brisan E., Camacho R., Moore A., Goldman H., Kohno T., Cattley R. C., Van G., Gaida K., Zhang M., Whoriskey J. S., Fong D., Yoshinaga S. K. Potent activity of soluble B7RP-1-Fc in therapy of murine tumors in syngeneic hosts. Int. J. Cancer 2003; 103(4)501–507, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Baskar S., Ostrand-Rosenberg S., Nabavi N., Nadler L. M., Freeman G. J., Glimcher L. H. Constitutive expression of B7 restores immunogenicity of tumor cells expressing truncated major histocompatibility complex class II molecules. Proc. Natl. Acad. Sci. USA 1993; 90(12)5687–5690, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Beissert S., Bluestone J. A., Mindt I., Voskort M., Metze D., Mehling A., Luger T. A., Schwarz T., Grabbe S. Reduced ultraviolet-induced carcinogenesis in mice with a functional disruption in B7-mediated costimulation. J. Immunol 1999; 163(12)6725–6731, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Blanco B., Holliger P., Alvarez-Vallina L. Autocrine costimulation: tumor-specific CD28-mediated costimulation of T cells by in situ production of a bifunctional B7-anti-CEA diabody fusion protein. Cancer Gene Ther 2002; 9(3)275–281, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Blank C., Brown I., Peterson A. C., Spiotto M., Iwai Y., Honjo T., Gajewski T. F. PD-L1/B7H-1 inhibits the effector phase of tumor rejection by T cell receptor (TCR) transgenic CD8+ T cells. Cancer Res 2004; 64(3)1140–1145, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Bosshart H. Levels of B7-2 in tumor cells of Hodgkin's disease. Immunol. Lett 2004; 92(3)217–220, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Boxhorn H. K., Smith J. G., Chang Y. J., Guerry D., Lee W. M., Rodeck U., Turka L. A., Eck S. L. Adenoviral transduction of melanoma cells with B7-1: antitumor immunity and immunosuppressive factors. Cancer Immunol. Immunother 1998; 46(5)283–292, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Brodie D., Collins A. V., Iaboni A., Fennelly J. A., Sparks L. M., Xu X. N., van der Merwe P. A., Davis S.J. LICOS, a primordial costimulatory ligand?. Curr. Biol 2000; 10(6)333–336, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Brown J. A., Dorfman D. M., Ma F. R., Sullivan E. L., Munoz O., Wood C. R., Greenfield E. A., Freeman G. J. Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production. J. Immunol 2003; 170(3)1257–1266, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Brown R., Murray A., Pope B., Sze D., Gibson J., Ho P. J., Joshua D. B7+ T cells in myeloma: an acquired marker of prior chronic antigen presentation. Leuk. Lymphoma 2004; 45(2)363–371, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Carreno B. M., Collins M. The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responses. Annu. Rev. Immunol 2002; 202: 9–2053, [CSA]
   Google Scholar
• Carter L., Fouser L. A., Jussif J., Fitz L., Deng B., Wood C. R., Collins M., Honjo T., Freeman G. J., Carreno B. M. PD-1:PD-L inhibitory pathway affects both CD4(+) and CD8(+) T cells and is overcome by IL-2. Eur. J. Immunol 2002; 32(3)634–643, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Castriconi R., Dondero A., Augugliaro R., Cantoni C., Carnemolla B., Sementa A. R., Negri F., Conte R., Corrias M. V., Moretta L., Moretta A., Bottino C. Identification of 4Ig-B7-H3 as a neuroblastoma-associated molecule that exerts a protective role from an NK cell-mediated lysis. Proc. Natl. Acad. Sci. USA 2004; 101(34)12640–12645, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Chamberlain R. S., Carroll M. W., Bronte V., Hwu P., Warren S., Yang J. C., Nishimura M., Moss B., Rosenberg S. A., Restifo N. P. Costimulation enhances the active immunotherapy effect of recombinant anticancer vaccines. Cancer Res 1996; 56(12)2832–2836, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Chambers C. A., Kuhns M. S., Egen J. G., Allison J. P. CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy. Annu. Rev. Immunol 2001; 1956: 5–19594, [CSA]
   Google Scholar
• Chapoval A. I., Ni J., Lau J. S., Wilcox R. A., Flies D. B., Liu D., Dong H., Sica G. L., Zhu G., Tamada K., Chen L. B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nat. Immunol 2001; 2(3)269–274, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Chen L. Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity. Nat. Rev. Immunol 2004; 4(5)336–347, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Chen L., Ashe S., Brady W. A., Hellstrom I., Hellstrom K. E., Ledbetter J. A., McGowan P., Linsley P. S. Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4. Cell 1992; 71(7)1093–1102, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Chen Y., Li J., Zhang J., Zhao T., Zou L., Tang Y., Zhang X., Wu Y. Sinomenine inhibits B7-H1 and B7-DC expression on human renal tubular epithelial cells. Int. Immunopharmacol 2005; 5(9)1446–1457, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Choi I. H., Zhu G., Sica G. L., Strome S. E., Cheville J. C., Lau J. S., Zhu Y., Flies D. B., Tamada K., Chen L. Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family. J. Immunol 2003; 171(9)4650–4654, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Collins A. V., Brodie D. W., Gilbert R. J., Iaboni A., Manso-Sancho R., Walse B., Stuart D. I., van der Merwe P. A., Davis S. J. The interaction properties of costimulatory molecules revisited. Immunity 2002; 17(2)201–210, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Cormier J. N., Salgaller M. L., Prevette T., Barracchini K. C., Rivoltini L., Restifo N. P., Rosenberg S. A., Marincola F. M. Enhancement of cellular immunity in melanoma patients immunized with a peptide from MART-1/Melan A. Cancer J. Sci. Am 1997; 3(1)37–44, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Coyle A. J., Gutierrez-Ramos J. C. The expanding B7 superfamily: increasing complexity in costimulatory signals regulating T cell function. Nat. Immunol 2001; 2(3)203–209, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Curiel T. J., Coukos G., Zou L., Alvarez X., Cheng P., Mottram P., Evdemon-Hogan M., Conejo-Garcia J.R., Zhang L., Burow M., Zhu Y., Wei S., Kryczek I., Daniel B., Gordon A., Myers L., Lackner A., Disis M. L., Knutson K. L., Chen L., Zou W. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat. Med 2004; 10(9)942–949, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Diefenbach A., Tomasello E., Lucas M., Jamieson A. M., Hsia J. K., Vivier E., Raulet D. H. Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D. Nat. Immunol 2002; 3(12)1142–1149, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Dong H., Strome S. E., Salomao D. R., Tamura H., Hirano F., Flies D. B., Roche P. C., Lu J., Zhu G., Tamada K., Lennon V. A., Celis E., Chen L. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat. Med 2002; 8(8)793–800, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Dong H., Zhu G., Tamada K., Chen L. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat. Med 1999; 5(12)1365–1369, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Dudley M. E., Wunderlich J. R., Robbins P. F., Yang J. C., Hwu P., Schwartzentruber D. J., Topalian S. L., Sherry R., Restifo N. P., Hubicki A. M., Robinson M. R., Raffeld M., Duray P., Seipp C. A., Rogers-Freezer L., Morton K. E., Mavroukakis S. A., White D. E., Rosenberg S. A. Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes. Science 2002; 298(5594)850–854, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Eppihimer M. J., Gunn J., Freeman G. J., Greenfield E. A., Chernova T., Erickson J., Leonard J. P. Expression and regulation of the PD-L1 immunoinhibitory molecule on microvascular endothelial cells. Microcirculation 2002; 9(2)133–145, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Ferrone S., Finerty J. F., Jaffee E. M., Nabel G. J. How much longer will tumour cells fool the immune system?. Immunol. Today 2000; 21(2)70–72, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMedGoogle Scholar
• Freeman G. J., Long A. J., Iwai Y., Bourque K., Chernova T., Nishimura H., Fitz L. J., Malenkovich N., Okazaki T., Byrne M. C., Horton H. F., Fouser L., Carter L., Ling V., Bowman M. R., Carreno B. M., Collins M., Wood C. R., Honjo T. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med 2000; 192(7)1027–1034, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Gajewski T. F., Fallarino F., Ashikari A., Sherman M. Immunization of HLA-A2+ melanoma patients with MAGE-3 or MelanA peptide-pulsed autologous peripheral blood mononuclear cells plus recombinant human interleukin 12. Clin. Cancer Res 2001; 7(3 Suppl)895s–901s, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Ganss R., Hanahan D. Tumor microenvironment can restrict the effectiveness of activated antitumor lymphocytes. Cancer Res 1998; 58(20)4673–4681, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Gilfillan S., Ho E. L., Cella M., Yokoyama W. M., Colonna M. NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation. Nat. Immunol 2002; 3(12)1150–1155, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Greenfield E. A., Nguyen K. A., Kuchroo V. K. CD28/B7 costimulation: a review. Crit. Rev. Immunol 1998; 18(5)389–418, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Greenwald R. J., Freeman G. J., Sharpe A. H. The B7 family revisited. Annu. Rev. Immunol 2005; 2351: 5–23548, [CSA]
   Google Scholar
• Greenwald R. J., Boussiotis V. A., Lorsbach R. B., Abbas A. K., Sharpe A. H. CTLA-4 regulates induction of anergy in vivo. Immunity 2001; 14(2)145–155, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Grimbacher B., Warnatz K., Peter H. H. The immunological synapse for B-cell memory: the role of the ICOS and its ligand for the longevity of humoral immunity. Curr. Opin. Allergy Clin. Immunol 2003; 3(6)409–419, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Hathcock K. S., Laszlo G., Pucillo C., Linsley P., Hodes R. J. Comparative analysis of B7–1 and B7–2 costimulatory ligands: expression and function. J. Exp. Med 1994; 180(2)631–640, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• He X. H., Liu Y., Xu L. H., Zeng Y. Y. Cloning and identification of two novel splice variants of human PD-L2. Acta Biochim. Biophys. Sin. (Shanghai) 2004a; 36(4)284–289, [CSA]
   PubMed Web of Science ®Google Scholar
• He Y. F., Zhang G. M., Wang X. H., Zhang H., Yuan Y., Li D., Feng Z. H. Blocking programmed death-1 ligand-PD-1 interactions by local gene therapy results in enhancement of antitumor effect of secondary lymphoid tissue chemokine. J. Immunol 2004b; 173(8)4919–4928, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Hirano F., Kaneko K., Tamura H., Dong H., Wang S., Ichikawa M., Rietz C., Flies D. B., Lau J. S., Zhu G., Tamada K., Chen L. Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity. Cancer Res 2005; 65(3)1089–1096, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Hodi F. S., Mihm M. C., Soiffer R. J., Haluska F. G., Butler M., Seiden M. V., Davis T., Henry-Spires R., MacRae S., Willman A., Padera R., Jaklitsch M. T., Shankar S., Chen T. C., Korman A., Allison J. P., Dranoff G. Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients. Proc. Natl. Acad. Sci. USA 2003; 100(8)4712–4717, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Huang B., Zhao J., Li H., He K.L., Chen Y., Mayer L., Unkeless J. C., Xiong H. Toll-like receptors on tumor cells facilitate evasion of immune surveillance. Cancer Res 2005; 65(12)5009–5014, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Ishida M., Iwai Y., Tanaka Y., Okazaki T., Freeman G. J., Minato N., Honjo T. Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues. Immunol. Lett 2002; 84(1)57–62, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Iwai Y., Terawaki S., Honjo T. PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells. Int. Immunol 2005; 17(2)133–144, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Iwai Y., Terawaki S., Ikegawa M., Okazaki T., Honjo T. PD-1 inhibits antiviral immunity at the effector phase in the liver. J. Exp. Med 2003; 198(1)39–50, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Iwai Y., Ishida M., Tanaka Y., Okazaki T., Honjo T., Minato N. Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc. Natl. Acad. Sci. USA 2002; 99(19)12293–12297, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Jain A., Slansky J. E., Matey L. C., Allen H. E., Pardoll D. M., Schulick R. D. Synergistic effect of a granulocyte-macrophage colony-stimulating factor-transduced tumor vaccine and systemic interleukin-2 in the treatment of murine colorectal cancer hepatic metastases. Ann. Surg. Oncol 2003; 10(7)810–820, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Jansson A., Barnes E., Klenerman P., Harlen M., Sorensen P., Davis S. J., Nilsson P. A theoretical framework for quantitative analysis of the molecular basis of costimulation. J. Immunol 2005; 175(3)1575–1585, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Kim J., Myers A. C., Chen L., Pardoll D., Truong-Tran Q. A., Lane A., McDyer J., Fortuno L., Schleimer R. P. Constitutive and inducible expression of B7 family of ligands by human airway epithelial cells. Am. J. Respir. Cell Mol. Biol 2005; 33(3)280–289, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Kjaergaard J., Peng L., Cohen P. A., Drazba J. A., Weinberg A. D., Shu S. Augmentation versus inhibition: effects of conjunctional OX-40 receptor monoclonal antibody and IL-2 treatment on adoptive immunotherapy of advanced tumor. J. Immunol 2001; 167(11)6669–6677, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Konishi J., Yamazaki K., Azuma M., Kinoshita I., Dosaka-Akita H., Nishimura M. B7-H1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression. Clin. Cancer Res 2004; 10(15)5094–5100, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Kryczek I., Zou L., Rodriguez P., Zhu G, Wei S., Mottram P., Brumlik M., Cheng P., Curiel T., Myers L., Lackner A., Alvarez X., Ochoa A., Chen L., Zou W. B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma. J. Exp. Med 2006; 203(4)871–881, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Lane A. P., Saatian B., Yu X. Y., Spannhake E. W. mRNA for genes associated with antigen presentation are expressed by human middle meatal epithelial cells in culture. Laryngoscope 2004; 114(10)1827–1832, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Latchman Y., Wood C. R., Chernova T., Chaudhary D., Borde M., Chernova I., Iwai Y., Long A. J., Brown J. A., Nunes R., Greenfield E. A., Bourque K., Boussiotis V. A., Carter L. L., Carreno B. M., Malenkovich N., Nishimura H., Okazaki T., Honjo T., Sharpe A. H., Freeman G. J. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat. Immunol 2001; 2(3)261–268, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Leach D. R., Krummel M. F., Allison J. P. Enhancement of antitumor immunity by CTLA-4 blockade. Science 1996; 271(5256)1734–1736, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Lenschow D. J., Su G. H., Zuckerman L. A., Nabavi N., Jellis C. L., Gray G. S., Miller J., Bluestone J. A. Expression and functional significance of an additional ligand for CTLA-4. Proc. Natl. Acad. Sci. USA 1993; 90(23)11054–11058, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Ling V., Wu P. W., Finnerty H. F., Bean K. M., Spaulding V., Fouser L. A., Leonard J. P., Hunter S. E., Zollner R., Thomas J. L., Miyashiro J. S., Jacobs K. A., Collins M. Cutting edge: identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor. J. Immunol 2000; 164(4)1653–1657, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Liu X., Gao J. X., Wen J., Yin L., Li O., Zuo T., Gajewski T. F., Fu Y.X., Zheng P., Liu Y. B7DC/PDL2 promotes tumor immunity by a PD-1-independent mechanism. J. Exp. Med 2003; 197(12)1721–1730, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Liu X., Bai X. F., Wen J., Gao J. X., Liu J., Lu P., Wang Y., Zheng P., Liu Y. B7H costimulates clonal expansion of, and cognate destruction of tumor cells by, CD8(+) T lymphocytes in vivo. J. Exp. Med 2001; 194(9)1339–1348, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Lohr J., Knoechel B., Jiang S., Sharpe A. H., Abbas A. K. The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens. Nat. Immunol 2003; 4(7)664–669, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Lollini P. L., Forni G. Specific and nonspecific immunity in the prevention of spontaneous tumours. Immunol. Today 1999; 20(8)347–350, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMedGoogle Scholar
• Loser K., Scherer A., Krummen M. B., Varga G., Higuchi T., Schwarz T., Sharpe A. H., Grabbe S., Bluestone J. A., Beissert S. An important role of CD80/CD86-CTLA-4 signaling during photocarcinogenesis in mice. J. Immunol 2005; 174(9)5298–5305, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Luo L., Chapoval A. I., Flies D. B., Zhu G., Hirano F., Wang S., Lau J. S., Dong H., Tamada K., Flies A. S., Liu Y., Chen L. B7-H3 enhances tumor immunity in vivo by costimulating rapid clonal expansion of antigen-specific CD8+ cytolytic T cells. J. Immunol 2004; 173(9)5445–5450, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Lute K. D., May K. F., Lu P., Zhang H., Kocak E., Mosinger B., Wolford C., Phillips G., Caligiuri M. A., Zheng P., Liu Y. Human CTLA-4-knock-in mice unravel the quantitative link between tumor immunity and autoimmunity induced by anti-CTLA-4 antibodies. Blood 2005; 106(9)3127–3133, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Maeda A., Yamamoto K., Yamashita K., Asagoe K., Nohgawa M., Kita K., Iwasaki H., Ueda T., Takahashi A., Sasada M. The expression of co-stimulatory molecules and their relationship to the prognosis of human acute myeloid leukaemia: poor prognosis of B7–2-positive leukaemia. Br. J. Haematol 1998; 102(5)1257–1262, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Magnus T., Schreiner B., Korn T., Jack C., Guo H., Antel J., Ifergan I., Chen L., Bischof F., Bar-Or A., Wiendl H. Microglial expression of the B7 family member B7 homolog 1 confers strong immune inhibition: implications for immune responses and autoimmunity in the CNS. J. Neurosci 2005; 25(10)2537–2546, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Mak T. W., Shahinian A., Yoshinaga S. K., Wakeham A., Boucher L. M., Pintilie M., Duncan G., Gajewska B. U., Gronski M., Eriksson U., Odermatt B., Ho A., Bouchard D., Whorisky J. S., Jordana M., Ohashi P. S., Pawson T., Bladt F., Tafuri A. Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses. Nat. Immunol 2003; 4(8)765–772, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Mazanet M. M., Hughes C. C. B7-H1 is expressed by human endothelial cells and suppresses T cell cytokine synthesis. J. Immunol 2002; 169(7)3581–3588, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Melichar B., Nash M. A., Lenzi R., Platsoucas C. D., Freedman R. S. Expression of costimulatory molecules CD80 and CD86 and their receptors CD28, CTLA-4 on malignant ascites CD3+ tumour-infiltrating lymphocytes (TIL) from patients with ovarian and other types of peritoneal carcinomatosis. Clin. Exp. Immunol 2000; 119(1)19–27, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Mokyr M. B., Kalinichenko T., Gorelik L., Bluestone J. A. Realization of the therapeutic potential of CTLA-4 blockade in low-dose chemotherapy-treated tumor-bearing mice. Cancer Res 1998; 58(23)5301–5304, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Nestle F. O., Alijagic S., Gilliet M., Sun Y., Grabbe S., Dummer R., Burg G., Schadendorf D. Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells. Nat. Med 1998; 4(3)328–332, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Ogasawara K., Yoshinaga S. K., Lanier L. L. Inducible costimulator costimulates cytotoxic activity and IFN-gamma production in activated murine NK cells. J. Immunol 2002; 169(7)3676–3685, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Ohigashi Y., Sho M., Yamada Y., Tsurui Y., Hamada K., Ikeda N., Mizuno T., Yoriki R., Kashizuka H., Yane K., Tsushima F., Otsuki N., Yagita H., Azuma M., Nakajima Y. Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer. Clin. Cancer Res 2005; 11(8)2947–2953, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Orsini E., Guarini A., Chiaretti S., Mauro F. R., Foa R. The circulating dendritic cell compartment in patients with chronic lymphocytic leukemia is severely defective and unable to stimulate an effective T-cell response. Cancer Res 2003; 63(15)4497–4506, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Pardoll D. T cells and tumours. Nature 2001; 411(6841)1010–1012, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Pecher G., Haring A., Kaiser L., Thiel E. Mucin gene (MUC1) transfected dendritic cells as vaccine: results of a phase I/II clinical trial. Cancer Immunol. Immunother 2002; 51(11–12)669–673, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Perez V. L., Van Parijs L., Biuckians A., Zheng X. X., Strom T. B., Abbas A. K. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity 1997; 6(4)411–417, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Peterson A. C., Harlin H., Gajewski T. F. Immunization with Melan-A peptide-pulsed peripheral blood mononuclear cells plus recombinant human interleukin-12 induces clinical activity and T-cell responses in advanced melanoma. J. Clin. Oncol 2003; 21(12)2342–2348, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Phan G. Q., Yang J. C., Sherry R. M., Hwu P., Topalian S.L., Schwartzentruber D. J., Restifo N. P., Haworth L.R., Seipp C. A., Freezer L. J., Morton K. E., Mavroukakis S. A., Duray P. H., Steinberg S. M., Allison J. P., Davis T. A., Rosenberg S. A. Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma. Proc. Natl. Acad. Sci. USA 2003; 100(14)8372–8377, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Pope B., Brown R. D., Gibson J., Yuen E., Joshua D. B7-2-positive myeloma: incidence, clinical characteristics, prognostic significance, and implications for tumor immunotherapy. Blood 2000; 96(4)1274–1279, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Prasad D. V., Nguyen T., Li Z., Yang Y., Duong J., Wang Y., Dong C. Murine B7-H3 is a negative regulator of T cells. J. Immunol 2004; 173(4)2500–2506, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Prasad D. V., Richards S., Mai X. M., Dong C. B7S1, a novel B7 family member that negatively regulates T cell activation. Immunity 2003; 18(6)863–873, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Radhakrishnan S., Nguyen L. T., Ciric B., Flies D., Van Keulen V. P., Tamada K., Chen L., Rodriguez M., Pease L. R. Immunotherapeutic potential of B7‐DC (PD-L2) cross-linking antibody in conferring antitumor immunity. Cancer Res 2004; 64(14)4965–4972, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Richter G., Burdach S. ICOS: a new costimulatory ligand/receptor pair and its role in T-cell activion. Onkologie 2004; 27(1)91–95, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMedGoogle Scholar
• Rosenberg S. A., Yang J. C., Restifo N. P. Cancer immunotherapy: moving beyond current vaccines. Nat. Med 2004; 10(9)909–915, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Rosenberg S. A. Progress in human tumour immunology and immunotherapy. Nature 2001; 411(6835)380–384, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Saatian B., Yu X. Y., Lane A. P., Doyle T., Casolaro V., Spannhake E. W. Expression of genes for B7-H3 and other T cell ligands by nasal epithelial cells during differentiation and activation. Am. J. Physiol. Lung Cell. Mol. Physiol 2004; 287(1)L217–225, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Salceda S., Tang T., Kmet M., Munteanu A., Ghosh M., Macina R., Liu W., Pilkington G., Papkoff J. The immunomodulatory protein B7-H4 is overexpressed in breast and ovarian cancers and promotes epithelial cell transformation. Exp. Cell Res 2005; 306(1)128–141, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Salomon B., Bluestone J. A. Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation. Annu. Rev. Immunol 2001; 1922: 5–19252, [CSA]
   Google Scholar
• Saudemont A., Jouy N., Hetuin D., Quesnel B. NK cells that are activated by CXCL10 can kill dormant tumor cells that resist CTL-mediated lysis and can express B7-H1 that stimulates T cells. Blood 2005; 105(6)2428–2435, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Saudemont A., Quesnel B. In a model of tumor dormancy, long-term persistent leukemic cells have increased B7-H1 and B7.1 expression and resist CTL-mediated lysis. Blood 2004; 104(7)2124–2133, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Schreiner B., Wischhusen J., Mitsdoerffer M., Schneider D., Bornemann A., Melms A., Tolosa E., Weller M., Wiendl H. Expression of the B7-related molecule ICOSL by human glioma cells in vitro and in vivo. Glia 2003; 44(3)296–301, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Schwartz J. C., Zhang X., Fedorov A. A., Nathenson S. G., Almo S. C. Structural basis for co-stimulation by the human CTLA-4/B7-2 complex. Nature 2001; 410(6828)604–608, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Shin T., Yoshimura K., Shin T., Crafton E. B., Tsuchiya H., Housseau F., Koseki H., Schulick R. D., Chen L., Pardoll D. M. In vivo costimulatory role of B7‐DC in tuning T helper cell 1 and cytotoxic T lymphocyte responses. J. Exp. Med 2005; 201(10)1531–1541, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Sica G. L., Choi I. H., Zhu G., Tamada K., Wang S. D., Tamura H., Chapoval A. I., Flies D. B., Bajorath J., Chen L. B7-H4, a molecule of the B7 family, negatively regulates T cell immunity. Immunity 2003; 18(6)849–861, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Singh S., Ross S. R., Acena M., Rowley D. A., Schreiber H. Stroma is critical for preventing or permitting immunological destruction of antigenic cancer cells. J. Exp. Med 1992; 175(1)139–146, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Sinkovics J. G., Horvath J. C. Vaccination against human cancers (review). Int. J. Oncol 2000; 16(1)81–96, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Smith K. M., Brewer J. M., Webb P., Coyle A. J., Gutierrez-Ramos C., Garside P. Inducible costimulatory molecule-B7-related protein 1 interactions are important for the clonal expansion and B cell helper functions of naive, Th1, and Th2 T cells. J. Immunol 2003; 170(5)2310–2315, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Stamper C. C., Zhang Y., Tobin J. F., Erbe D. V., Ikemizu S., Davis S. J., Stahl M. L., Seehra J., Somers W. S., Mosyak L. Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses. Nature 2001; 410(6828)608–611, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Subudhi S. K., Zhou P., Yerian L. M., Chin R. K., Lo J.C., Anders R. A., Sun Y., Chen L., Wang Y., Alegre M. L., Fu Y. X. Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection. J. Clin. Invest 2004; 113(5)694–700, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Suh W. K., Wang S. X., Jheon A. H., Moreno L., Yoshinaga S. K., Ganss B., Sodek J., Grynpas M. D., Mak T. W. The immune regulatory protein B7-H3 promotes osteoblast differentiation and bone mineralization. Proc. Natl. Acad. Sci. USA 2004; 101(35)12969–12973, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Suh W. K., Gajewska B. U., Okada H., Gronski M. A., Bertram E. M., Dawicki W., Duncan G. S., Bukczynski J., Plyte S., Elia A., Wakeham A., Itie A., Chung S., Da Costa J., Arya S., Horan T., Campbell P., Gaida K., Ohashi P. S., Watts T. H., Yoshinaga S. K., Bray M. R., Jordana M., Mak T. W. The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses. Nat. Immunol 2003; 4(9)899–906, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Sun M., Richards S., Prasad D. V., Mai X. M., Rudensky A., Dong C. Characterization of mouse and human B7-H3 genes. J. Immunol 2002; 168(12)6294–6297, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Sun X., Vale M., Leung E., Kanwar J. R., Gupta R., Krissansen G. W. Mouse B7-H3 induces antitumor immunity. Gene Ther 2003; 10(20)1728–1734, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Swallow M. M., Wallin J. J., Sha W. C. B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFalpha. Immunity 1999; 11(4)423–432, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Sykulev Y., Brunmark A., Tsomides T. J., Kageyama S., Jackson M., Peterson P. A., Eisen H. N. High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins. Proc. Natl. Acad. Sci. USA 1994; 91(24)11487–11491, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Tamura H., Dan K., Tamada K., Nakamura K., Shioi Y., Hyodo H., Wang S. D., Dong H., Chen L., Ogata K. Expression of functional B7-H2 and B7.2 costimulatory molecules and their prognostic implications in de novo acute myeloid leukemia. Clin. Cancer Res 2005; 11(16)5708–5717, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Tamura H., Dong H., Zhu G., Sica G. L., Flies D. B., Tamada K., Chen L. B7‐H1 costimulation preferentially enhances CD28-independent T-helper cell function. Blood 2001; 97(6)1809–1816, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Taylor P. A., Lees C. J., Fournier S., Allison J. P., Sharpe A. H., Blazar B. R. B7 expression on T cells down-regulates immune responses through CTLA-4 ligation via T-T interactions [corrections]. J. Immunol 2004; 172(1)34–39, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Thompson R. H., Gillett M. D., Cheville J. C., Lohse C. M., Dong H., Webster W. S., Krejci K. G., Lobo J. R., Sengupta S., Chen L., Zincke H., Blute M.L., Strome S. E., Leibovich B. C., Kwon E. D. Costimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target. Proc. Natl. Acad. Sci. USA 2004; 101(49)17174–17179, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Tirapu I., Huarte E., Guiducci C., Arina A., Zaratiegui M., Murillo O., Gonzalez A., Berasain C., Berraondo P., Fortes P., Prieto J., Colombo M. P., Chen L., Melero I. Low surface expression of B7–1 (CD80) is an immunoescape mechanism of colon carcinoma. Cancer Res 2006; 66(4)2442–2450, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Todo T., Martuza R. L., Dallman M. J., Rabkin S. D. In situ expression of soluble B7-1 in the context of oncolytic herpes simplex virus induces potent antitumor immunity. Cancer Res 2001; 61(1)153–161, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Trentin L., Perin A., Siviero M., Piazza F., Facco M., Gurrieri C., Galvan S., Adami F., Agostini C., Pizzolo G., Zambello R., Semenzato G. B7 costimulatory molecules from malignant cells in patients with B-cell chronic lymphoproliferative disorders trigger t-cell proliferation. Cancer 2000; 89(6)1259–1268, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Tringler B., Zhuo S., Pilkington G., Torkko K. C., Singh M., Lucia M. S., Heinz D. E., Papkoff J., Shroyer K. R. B7-h4 is highly expressed in ductal and lobular breast cancer. Clin. Cancer Res 2005; 11(5)1842–1848, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Tseng S. Y., Otsuji M., Gorski K., Huang X., Slansky J. E., Pai S. I., Shalabi A., Shin T., Pardoll D. M., Tsuchiya H. B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. J. Exp. Med 2001; 193(7)839–846, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Ullrich S. E., Pride M. W., Moodycliffe A. M. Antibodies to the costimulatory molecule CD86 interfere with ultraviolet radiation-induced immune suppression. Immunology 1998; 94(3)417–423, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• van Elsas A., Hurwitz A. A., Allison J. P. Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation. J. Exp. Med 1999; 190(3)355–366, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Wallin J. J., Liang L., Bakardjiev A., Sha W. C. Enhancement of CD8+ T cell responses by ICOS/B7h costimulation. J. Immunol 2001; 167(1)132–139, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Wang L., Fraser C. C., Kikly K., Wells A. D., Han R., Coyle A. J., Chen L., Hancock W. W. B7-H3 promotes acute and chronic allograft rejection. Eur. J. Immunol 2005; 35(2)428–438, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Wang S., Chen L. Co-signaling molecules of the B7-CD28 family in positive and negative regulation of T lymphocyte responses. Microbes Infect 2004; 6(8)759–766, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Wang S., Bajorath J., Flies D. B., Dong H., Honjo T., Chen L. Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction. J. Exp. Med 2003; 197(9)1083–1091, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Wintterle S., Schreiner B., Mitsdoerffer M., Schneider D., Chen L., Meyermann R., Weller M., Wiendl H. Expression of the B7-related molecule B7-H1 by glioma cells: a potential mechanism of immune paralysis. Cancer Res 2003; 63(21)7462–7467, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Yamazaki T., Akiba H., Koyanagi A., Azuma M., Yagita H., Okumura K. Blockade of B7-H1 on Macrophages Suppresses CD4+ T Cell Proliferation by Augmenting IFN-{gamma}-Induced Nitric Oxide Production. J. Immunol 2005; 175(3)1586–1592, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Yamazaki T., Akiba H., Iwai H., Matsuda H., Aoki M., Tanno Y., Shin T., Tsuchiya H., Pardoll D. M., Okumura K., Azuma M., Yagita H. Expression of programmed death 1 ligands by murine T cells and APC. J. Immunol 2002; 169(10)5538–5545, [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Ye Z., Hellstrom I., Hayden-Ledbetter M., Dahlin A., Ledbetter J. A., Hellstrom K. E. Gene therapy for cancer using single-chain Fv fragments specific for 4-1BB. Nat. Med 2002; 8(4)343–348, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Yoshinaga S. K., Whoriskey J. S., Khare S. D., Sarmiento U., Guo J., Horan T., Shih G., Zhang M., Coccia M. A., Kohno T., Tafuri-Bladt A., Brankow D., Campbell P., Chang D., Chiu L., Dai T., Duncan G., Elliott G. S., Hui A., McCabe S. M., Scully S., Shahinian A., Shaklee C. L., Van G., Mak T. W., Senaldi G. T‐cell co-stimulation through B7RP-1 and ICOS. Nature 1999; 402(6763)827–832, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Youngnak P., Kozono Y., Kozono H., Iwai H., Otsuki N., Jin H., Omura K., Yagita H., Pardoll D. M., Chen L., Azuma M. Differential binding properties of B7-H1 and B7-DC to programmed death-1. Biochem. Biophys. Res. Commun 2003; 307(3)672–677, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Zang X., Loke P., Kim J., Murphy K., Waitz R., Allison J. P. B7x: a widely expressed B7 family member that inhibits T cell activation. Proc. Natl. Acad. Sci. USA 2003; 100(18)10388–10392, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Zuberek K., Ling V., Wu P., Ma H. L., Leonard J. P., Collins M., Dunussi-Joannopoulos K. Comparable in vivo efficacy of CD28/B7, ICOS/GL50, and ICOS/GL50B costimulatory pathways in murine tumor models: IFNgamma-dependent enhancement of CTL priming, effector functions, and tumor specific memory CTL. Cell. Immunol 2003; 225(1)53–63, [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar