Publication Cover
Immunological Investigations
A Journal of Molecular and Cellular Immunology
Volume 35, 2006 - Issue 3-4
150
Views
17
CrossRef citations to date
0
Altmetric
Original

Antigen Presentation Machinery (APM) Modulation and Soluble HLA Molecules in the Tumor Microenvironment: Do They Provide Tumor Cells with Escape Mechanisms from Recognition by Cytotoxic T Lymphocytes?

&
Pages 485-503 | Published online: 07 Jul 2009

REFERENCES

  • Abarca-Heidemann K., Friederichs S., Klamp T., Boehm U., Guethlein L. A., Ortmann B. Regulation of the expression of mouse TAP-associated glycoprotein (tapasin) by cytokines. Immunol. Lett 2002; 83: 197–207, [INFOTRIEVE], [CSA]
  • Adachi T., Schamel W. W., Kim K. M., Watanabe T., Becker B., Nielsen P. J., Reth M. The specificity of association of the IgD molecule with the accessory proteins BAP31/BAP29 lies in the IgD transmembrane sequence. EMBO J 1996; 15: 1534–1541, [INFOTRIEVE], [CSA]
  • Adamashvili I., Wolf R., Aultman D., Milford E. L., Jaffe S., Hall V., Pressly T., Minagar A., Kelley R. Soluble HLA-I (s-HLA-I) synthesis in systemic lupus erythematosus. Rheumatol. Int 2003; 23: 294–300, [INFOTRIEVE], [CSA], [CROSSREF]
  • Adrian C. F., Moreau P., Riteau B., Ibrahim E. C., Le Danff C., Dausset J., Rouas-Freiss N., Carosella E. D., Paul P. HLA-G expression in human melanoma cells: protection from NK cytolysis. J. Reprod. Immunol 1999; 43: 183–193, [CSA], [CROSSREF]
  • Androlewicz M. J., Ortmann B., van Endert P. M., Spies T., Cresswell P. Characteristics of peptide and major histocompatibility complex class I/beta 2-microglobulin binding to the transporters associated with antigen processing (TAP1 and TAP2). Proc. Natl. Acad. Sci. U.S.A 1994; 91: 12716–12720, [INFOTRIEVE], [CSA], [CROSSREF]
  • Annaert W. G., Becker B., Kistner U., Reth M., Jahn R. Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31. J. Cell Biol 1997; 139: 1397–1410, [INFOTRIEVE], [CSA], [CROSSREF]
  • Arnold D., Driscoll J., Androlewicz M., Hughes E., Cresswell P., Spies T. Proteasome subunits encoded in the MHC are not generally required for the processing of peptides bound by MHC class I molecules. Nature 1992; 360: 171–174, [INFOTRIEVE], [CSA], [CROSSREF]
  • Aulitzky W. E., Grosse-Wilde H., Westhoff U., Tilg H., Aulitzky W., Gastl G., Herold M., Huber C. Enhanced serum levels of soluble HLA class I molecules are induced by treatment with recombinant interferon-gamma (IFN-gamma). Clin. Exp. Immunol 1991; 86: 236–239, [INFOTRIEVE], [CSA]
  • Basler M., Youhnovski N., Van Den B. M., Przybylski M., Groettrup M. Immunoproteasomes down-regulate presentation of a subdominant T cell epitope from lymphocytic choriomeningitis virus. J. Immunol 2004; 173: 3925–3934, [INFOTRIEVE], [CSA]
  • Cebecauer M., Guillaume P., Hozak P., Mark S., Everett H., Schneider P., Luescher I. F. Soluble MHC-peptide complexes induce rapid death of CD8+ CTL. J. Immunol 2005; 174: 6809–6819, [INFOTRIEVE], [CSA]
  • Chang C. C., Campoli M., Ferrone S. Classical and nonclassical HLA class I antigen and NK cell-activating ligand changes in malignant cells: current challenges and future directions. Adv. Cancer Res 2005; 9318: 9–93234, [CSA]
  • Contini P., Ghio M., Merlo A., Brenci S., Filaci G., Indiveri F., Puppo F. Soluble HLA class I/CD8 ligation triggers apoptosis in EBV-specific CD8+ cytotoxic T lymphocytes by Fas/Fas-ligand interaction. Hum. Immunol 2000; 61: 1347–1351, [INFOTRIEVE], [CSA], [CROSSREF]
  • Contini P., Ghio M., Merlo A., Poggi A., Indiveri F., Puppo F. Apoptosis of antigen-specific T lymphocytes upon the engagement of CD8 by soluble HLA class I molecules is Fas ligand/Fas mediated: evidence for the involvement of p56lck, calcium calmodulin kinase II, and calcium-independent protein kinase C signaling pathways and for NF-kappaB and NF-AT nuclear translocation. J. Immunol 2005; 175: 7244–7254, [INFOTRIEVE], [CSA]
  • Contini P., Ghio M., Poggi A., Filaci G., Indiveri F., Ferrone S., Puppo F. Soluble HLA-A,-B,-C and -G molecules induce apoptosis in T and NK CD8+ cells and inhibit cytotoxic T cell activity through CD8 ligation. Eur. J. Immunol 2003; 33: 125–134, [INFOTRIEVE], [CSA], [CROSSREF]
  • Coux O., Tanaka K., Goldberg A. L. Structure and functions of the 20S and 26S proteasomes. Annu. Rev. Biochem 1996; 65: 801–847, [INFOTRIEVE], [CSA], [CROSSREF]
  • Cresswell P., Bangia N., Dick T., Diedrich G. The nature of the MHC class I peptide loading complex. Immunol. Rev 1999; 17: 221–228, [CSA], [CROSSREF]
  • Dal Porto J., Johansen T. E., Catipovic B., Parfiit D. J., Tuveson D., Gether U., Kozlowski S., Fearon D. T., Schneck J. P. A soluble divalent class I major histocompatibility complex molecule inhibits alloreactive T cells at nanomolar concentrations. Proc. Natl. Acad. Sci. U.S.A 1993; 90: 6671–6675, [INFOTRIEVE], [CSA], [CROSSREF]
  • Davies H. S., Pollard S. G., Calne R. Y. Soluble HLA antigens in the circulation of liver graft recipients. Transplantation 1989; 47: 524–527, [INFOTRIEVE], [CSA]
  • Demaria S., Bushkin Y. Soluble HLA proteins with bound peptides are released from the cell surface by the membrane metalloproteinase. Hum. Immunol 2000; 61: 1332–1338, [INFOTRIEVE], [CSA], [CROSSREF]
  • Demaria S., Schwab R., Gottesman S. R., Bushkin Y. Soluble beta 2-microglobulin-free class I heavy chains are released from the surface of activated and leukemia cells by a metalloprotease. J. Biol. Chem 1994; 269: 6689–6694, [INFOTRIEVE], [CSA]
  • Derynck R., Akhurst R. J., Balmain A. TGF-beta signaling in tumor suppression and cancer progression. Nat. Genet 2001; 29: 117–129, [INFOTRIEVE], [CSA], [CROSSREF]
  • Dick T. P., Ruppert T., Groettrup M., Kloetzel P. M., Kuehn L., Koszinowski U. H., Stevanovic S., Schild H., Rammensee H. G. Coordinated dual cleavages induced by the proteasome regulator PA28 lead to dominant MHC ligands. Cell 1996; 86: 253–262, [INFOTRIEVE], [CSA], [CROSSREF]
  • Dovhey S. E., Ghosh N. S., Wright K. L. Loss of interferon-gamma inducibility of TAP1 and LMP2 in a renal cell carcinoma cell line. Cancer Res 2000; 60: 5789–5796, [INFOTRIEVE], [CSA]
  • Driscoll J., Brown M. G., Finley D., Monaco J. J. MHC-linked LMP gene products specifically alter peptidase activities of the proteasome. Nature 1993; 365: 262–264, [INFOTRIEVE], [CSA], [CROSSREF]
  • Ferreira A., Villar M. L., Alvarez Cermeno, Revilla J. C., Garcia Y., Rodriguez M. C., Fontan G., Gonzalez-Porque P. Quantification of soluble serum HLA class I antigens in healthy volunteers and AIDS patients. Clin. Chim. Acta 1988; 174: 207–211, [INFOTRIEVE], [CSA], [CROSSREF]
  • Ferrone S., Mittal K. K., Pellegrino M. A., Allison J. P., Reisfeld R. A. Immunogenicity of HLA antigens purified from serum. Transplantation 1977; 23: 7–15, [INFOTRIEVE], [CSA]
  • Ferrone S., Pellegrino M. A., Billing R., Terasaki P. I., Reisfeld R. A. Production of anti-W24 xenoantisera in rabbits. Tissue Antigens 1975; 5: 41–47, [INFOTRIEVE], [CSA]
  • Fournel S., Aguerre-Girr M., Huc X., Lenfant F., Alam A., Toubert A., Bensussan A., Le Bouteiller P. Cutting edge: soluble HLA-G1 triggers CD95/CD95 ligand-mediated apoptosis in activated CD8+ cells by interacting with CD8. J. Immunol 2000; 164: 6100–6104, [INFOTRIEVE], [CSA]
  • Gaczynska M., Rock K. L., Goldberg A. L. Gamma-interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes. Nature 1993; 365: 264–267, [INFOTRIEVE], [CSA], [CROSSREF]
  • Gaczynska M., Rock K. L., Spies T., Goldberg A. L. Peptidase activities of proteasomes are differentially regulated by the major histocompatibility complex-encoded genes for LMP2 and LMP7. Proc. Natl. Acad. Sci. U.S.A 1994; 91: 9213–9217, [INFOTRIEVE], [CSA], [CROSSREF]
  • Gao B., Adhikari R., Howarth M., Nakamura K., Gold M. C., Hill A. B., Knee R., Michalak M., Elliott T. Assembly and antigen-presenting function of MHC class I molecules in cells lacking the ER chaperone calreticulin. Immunity 2002; 16: 99–109, [INFOTRIEVE], [CSA], [CROSSREF]
  • Garbi N., Tanaka S., van den B. M., Momburg F., Hammerling G. J. Accessory molecules in the assembly of major histocompatibility complex class I/peptide complexes: how essential are they for CD8(+) T-cell immune responses?. Immunol. Rev 2005; 20: 777–788, [CSA]
  • Garbi N., Tiwari N., Momburg F., Hammerling G. J. A major role for tapasin as a stabilizer of the TAP peptide transporter and consequences for MHC class I expression. Eur. J. Immunol 2003; 33: 264–273, [INFOTRIEVE], [CSA], [CROSSREF]
  • Geiser A. G., Letterio J. J., Kulkarni A. B., Karlsson S., Roberts A. B., Sporn M. B. Transforming growth factor beta 1 (TGF-beta 1) controls expression of major histocompatibility genes in the postnatal mouse: aberrant histocompatibility antigen expression in the pathogenesis of the TGF-beta 1 null mouse phenotype. Proc. Natl. Acad. Sci. U.S.A 1993; 90: 9944–9948, [INFOTRIEVE], [CSA], [CROSSREF]
  • Gelder F. B., McDonald J. C., Landreneau M. D., McMillan R. M., Aultman D. F. Identification, characterization, and quantitation of soluble HLA antigens in the circulation and peritoneal dialysate of renal patients. Ann. Surg 1991; 213: 591–597, [INFOTRIEVE], [CSA]
  • Giacomini P., Aguzzi A., Pestka S., Fisher P. B., Ferrone S. Modulation by recombinant DNA leukocyte (alpha) and fibroblast (beta) interferons of the expression and shedding of HLA- and tumor-associated antigens by human melanoma cells. J. Immunol 1984; 133: 1649–1655, [INFOTRIEVE], [CSA]
  • Giacomini P., Fraioli R., Calabro A. M., Di Filippo F., Natali P. G. Class I major histocompatibility complex enhancement by recombinant leukocyte interferon in the peripheral blood mononuclear cells and plasma of melanoma patients. Cancer Res 1991; 51: 652–656, [INFOTRIEVE], [CSA]
  • Goldberg J., Shrikant P., Mescher M. F. In vivo augmentation of tumor-specific CTL responses by class I/peptide antigen complexes on microspheres (large multivalent immunogen). J. Immunol 2003; 170: 228–235, [INFOTRIEVE], [CSA]
  • Grandea A. G., III, Golovina T. N., Hamilton S. E., Sriram V., Spies T., Brutkiewicz R. R., Harty J. T., Eisenlohr L. C., Van Kaer L. Impaired assembly yet normal trafficking of MHC class I molecules in Tapasin mutant mice. Immunity 2000; 13: 213–222, [INFOTRIEVE], [CSA], [CROSSREF]
  • Griffin T. A., Nandi D., Cruz M., Fehling H. J., Kaer L. V., Monaco J. J., Colbert R. A. Immunoproteasome assembly: cooperative incorporation of interferon gamma (IFN-gamma)-inducible subunits. J. Exp. Med 1998; 187: 97–104, [INFOTRIEVE], [CSA], [CROSSREF]
  • Groettrup M., Soza A., Eggers M., Kuehn L., Dick T. P., Schild H., Rammensee H. G., Koszinowski U. H., Kloetzel P. M. A role for the proteasome regulator PA28alpha in antigen presentation. Nature 1996; 381: 166–168, [INFOTRIEVE], [CSA], [CROSSREF]
  • Groh V., Wu J., Yee C., Spies T. Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation. Nature 2002; 419: 734–738, [INFOTRIEVE], [CSA], [CROSSREF]
  • Hagihara M., Shimura T., Takebe K., Munkhbat B., Hosoi K., Kagawa T., Watanabe N., Matsuzaki S., Yamamoto K., Sato K., Tsuji K. Serum concentrations of soluble HLA-class I and CD8 forms in patients with viral hepatic disorders. J. Gastroenterol 1997; 32: 338–343, [INFOTRIEVE], [CSA]
  • Hagihara M., Shimura T., Yamamoto K., Sujirachato K., Tsuji S., Yamamura M., Tsuji K. Clinical significance of serum soluble HLA class I antigens in systemic lupus erythematosus. Tokai J. Exp. Clin. Med 1993; 18: 61–64, [INFOTRIEVE], [CSA]
  • Hayashi T., Kobayashi Y., Kohsaka S., Sano K. The mutation in the ATP-binding region of JAK1, identified in human uterine leiomyosarcomas, results in defective interferon-gamma inducibility of TAP1 and LMP2. Oncogene 2006, [CSA]
  • Hicklin D. J., Marincola F. M., Ferrone S. HLA class I antigen downregulation in human cancers: T-cell immunotherapy revives an old story. Mol Med Today 1999; 5: 178–186, [INFOTRIEVE], [CSA], [CROSSREF]
  • Inostroza J., Munoz P., Espinoza R., Millaqueo L., Diaz P., Leiva L., Sorensen R. Quantitation of soluble HLA class I heterodimers and beta 2-microglobulin in patients with active pulmonary tuberculosis. Hum. Immunol 1994; 40: 179–182, [INFOTRIEVE], [CSA], [CROSSREF]
  • Kobayashi S., Yoshida K., Ward J. M., Letterio J. J., Longenecker G., Yaswen L., Mittleman B., Mozes E., Roberts A. B., Karlsson S., Kulkarni A. B. Beta 2-microglobulin-deficient background ameliorates lethal phenotype of the TGF-beta 1 null mouse. J. Immunol 1999; 163: 4013–4019, [INFOTRIEVE], [CSA]
  • Krangel M. S. Secretion of HLA-A and -B antigens via an alternative RNA splicing pathway. J. Exp. Med 1986; 163: 1173–1190, [INFOTRIEVE], [CSA], [CROSSREF]
  • Kuckelkorn U., Frentzel S., Kraft R., Kostka S., Groettrup M., Kloetzel P. M. Incorporation of major histocompatibility complex–encoded subunits LMP2 and LMP7 changes the quality of the 20S proteasome polypeptide processing products independent of interferon-gamma. Eur. J. Immunol 1995; 25: 2605–2611, [INFOTRIEVE], [CSA]
  • Kurte M., Lopez M., Aguirre A., Escobar A., Aguillon J. C., Charo J., Larsen C. G., Kiessling R., Salazar-Onfray F. A synthetic peptide homologous to functional domain of human IL-10 down-regulates expression of MHC class I and Transporter associated with Antigen Processing 1/2 in human melanoma cells. J. Immunol 2004; 173: 1731–1737, [INFOTRIEVE], [CSA]
  • Lambert G., Becker B., Schreiber R., Boucherot A., Reth M., Kunzelmann K. Control of cystic fibrosis transmembrane conductance regulator expression by BAP31. J. Biol. Chem 2001; 276: 20340–20345, [INFOTRIEVE], [CSA]
  • Letterio J. J. TGF-beta signaling in T cells: roles in lymphoid and epithelial neoplasia. Oncogene 2005; 24: 5701–5712, [INFOTRIEVE], [CSA], [CROSSREF]
  • Li E., Bestagno M., Burrone O. Molecular cloning and characterization of a transmembrane surface antigen in human cells. Eur. J. Biochem 1996; 238: 631–638, [INFOTRIEVE], [CSA], [CROSSREF]
  • Ljunggren G., Anderson D. J. Cytokine induced modulation of MHC class I and class II molecules on human cervical epithelial cells. J. Reprod. Immunol 1998; 38: 123–138, [INFOTRIEVE], [CSA], [CROSSREF]
  • Lopez-Albaitero A., Nayak J. V., Ogino T., Machandia A., Gooding W., DeLeo A. B., Ferrone S., Ferris R. L. Role of antigen-processing machinery in the in vitro resistance of squamous cell carcinoma of the head and neck cells to recognition by CTL. J. Immunol 2006; 176: 3402–3409, [INFOTRIEVE], [CSA]
  • Maile R., Wang B., Schooler W., Meyer A., Collins E. J., Frelinger J. A. Antigen-specific modulation of an immune response by in vivo administration of soluble MHC class I tetramers. J. Immunol 2001; 167: 3708–3714, [INFOTRIEVE], [CSA]
  • Marincola F. M., Jaffee E. M., Hicklin D. J., Ferrone S. Escape of human solid tumors from T-cell recognition: molecular mechanisms and functional significance. Adv. Immunol 2000; 74: 181–273, [INFOTRIEVE], [CSA]
  • Matsuda M., Salazar F., Petersson M., Masucci G., Hansson J., Pisa P., Zhang Q. J., Masucci M. G., Kiessling R. Interleukin 10 pretreatment protects target cells from tumor- and allo-specific cytotoxic T cells and downregulates HLA class I expression. J. Exp. Med 1994; 180: 2371–2376, [INFOTRIEVE], [CSA], [CROSSREF]
  • Michalek M. T., Grant E. P., Gramm C., Goldberg A. L., Rock K. L. A role for the ubiquitin-dependent proteolytic pathway in MHC class I-restricted antigen presentation. Nature 1993; 363: 552–554, [INFOTRIEVE], [CSA], [CROSSREF]
  • Morel S., Levy F., Burlet-Schiltz O., Brasseur F., Probst-Kepper M., Peitrequin A. L., Monsarrat B., Van Velthoven R., Cerottini J. C., Boon T., Gairin J. E., Van den Eynde B. J. Processing of some antigens by the standard proteasome but not by the immunoproteasome results in poor presentation by dendritic cells. Immunity 2000; 12: 107–117, [INFOTRIEVE], [CSA], [CROSSREF]
  • Nakanishi K., Kobayashi T., Komatsu Y., Kogawa N., Hagihara M., Tsuji K. Synchronous decline of serum-soluble HLA class I antigen and beta-cell function in insulin-dependent diabetes mellitus. Clin. Immunol. Immunopathol 1997; 85: 246–252, [INFOTRIEVE], [CSA], [CROSSREF]
  • Nandi D., Jiang H., Monaco J. J. Identification of MECL-1 (LMP-10) as the third IFN-gamma-inducible proteasome subunit. J. Immunol 1996; 156: 2361–2364, [INFOTRIEVE], [CSA]
  • Nocito M., Montalban C., Gonzalez-Porque P., Villar L. M. Increased soluble serum HLA class I antigens in patients with lymphoma. Hum. Immunol 1997; 58: 106–111, [INFOTRIEVE], [CSA], [CROSSREF]
  • O'Herrin S. M., Slansky J. E., Tang Q., Markiewicz M. A., Gajewski T. F., Pardoll D. M., Schneck J. P., Bluestone J. A. Antigen-specific blockade of T cells in vivo using dimeric MHC peptide. J. Immunol 2001; 167: 2555–2560, [CSA]
  • Ogino T., Bandoh N., Hayashi T., Miyokawa N., Harabuchi Y., Ferrone S. Association of tapasin and HLA class I antigen down-regulation in primary maxillary sinus squamous cell carcinoma lesions with reduced survival of patients. Clin. Cancer Res 2003; 9: 4043–4051, [INFOTRIEVE], [CSA]
  • Ortmann B., Copeman J., Lehner P. J., Sadasivan B., Herberg J. A., Grandea A. G., Riddell S. R., Tampe R., Spies T., Trowsdale J., Cresswell P. A critical role for tapasin in the assembly and function of multimeric MHC class I-TAP complexes. Science 1997; 277: 1306–1309, [INFOTRIEVE], [CSA], [CROSSREF]
  • Paquet M. E., Cohen-Doyle M., Shore G. C., Williams D. B. Bap29/31 influences the intracellular traffic of MHC class I molecules. J. Immunol 2004; 172: 7548–7555, [INFOTRIEVE], [CSA]
  • Park C. W., Yun S. N., Yang C. W., Kim T. G., Han H., Choi E. J., Chang Y. S., Bang B. K. Serum and urine soluble HLA class I antigen concentrations are increased in patients with hemorrhagic fever with renal syndrome. Korean J. Intern. Med 1997; 12: 52–57, [INFOTRIEVE], [CSA]
  • Paz P., Brouwenstijn N., Perry R., Shastri N. Discrete proteolytic intermediates in the MHC class I antigen processing pathway and MHC I-dependent peptide trimming in the ER. Immunity 1999; 11: 241–251, [INFOTRIEVE], [CSA], [CROSSREF]
  • Pellegrino M. A., Ferrone S., Pellegrino A. G., Oh S. K., Reisfeld R. A. Evaluation of two sources of soluble HL-A antigens: platelets and serum. Eur. J. Immunol 1974; 4: 250–255, [INFOTRIEVE], [CSA]
  • Pellegrino M. A., Indiveri F., Fagiolo U., Antonello A., Ferrone S. Immunogenicity of serum HLA antigens in allogeneic combinations. Transplantation 1982; 33: 530–533, [INFOTRIEVE], [CSA]
  • Petersson M., Charo J., Salazar-Onfray F., Noffz G., Mohaupt M., Qin Z., Klein G., Blankenstein T., Kiessling R. Constitutive IL-10 production accounts for the high NK sensitivity, low MHC class I expression, and poor transporter associated with antigen processing (TAP)-1/2 function in the prototype NK target YAC-1. J. Immunol 1998; 161: 2099–2105, [INFOTRIEVE], [CSA]
  • Puppo F., Contini P., Ghio M., Brenci S., Scudeletti M., Filaci G., Ferrone S., Indiveri F. Soluble human MHC class I molecules induce soluble Fas ligand secretion and trigger apoptosis in activated CD8(+) Fas (CD95)(+) T lymphocytes. Int. Immunol 2000; 12: 195–203, [INFOTRIEVE], [CSA], [CROSSREF]
  • Puppo F., Contini P., Ghio M., Indiveri F. Soluble HLA class I molecules/CD8 ligation trigger apoptosis of CD8+ cells by Fas/Fas-ligand interaction. ScientificWorld Journal 2002; 2: 421–423, [INFOTRIEVE], [CSA]
  • Puppo F., Indiveri F., Scudeletti M., Ferrone S. Soluble HLA antigens: new roles and uses. Immunol. Today 1997; 18: 154–155, [INFOTRIEVE], [CSA], [CROSSREF]
  • Puppo F., Orlandini A., Ruzzenenti R., Comuzio S., Salamito A., Farinelli A., Stagnaro R., Indiveri F. HLA class I soluble antigen serum levels in HIV-positive subjects–correlation with cellular and serological parameters. Cancer Detect. Prev 1990; 14: 321–323, [INFOTRIEVE], [CSA]
  • Puppo F., Scudeletti M., Indiveri F., Ferrone S. Serum HLA class I antigens: markers and modulators of an immune response?. Immunol. Today 1995; 16: 124–127, [INFOTRIEVE], [CSA], [CROSSREF]
  • Rhynes V. K., McDonald J. C., Gelder F. B., Aultman D. F., Hayes J. M., McMillan R. W., Mancini M. C. Soluble HLA class I in the serum of transplant recipients. Ann. Surg 1993; 217: 485–489, [INFOTRIEVE], [CSA]
  • Richiardi P., Pellegrino M. A., Ferrone S. Xenoantisera to allotypic specificities of HLA-A and B antigens. Serological characterization. Transplantation 1979; 28: 333–338, [INFOTRIEVE], [CSA]
  • Rock K. L., Gramm C., Rothstein L., Clark K., Stein R., Dick L., Hwang D., Goldberg A. L. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 1994; 78: 761–771, [INFOTRIEVE], [CSA], [CROSSREF]
  • Sadasivan B., Lehner P. J., Ortmann B., Spies T., Cresswell P. Roles for calreticulin and a novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP. Immunity 1996; 5: 103–114, [INFOTRIEVE], [CSA], [CROSSREF]
  • Sakaguchi K., Koide N., Takenami T., Matsushima H., Takabatake H., Ferrone S., Tsuji T. Soluble HLA class I antigens in sera of patients with chronic hepatitis. Gastroenterol. Jpn 1992; 27: 206–211, [INFOTRIEVE], [CSA]
  • Salazar-Onfray F., Charo J., Petersson M., Freland S., Noffz G., Qin Z., Blankenstein T., Ljunggren H. G., Kiessling R. Down-regulation of the expression and function of the transporter associated with antigen processing in murine tumor cell lines expressing IL-10. J. Immunol 1997; 159: 3195–3202, [INFOTRIEVE], [CSA]
  • Saric T., Chang S. C., Hattori A., York I. A., Markant S., Rock K. L., Tsujimoto M., Goldberg A. L. An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides. Nat Immunol 2002; 3: 1169–1176, [INFOTRIEVE], [CSA], [CROSSREF]
  • Serwold T., Gaw S., Shastri N. ER aminopeptidases generate a unique pool of peptides for MHC class I molecules. Nat Immunol 2001; 2: 644–651, [INFOTRIEVE], [CSA], [CROSSREF]
  • Shepherd J. C., Schumacher T. N., Ashton-Rickardt P. G., Imaeda S., Ploegh H. L., Janeway C. A., Jr., Tonegawa S. TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective. Cell 1993; 74: 577–584, [INFOTRIEVE], [CSA], [CROSSREF]
  • Shimura T., Hagihara M., Yamamoto K., Takebe K., Munkhbat B., Ogoshi K., Mitomi T., Nagamachi Y., Tsuji K. Quantification of serum-soluble HLA class I antigens in patients with gastric cancer. Hum. Immunol 1994; 40: 183–186, [INFOTRIEVE], [CSA], [CROSSREF]
  • Sibille C., Gould K. G., Willard-Gallo K., Thomson S., Rivett A. J., Powis S., Butcher G. W., De Baetselier P. LMP2+ proteasomes are required for the presentation of specific antigens to cytotoxic T lymphocytes. Curr. Biol 1995; 5: 923–930, [INFOTRIEVE], [CSA], [CROSSREF]
  • Spies T., DeMars R. Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter. Nature 1991; 351: 323–324, [INFOTRIEVE], [CSA], [CROSSREF]
  • Spiliotis E. T., Manley H., Osorio M., Zuniga M. C., Edidin M. Selective export of MHC class I molecules from the ER after their dissociation from TAP. Immunity 2000; 13: 841–851, [INFOTRIEVE], [CSA], [CROSSREF]
  • Stoltze L., Schirle M., Schwarz G., Schroter C., Thompson M. W., Hersh L. B., Kalbacher H., Stevanovic S., Rammensee H. G., Schild H. Two new proteases in the MHC class I processing pathway. Nat Immunol 2000; 1: 413–418, [INFOTRIEVE], [CSA], [CROSSREF]
  • Sun Y., Sijts A. J., Song M., Janek K., Nussbaum A. K., Kral S., Schirle M., Stevanovic S., Paschen A., Schild H., Kloetzel P. M., Schadendorf D. Expression of the proteasome activator PA28 rescues the presentation of a cytotoxic T lymphocyte epitope on melanoma cells. Cancer Res 2002; 62: 2875–2882, [INFOTRIEVE], [CSA]
  • Tambutti M. L., Ferraris J. R., Redal M. A., Ramirez J. A., Prigoshin N. Soluble HLA class I antigens in pediatric patients with renal transplants from related living donors without acute rejection and treated with triple therapy. Hum. Immunol 1996; 50: 135–139, [INFOTRIEVE], [CSA], [CROSSREF]
  • Tilg H., Westhoff U., Vogel W., Aulitzky W. E., Herold M., Margreiter R., Huber C., Grosse-Wilde H. Soluble HLA class I serum concentrations increase with transplant-related complications after liver transplantation. J. Hepatol 1992; 14: 417–419, [INFOTRIEVE], [CSA], [CROSSREF]
  • Toutirais O., Chartier P., Dubois D., Bouet F., Leveque J., Catros-Quemener V., Genetet N. Constitutive expression of TGF-beta1, interleukin-6 and interleukin-8 by tumor cells as a major component of immune escape in human ovarian carcinoma. Eur. Cytokine Netw 2003; 14: 246–255, [INFOTRIEVE], [CSA]
  • Tzai T. S., Shiau A. L., Liu L. L., Wu C. L. Immunization with TGF-beta antisense oligonucleotide-modified autologous tumor vaccine enhances the antitumor immunity of MBT-2 tumor-bearing mice through upregulation of MHC class I and Fas expressions. Anticancer Res 2000; 20: 1557–1562, [INFOTRIEVE], [CSA]
  • Van Kaer L., Ashton-Rickardt P. G., Ploegh H. L., Tonegawa S. TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4–8+ T cells. Cell 1992; 71: 1205–1214, [INFOTRIEVE], [CSA], [CROSSREF]
  • van Rood J. J., van Leeuwen A., van Santen M. C. Anti HL-A2 inhibitor in normal human serum. Nature 1970; 226: 366–367, [INFOTRIEVE], [CSA], [CROSSREF]
  • Waldmann T. A., Dubois S., Tagaya Y. Contrasting roles of IL-2 and IL-15 in the life and death of lymphocytes: implications for immunotherapy. Immunity 2001; 14: 105–110, [INFOTRIEVE], [CSA]
  • Wei M. L., Cresswell P. HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides. Nature 1992; 356: 443–446, [INFOTRIEVE], [CSA], [CROSSREF]
  • Wojtowicz-Praga S. Reversal of tumor-induced immunosuppression by TGF-beta inhibitors. Invest. New. Drugs 2003; 21: 21–32, [INFOTRIEVE], [CSA]
  • Wright K. L., White L. C., Kelly A., Beck S., Trowsdale J., Ting J. P. Coordinate regulation of the human TAP1 and LMP2 genes from a shared bidirectional promoter. J. Exp. Med 1995; 181: 1459–1471, [INFOTRIEVE], [CSA]
  • Xu X. N., Purbhoo M. A., Chen N., Mongkolsapaya J., Cox J. H., Meier U. C., Tafuro S., Dunbar P. R., Sewell A. K., Hourigan C. S., Appay V., Cerundolo V., Burrows S. R., McMichael A. J., Screaton G. R. A novel approach to antigen-specific deletion of CTL with minimal cellular activation using alpha3 domain mutants of MHC class I/peptide complex. Immunity 2001; 14: 591–602, [INFOTRIEVE], [CSA], [CROSSREF]
  • York I. A., Chang S. C., Saric T., Keys J. A., Favreau J. M., Goldberg A. L., Rock K. L. The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8–9 residues. Nat. Immunol 2002; 3: 1177–1184, [INFOTRIEVE], [CSA], [CROSSREF]
  • Zavazava N., Kronke M. Soluble HLA class I molecules induce apoptosis in alloreactive cytotoxic T lymphocytes. Nat. Med 1996; 2: 1005–1010, [INFOTRIEVE], [CSA], [CROSSREF]
  • Zeidler R., Eissner G., Meissner P., Uebel S., Tampe R., Lazis S., Hammerschmidt W. Downregulation of TAP1 in B lymphocytes by cellular and Epstein-Barr virus-encoded interleukin-10. Blood 1997; 90: 2390–2397, [INFOTRIEVE], [CSA]

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.