Induction of Auto-reactive Regulatory T Cells by Stimulation with Immature Autologous Dendritic Cells

REFERENCES

• Akbar A. N., Taams L. S., Salmon M., Vukmanovic-Stejic M. The peripheral generation of CD4 + CD25+ regulatory T cells. Immunology 2003; 109: 319–325
   PubMed Web of Science ®Google Scholar
• Annacker O., Pimenta-Araujo R., Burlen-Defranoux O., Bandeira A. On the ontogeny and physiology of regulatory T cells. Immunol. Rev. 2001; 182: 5–17
   PubMedGoogle Scholar
• Buenafe A. C., Tsaknaridis L., Spencer L., Hicks K. S., McMahan R. H., Watson L., Culbertson N. E., Latocha D., Wegmann K., Finn T., Bartholomew R., Burrows G. G., Whitham R., Bourdette D. N., Jones R. E., Offner H., Chou Y. K., Vandenbark A. A. Specificity of regulatory CD4 + CD25+ T cells for self-T cell receptor determinants. J. Neurosci. Res. 2004; 76: 129–140
   PubMed Web of Science ®Google Scholar
• Ciubotariu R., Colovai A. I., Pennesi G., Liu Z., Smith D., Berlocco P., Cortesini R., Suciu-Foca N. Specific suppression of human CD4+ Th cell responses to pig MHC antigens by CD8 + CD28- regulatory T cells. J. Immunol. 1998; 161: 5193–5202
   PubMed Web of Science ®Google Scholar
• Dhodapkar M. V., Steinman R. M., Krasovsky J., Munz C., Bhardwaj N. Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells. J. Exp. Med. 2001; 193: 233–238
   PubMed Web of Science ®Google Scholar
• Fazekas de St Groth B., Smith A. L., Higgins C. A. T cell activation: in vivo veritas. Immunol. Cell. Biol. 2004; 82: 260–268
   PubMedGoogle Scholar
• Fontenot J. D., Gavin M. A., Rudensky A. Y. Foxp3 programs the development and function of CD4 + CD25+ regulatory T cells. Nat. Immunol. 2003; 4: 330–336
   PubMed Web of Science ®Google Scholar
• Gunnlaugsdottir B., Maggadottir S. M., Ludviksson B. R. Anti-CD28-induced co-stimulation and TCR avidity regulates the differential effect of TGF-beta1 on CD4+ and CD8+ naive human T-cells. Int. Immunol. 2005; 17: 35–44
   PubMedGoogle Scholar
• Heath W. R., Kurts C., Miller J. F. A. P., Carbone F. R. Cross-tolerance: a pathway for inducing tolerance to peripheral tissue antigens. J. Exp. Med. 1998; 187: 1549–1553
   PubMed Web of Science ®Google Scholar
• Hori S., Nomura T., Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299: 1057–1061
   PubMed Web of Science ®Google Scholar
• Jin Y., Fuller L., Esquenazi V., Blomberg B. B., Rosen A., Tzakis A. G., Ricordi C., Miller J. Bone marrow cells inhibit the generation of autologous EBV-specific CTL. Hum. Immunol. 2000; 61: 538–547
   PubMedGoogle Scholar
• Jin Y., Fuller L., Wei Y., Blomberg B. B., Miller J., Esquenazi V. Bone marrow cells promote TH2 polarization and inhibit virus-specific CTL generation. Hum. Immunol. 2001; 61: 1233–1241
   Google Scholar
• Jin Y., Fuller L., Carreno M., Esquenazi V., Blomberg B. B., Wei Y. T., Ciancio G., Burke G. W., 3rd, Tzakis A., Ricordi C., Miller J. Functional and phenotypic properties of peripheral T cells anergized by autologous CD3+ depleted bone marrow cells. Hum. Immunol. 2002; 63: 567–575
   PubMedGoogle Scholar
• Jin Y., Fuller L., Ciancio G., Burke G. W., 3rd, Tzakis A. G., Ricordi C., Miller J., Esquenazi V. Antigen presentation and immune regulatory capacity of immature and mature-enriched antigen presenting (dendritic) cells derived from human bone marrow. Hum. Immunol. 2004; 65: 93–103
   PubMedGoogle Scholar
• Jonuleit H., Schmitt E., Schuler G., Knop J., Enk A. H. Induction of interleukin 10–producing, nonproliferating CD4+ T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J. Exp. Med. 2000; 192: 1213–1222
   PubMed Web of Science ®Google Scholar
• Kemper C., Chan A. C., Green J. M., Brett K. A., Murphy K. M., Atkinson J. P. Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype. Nature 2003; 421: 388–392
   PubMed Web of Science ®Google Scholar
• Laufer T. M., DeKoning J., Markowitz J. S., Lo D., Glimcher L. H. Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex. Nature 1996; 383: 81–85
   PubMedGoogle Scholar
• Liu K., Lyoda T., Saternus M., Kimura K., Inaba K., Steinman R. M. Immune tolerance after delivery of dying cells to dendritic cells in situ. J. Exp. Med. 2002; 196: 1091–1097
   PubMed Web of Science ®Google Scholar
• Mathew J. M., Carreno M., Fuller L., Ricordi C., Tzakis A., Esquenazi V., Miller J. Modulatory effects of human donor bone marrow cells on allogeneic cellular immune responses. Transplantation 1997; 63: 686–692
   PubMedGoogle Scholar
• Mathew J. M., Garcia-Morales R., Fuller L., Rosen A., Ciancio G., Burke G. W., Carreno M., Temple J. D., Tzakis A. G., Ricordi C., Miller J., Esquenazi V. Donor bone marrow-derived chimeric cells present in renal transplant recipients infused with donor marrow. I. Potent regulators of recipient anti-donor immune responses. Transplantation 2000; 70: 1675–1682
   PubMedGoogle Scholar
• Modigliani Y., Bandeira A., Coutinho A. A model for developmentally acquired thymus-dependent tolerance to central and peripheral antigens. Immunol. Rev. 1996; 149: 155–175
   PubMedGoogle Scholar
• Pacholczyk R., Kraj P., Ignatowicz L. Peptide specificity of thymic selection of CD4 + CD25+ T cells. J. Immunol. 2002; 168: 613–620
   PubMed Web of Science ®Google Scholar
• Read S., Powrie F. CD4+ regulatory T cells. Curr. Opin. Immunol. 2001; 13: 644–649
   PubMed Web of Science ®Google Scholar
• Romagnoli P., Hudrisier D., van Meerwijk J. P. Preferential recognition of self antigens despite normal thymic deletion of CD4 + CD25+ regulatory T cells. J. Immunol. 2002; 168: 1644–1648
   PubMed Web of Science ®Google Scholar
• Roncarolo M. G., Bacchetta R., Bordignon C., Narula S., Levings M. K. Type 1 T regulatory cells. Immunol. Rev. 2001a; 182: 68–79
   PubMed Web of Science ®Google Scholar
• Roncarolo M. G., Levings M. K., Traversari C. Differentiation of T regulatory cells by immature dendritic cells. J. Exp. Med. 2001b; 193: F5–F9
   PubMed Web of Science ®Google Scholar
• Sakaguchi S. Regulatory T cells: key controllers of immunologic self-tolerance. Cell 2000; 101: 455–458
   PubMed Web of Science ®Google Scholar
• Sakaguchi S. The origin of FOXP3-expressing CD4+ regulatory T cells: thymus or periphery. J. Clin. Invest. 2003; 112: 1310–1312
   PubMed Web of Science ®Google Scholar
• Sakaguchi S., Sakaguchi N., Shimizu J., Yamazaki S., Sakihama T., Itoh M., Kuniyasu Y., Nomura T., Toda M., Takahashi T. Immunologic tolerance maintained by CD25 + CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol. Rev. 2000; 182: 18–32
   Google Scholar
• Saodi A., Sedon B., Heath V., Fowell V., Mason D. The physiological role of regulatory T cells in the prevention of autoimmunity: the function of the thymus in the generation of the regulatory T cell subset. Immunol. Rev. 1996; 149: 195–216
   PubMedGoogle Scholar
• Scheinecker C., McHugh R., Shevach E. M., Germain R. N. Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node. J. Exp. Med. 2002; 196: 1079–1090
   PubMed Web of Science ®Google Scholar
• Seddon B., Mason D. Peripheral autoantigen induces regulatory T cells that prevent autoimmunity. J. Exp. Med. 1999; 189: 877–882
   PubMed Web of Science ®Google Scholar
• Shevach E. M. Regulatory T cells in autoimmunity. Ann. Rev. Immunol. 2000; 18: 423–449
   PubMed Web of Science ®Google Scholar
• Shevach E. M. Certified professionals: CD4 + CD25+ suppressor T cells. J. Exp. Med. 2001; 193: F41–F46
   PubMed Web of Science ®Google Scholar
• Shevach E. M., McHugh R. S., Piccirillo C. A., Thornton A. M. Control of T-cell activation by CD4+ CD25+ suppressor T cells. Immunol. Rev. 2001; 182: 58–67
   PubMed Web of Science ®Google Scholar
• Skapenko A., Kalden J. R., Lipsky P. E., Schulze-Koops H. The IL-4 receptor alpha-chain-binding cytokines, IL-4 and IL-13, induce forkhead box P3-expressing CD25 + CD4+ regulatory T cells from CD25-CD4+ precursors. J. Immunol. 2005; 175: 6107–6116
   PubMed Web of Science ®Google Scholar
• Sonoda K. H., Exley M., Snapper S., Balk S. P., Stein-Streilein J. CD1-reactive natural killer T cells are required for development of systemic tolerance through an immune-privileged site. J. Exp. Med. 1999; 190: 1215–1226
   PubMed Web of Science ®Google Scholar
• Strober W., James S. P. Immunoregulatory function of human autoreactive T-cell lines and clones. Immunol. Rev. 1990; 116: 117–138
   PubMedGoogle Scholar
• Walker L. S. K., Chodos A., Eggena M., Dooms H., Abbas A. K. Antigen-dependent proliferation of CD4+CD25+ regulatory T cells in vivo. J. Exp. Med. 2003; 198: 249–258
   PubMed Web of Science ®Google Scholar
• Yamagiwa S., Gray J. D., Hashimoto S., Horwitz D. A. A role for TGF-beta in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral blood. J. Immunol. 2001; 166: 7282–7289
   PubMed Web of Science ®Google Scholar
• Yamazaki S., Iyoda T., Tarbell K., Olsen K., Velinzon K., Inaba K., Steinman R. M. Direct expansion of functional CD25+CD4+ regulatory T cells by antigen-processing dendritic cells. J. Exp. Med. 2003; 198: 235–247
   PubMed Web of Science ®Google Scholar
• Zhang Z. X., Yang L., Young K. J., DuTemple B., Zhang L. Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression. Nat. Med. 2000; 6: 782–789
   PubMed Web of Science ®Google Scholar
• Zheng S. G., Wang J. H., Gray J. D., Soucier H., Horwitz D. A. Natural and induced CD4 + CD25+ cells educate CD4+CD25-cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10. J. Immunol. 2004; 172: 5213–5221
   PubMed Web of Science ®Google Scholar
• Zheng S. G., Wang J. H., Stohl W., Kim K. S., Gray J. D., Horwitz D. A. TGF-beta requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4+CD25+ regulatory cells. J. Immunol. 2006; 176: 3321–3329
   PubMed Web of Science ®Google Scholar