Advanced search
Publication Cover
Immunological Investigations
A Journal of Molecular and Cellular Immunology
Volume 38, 2009 - Issue 1
Submit an article Journal homepage
109
Views
4
CrossRef citations to date
0
Altmetric
Original

Effects of the CCR5-Δ32 Mutation on Hepatitis C Virus-Specific Immune Responses in Patients with Haemophilia

Golo Ahlenstiel Department of Internal Medicine I, University of Bonn, Sigmund-Freud-Strasse 25, 53105, Bonn, Germany
,
Rainer P. Woitas Department of Internal Medicine I, University of Bonn, Sigmund-Freud-Strasse 25, 53105, Bonn, Germany
,
Agathe Iwan Department of Internal Medicine I, University of Bonn, Sigmund-Freud-Strasse 25, 53105, Bonn, Germany
,
Jacob Nattermann Department of Internal Medicine I, University of Bonn, Sigmund-Freud-Strasse 25, 53105, Bonn, Germany
,
Georg Feldmann Department of Internal Medicine I, University of Bonn, Sigmund-Freud-Strasse 25, 53105, Bonn, Germany
,
Jürgen K. Rockstroh Department of Internal Medicine I, University of Bonn, Sigmund-Freud-Strasse 25, 53105, Bonn, Germany
,
Johannes Oldenburg Institute of Experimental Haematology, University of Bonn, Sigmund-Freud-Strasse 25, 53105, Bonn, Germany
,
Bernd Kupfer Institute of Medical Microbiology and Immunology, University of Bonn, Sigmund-Freud-Strasse 25, 53105, Bonn, Germany
,
Tilman Sauerbruch Department of Internal Medicine I, University of Bonn, Sigmund-Freud-Strasse 25, 53105, Bonn, Germany
&
Ulrich Spengler Department of Internal Medicine I, University of Bonn, Sigmund-Freud-Strasse 25, 53105, Bonn, GermanyCorrespondence[email protected]
 show all
Pages 1-13 | Published online: 07 Jul 2009

REFERENCES

  • Ahlenstiel G., Berg T., Woitas R. P., et al. Effects of the CCR5-Delta32 mutation on antiviral treatment in chronic hepatitis C. J. Hepatol. 2003; 39(2)245–252
  • Algood H. M., Flynn J. L. CCR5-deficient mice control Mycobacterium tuberculosis infection despite increased pulmonary lymphocytic infiltration. J. Immunol. 2004; 173(5)3287–3296
  • Apolinario A., Majano P. L., Alvarez-Perez E., et al. Increased expression of T cell chemokines and their receptors in chronic hepatitis C: relationship with the histological activity of liver disease. Amer. J. Gastroenterol. 2002; 97(11)2861–2870
  • Belnoue E., Kayibanda M., Deschemin J. C., et al. CCR5 deficiency decreases susceptibility to experimental cerebral malaria. Blood 2003; 101(11)4253–4259
  • Choo Q. L., Kuo G., Weiner A. J., Overby L. R., Bradley D. W., Houghton M. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 1989; 244(4902)359–362
  • Cramp M. E., Carucci P., Rossol S., et al. Hepatitis C virus (HCV) specific immune responses in anti-HCV positive patients without hepatitis C viraemia. Gut 1999; 44(3)424–429
  • Diepolder H. M., Zachoval R., Hoffmann R. M., et al. Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection. Lancet 1995; 346(8981)1006–1007
  • Fujihashi K., McGhee J. R., Beagley K. W., et al. Cytokine-specific ELISPOT assay. Single cell analysis of IL-2, IL-4 and IL-6 producing cells. J. Immunol. Meth. 1993; 160(2)181–189
  • Glass W. G., Liu M. T., Kuziel W. A., Lane T. E. Reduced macrophage infiltration and demyelination in mice lacking the chemokine receptor CCR5 following infection with a neurotropic coronavirus. Virology 2001; 288(1)8–17
  • Hellier S., Frodsham A. J., Hennig B. J., et al. Association of genetic variants of the chemokine receptor CCR5 and its ligands, RANTES and MCP-2, with outcome of HCV infection. Hepatology 2003; 38(6)1468–1476
  • Hoffmann R. M., Diepolder H. M., Zachoval R., et al. Mapping of immunodominant CD4+ T lymphocyte epitopes of hepatitis C virus antigens and their relevance during the course of chronic infection. Hepatology 1995; 21(3)632–638
  • Huang Y., Paxton W. A., Wolinsky S. M., et al. The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nat. Med. 1996; 2(11)1240–1243
  • Imberti L., Cariani E., Bettinardi A., et al. An immunoassay for specific amplified HCV sequences. J. Virol Meth. 1991; 34(3)233–43
  • Machado F. S., Koyama N. S., Carregaro V., et al. CCR5 plays a critical role in the development of myocarditis and host protection in mice infected with Trypanosoma cruzi. J. Infect. Dis. 2005; 191(4)627–636
  • Mangia A., Santoro R., D'Agruma L., Andriulli A. HCV chronic infection and CCR5-delta32/delta32. Gastroenterology 2003; 124(3)868–869
  • Mantovani A. The chemokine system: redundancy for robust outputs. Immunol. Today 1999; 20(6)254–257
  • Missale G., Bertoni R., Lamonaca V., et al. Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response. J. Clin. Invest. 1996; 98(3)706–714
  • Nansen A., Christensen J. P., Andreasen S. O., Bartholdy C., Christensen J. E., Thomsen A. R. The role of CC chemokine receptor 5 in antiviral immunity. Blood 2002; 99(4)1237–1245
  • Promrat K., McDermott D. H., Gonzalez C. M., et al. Associations of chemokine system polymorphisms with clinical outcomes and treatment responses of chronic hepatitis C. Gastroenterology 2003; 124(2)352–360
  • Samson M., Libert F., Doranz B. J., et al. Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 1996; 382(6593)722–725
  • Wald O., Pappo O., Ari Z. B., et al. The CCR5Delta32 allele is associated with reduced liver inflammation in hepatitis C virus infection. Eur. J. Immunogenet. 2004; 31(6)249–252
  • Woitas R. P., Ahlenstiel G., Iwan A., et al. Frequency of the HIV-protective CC chemokine receptor 5-Delta32/Delta32 genotype is increased in hepatitis C. Gastroenterology 2002; 122(7)1721–1728
  • Woitas R. P., Ahlenstiel G., Sauerbruch T., Spengler U. Reply. Gastroenterology 2003; 124(5)1560–1561
  • Zhang M., Goedert J. J., O'Brien T. R. High frequency of CCR5-delta32 homozygosity in HCV-infected, HIV-1-uninfected hemophiliacs results from resistance to HIV-1. Gastroenterology 2003; 124(3)867–868

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.