Altered Immunodominance Hierarchies of Influenza A Virus-Specific H-2^b-Restricted CD8⁺ T Cells in the Absence of Terminal Deoxynucleotidyl Transferase

REFERENCES

• Belz G. T., Xie W., Altman J. D., Doherty P. C. A previously unrecognized H2D(b)-restricted peptide prominent in the primary influenza A virus-specific CD8(+) T-cell response is much less apparent following secondary challenge. J. Virol. 2000; 74: 3486–3493
   PubMed Web of Science ®Google Scholar
• Benedict C. L., Gilfillan S., Thai T. H., Kearney J. F. Terminal deoxynucleotidyl transferase and repertoire development. Immunol. Rev. 2000; 175: 150–157
   PubMed Web of Science ®Google Scholar
• Bogue M., Gilfillan S., Benoist C., Mathis D. Regulation of N-region diversity in antigen receptors through thymocyte differentiation and thymus ontogeny. Proc. Natl. Acad. Sci. U.S.A. 1992; 89: 11011–11015
   PubMed Web of Science ®Google Scholar
• Bonati A., Zanelli P., Savi M., Neri T. M. TCR-beta chain gene rearrangement and expression in human T-cell development and in leukemia. Leukemia 1994; 8: 918–923
   PubMed Web of Science ®Google Scholar
• Cabaniols J. P., Fazilleau N., Casrouge A., Kourilsky P., Kanellopoulos J. M. Most alpha/beta T cell receptor diversity is due to terminal deoxynucleotidyl transferase. J. Exp. Med. 2001; 194: 1385–1390
   PubMed Web of Science ®Google Scholar
• Chen W., Khilko S., Fecondo J., Margulies D. H., McCluskey J. Determinant selection of major histocompatibility complex class I-restricted antigenic peptides is explained by class I-peptide affinity and is strongly influenced by nondominant anchor residues. J. Exp. Med. 1994; 180: 1471–1483
   PubMed Web of Science ®Google Scholar
• Chen W., Norbury C. C., Cho Y., Yewdell J. W., Bennink J. R. Immunoproteasomes shape immunodominance hierarchies of antiviral CD8(+) T cells at the levels of T cell repertoire and presentation of viral antigens. J. Exp. Med. 2001; 193: 1319–1326
   PubMed Web of Science ®Google Scholar
• Chen W., Pang K., Masterman K. A., Kennedy G., Basta S., Dimopoulos N., Hornung F., Smyth M., Bennink J. R., Yewdell J. W. Reversal in the immunodominance hierarchy in secondary CD8+ T cell responses to influenza A virus: roles for cross-presentation and lysis-independent immunodomination. J. Immunol. 2004; 173: 5021–5027
   PubMed Web of Science ®Google Scholar
• Crowe S. R., Turner S. J., Miller S. C., Roberts A. D., Rappolo R. A., Doherty P. C., Ely K. H., Woodland D. L. Differential antigen presentation regulates the changing patterns of CD8+ T cell immunodominance in primary and secondary influenza virus infections. J. Exp. Med. 2003; 198: 399–410
   PubMed Web of Science ®Google Scholar
• Davis M. M., Bjorkman P. J. T-cell antigen receptor genes and T-cell recognition. Nature 1988; 334: 395–402
   PubMed Web of Science ®Google Scholar
• Deng Y., Yewdell J. W., Eisenlohr L. C., Bennink J. R. MHC affinity, peptide liberation, T cell repertoire, and immunodominance all contribute to the paucity of MHC class I-restricted peptides recognized by antiviral CTL. J. Immunol. 1997; 158: 1507–1515
   PubMed Web of Science ®Google Scholar
• Flynn K. J., Belz G. T., Altman J. D., Ahmed R., Woodland D. L., Doherty P. C. Virus-specific CD8+ T cells in primary and secondary influenza pneumonia. Immunity. 1998; 8: 683–691
   PubMed Web of Science ®Google Scholar
• Gavin M. A., Bevan M. J. Increased peptide promiscuity provides a rationale for the lack of N regions in the neonatal T cell repertoire. Immunity. 1995; 3: 793–800
   PubMed Web of Science ®Google Scholar
• Gileadi U., Moins-Teisserenc H. T., Correa I., Booth B. L., Jr, Dunbar P. R., Sewell A. K., Trowsdale J., Phillips R. E., Cerundolo V. Generation of an immunodominant CTL epitope is affected by proteasome subunit composition and stability of the antigenic protein. J. Immunol. 1999; 163: 6045–6052
   PubMed Web of Science ®Google Scholar
• Gilfillan S., Bachmann M., Trembleau S., Adorini L., Kalinke U., Zinkernagel R., Benoist C., Mathis D. Efficient immune responses in mice lacking N-region diversity. Eur. J. Immunol. 1995; 25: 3115–3122
   PubMed Web of Science ®Google Scholar
• Gilfillan S., Dierich A., Lemeur M., Benoist C., Mathis D. Mice lacking TdT: mature animals with an immature lymphocyte repertoire. Science 1993; 261: 1175–1178
   PubMed Web of Science ®Google Scholar
• Haeryfar S. M., DiPaolo R. J., Tscharke D. C., Bennink J. R., Yewdell J. W. Regulatory T cells suppress CD8+ T cell responses induced by direct priming and cross-priming and moderate immunodominance disparities. J. Immunol. 2005; 174: 3344–3351
   PubMed Web of Science ®Google Scholar
• Haeryfar S. M., Hickman H. D., Irvine R. R., Tscharke D. C., Bennink J. R., Yewdell J. W. Terminal deoxynucleotidal transferase establishes and broadens antiviral CD8+ T cell immunodominance hierarchies. J. Immunol. 2008; 181: 649–659
   PubMed Web of Science ®Google Scholar
• Heemels M. T., Ploegh H. Generation, translocation, and presentation of MHC class I-restricted peptides. Annu. Rev. Biochem. 1995; 64: 463–491
   PubMed Web of Science ®Google Scholar
• Kedl R. M., Kappler J. W., Marrack P. Epitope dominance, competition and T cell affinity maturation. Curr. Opin. Immunol. 2003; 15: 120–127
   PubMed Web of Science ®Google Scholar
• Kedl R. M., Rees W. A., Hildeman D. A., Schaefer B., Mitchell T., Kappler J., Marrack P. T cells compete for access to antigen-bearing antigen-presenting cells. J. Exp. Med. 2000; 192: 1105–1113
   PubMed Web of Science ®Google Scholar
• Khilko S. N., Corr M., Boyd L. F., Lees A., Inman J. K., Margulies D. H. Direct detection of major histocompatibility complex class I binding to antigenic peptides using surface plasmon resonance. Peptide immobilization and characterization of binding specificity. J. Biol. Chem. 1993; 268: 15425–15434
   PubMed Web of Science ®Google Scholar
• Komori T., Okada A., Stewart V., Alt F. W. Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes. Science 1993; 261: 1171–1175
   PubMed Web of Science ®Google Scholar
• La Gruta N. L., Kedzierska K., Pang K., Webby R., Davenport M., Chen W., Turner S. J., Doherty P. C. A virus-specific CD8+ T cell immunodominance hierarchy determined by antigen dose and precursor frequencies. Proc. Natl. Acad. Sci. U.S.A. 2006; 103: 994–999
   PubMed Web of Science ®Google Scholar
• Nguyen H. H., Zemlin M., Ivanov I. I., Andrasi J., Zemlin C., Vu H. L., Schelonka R., Schroeder H. W., Jr., Mestecky J. Heterosubtypic immunity to influenza A virus requires a properly diversified antibody repertoire. J. Virol. 2007; 81: 9331–9338
   PubMed Web of Science ®Google Scholar
• Nikolich-Zugich J., Slifka M. K., Messaoudi I. The many important facets of T-cell repertoire diversity. Nat. Rev. Immunol. 2004; 4: 123–132
   PubMed Web of Science ®Google Scholar
• Probst H. C., Tschannen K., Gallimore A., Martinic M., Basler M., Dumrese T., Jones E., van den Broek M. F. Immunodominance of an antiviral cytotoxic T cell response is shaped by the kinetics of viral protein expression. J. Immunol. 2003; 171: 5415–5422
   PubMed Web of Science ®Google Scholar
• Sette A., Fikes J. Epitope-based vaccines: an update on epitope identification, vaccine design and delivery. Curr. Opin. Immunol. 2003; 15: 461–470
   PubMed Web of Science ®Google Scholar
• Townsend A. R., Rothbard J., Gotch F. M., Bahadur G., Wraith D., McMichael A. J. The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides. Cell 1986; 44: 959–968
   PubMed Web of Science ®Google Scholar
• Yewdell J. W., Bennink J. R. Immunodominance in major histocompatibility complex class I-restricted T lymphocyte responses. Annu. Rev. Immunol. 1999; 17: 51–88
   PubMed Web of Science ®Google Scholar
• Yewdell J. W., Haeryfar S. M. Understanding presentation of viral antigens to CD8+ T cells in vivo: the key to rational vaccine design. Annu. Rev. Immunol. 2005; 23: 651–682
   PubMed Web of Science ®Google Scholar