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Immunological Investigations
A Journal of Molecular and Cellular Immunology
Volume 37, 2008 - Issue 8
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Original

Immunological Potential of Helix vulgaris and Rapana venosa Hemocyanins

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Pages 822-840 | Published online: 07 Jul 2009

REFERENCES

  • Avrameas S. Coupling of enzymes to proteins with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies. Immunochemistry 1969; 6: 43–52
  • Ballweber P., Markl J., Burmester T. Complete hemocyanin subunit sequences of the hunting spider Cupiennius salei recent hemocyanin remodeling in entelegyne spiders. J. Biol. Chem. 2002; 277: 14451–14457
  • Beck A., Hillen N., Dolashki A., Stevanovic S., Salvato B., Voelter W., Dolashka-Angelova P. Oligosaccharide structure of a functional unit RvH1-b of Rapana venosa hemocyanin using HPLC/electrospray ionization mass spectrometry. Biochimie 2007; 89(8)938–949
  • Bergmann S., Lieb B., Ruth P., Markl J. The hemocyanin from a living fossil, the Cephalopod Nautilus pompilius: protein structure, gene organization, and evolution. J. Mol. Evol. 2006; 62(3)362–374
  • Bergmann S., Markl J., Lieb B. The first complete cDNA sequence of the hemocyanin from a Bivalve, the protobranch Nucula nucleus. J. Mol. Evol. 2007; 64: 500–510
  • Costopoulou D., Leondiadis L., Czarnecki J., Ferderigos N., Ithakissios D. S., Livaniou E., Evangelatos G.P. Direct ELISA method for the specific determination of prothymosin alpha in human specimens. J. Immunoassay 1998; 19: 295–316
  • Dolashka-Angelova P., Beck A., Dolashki A., Beltramini M., Stevanovic S., Salvato B., Hristova R., Velkova L., Voelter W. Carbohydrate moieties of molluscan Rapana venosa hemocyanin. Micron 2004; 35: 101–104
  • Dolashka-Angelova P., Beck A., Dolashki A., Beltramini M., Stevanovic S., Salvato B., Veolter W. Characterization of the carbohydrate moieties of the functional unit RvH1-a of Rapana venosa haemocyanin using HPLC /electrospray ionization MS and glycosidase digestion. Biochem. J. 2003a; 374: 185–192
  • Dolashka-Angelova P., Dolashki A., Savvides S.N., Hristova R., Van Beeumen J., Voelter W., Devreese B., Weser U., Di Muro P., Salvato B., Stevanovic S. Structure of hemocyanin subunit CaeSS2 of the crustacean mediterranean crab Carcinus aestuarii. J. Biochem. 2005; 138: 303–312
  • Dolashka-Angelova P., Schwarz H., Dolashki A., Beltramini M., Salvato B., Schick M., Saeed M., Voelter W. Characterization of the reassociation and oligomeric stability of Rapana venosa hemocyanin (RvH) and its structural subunits. Biochim. Biophys. Acta 2003b; 1646(1–2)77–85
  • Dolashka-Angelova P., Stefanovic S., Dolashki A., Devreese B., Tzvetkova B., Voelter W., Van Beeumen J., Salvato B. A challenging insight on the structural unit 1 of molluscan Rapana venosa hemocyanin. Arch. Biochem. Biophys 2007; 459(1)50–58
  • Dolashka-Angelova P., Velkova L., Sandra K., Dolashki A., Gardeva M., Stevanovic S., Voelter W., Devreese B., Van Beeumen J. Oligosaccharide structures of molluscan hemocyanins: Are they really methylated?. Int. Symposium “Protein Structure-Function Relationships”, Karachi 11–14.01.2007, Pakist. J. Biochem 2007
  • Enkemann S.A., Ward R.D., Berger SL. Mobility within the nucleus and neighboring cytosol is a key feature of prothymosin-α. J. Histochem. Cytochem. 2000; 48: 1341–1355
  • Freire M., Diaz-Jullien C., Covelo G. Developments in prothymosin α-research. Recent Res. Devel. Proteins 2002; 1: 257–276
  • Gast K., Damaschun H., Eckert K., Schulze-Forster K., Maurer H. R., Mueller-Frohne M., Zirwer D., Czarnecki J., Damaschun G. Prothymosin alpha: a biologically active protein with random coil conformation. Biochemistry 1995; 34: 13211–13218
  • Gathuru J.K., Koide F., Ragupathi G., Adams J.L., Kerns R.T., Coleman T. P., Livingston P. O. Identification of DhbcAg as a potent carrier protein comparable to KLH for augmenting MUC1 antigenicity. Vaccine 2005; 23: 4727–4733
  • Gielens C., De Geest N., Compernolle F., Préaux G. Glycosylation sites of hemocyanins of Helix pomatia and Sepia officinalis. Micron 2004; 35(1–2)99–100
  • Gielens C., De Sadeleer J., Preaux G., Lontie R. Identification, separation and characterization of the hemocyanin components of Helix aspersa. Comp. Biochem. Physiol. 1987; 88 B(1)181–186
  • Hannappel E., Huff T. The thymosins. Prothymosin alpha, parathymosin, and beta-thymosins: structure and function. Vitam Horm. 2003; 66: 257–296
  • Harris J.R., Markl J. Keyhole limpet hemocyanin (KLH): a biomedical review. Micron 1999; 30: 597–623
  • Herscowitz H.B., Harold W., Stravitzky A.B. Immunochemical and immunogenetic properties of a purified keyhole limpet hemocyanin. Immunology 1972; 22: 51–61
  • Klimentzou P., Paravatou-Petsotas M., Zikos C., Beck A., Skopeliti M., Czarnecki J., Tsitsilonis O., Voelter W., Livaniou E., Evangelatos GP. Development and immunochemical evaluation of antibodies Y for the poorly immunogenic polypeptide prothymosin alpha. Peptides 2006; 27: 183–193
  • Kurokawa T., Wuhrer M., Lochnit G., Geyer H., Markl J., Geyer R. Hemocyanin from the keyhole limpet Megathura crenulata (KLH) carries a novel type of N-glycans with Gal(β1–6)Man-motifs. Eur. J. Biochem. 2002; 269: 5459–5473
  • Lambert O., Boisset N., Taveau J.C., Préau G., Lamy J.N. Three-dimensional reconstruction of the alpha D and beta C - hemocyanins of Helix pomatia from frozen-hydrated Specimens. J. Mol. Biol. April 28, 1995; 248(2)431–438
  • Lamm D.L., Morales A., Grossman H.B. Keyhole limpet hemocyanin (KLH) immunotherapy of papillary and in situ transitional cell carcinoma of bladder. A multicenter phase I-II clinical trial. J. Urol. 1996; 155A: 1405–1412
  • Livaniou E., Mihelic M., Evangelatos G.P., Haritos A., Voelter W. A thymosin beta 4 ELISA using an antibody against the N terminal fragment thymosin beta 4 [1–14]. J. Immunol. Meth. 1992; 148(1–2)9–14
  • Lommerse J.P.M., Thomas-Oates J.E., Gielens C., Preaux G., Kamerling J.P., Vliegenthart J.F.G. Primary structure of 21 novel monoantennary and diantennary N-linked carbohydrate chains from alpha-D-hemocyanin of Helix pomatia. Eur. J. Biochem. 1997; 249: 195–222
  • Miller K., Cuff M., Lang W., Varga-Weisz P., Field K., Van Holde K. Sequence of the Octopus dofleini hemocyanin subunit: structural and evolutionary implications. J. Mol. Biol. 1998; 278: 827–842
  • Moltedo F., Faunes D., Haussmann P., De Ioannes A., De Ioannes Puente, J., DLW4] [, Becker M. Immunotherapeutic effect of concholepas hemocyanin in the murine bladder cancer model: evidence for conserved antitumor properties among hemocyanins. J. Urol. 2006; 176(6)2690–2695
  • Rittenberg M.B., Amkraut A.A. Immunogenicity of trinitrophenyl-hemocyanin: production of primary and secondary anti-hapten precipitins. J. Immunol. Sep. 1966; 97(3)421–430
  • Salvato B., Beltramini M. Hemocyanin: Molecular architecture: structure and reactivity of the binuclear copper active site. Life Chem. Rep. 1990; 8: 1–47
  • Sandra K., Dolashka-Angelova P., Devreese B., Van Beeumen J. New insights in Rapana venosa hemocyani N-glycosylation resulting from on-line mass spectrometric analyses. Glycobiology 2007; 17(2)141–156
  • Schnurr M., Galambos P., Scholz C., Then F., Dauer M., Endres S., Eigler A. Tumor cell lysate-pulsed human dendritic cells induce a T-cell response against pancreatic carcinoma cells: an in vitro model for assessment of tumor vaccines. Cancer Res. 2001; 61: 6445–6450
  • Schütz J., Dolashka-Angelova P., Abrashev R., Nicolov P., Voelter W. Isolation and spectroscopic characterization of the structural subunits of keyhole limpet hemocyanin. Biochim. Biophys. Acta 2001; 1546: 325–336
  • Sukhacheva E.A., Evstafieva A.G., Fateeva T.V., Shakulov V.R., Efimova N.A., Karapetian R.N., Rubtsov Y.P., Vartapetian A.B. Sensing prothymosin alpha origin, mutations and conformation with monoclonal antibodies. J. Immunol. Meth. 2002; 266: 185–196
  • Toshkova R., Velkova L., Voelter W., Dolashka-Angelova P. Protective effect of Rapana venosa hemocyanin (RvH) on survivability of hamsters with transplanted myeloid Graffi tumours. Comptes rendus de I'Academie Bulgare des sciences 2006; 59(9)977–982
  • Vaitukaitis J.L. Production of antisera with small doses of immunogen: multiple intradermal injections. Meth. Enzymol. 1981; 73: 46–52
  • Van Holde K.E., Miller K.I. Hemocyanins. Adv. Protein Chem. 1995; 47: 1–81
  • Wuhrer M., Robijn M., Koeleman C.A.M., Balog C.I.A., Geyer R., Deelder A.M., Hokke C.H. A novel Gal(β1–4)Gal(β1–4)Fuc(α1–6)-core modification attached to the proximal N-acetylglucosamine of keyhole limpet hemocyanin (KLH) N-glycans. Biochem. J 2004; 378: 625–632

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