Publication Cover
Immunological Investigations
A Journal of Molecular and Cellular Immunology
Volume 45, 2016 - Issue 6
313
Views
11
CrossRef citations to date
0
Altmetric
Original Articles

Dendritic Cell Immunotherapy Combined with Cytokine-Induced Killer Cells Effectively Suppresses Established Hepatocellular Carcinomas in Mice

, , , , , , , , & show all

References

  • Andersen MH, Keikavoussi P, Brocker EB, et al. (2001). Induction of systemic CTL responses in melanoma patients by dendritic cell vaccination: Cessation of CTL responses is associated with disease progression. Int J Cancer, 94 (6), 820–4.
  • Asada H, Kishida T, Hirai H, et al. (2006). Combination vaccine of dendritic cells (DCs) and T cells effectively suppressed preestablished malignant melanoma in mice. Cancer Lett, 240 (1), 83–93. doi: 10.1016/j.canlet.2005.08.030.
  • Baker J, Verneris MR, Ito M, et al. (2001). Expansion of cytolytic CD8(+) natural killer T cells with limited capacity for graft-versus-host disease induction due to interferon gamma production. Blood, 97 (10), 2923–31.
  • Banchereau J, Steinman RM. (1998). Dendritic cells and the control of immunity. Nature, 392 (6673), 245–52. doi: 10.1038/32588.
  • Chang DH, Dhodapkar MV. (2003). Dendritic cells and immunotherapy for cancer. Int J Hematol, 77 (5), 439–43.
  • Duan XZ, Zhuang H, Wang M, et al. (2005). Decreased numbers and impaired function of circulating dendritic cell subsets in patients with chronic hepatitis B infection (R2). J Gastroenterol Hepatol, 20 (2), 234–42. doi: 10.1111/j.1440-1746.2004.03529.x.
  • El-Serag HB. (2011). Hepatocellular carcinoma. N Engl J Med, 365 (12), 1118–27. doi: 10.1056/NEJMra1001683.
  • El-Serag HB, Rudolph KL. (2007). Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis. Gastroenterol, 132 (7), 2557–76. doi: 10.1053/j.gastro.2007.04.061.
  • Eshima K, Chiba S, Suzuki H, et al. (2012). Ectopic expression of a T-box transcription factor, eomesodermin, renders CD4(+) Th cells cytotoxic by activating both perforin- and FasL-pathways. Immunol Lett, 144 (1–2), 7–15. doi: 10.1016/j.imlet.2012.02.013.
  • Ikai I, Arii S, Okazaki M, et al. (2007). Report of the 17th nationwide follow-up survey of primary liver cancer in Japan. Hepatol Res, 37 (9), 676–91. doi: 10.1111/j.1872-034X.2007.00119.x.
  • Kakumu S, Ito S, Ishikawa T, et al. (2000). Decreased function of peripheral blood dendritic cells in patients with hepatocellular carcinoma with hepatitis B and C virus infection. J Gastroenterol Hepatol, 15 (4), 431–6.
  • Khazaie K, von Boehmer H. (2006). The impact of CD4+CD25+ Treg on tumor specific CD8+ T cell cytotoxicity and cancer. Semin Cancer Biol, 16 (2), 124–36. doi: 10.1016/j.semcancer.2005.11.006.
  • Kondo Y, Shimosegawa T. (2015). Significant roles of regulatory T cells and myeloid derived suppressor cells in hepatitis B virus persistent infection and hepatitis B virus-related HCCs. Int J Mol Sci, 16 (2), 3307–22. doi: 10.3390/ijms16023307.
  • Lim DS, Kim JH, Lee DS, et al. (2007). DC immunotherapy is highly effective for the inhibition of tumor metastasis or recurrence, although it is not efficient for the eradication of established solid tumors. Cancer Immunol Immunother, 56 (11), 1817–29. doi: 10.1007/s00262-007-0325-0.
  • Lu PH, Negrin RS. (1994). A novel population of expanded human CD3+CD56+ cells derived from T cells with potent in vivo antitumor activity in mice with severe combined immunodeficiency. J Immunol, 153 (4), 1687–96.
  • Mellman I, Steinman RM. (2001). Dendritic cells: Specialized and regulated antigen processing machines. Cell 106 (3), 255–8.
  • Nestle FO, Alijagic S, Gilliet M, et al. (1998). Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells. Nat Med, 4 (3), 328–32.
  • Nishikawa H, Arimoto A, Wakasa T, et al. (2013). Comparison of clinical characteristics and survival after surgery in patients with non-B and non-C hepatocellular carcinoma and hepatitis virus-related hepatocellular carcinoma. J Cancer, 4 (6), 502–13. doi: 10.7150/jca.6503.
  • O’Neill DW, Adams S, Bhardwaj N. (2004). Manipulating dendritic cell biology for the active immunotherapy of cancer. Blood, 104 (8), 2235–46. doi: 10.1182/blood-2003-12-4392.
  • Schmidt J, Eisold S, Buchler MW, Marten A. (2004). Dendritic cells reduce number and function of CD4+CD25+ cells in cytokine-induced killer cells derived from patients with pancreatic carcinoma. Cancer Immunol Immunother 53 (11), 1018–26. doi: 10.1007/s00262-004-0554-4.
  • Schmidt-Wolf IG, Lefterova P, Mehta BA, et al. (1993). Phenotypic characterization and identification of effector cells involved in tumor cell recognition of cytokine-induced killer cells. Exp Hematol, 21 (13), 1673–9.
  • Schmidt-Wolf IG, Negrin RS, Kiem HP, et al. (1991). Use of a SCID mouse/human lymphoma model to evaluate cytokine-induced killer cells with potent antitumor cell activity. J Exp Med, 174 (1), 139–49.
  • Tada F, Abe M, Hirooka M, et al. (2012). Phase I/II study of immunotherapy using tumor antigen-pulsed dendritic cells in patients with hepatocellular carcinoma. Int J Oncol, 41 (5), 1601–9. doi: 10.3892/ijo.2012.1626.
  • Vivarelli M, Montalti R, Risaliti A. (2013). Multimodal treatment of hepatocellular carcinoma on cirrhosis: An update. World J Gastroenterol, 19 (42), 7316–26. doi: 10.3748/wjg.v19.i42.7316.
  • Yu JS, Liu G, Ying H, et al. (2004). Vaccination with tumor lysate-pulsed dendritic cells elicits antigen-specific, cytotoxic T-cells in patients with malignant glioma. Cancer Res, 64 (14), 4973–9. doi: 10.1158/0008-5472.CAN-03-3505.
  • Zamarron BF, Chen W. (2011). Dual roles of immune cells and their factors in cancer development and progression. Int J Biol Sci, 7 (5), 651–8.
  • Zhao HQ, Li WM, Lu ZQ, Yao YM. (2014). Roles of Tregs in development of hepatocellular carcinoma: A meta-analysis. World J Gastroenterol, 20 (24), 7971–8. doi: 10.3748/wjg.v20.i24.7971.
  • Zhong R, Teng J, Han B, Zhong H. (2011). Dendritic cells combining with cytokine-induced killer cells synergize chemotherapy in patients with late-stage non-small cell lung cancer. Cancer Immunol Immunother, 60 (10), 1497–502. doi: 10.1007/s00262-011-1060-0.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.