Association between Functional CYP2D6 Polymorphisms and Susceptibility to Autoimmune Diseases: A Meta-Analysis

References

• Aceves Avila FJ, Esquivel Nava GA, Gallegos Arreola MP, et al. (2004). Cyclophosphamide boluses induce micronuclei expression in buccal mucosa cells of patients with systemic lupus erythematosus independent of cytochrome P450 2D6 status. J Rheumatol, 31, 1335–1339.
   PubMed Web of Science ®Google Scholar
• Arakawa H, Jinnin M, Muchemwa FC, et al. (2011). Adiponectin expression is decreased in the involved skin and sera of diffuse cutaneous scleroderma patients. Exp Dermatol, 20, 764–766.
   PubMed Web of Science ®Google Scholar
• Baranska M, Rychlik-Sych M, Kaszuba A, et al. (2016). Genetic polymorphism of CYP2D6 in patients with systemic lupus erythematosus and systemic sclerosis. Autoimmunity, 1–6.
   Google Scholar
• Bashir S, Harris G, Denman MA, et al. (1993). Oxidative DNA damage and cellular sensitivity to oxidative stress in human autoimmune diseases. Ann Rheumatic Dis, 52, 659–666.
   PubMed Web of Science ®Google Scholar
• Becker KG. (2004). The common variants/multiple disease hypothesis of common complex genetic disorders. Med Hypotheses, 62, 309–317.
   PubMed Web of Science ®Google Scholar
• Bertilsson L, Dahl ML, Dalén P, Al‐Shurbaji A. (2002). Molecular genetics of CYP2D6: clinical relevance with focus on psychotropic drugs. Br J Clin Pharmacol, 53, 111–122.
   PubMed Web of Science ®Google Scholar
• Beyeler C, Armstrong M, Bird HA, et al. (1996). Relationship between genotype for the cytochrome P450 CYP2D6 and susceptibility to ankylosing spondylitis and rheumatoid arthritis. Ann Rheum Dis, 55, 66–68.
   PubMed Web of Science ®Google Scholar
• Brown MA, Edwards S, Hoyle E, et al. (2000). Polymorphisms of the CYP2D6 gene increase susceptibility to ankylosing spondylitis. Hum Mol Genet, 9, 1563–1566.
   PubMed Web of Science ®Google Scholar
• Brown MA, Wordsworth BP, Reveille JD. (2002). Genetics of ankylosing spondylitis. Clin Exp Rheumatol, 20, S43–S49.
   PubMed Web of Science ®Google Scholar
• Budulgan M, Dilek B, Dag SB, et al. (2014). Relationship between serum leptin level and disease activity in patients with systemic sclerosis. Clin Rheumatol, 33, 335–339.
   PubMed Web of Science ®Google Scholar
• Daly A, Brockmoller J, Broly F, et al. (1996). Nomenclature for human CYP2D6 alleles. Pharmacogenet Genomics, 6, 193–201.
   Web of Science ®Google Scholar
• DerSimonian R, Laird N. (1986). Meta-analysis in clinical trials. Control Clin Trials, 7, 177–188.
   PubMed Web of Science ®Google Scholar
• Dudarewicz M, Rychlik-Sych M, Baranska M, et al. (2014). Significance of the genetic polymorphism of CYP2D6 and NAT2 in patients with inflammatory bowel diseases. Pharmacol Rep, 66, 686–690.
   PubMed Web of Science ®Google Scholar
• Egger M, Davey Smith G, Schneider M, Minder C. (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ, 315, 629–634.
   PubMed Web of Science ®Google Scholar
• Erden G, Acar FS, Inal EE, et al. (2009). Frequency of mutated allele CYP2D6*4 in the Turkish ankylosing spondylitis patients and healthy controls. Rheumatol Int, 29, 1431–1434.
   PubMed Web of Science ®Google Scholar
• Gaedigk A, Gotschall RR, Forbes NS, et al. (1999). Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data. Pharmacogenet Genomics, 9, 669–682.
   Web of Science ®Google Scholar
• Higgins JP, Thompson SG. (2002). Quantifying heterogeneity in a meta-analysis. Stat Med, 21, 1539–1558.
   PubMed Web of Science ®Google Scholar
• Ingelman-Sundberg M. (2005). Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity. Pharmacogenomics J, 5, 6–13.
   PubMed Web of Science ®Google Scholar
• Kang SH, Chung BH, Choi SR, et al. (2011). Comparison of clinical outcomes by different renal replacement therapy in patients with end-stage renal disease secondary to lupus nephritis. Korean J Int Med, 26, 60–67.
   PubMedGoogle Scholar
• Kimura Y, Selmi C, Leung PS, et al. (2005). Genetic polymorphisms influencing xenobiotic metabolism and transport in patients with primary biliary cirrhosis. Hepatology, 41, 55–63.
   PubMed Web of Science ®Google Scholar
• Kortunay S, Bozkurt A, Bathum L, et al. (1999) CYP2D6 polymorphism in systemic lupus erythematosus patients. Eur J Clin Pharmacol, 55, 21–25.
   PubMed Web of Science ®Google Scholar
• Kotulska A, Kucharz EJ, Brzezinska-Wcislo L, Wadas U. (2001). A decreased serum leptin level in patients with systemic sclerosis. Clin Rheumatol, 20, 300–302.
   PubMed Web of Science ®Google Scholar
• Kovacic P, Jacintho JD. (2003). Systemic lupus erythematosus and other autoimmune diseases from endogenous and exogenous agents: unifying theme of oxidative stress. Mini Rev Med Chem, 3, 568–575.
   PubMed Web of Science ®Google Scholar
• Lakota K, Wei J, Carns M, et al. (2012). Levels of adiponectin, a marker for PPAR-gamma activity, correlate with skin fibrosis in systemic sclerosis: potential utility as biomarker? Arthritis Res Ther, 14, R102.
   PubMed Web of Science ®Google Scholar
• Lee Y, Woo J, Choi S, et al. (2010). Induction and maintenance therapy for lupus nephritis: a systematic review and meta-analysis. Lupus, 19, 703–710.
   PubMed Web of Science ®Google Scholar
• Lee YH, Choi SJ, Ji JD, Song GG. (2012). Candidate gene studies of fibromyalgia: a systematic review and meta-analysis. Rheumatol Int, 32, 417–426.
   PubMed Web of Science ®Google Scholar
• Lu Y, Peng Q, Zeng Z, et al. (2014). CYP2D6 phenotypes and Parkinson’s disease risk: A meta-analysis. J Neurol Sci, 336, 161–168.
   PubMed Web of Science ®Google Scholar
• Lu Y, Qin X, Li S, et al. (2014). Quantitative assessment of CYP2D6 polymorphisms and risk of Alzheimer’s disease: A meta-analysis. J Neurol Sci, 343, 15–22.
   PubMed Web of Science ®Google Scholar
• Marrack P, Kappler J, Kotzin BL. (2001). Autoimmune disease: why and where it occurs. Nat Med, 7, 899–905.
   PubMed Web of Science ®Google Scholar
• Masui Y, Asano Y, Akamata K, et al. (2014). Serum resistin levels: a possible correlation with pulmonary vascular involvement in patients with systemic sclerosis. Rheumatol Int, 34, 1165–1170.
   PubMed Web of Science ®Google Scholar
• Masui Y, Asano Y, Shibata S, et al. (2012). Serum adiponectin levels inversely correlate with the activity of progressive skin sclerosis in patients with diffuse cutaneous systemic sclerosis. J Eur Acad Dermatol Venereol, 26, 354–360.
   PubMed Web of Science ®Google Scholar
• Meyer UA. (1994). Pharmacogenetics: the slow, the rapid, and the ultrarapid. Proc Natl Acad Sci, 91, 1983–1984.
   PubMed Web of Science ®Google Scholar
• Moher D, Liberati A, Tetzlaff J, et al. (2009). Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med, 6, e1000097.
   PubMed Web of Science ®Google Scholar
• Munafò MR, Flint J. (2004). Meta-analysis of genetic association studies. Trends Genet, 20, 439–444.
   PubMed Web of Science ®Google Scholar
• Nath SK, Harley JB, Lee YH. (2005). Polymorphisms of complement receptor 1 and interleukin-10 genes and systemic lupus erythematosus: a meta-analysis. Human Genet, 118, 225–234.
   PubMed Web of Science ®Google Scholar
• Niewinski P, Orzechowska-Juzwenko K, Hurkacz M, et al. (2002). CYP2D6 extensive, intermediate, and poor phenotypes and genotypes in a Polish population. Eur J Clin Pharmacol, 58, 533–535.
   PubMed Web of Science ®Google Scholar
• Olewicz-Gawlik A, Danczak-Pazdrowska A, Kuznar-Kaminska B, et al. (2015). Circulating adipokines and organ involvement in patients with systemic sclerosis. Acta Reumatol Port, 40, 156–162.
   PubMed Web of Science ®Google Scholar
• Pehlivan Y, Onat AM, Ceylan N, et al. (2012). Serum leptin, resistin and TNF-alpha levels in patients with systemic sclerosis: the role of adipokines in scleroderma. Int J Rheum Dis, 15, 374–379.
   PubMed Web of Science ®Google Scholar
• Rendic S, Carlo FJD. (1997). Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors. Drug Metab Rev, 29, 413–580.
   Google Scholar
• Riccieri V, Stefanantoni K, Vasile M, et al. (2011). Abnormal plasma levels of different angiogenic molecules are associated with different clinical manifestations in patients with systemic sclerosis. Clin Exp Rheumatol, 29, S46–S52.
   PubMed Web of Science ®Google Scholar
• Rychlik-Sych M, Baranska M, Wojtczak A, et al. (2015). The impact of the CYP2D6 gene polymorphism on the risk of pemphigoid. Int J Dermatol, 54, 1396–1401.
   PubMed Web of Science ®Google Scholar
• Sabbagh N, Marez D, Queyrel V, et al. (1998). Genetic analysis of the cytochrome P450 CYP2D6 polymorphism in patients with systemic lupus erythematosus. Pharmacogenetics, 8, 191–194.
   PubMedGoogle Scholar
• Salanti G, Amountza G, Ntzani EE, Ioannidis JP. (2005). Hardy–Weinberg equilibrium in genetic association studies: an empirical evaluation of reporting, deviations, and power. Eur J Hum Genet, 13, 840–848.
   PubMed Web of Science ®Google Scholar
• Steijns LS, Van Der Weide J. (1998). Ultrarapid drug metabolism: PCR-based detection of CYP2D6 gene duplication. Clin Chem, 44, 914–917.
   PubMed Web of Science ®Google Scholar
• Tomcik M, Arima K, Hulejova H, et al. (2012). Adiponectin relation to skin changes and dyslipidemia in systemic sclerosis. Cytokine, 58, 165–168.
   PubMed Web of Science ®Google Scholar
• Wang B, Yang L-P, Zhang X-Z, et al. (2009). New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme. Drug Metab Rev, 41, 573–643.
   PubMed Web of Science ®Google Scholar
• Winsz-Szczotka K, Kuznik-Trocha K, Komosinska-Vassev K, et al. (2014). Relationship between adiponectin, leptin, IGF-1 and total lipid peroxides plasma concentrations in patients with systemic sclerosis: possible role in disease development. Int J Rheum Dis. 19, 706–714.
   Google Scholar
• Wittke-Thompson JK, Pluzhnikov A, Cox NJ. (2005). Rational inferences about departures from Hardy-Weinberg equilibrium. Am J Hum Genet, 76, 967–986.
   PubMed Web of Science ®Google Scholar