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Immunological Investigations
A Journal of Molecular and Cellular Immunology
Volume 46, 2017 - Issue 2
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Original Articles

Interferon-gamma (IFN-γ) is Elevated in Wound Exudate from Hidradenitis Suppurativa

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References

  • Amano M, Grant A, Kerdel FA. (2010). A prospective open-label clinical trial of adalimumab for the treatment of hidradenitis suppurativa. Int J Dermatol, 49(8), 950–955.
  • Angel DE, Lloyd P, Carville K, Santamaria N. (2011). The clinical efficacy of two semi-quantitative wound-swabbing techniques in identifying the causative organism(s) in infected cutaneous wounds. Int Wound J, 8(2), 176–185.
  • Bechara FG, Sand M, Skrygan M, et al. (2012). Acne inversa: evaluating antimicrobial peptides and proteins. Ann Dermatol, 24(4), 393–397.
  • Bouma G, Strober W. (2003). The immunological and genetic basis of inflammatory bowel disease. Nat Rev Immunol, 3(7), 521–533.
  • Calmon-Hamaty F, Combe B., Hahne M., Morel J. (2011). Lymphotoxin alpha revisited: general features and implications in rheumatoid arthritis. Arthritis Res Ther, 13(4), 232.
  • Calmon-Hamaty F, Combe B, Hahne M, Morel J. (2011). Lymphotoxin alpha stimulates proliferation and pro-inflammatory cytokine secretion of rheumatoid arthritis synovial fibroblasts. Cytokine, 53(2), 207–214.
  • Charles CA, Romanelli P, Martinez ZB, et al. (2009). Tumor necrosis factor–alfa in nonhealing venous leg ulcers. J Am Acad Dermatol, 60(6), 951–955.
  • Chiang EY, Kolumam GA, Yu X, et al. (2009). Targeted depletion of lymphotoxin-alpha-expressing TH1 and TH17 cells inhibits autoimmune disease. Nat Med, 15(7), 766–773.
  • Chowdhury F, Williams A, Johnson P. (2009). Validation and comparison of two multiplex technologies, Luminex® and Mesoscale Discovery, for human cytokine profiling. J Immunol Methods, 340(1), 55–64.
  • Cosmatos I, Matcho A, Weinstein R, et al. (2013). Analysis of patient claims data to determine the prevalence of hidradenitis suppurativa in the United States. J Am Acad Dermatol, 69(5), 819.
  • Danby FW, Jemec GB, Marsch W, von Laffert M. (2013). Preliminary findings suggest hidradenitis suppurativa may be due to defective follicular support. Br J Dermatol, 168(5), 1034–1039.
  • DeFazio MV, Economides JM, King KS, et al. (2015). Outcomes after combined radical resection and targeted biologic therapy for the management of recalcitrant hidradenitis suppurativa. Ann Plast Surg, 77(2), 217–222.
  • Domenech C, Matarredona J, Escribano-Stable JC, et al. (2012). Facial hidradenitis suppurativa in a 28-year-old male responding to finasteride. Dermatology, 224(4), 307–308.
  • Dreno B, Khammari A, Brocard A, et al. (2012). Hidradenitis suppurativa: the role of deficient cutaneous innate immunity. Arch Dermatol, 148(2), 182–186.
  • Emelianov VU, Bechara FG, Glaser R, et al. (2012). Immunohistological pointers to a possible role for excessive cathelicidin (LL-37) expression by apocrine sweat glands in the pathogenesis of hidradenitis suppurativa/acne inversa. Br J Dermatol, 166(5), 1023–1034.
  • Eming SA, Krieg T, Davidson JM. (2007). Inflammation in wound repair: molecular and cellular mechanisms. J Invest Dermatol, 127, 514–525.
  • Eming SA, Martin P, Tomic-Canic M. (2014). Wound repair and regeneration: Mechanisms, signaling, and translation. Sci Trans Med, 6(265), 265sr266–265sr266.
  • Esmann S, Dufour DN, Jemec GB. (2010). Questionnaire-based diagnosis of hidradenitis suppurativa: specificity, sensitivity and positive predictive value of specific diagnostic questions. Br J Dermatol, 163(1), 102–106.
  • Giatrakos S, Huse K, Kanni T, et al. (2013). Haplotypes of IL-12Rbeta1 impact on the clinical phenotype of hidradenitis suppurativa. Cytokine, 62(2), 297–301.
  • Gommerman JL, Browning JL. (2003). Lymphotoxin/light, lymphoid microenvironments and autoimmune disease. Nat Rev Immunol, 3(8), 642–655.
  • Grant A, Gonzalez T, Montgomery MO, et al. (2010). Infliximab therapy for patients with moderate to severe hidradenitis suppurativa: a randomized, double-blind, placebo-controlled crossover trial. J Am Acad Dermatol, 62(2), 205–217.
  • Haslund P, Lee RA, Jemec GB. (2009). Treatment of hidradenitis suppurativa with tumour necrosis factor-alpha inhibitors. Acta Derm Venereol, 89(6), 595–600.
  • Hessam S, Sand M, Gambichler T, Bechara FG. (2015). Correlation of inflammatory serum markers with disease severity in patients with hidradenitis suppurativa (HS). J Am Acad Dermatol, 73(6), 998–1005.
  • Hofmann SC, Saborowski V, Lange S, et al. (2012). Expression of innate defense antimicrobial peptides in hidradenitis suppurativa. J Am Acad Dermatol, 66(6), 966–974.
  • Iizuka K, Chaplin DD, Wang Y, et al. (1999). Requirement for membrane lymphotoxin in natural killer cell development. Proc Natl Acad Sci USA, 96(11), 6336–6340.
  • Jahns AC, Killasli H, Nosek D, et al. (2014). Microbiology of hidradenitis suppurativa (acne inversa): a histological study of 27 patients. APMIS, 122(9), 804–809.
  • Jemec GB. (2013). Predicting response to anti-TNF-alpha treatment in Hidradenitis suppurativa. Br J Dermatol, 168(2), 233.
  • Jemec GBE. (2012). Hidradenitis suppurativa. N Engl J Med 366(2), 158–164.
  • Kanni T, Tzanetakou V, Savva A, et al. (2015). Compartmentalized cytokine responses in hidradenitis suppurativa. PLoS ONE, 10(6), e0130522.
  • Kelly G, Sweeney CM, Tobin A-M, Kirby B. (2014). Hidradenitis suppurativa: the role of immune dysregulation. Int J Dermatol, 53(10), 1186–1196.
  • Kimball AB, Kerdel F, Adams D, et al. (2012). Adalimumab for the treatment of moderate to severe Hidradenitis suppurativa: a parallel randomized trial. Ann Intern Med, 157(12), 846–855.
  • Kimball AB, Okun MM, Williams DA, et al. (2016). Two Phase 3 trials of adalimumab for hidradenitis suppurativa. N Engl J Med, 375(5), 422–434.
  • Kirsner R. (2010). Biological agents for chronic wounds. Am J Clin Dermatol, 11(1), 23–25.
  • Laffert Mv, Helmbold P, Wohlrab J, et al. (2010). Hidradenitis suppurativa (acne inversa): early inflammatory events at terminal follicles and at interfollicular epidermis. Exp Dermatol, 19(6), 533–537.
  • Lesage C, Adnot-Desanlis L, Perceau G, et al. (2012). Efficacy and tolerance of prolonged infliximab treatment of moderate-to-severe forms of hidradenitis suppurativa. Eur J Dermatol, 22(5), 640–644.
  • Li J, Chen J, Kirsner R. (2007). Pathophysiology of acute wound healing. Clin Dermatol, 25(1), 9–18.
  • Loots MA, Lamme EN, Zeegelaar J, et al. (1998). Differences in cellular infiltrate and extracellular matrix of chronic diabetic and venous ulcers versus acute wounds. J Invest Dermatol, 111(5), 850–857.
  • Miller I, Lynggaard CD, Lophaven S, et al. (2011). A double-blind placebo-controlled randomized trial of adalimumab in the treatment of hidradenitis suppurativa. Br J Dermatol, 165(2), 391–398.
  • Neurath MF, Weigmann B, Finotto S, et al. (2002). The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn’s disease. J Exp Med, 195(9), 1129–1143.
  • Ohmori Y, Schreiber RD, Hamilton TA. (1997). Synergy between Interferon-γ and Tumor Necrosis Factor-α in transcriptional activation is mediated by cooperation between signal transducer and activator of transcription 1 and nuclear factor κB. J Biol Chem, 272(23), 14899–14907.
  • Randhawa HK, Hamilton J, Pope E. (2013). Finasteride for the treatment of hidradenitis suppurativa in children and adolescents. JAMA Dermatol, 149(6), 732–735.
  • Sadir R, Forest E, Lortat-Jacob H. (1998). The heparan sulfate binding sequence of Interferon-γ increased the on rate of the Interferon-γ-Interferon-γ receptor complex formation. J Biol Chem, 273(18), 10919–10925.
  • Sartorius K, Emtestam L, Jemec GBE, Lapins J. (2009). Objective scoring of hidradenitis suppurativa reflecting the role of tobacco smoking and obesity. Br J Dermatol 161(4), 831–839.
  • Sartorius K, Killasli H, Heilborn J, et al. (2010). Interobserver variability of clinical scores in hidradenitis suppurativa is low. Br J Dermatol, 162(6), 1261–1268.
  • Schlapbach C, Hanni T, Yawalkar N, Hunger RE. (2011). Expression of the IL-23/Th17 pathway in lesions of hidradenitis suppurativa. J Am Acad Dermatol, 65(4), 790–798.
  • Schoenborn JR, Wilson CB. (2007). Regulation of interferon-gamma during innate and adaptive immune responses. Adv Immunol, 96, 41–101.
  • Schroder K, Hertzog PJ, Ravasi T, Hume DA. (2004). Interferon-γ: an overview of signals, mechanisms and functions. J Leukocyte Biol, 75(2), 163–189.
  • Sharon VR, Garcia MS, Bagheri S, et al. (2012). Management of recalcitrant hidradenitis suppurativa with ustekinumab. Acta Derm Venereol, 92(3), 320–321.
  • van der Zee HH, Laman JD, de Ruiter L, et al. (2012). Adalimumab (antitumour necrosis factor-alpha) treatment of hidradenitis suppurativa ameliorates skin inflammation: an in situ and ex vivo study. Br J Dermatol, 166(2), 298–305.
  • Van Rappard DC, Mekkes JR. (2012). Treatment of severe hidradenitis suppurativa with infliximab in combination with surgical interventions. Br J Dermatol, 167(1), 206–208.
  • Vazquez BG, Alikhan A, Weaver AL, et al. (2013). Incidence of hidradenitis suppurativa and associated factors: a population-based study of Olmsted County, Minnesota. J Invest Dermatol, 133(1), 97–103.
  • Vila-del Sol V, Punzón C, Fresno M. (2008). IFN-γ-Induced TNF-α expression is regulated by interferon regulatory factors 1 and 8 in mouse macrophages. J Immun, 181(7), 4461–4470.
  • Weinstein DA, Kirsner RS. (2010). Refractory ulcers: The role of tumor necrosis factor–α. J Am Acad Dermatol, 63(1), 146–154.
  • Yazdanyar S, Jemec GB. (2011). Hidradenitis suppurativa: a review of cause and treatment. Curr Opin Infect Dis, 24(2), 118–123.

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