Publication Cover
Immunological Investigations
A Journal of Molecular and Cellular Immunology
Volume 47, 2018 - Issue 7
252
Views
17
CrossRef citations to date
0
Altmetric
Original Articles

Hyperglycemia Affects the Expression of Inflammatory Genes in Peripheral Blood Mononuclear Cells of Patients with Type 2 Diabetes

ORCID Icon &

References

  • Akbari M, Hassan-Zadeh V. (2018). IL-6 signalling pathways and the development of type 2 diabetes. Inflammopharmacology. doi:10.1007/s10787-018-0458-0.
  • Arkan MC, Hevener AL, Greten FR, et al. (2005). IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med, 11, 191–198. doi:10.1038/nm1185.
  • Boni-Schnetzler M, Thorne J, Parnaud G, et al. (2008). Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation. J Clin Endocrinol Metab, 93, 4065–4074. doi:10.1210/jc.2008-0396.
  • Cai D, Yuan M, Frantz DF, et al. (2005). Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med, 11, 183–190. doi:10.1038/nm1166.
  • Carey AL, Steinberg GR, Macaulay SL, et al. (2006). Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase. Diabetes, 55, 2688–2697. doi:10.2337/db05-1404.
  • Dalton BJ, Connor JR, Johnson WJ. (1989). Interleukin-1 induces interleukin-1 alpha and interleukin-1 beta gene expression in synovial fibroblasts and peripheral blood monocytes. Arthritis Rheum, 32, 279–287. doi:10.1002/anr.1780320309.
  • Dasu MR, Devaraj S, Jialal I. (2007). High glucose induces IL-1beta expression in human monocytes: mechanistic insights. Am J Physiol Endocrinol Metab, 293, E337–46. doi:10.1152/ajpendo.00718.2006.
  • Donath MY, Gross DJ, Cerasi E, Kaiser N. (1999). Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes. Diabetes, 48, 738–744. doi:10.2337/diabetes.48.4.738.
  • Donath MY, Shoelson SE. (2011). Type 2 diabetes as an inflammatory disease. Nat Rev Immunol, 11, 98–107. doi:10.1038/nri2925.
  • Ehses JA, Perren A, Eppler E, et al. (2007). Increased number of islet-associated macrophages in type 2 diabetes. Diabetes, 56, 2356–2370. doi:10.2337/db06-1650.
  • Esser N, Legrand-Poels S, Piette J, et al. (2014). Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes. Diabetes Res Clin Pract, 105, 141–150. doi:10.1016/j.diabres.2014.04.006.
  • Herder C, Brunner EJ, Rathmann W, et al. (2009). Elevated levels of the anti-inflammatory interleukin-1 receptor antagonist precede the onset of type 2 diabetes: the Whitehall II study. Diabetes Care, 32, 421–423. doi:10.2337/dc08-1161.
  • Herder C, Nuotio ML, Shah S, et al. (2014). Genetic determinants of circulating interleukin-1 receptor antagonist levels and their association with glycemic traits. Diabetes, 63, 4343–4359. doi:10.2337/db14-0731.
  • Hunter CA, Jones SA. (2015). IL-6 as a keystone cytokine in health and disease. Nat Immunol, 16, 448–457. doi:10.1038/ni.3153.
  • Jager J, Gremeaux T, Cormont M, et al. (2007). Interleukin-1b-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression. Endocrinology, 148, 241–251. doi:10.1210/en.2006-0692.
  • Kaizer EC, Glaser CL, Chaussabel D, et al. (2007). Gene expression in peripheral blood mononuclear cells from children with diabetes. J Clin Endocrinol Metab, 92, 3705–3711. doi:10.1210/jc.2007-0979.
  • Klover PJ, Zimmers TA, Koniaris LG, Mooney RA. (2003). Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice. Diabetes, 52, 2784–2789. doi:10.2337/diabetes.52.11.2784.
  • Lagathu C, Bastard JP, Auclair M, et al. (2003). Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: prevention by rosiglitazone. Biochem Biophys Res Commun, 311, 372–379. doi:10.1016/j.bbrc.2003.10.013.
  • Libert C, Takahashi N, Cauwels A, et al. (1994). Response of interleukin-6-deficient mice to tumor necrosis factor-induced metabolic changes and lethality. Eur J Immunol, 24, 2237–2242. doi:10.1002/(ISSN)1521-4141.
  • Liu Y, Biarnes Costa M, Gerhardinger C. (2012). IL-1beta is upregulated in the diabetic retina and retinal vessels: cell-specific effect of high glucose and IL-1beta autostimulation. PLoS One, 7, e36949. doi:10.1371/journal.pone.0036949.
  • Maedler K, Sergeev P, Ris F, et al. (2002). Glucose-induced beta cell production of IL-1b contributes to glucotoxicity in human pancreatic islets. J Clin Invest, 110, 851. doi:10.1172/JCI200215318.
  • Mauer J, Chaurasia B, Goldau J, et al. (2014). Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin. Nat Immunol, 15, 423–430. doi:10.1038/ni.2865.
  • Mito N, Hiyoshi T, Hosoda T, et al. (2002). Effect of obesity and insulin on immunity in non-insulin-dependent diabetes mellitus. Eur J Clin Nutr, 56, 347–351. doi:10.1038/sj.ejcn.1601324.
  • Navarro-Gonzalez J, Mora-Fernandez C, Gomez-Chinchon M, et al. (2010). Serum and gene expression profile of tumor necrosis factor-alpha and interleukin-6 in hypertensive diabetic patients: effect of amlodipine administration. Int J Immunopathol Pharmacol, 23, 51–59. doi:10.1177/039463201002300105.
  • Pedersen BK, Febbraio MA. (2008). Muscle as an endocrine organ: focus on muscle-derived interleukin-6. Physiol Rev, 88, 1379–1406. doi:10.1152/physrev.90100.2007.
  • Pickup JC, Chusney GD, Thomas SM, Burt D. (2000). Plasma interleukin-6, tumour necrosis factor alpha and blood cytokine production in type 2 diabetes. Life Sci, 67, 291–300. doi:10.1016/S0024-3205(00)00622-6.
  • Reinhold D, Ansorge S, Schleicher ED. (1996). Elevated glucose levels stimulate transforming growth factor-beta 1 (TGF-beta 1), suppress interleukin IL-2, IL-6 and IL-10 production and DNA synthesis in peripheral blood mononuclear cells. Horm Metab Res, 28, 267–270. doi:10.1055/s-2007-979789.
  • Rotter V, Nagaev I, Smith U. (2003). Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects. J Biol Chem, 278, 45777–45784. doi:10.1074/jbc.M301977200.
  • Schmittgen TD, Livak KJ. (2008). Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc, 3, 1101–1108. doi:10.1038/nprot.2008.73.
  • Senn JJ, Klover PJ, Nowak IA, Mooney RA. (2002). Interleukin-6 induces cellular insulin resistance in hepatocytes. Diabetes, 51, 3391–3399. doi:10.2337/diabetes.51.12.3391.
  • Spindler MP, Ho AM, Tridgell D, et al. (2016). Acute hyperglycemia impairs IL-6 expression in humans. Immun Inflamm Dis, 4, 91–97. doi:10.1002/iid3.97.
  • Spranger J, Kroke A, Mohlig M, et al. (2003). Inflammatory cytokines and the risk to develop type 2 diabetes. Diabetes, 52, 812–817. doi:10.2337/diabetes.52.3.812.
  • Steensberg A, Fischer CP, Keller C, et al. (2003). IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans. Am J Physiol Endocrinol Metab, 285, E433–7. doi:10.1152/ajpendo.00074.2003.
  • Stouthard JM, Oude Elferink RP, Sauerwein HP. (1996). Interleukin-6 enhances glucose transport in 3T3-L1 adipocytes. Biochem Biophys Res Commun, 220, 241–245. doi:10.1006/bbrc.1996.0389.
  • Stumvoll M, Goldstein BJ, van Haeften TW. (2005). Type 2 diabetes: principles of pathogenesis and therapy. Lancet, 365, 1333–1346. doi:10.1016/S0140-6736(05)61032-X.
  • Tsiotra PC, Tsigos C, Anastasiou E, et al. (2008). Peripheral mononuclear cell resistin mRNA expression is increased in type 2 diabetic women. Mediators Inflamm, 2008, 892864. doi:10.1155/2008/892864.
  • van Greevenbroek MM, Schalkwijk CG, Stehouwer CD. (2013). Obesity-associated low-grade inflammation in type 2 diabetes mellitus: causes and consequences. Neth J Med, 71, 174–187.
  • Warner SJ, Auger KR, Libby P. (1987a). Human interleukin 1 induces interleukin 1 gene expression in human vascular smooth muscle cells. J Exp Med, 165, 1316–1331. doi:10.1084/jem.165.5.1316.
  • Warner SJ, Auger KR, Libby P. (1987b, Sep 15). Interleukin 1 induces interleukin 1. II. Recombinant human interleukin 1 induces interleukin 1 production by adult human vascular endothelial cells. J Immunol, 139, 1911–1917.
  • Wunderlich FT, Strohle P, Konner AC, et al. (2010). Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflammation and improves systemic insulin action. Cell Metab, 12, 237–249. doi:10.1016/j.cmet.2010.06.011.
  • Xing Z, Gauldie J, Cox G, et al. (1998). IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses. J Clin Invest, 101, 311–320. doi:10.1172/JCI1368.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.