Antimetabolic Agent 3-Bromopyruvate Exerts Myelopotentiating Action in a Murine Host Bearing a Progressively Growing Ascitic Thymoma

References

• Attia YM, El-Abhar HS, Al Marzabani MM, Shouman SA. (2015). Targeting glycolysis by 3-bromopyruvate improves tamoxifen cytotoxicity of breast cancer cell lines. BMC Cancer, 15, 838. doi:10.1186/s12885-015-1850-4
   PubMed Web of Science ®Google Scholar
• Azevedo-Silva J, Queirós O, Baltazar F, et al. (2016). The anticancer agent 3-bromopyruvate: a simple but powerful molecule taken from the lab to the bedside. J Bioenerg Biomembr, 48(4), 349–362. doi:10.1007/s10863-016-9670-z
   PubMed Web of Science ®Google Scholar
• Baltazar F. (2014). Significance of monocarboxylate transporter (MCT) expression in human tumors. Front Pharmacol. doi:10.3389/conf.fphar.2014.61.00004
   Google Scholar
• Bian Z, Shi L, Venkataramani M, et al. (2018). Tumor conditions induce bone marrow expansion of granulocytic, but not monocytic, immunosuppressive leukocytes with increased CXCR2 expression in mice. Eur J Immunol, 48(3), 532–542. doi:10.1002/eji.201746976
   PubMed Web of Science ®Google Scholar
• Birsoy K, Wang T, Possemato R, et al. (2013). MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors. Nat Genet, 45(1), 104–108. doi:10.1038/ng.2471
   PubMed Web of Science ®Google Scholar
• Buijs M, Wijlemans JW, Kwak BK, et al. (2013). Antiglycolytic therapy combined with an image-guided minimally invasive delivery strategy for the treatment of breast cancer. JVIR, 24(5), 737–743. doi:10.1016/j.jvir.2013.01.013
   Web of Science ®Google Scholar
• Calviño E, Estañ MC, Sánchez-Martín C, et al. (2014). Regulation of death induction and chemosensitizing action of 3-bromopyruvate in myeloid leukemia cells: energy depletion, oxidative stress, and protein kinase activity modulation. J Pharmacol Exp Ther, 348(2), 324–335. doi:10.1124/jpet.113.206714
   PubMed Web of Science ®Google Scholar
• Chang JM, Chung JW, Jae HJ, et al. (2007). Local toxicity of hepatic arterial infusion of hexokinase II inhibitor, 3-bromopyruvate: in vivo investigation in normal rabbit model. Acad Radiol, 14, 85–92. doi:10.1016/j.acra.2006.09.059
   PubMed Web of Science ®Google Scholar
• Cheok CF. (2012). Protecting normal cells from the cytotoxicity of chemotherapy. Cell Cycle, 11(12), 2227–2228. doi:10.4161/cc.20961
   PubMed Web of Science ®Google Scholar
• Choi YK, Park K-G. (2018). Targeting glutamine metabolism for cancer treatment. Biomol Ther, 26(1), 19–28. doi:10.4062/biomolther.2017.178
   PubMed Web of Science ®Google Scholar
• De Palma M, Lewis CE. (2013). Macrophage regulation of tumor responses to anticancer therapies. Cancer Cell, 23(3), 277–286. doi:10.1016/j.ccr.2013.02.013
   PubMed Web of Science ®Google Scholar
• Ehrke E, Arend C, Dringen R. (2015). 3-bromopyruvate inhibits glycolysis, depletes cellular glutathione, and compromises the viability of cultured primary rat astrocytes. J Neurosci Res, 93, 1138–1146. doi:10.1002/jnr.23474
   PubMed Web of Science ®Google Scholar
• Elwan N, Salem ML, Kobtan A, et al. (2018). High numbers of myeloid derived suppressor cells in peripheral blood and ascitic fluid of cirrhotic and HCC patients. Immunol Invest, 47, 169–180. doi:10.1080/08820139.2017.1407787
   PubMed Web of Science ®Google Scholar
• Fang H, Wu Y, Huang X, et al. (2011). Toll-like receptor 4 (TLR4) is essential for Hsp70-like protein 1 (HSP70L1) to activate dendritic cells and induce Th1 response. J Biol Chem, 286, 30393–30400. doi:10.1074/jbc.M111.266528
   PubMed Web of Science ®Google Scholar
• Fibbe WE, van Damme J, Billiau A, et al. (1988). Interleukin 1 induces human marrow stromal cells in long-term culture to produce granulocyte colony-stimulating factor and macrophage colony-stimulating factor. Blood, 71, 430–435.
   PubMed Web of Science ®Google Scholar
• Furuta E, Pai SK, Zhan R, et al. (2008). Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1. Cancer Res, 68, 1003–1011. doi:10.1158/0008-5472.CAN-07-2489
   PubMed Web of Science ®Google Scholar
• Ganapathy-Kanniappan S, Geschwind J-FH, Kunjithapatham R, et al. (2009). Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is pyruvylated during 3-bromopyruvate mediated cancer cell death. Anticancer Res, 29, 4909–4918.
   PubMed Web of Science ®Google Scholar
• Ghirelli C, Hagemann T. (2013). Targeting immunosuppression for cancer therapy. J Clin Invest, 123(6), 2355–2357. doi:10.1172/JCI69999
   PubMed Web of Science ®Google Scholar
• Gong L, Wei Y, Yu X, et al. (2014). 3-Bromopyruvic acid, a hexokinase II inhibitor, is an effective antitumor agent on the hepatoma cells: in vitro and in vivo findings. Anticancer Agents Med Chem, 14. 771–776. doi:10.2174/1871520614666140416105309
   PubMed Web of Science ®Google Scholar
• Hanahan D, Weinberg RA. (2011). Hallmarks of cancer: the next generation. Cell, 144, 646–674. doi:10.1016/j.cell.2011.02.013
   PubMed Web of Science ®Google Scholar
• Hume DA, Underhill DM, Sweet MJ, et al. (2001). Macrophages exposed continuously to lipopolysaccharide and other agonists that act via toll-like receptors exhibit a sustained and additive activation state. BMC Immunol, 2. 11. doi:10.1186/1471-2172-2-11
   PubMedGoogle Scholar
• Kant S, Kumar A, Singh SM. (2013). Myelopoietic efficacy of orlistat in murine hosts bearing T cell lymphoma: implication in macrophage differentiation and activation. PLoS One, 8, e82396. doi:10.1371/journal.pone.0082396
   PubMed Web of Science ®Google Scholar
• Kant S, Kumar A, Singh SM. (2014). Tumor growth retardation and chemosensitizing action of fatty acid synthase inhibitor orlistat on T cell lymphoma: implication of reconstituted tumor microenvironment and multidrug resistance phenotype. Biochim Biophys Acta, 1840, 294–302. doi:10.1016/j.bbagen.2013.09.020
   PubMed Web of Science ®Google Scholar
• Kumar A, Kant S, Singh SM. (2013a). Antitumor and chemosensitizing action of dichloroacetate implicates modulation of tumor microenvironment: a role of reorganized glucose metabolism, cell survival regulation and macrophage differentiation. Toxicol Appl Pharmacol, 273, 196–208. doi:10.1016/j.taap.2013.09.005
   PubMed Web of Science ®Google Scholar
• Kumar A, Kant S, Singh SM. (2013b). Targeting monocarboxylate transporter by α-cyano-4-hydroxycinnamate modulates apoptosis and cisplatin resistance of Colo205 cells: implication of altered cell survival regulation. Apoptosis Int J Program Cell Death, 18, 1574–1585. doi:10.1007/s10495-013-0894-7
   PubMed Web of Science ®Google Scholar
• Kunjithapatham R, Geschwind J-FH, Rao PP, et al. (2013). Systemic administration of 3-bromopyruvate reveals its interaction with serum proteins in a rat model. BMC Res Notes, 6, 277. doi:10.1186/1756-0500-6-277
   PubMedGoogle Scholar
• Lee C-T, Repasky EA. (2012). Opposing roles for heat and heat shock proteins in macrophage functions during inflammation: a function of cell activation state? Front Immunol, 3, 140. doi:10.3389/fimmu.2012.00140
   PubMed Web of Science ®Google Scholar
• Li J, Yan F, Wei F, Ren X. (2017). The role of toll-like receptor 4 in tumor microenvironment. Oncotarget, 8, 66656–66667. doi:10.18632/oncotarget.19105
   PubMedGoogle Scholar
• Lis P, Dyląg M, Niedźwiecka K, et al. (2016). The HK2 dependent “Warburg Effect” and mitochondrial oxidative phosphorylation in cancer: targets for effective therapy with 3-bromopyruvate. Mol Basel Switz, 21, 1730. doi:10.3390/molecules21121730
   Web of Science ®Google Scholar
• Liu H, Yan Y, Zhang F, Wu Q. (2019). The immuno-enhancement effects of tubiechong (Eupolyphaga sinensis) lyophilized powder in cyclophosphamide-induced immunosuppressed mice. Immunol Invest, 1–16. doi:10.1080/08820139.2019.1588291
   PubMed Web of Science ®Google Scholar
• Luong M, Zhang Y, Chamberlain T, et al. (2012). Stimulation of TLR4 by recombinant HSP70 requires structural integrity of the HSP70 protein itself. J Inflamm, 9, 11. doi:10.1186/1476-9255-9-11
   Google Scholar
• Mellman I, Coukos G, Dranoff G. (2011). Cancer immunotherapy comes of age. Nature, 480, 480–489. doi:10.1038/nature10673
   PubMed Web of Science ®Google Scholar
• Mirantes C, Passegué E, Pietras EM. (2014). Pro-inflammatory cytokines: emerging players regulating HSC function in normal and diseased hematopoiesis. Exp Cell Res, 329, 248–254. doi:10.1016/j.yexcr.2014.08.017
   PubMed Web of Science ®Google Scholar
• Misharin AV, Morales-Nebreda L, Mutlu GM, et al. (2013). Flow cytometric analysis of macrophages and dendritic cell subsets in the mouse lung. Am J Respir Cell Mol Biol, 49, 503–510. doi:10.1165/rcmb.2013-0086M:
   PubMed Web of Science ®Google Scholar
• Mosser DM, Zhang X. (2008). Activation of murine macrophages. Curr Protoc Immunol Chapter, 14(Unit), 14.2. doi:10.1002/0471142735.im1402s83
   Google Scholar
• Noy R, Pollard JW. (2014). Tumor-associated macrophages: from mechanisms to therapy. Immunity, 41, 49–61. doi:10.1016/j.immuni.2014.06.010
   PubMed Web of Science ®Google Scholar
• Pan Q, Sun Y, Jin Q, et al. (2016). Hepatotoxicity and nephrotoxicity of 3-bromopyruvate in mice. Acta Cir Bras, 31, 724–729. doi:10.1590/S0102-865020160110000004
   PubMed Web of Science ®Google Scholar
• Parameswaran N, Patial S. (2010). Tumor necrosis factor-α signaling in macrophages. Crit Rev Eukaryot Gene Expr, 20. 87–103. doi:10.1615/CritRevEukarGeneExpr.v20.i2.10
   PubMed Web of Science ®Google Scholar
• Raghavendran HRB, Sathyanath R, Shin J, et al. (2012). Panax ginseng modulates cytokines in bone marrow toxicity and myelopoiesis: ginsenoside Rg1 partially supports myelopoiesis. PLoS One, 7. doi:10.1371/journal.pone.0033733
   PubMed Web of Science ®Google Scholar
• Riddell JR, Wang X-Y, Minderman H, Gollnick SO. (2010). Peroxiredoxin 1 stimulates secretion of pro-inflammatory cytokines by binding to toll-like receptor 4. J Immunol Baltim Md, 1950(184), 1022–1030. doi:10.4049/jimmunol.0901945
   Web of Science ®Google Scholar
• Shao L, Wang Y, Chang J, et al. (2013). Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury. Transl Cancer Res, 2, 397–411. doi:10.3978/j.issn.2218-676X.2013.07.03
   PubMed Web of Science ®Google Scholar
• Takebe K, Takahashi-Iwanaga H, Iwanaga T. (2011). Intensified expressions of a monocarboxylate transporter in consistently renewing tissues of the mouse. Biomed Res Tokyo Jpn, 32, 293–301.
   PubMed Web of Science ®Google Scholar
• Teicher BA, Linehan WM, Helman LJ. (2012). Targeting cancer metabolism. Clin Cancer Res Off J Am Assoc Cancer Res, 18, 5537–5545. doi:10.1158/1078-0432.CCR-12-2587
   PubMed Web of Science ®Google Scholar
• Tissue expression of SLC16A1 - Summary - The Human Protein Atlas [WWW Document]. (n.d.). URL https://www.proteinatlas.org/ENSG00000155380-SLC16A1/tissue (accessed August 23 2018).
   Google Scholar
• Valenti D, Vacca RA, de Bari L. (2015). 3-Bromopyruvate induces rapid human prostate cancer cell death by affecting cell energy metabolism, GSH pool and the glyoxalase system. J Bioenerg Biomembr, 47, 493–506. doi:10.1007/s10863-015-9631-y
   PubMed Web of Science ®Google Scholar
• Vander Heiden MG. (2011). Targeting cancer metabolism: a therapeutic window opens. Nat Rev Drug Discov, 10, 671–684. doi:10.1038/nrd3504
   PubMed Web of Science ®Google Scholar
• Vishvakarma NK, Kumar A, Kumar A, et al. (2012). Myelopotentiating effect of curcumin in tumor-bearing host: role of bone marrow resident macrophages. Toxicol Appl Pharmacol, 263, 111–121. doi:10.1016/j.taap.2012.06.004
   PubMed Web of Science ®Google Scholar
• Vishvakarma NK, Singh SM. (2011a). Mechanisms of tumor growth retardation by modulation of pH regulation in the tumor-microenvironment of a murine T cell lymphoma. Biomed Pharmacother Biomedecine Pharmacother, 65, 27–39. doi:10.1016/j.biopha.2010.06.012
   PubMed Web of Science ®Google Scholar
• Vishvakarma NK, Singh SM. (2011b). Augmentation of myelopoiesis in a murine host bearing a T cell lymphoma following in vivo administration of proton pump inhibitor pantoprazole. Biochimie, 93, 1786–1796. doi:10.1016/j.biochi.2011.06.022
   PubMed Web of Science ®Google Scholar
• Wang C-H, Chou P-C, Chung F-T, et al. (2017). Heat shock protein70 is implicated in modulating NF-κB activation in alveolar macrophages of patients with active pulmonary tuberculosis. Sci Rep, 7, 1214. doi:10.1038/s41598-017-01405-z
   PubMed Web of Science ®Google Scholar
• Weinberg SE, Chandel NS. (2015). Targeting mitochondria metabolism for cancer therapy. Nat Chem Biol, 11, 9–15. doi:10.1038/nchembio.1712
   PubMed Web of Science ®Google Scholar
• Wu C, Xue Y, Wang P, et al. (2014). IFN-γ primes macrophage activation by increasing phosphatase and tensin homolog via downregulation of miR-3473b. J Immunol, 193, 3036–3044. doi:10.4049/jimmunol.1302379
   PubMed Web of Science ®Google Scholar
• Xintaropoulou C, Ward C, Wise A, et al. (2015). A comparative analysis of inhibitors of the glycolysis pathway in breast and ovarian cancer cell line models. Oncotarget, 6, 25677–25695. doi:10.18632/oncotarget.4499
   PubMedGoogle Scholar
• Yadav S, Kujur PK, Pandey SK, et al. (2017a). Antitumor action of 3-bromopyruvate implicates reorganized tumor growth regulatory components of tumor milieu, cell cycle arrest and induction of mitochondria-dependent tumor cell death. Toxicol Appl Pharmacol, 339, 52–64. doi:10.1016/j.taap.2017.12.004
   PubMed Web of Science ®Google Scholar
• Yadav S, Pandey SK, Goel Y, et al. (2018). Protective and recuperative effects of 3-bromopyruvate on immunological, hepatic and renal homeostasis in a murine host bearing ascitic lymphoma: implication of niche dependent differential roles of macrophages. Biomed Pharmacother, 99, 970–985. doi:10.1016/j.biopha.2018.01.149
   PubMed Web of Science ®Google Scholar
• Yadav S, Pandey SK, Kumar A, et al. (2017b). Antitumor and chemosensitizing action of 3-bromopyruvate: implication of deregulated metabolism. Chem Biol Interact, 270, 73–89. doi:10.1016/j.cbi.2017.04.015
   PubMed Web of Science ®Google Scholar
• Zhang Q, Pan J, North PE, et al. (2012). Aerosolized 3-bromopyruvate inhibits lung tumorigenesis without causing liver toxicity. Cancer Prev Res Phila Pa, 5, 717–725. doi:10.1158/1940-6207.CAPR-11-0338
   PubMed Web of Science ®Google Scholar
• Zheng L, He M, Long M, et al. (2004). Pathogen-induced apoptotic neutrophils express heat shock proteins and elicit activation of human macrophages. J Immunol, 173, 6319–6326. doi:10.4049/jimmunol.173.10.6319
   PubMed Web of Science ®Google Scholar