Association of HLA-G 3’UTR Polymorphisms with Soluble HLA-G Levels and Disease Activity in Patients with Rheumatoid Arthritis: A Case-Control Study

References

• Agnihotri V, Gupta A, Kumar R, et al. (2017). Promising link of HLA-G polymorphism, tobacco consumption and risk of Head and Neck Squamous Cell Carcinoma (HNSCC) in North Indian population. Hum Immunol, 78(2), 172–178. doi:10.1016/j.humimm.2016.12.007.
   PubMed Web of Science ®Google Scholar
• American College of Rheumatology Subcommittee on Rheumatoid Arthritis Guidelines. (2002). Guidelines for the management of rheumatoid arthritis: 2002 update. Arthritis Rheum, 46, 328–346. doi:10.1002/art.10148.
   PubMed Web of Science ®Google Scholar
• Baricordi OR, Govoni M, Rizzo R, Trotta F. (2007). In rheumatoid arthritis, a polymorphism in the HLA‐G gene concurs in the clinical response to methotrexate treatment. Ann Rheum Dis, 66, 1125–1126. doi:10.1136/ard.2006.064022.
   PubMedGoogle Scholar
• Bortolotti D, Gentili V, Rotola A, et al. (2014). Impact of HLA-G analysis in prevention, diagnosis and treatment of pathological conditions. World J Methodol, 4, 11–25. doi:10.5662/wjm.v4.i1.11.
   PubMedGoogle Scholar
• Carlini F, Ferreira V, Buhler S, et al. (2016). Association of HLA-A and non-classical HLA class I alleles. PLoS One, 11, e0163570. doi:10.1371/journal.pone.0163570.
   PubMed Web of Science ®Google Scholar
• Castelli EC, Mendes-Junior CT, Veiga-Castelli LC, et al. (2011). A comprehensive study of polymorphic sites along the HLA-G gene: implication for gene regulation and evolution. Mol Biol Evol, 28, 3069–3086. doi:10.1093/molbev/msr138.
   PubMed Web of Science ®Google Scholar
• Castelli EC, Moreau P, Oya E Chiromatzo A, et al. (2009). In silico analysis of microRNAS targeting the HLA-G 3ʹ untranslated region alleles and haplotypes. Hum Immunol, 70, 1020–1025. doi:10.1016/j.humimm.2009.07.028.
   PubMed Web of Science ®Google Scholar
• Castelli EC, Ramalho J, Porto IOP, et al. (2014). Insights into HLA-G genetics provided by worldwide haplotype diversity. Front Immunol, 5, 476. doi:10.3389/fimmu.2014.00476.
   PubMed Web of Science ®Google Scholar
• Catamo E, Addobbati C, Segat L, et al. (2014). HLA-G gene polymorphisms associated with susceptibility to rheumatoid arthritis disease and its severity in Brazilian patients. Tissue Antigens, 84, 308–315. doi:10.1111/tan.12396.
   PubMedGoogle Scholar
• Chinniah R, Rajendran MS, Sivanadham R, et al. (2019). Association of HLA class II alleles/haplotypes and amino acid variations in the peptide binding pockets with rheumatoid arthritis. Int J Rheum Dis. doi:10.1111/1756-185X.13612
   PubMed Web of Science ®Google Scholar
• Degani Veit T, Bogo Chies JA, Switala M, et al. (2015). The paradox of high availability and low recognition of soluble HLA-G by LILRB1 receptor in rheumatoid arthritis patients. PLoS ONE 10, 10. doi:10.1371/journal.pone.0123838.
   Google Scholar
• Donadi EA, Castelli EC, Arnaiz-Villena A, et al. (2011). Implications of the polymorphism of HLA-G on its function, regulation, evolution and disease association. Cell Mol Life Sci CMLS, 68, 369–395. doi:10.1007/s00018-010-0580-7.
   PubMed Web of Science ®Google Scholar
• Durmanova V, Bandzuchova H, Zilinska Z, et al. (2019). Association of HLA-G polymorphisms in the 3ʹUTR region and soluble HLA-G with kidney graft outcome. Immunol Invest, 48, 644–658. doi:10.1080/08820139.2019.1610888.
   PubMed Web of Science ®Google Scholar
• Funovits J, Aletaha D, Bykerk V, et al. (2010). The 2010 American College of Rheumatology/European League Against Rheumatism classification criteria for rheumatoid arthritis: Methodological report phase I. Ann Rheum Dis, 69, 1589–1595. doi:10.1136/ard.2010.130310.
   PubMed Web of Science ®Google Scholar
• Gautam S, Tolahunase M, Kumar U, Dada R. (2019). Impact of yoga based mind-body intervention on systemic inflammatory markers and co-morbid depression in active rheumatoid arthritis patients: A randomized controlled trial. Restor Neurol Neurosci, 37, 41–59. doi:10.3233/RNN-180875.
   PubMed Web of Science ®Google Scholar
• Gregori S, Amodio G, Quattrone F, Panina-Bordignon P. (2015). HLA-G orchestrates the early interaction of human trophoblasts with the maternal niche. Front Immunol, 6, 128. doi:10.3389/fimmu.2015.00128.
   PubMed Web of Science ®Google Scholar
• Hashemi M, Mokhtari M, Khazaeian S, et al. (2017). Evaluation of HLA-G 14-bp ins/del and +3142G>C polymorphisms with susceptibility to recurrent spontaneous abortion. Taiwan J Obstet Gynecol, 56, 276–280. doi:10.1016/j.tjog.2017.04.002.
   PubMed Web of Science ®Google Scholar
• Hashemi M, Sandoughi M, Fazeli SA, et al. (2016). Evaluation of HLA-G 14 bp Ins/Del and +3142G>C polymorphism with susceptibility and early disease activity in rheumatoid arthritis. Adv Med, 2016, 4985745. doi:10.1155/2016/4985745.
   PubMedGoogle Scholar
• Hoy DG, Smith E, Cross M, et al. (2015). Reflecting on the global burden of musculoskeletal conditions: Lessons learnt from the global burden of disease 2010 study and the next steps forward. Ann Rheum Dis, 74, 4–7. doi:10.1136/annrheumdis-2014-205393.
   PubMed Web of Science ®Google Scholar
• Hviid TVF, Christiansen OB. (2005). Linkage disequilibrium between human leukocyte antigen (HLA) class II and HLA-G–possible implications for human reproduction and autoimmune disease. Hum Immunol, 66, 688–699. doi:10.1016/j.humimm.2005.03.003.
   PubMed Web of Science ®Google Scholar
• Hviid TVF, Hylenius S, Rørbye C, Nielsen LG. (2003). HLA-G allelic variants are associated with differences in the HLA-G mRNA isoform profile and HLA-G mRNA levels. Immunogenetics, 55, 63–79. doi:10.1007/s00251-003-0547-z.
   PubMed Web of Science ®Google Scholar
• Indian Genome Variation Consortium. (2008). Genetic landscape of the people of India: A canvas for disease gene exploration. J Genet, 87, 3–20. doi:10.1007/s12041-008-0002-x.
   PubMed Web of Science ®Google Scholar
• Kampstra ASB, Toes REM. (2017). HLA class II and rheumatoid arthritis: The bumpy road of revelation. Immunogenetics, 69, 597–603. doi:10.1007/s00251-017-0987-5.
   PubMed Web of Science ®Google Scholar
• Kim SK, Chung JH, Kim DH, et al. (2012). Lack of association between promoter polymorphisms of HLA-G gene and rheumatoid arthritis in Korean population. Rheumatol Int, 32, 509–512. doi:10.1007/s00296-010-1735-4.
   PubMed Web of Science ®Google Scholar
• Klareskog L, Stolt P, Lundberg K, et al. (2006). A new model for an etiology of rheumatoid arthritis: Smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum, 54, 38–46. doi:10.1002/art.21575.
   PubMed Web of Science ®Google Scholar
• Kooloos WM, Wessels JA, van der Straaten T, et al. (2010). Functional polymorphisms and methotrexate treatment outcome in recent-onset rheumatoid arthritis. Pharmacogenomics, 11, 163–175. doi:10.2217/pgs.09.139.
   PubMed Web of Science ®Google Scholar
• Lee YH, Bae S-C. (2015). Association between a functional HLA-G 14-bp insertion/deletion polymorphism and susceptibility to autoimmune diseases: A meta-analysis. Cell Mol Biol Noisy–Gd Fr, 61, 24–30.
   PubMed Web of Science ®Google Scholar
• Lee YH, Bae S-C, Song GG. (2015). Meta-analysis of associations between functional HLA-G polymorphisms and susceptibility to systemic lupus erythematosus and rheumatoid arthritis. Rheumatol Int, 35, 953–961. doi:10.1007/s00296-014-3155-3.
   PubMed Web of Science ®Google Scholar
• Mariaselvam CM, Chaaben AB, Salah S, et al. (2015). Human leukocyte antigen-G polymorphism influences the age of onset and autoantibody status in rheumatoid arthritis. Tissue Antigens, 85(3), 182–189. doi:10.1111/tan.12521.
   PubMedGoogle Scholar
• Miller SA, Dykes DD, Polesky HF. (1988). A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res, 16, 1215. doi:10.1093/nar/16.3.1215.
   PubMed Web of Science ®Google Scholar
• Okada Y, Suzuki A, Ikari K, et al. (2016). Contribution of a non-classical HLA gene, HLA-DOA, to the risk of rheumatoid arthritis. Am J Hum Genet, 99, 366–374. doi:10.1016/j.ajhg.2016.06.019.
   PubMed Web of Science ®Google Scholar
• Okada Y, Wu D, Trynka G, et al. (2014). Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature, 506, 376–381. doi:10.1038/nature12873.
   PubMed Web of Science ®Google Scholar
• Ouni N, Chaaben AB, Kablouti G, et al. (2019). The impact of HLA-G 3ʹUTR polymorphisms in breast cancer in a Tunisian population. Immunol Invest, 48, 521–532. doi:10.1080/08820139.2019.1569043.
   PubMed Web of Science ®Google Scholar
• Padyukov L, Seielstad M, Ong RTH, et al. (2011). A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis. Ann Rheum Dis, 70, 259–265. doi:10.1136/ard.2009.126821.
   PubMed Web of Science ®Google Scholar
• Raychaudhuri S, Sandor C, Stahl EA, et al. (2012). Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis. Nat Genet, 44, 291–296. doi:10.1038/ng.1076.
   PubMed Web of Science ®Google Scholar
• Rebmann V, König L, Nardi FDS, et al. (2016). The potential of HLA-G-bearing extracellular vesicles as a future element in HLA-G immune biology. Front Immunol, 7, 173. doi:10.3389/fimmu.2016.00173.
   PubMed Web of Science ®Google Scholar
• Rizzo R, Bortolotti D, Bolzani S, Fainardi E. (2014). HLA-G molecules in autoimmune diseases and infections. Front Immunol, 5, 592. doi:10.3389/fimmu.2014.00592.
   PubMed Web of Science ®Google Scholar
• Rizzo R, Rubini M, Govoni M, et al. (2006). HLA-G 14-bp polymorphism regulates the methotrexate response in rheumatoid arthritis. Pharmacogenet Genomics, 16, 615–623. doi:10.1097/01.fpc.0000230115.41828.3a.
   PubMed Web of Science ®Google Scholar
• Rizzo R, Trentini A, Bortolotti D, et al. (2013). Matrix metalloproteinase-2 (MMP-2) generates soluble HLA-G1 by cell surface proteolytic shedding. Mol Cell Biochem, 381, 243–255. doi:10.1007/s11010-013-1708-5.
   PubMed Web of Science ®Google Scholar
• Rokhafrooz S, Ghadiri A, Ghandil P, et al. (2018). Association between HLA-G 14bp gene polymorphism and serum sHLA-G protein concentrations in preeclamptic patients and normal pregnant women. Immunol Invest, 47, 558–568. doi:10.1080/08820139.2018.1467925.
   PubMed Web of Science ®Google Scholar
• Rosenblum MD, Remedios KA, Abbas AK. (2015). Mechanisms of human autoimmunity. J Clin Invest, 125, 2228–2233. doi:10.1172/JCI78088.
   PubMed Web of Science ®Google Scholar
• Rousseau P, Le Discorde M, Mouillot G, et al. (2003). The 14 bp deletion-insertion polymorphism in the 3ʹ UT region of the HLA-G gene influences HLA-G mRNA stability. Hum Immunol, 64, 1005–1010. doi:10.1016/j.humimm.2003.08.347.
   PubMed Web of Science ®Google Scholar
• Rudan I, Sidhu S, Papana A, Global Health Epidemiology Reference Group (GHERG). (2015). Prevalence of rheumatoid arthritis in low- and middle-income countries: A systematic review and analysis. J Glob Health, 5, 010409. doi:10.7189/jogh.05.010409.
   PubMed Web of Science ®Google Scholar
• Sabbagh A, Luisi P, Castelli EC, Gineau L, Courtin D, Milet J, Massaro JD, Laayouni H, Moreau P, Donadi EA, et al. 2014. Worldwide genetic variation at the 3ʹ untranslated region of the HLA-G gene: balancing selection influencing genetic diversity. Genes Immun. 15(2):95–106. doi:10.1038/gene.2013.67.
   PubMed Web of Science ®Google Scholar
• Shiroishi M, Kuroki K, Rasubala L, et al. (2006). Structural basis for recognition of the nonclassical MHC molecule HLA-G by the leukocyte Ig-like receptor B2 (LILRB2/LIR2/ILT4/CD85d). Proc Natl Acad Sci USA, 103, 16412–16417. doi:10.1073/pnas.0605228103.
   PubMed Web of Science ®Google Scholar
• Sokka T, Kautiainen H, Pincus T, et al. (2010). Work disability remains a major problem in rheumatoid arthritis in the 2000s: Data from 32 countries in the QUEST-RA study. Arthritis Res Ther, 12, R42. doi:10.1186/ar2951.
   PubMed Web of Science ®Google Scholar
• Stamp LK, O’Donnell JL, Chapman PT, et al. (2009). Lack of association between HLA-G 14 bp insertion/deletion polymorphism and response to long-term therapy with methotrexate response in rheumatoid arthritis. Ann Rheum Dis, 68, 154–155. doi:10.1136/ard.2008.089383.
   PubMed Web of Science ®Google Scholar
• Sundaresh A, Wu C-L, Chinnadurai RK, et al. (2018). The HLA-G genetic contribution to bipolar disorder: A trans-ethnic replication. Immunol Invest, 47, 593–604. doi:10.1080/08820139.2018.1469649.
   PubMed Web of Science ®Google Scholar
• Tan Z, Randall G, Fan J, et al. (2007). Allele-specific targeting of microRNAs to HLA-G and risk of asthma. Am J Hum Genet, 81, 829–834. doi:10.1086/521200.
   PubMed Web of Science ®Google Scholar
• Tawfeek GA-E, Alhassanin S. (2018). HLA-G gene polymorphism in Egyptian patients with non-Hodgkin lymphoma and its clinical outcome. Immunol Invest, 47, 315–325. doi:10.1080/08820139.2018.1430826.
   PubMed Web of Science ®Google Scholar
• Veit TD, Chies JAB. (2009). Tolerance versus immune response – microRNAs as important elements in the regulation of the HLA-G gene expression. Transpl Immunol, 20, 229–231. doi:10.1016/j.trim.2008.11.001.
   PubMed Web of Science ®Google Scholar
• Veit TD, de Lima CPS, Cavalheiro LC, et al. (2014). HLA-G +3142 polymorphism as a susceptibility marker in two rheumatoid arthritis populations in Brazil. Tissue Antigens, 83, 260–266. doi:10.1111/tan.12311.
   PubMedGoogle Scholar
• Veit TD, Vianna P, Scheibel I, et al. (2008). Association of the HLA-G 14-bp insertion/deletion polymorphism with juvenile idiopathic arthritis and rheumatoid arthritis. Tissue Antigens, 71, 440–446. doi:10.1111/j.1399-0039.2008.01019.x.
   PubMedGoogle Scholar
• Zanelli E, Breedveld FC, de Vries RR. (2000). HLA class II association with rheumatoid arthritis: Facts and interpretations. Hum Immunol, 61, 1254–1261. doi:10.1016/S0198-8859(00)00185-3.
   PubMed Web of Science ®Google Scholar