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Immunological Investigations
A Journal of Molecular and Cellular Immunology
Volume 49, 2020 - Issue 4
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Original Articles

Impact of Toll-like Receptors 2(TLR2) and TLR 4 Gene Variations on HCV Susceptibility, Response to Treatment and Development of Hepatocellular Carcinoma in Cirrhotic HCV Patients

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References

  • Al-Qahtani AA, Al-Anazi MR, Al-Zoghaibi F, Abdo AA, Sanai FM, Khan MQ, Albenmousa A, Al-Ashgar HI, Al-Ahdal MN. 2014. The association of toll-like receptor 4 polymorphism with hepatitis C virus infection in Saudi Arabian patients. Biomed Res Int. doi:10.1155/2014/357062
  • Braem MGM, Schouten LJ, Peeters PHM, Van Den Brandt PA, Onland-Moret NC. 2011. Genetic susceptibility to sporadic ovarian cancer: a systematic review. Biochim Biophys Acta. 1816:132–46.
  • Bruix J, Sherman M. 2011. Management of hepatocellular carcinoma: an update. Hepatology. 53:1020–22.
  • Chaiwiang N, Poyomtip T. 2019. The associations between Toll-like receptor 4 gene polymorphisms and hepatitis C virus infection: a systematic review and meta-analysis. Biosci Rep. 39:BSR20182470.
  • Chen D, Xie W, Yongkui L, Shining S, Nong L, Jia Y, Liu Y, Zhou W, Wang H, Tan A. 2017. Gene polymorphisms of TLR2 and TLR3 in HBV clearance and HBV-related hepatocellular carcinoma in a Chinese male population. Int J Biol Markers. 32:195–201.
  • Chen W-M, Abecasis GR. 2007. Family-based association tests for genomewide association scans. Am J Hum Gene. 81:913–26.
  • El-Bendary M, Neamatallah M, Elalfy H, Besheer T, Elkholi A, El-Diasty M, Elsareef M, Zahran M, El-Aarag B, Gomaa A. 2018. The association of single nucleotide polymorphisms of Toll-like receptor 3, Toll-like receptor 7 and Toll-like receptor 8 genes with the susceptibility to HCV infection. Br J Biomed Sci. 75:175–81.
  • El-Bendary M, Neamatallah M, Elalfy H, Besheer T, El-Setouhy M, Youssef MM, Zein M, Elhammady D, Hegazy A, Esmat G. 2019a. Association of genetic polymorphisms of chemokines and their receptors with clearance or persistence of hepatitis C virus infection. Br J Biomed Sci. 76:11–16.
  • El-Bendary M, Neamatallah M, Elalfy H, Besheer T, Kamel E, Mousa H, Eladl A-H, El-Setouhy M, El-Gilany A-H, El-Waseef A. 2019b. HLA class II-DRB1 alleles with hepatitis c virus infection outcome in Egypt: A multicentre family-based study. Ann Hepatol. 18:68–77.
  • El‐Bendary M, Neamatallah M, Esmat G, Kamel E, Elalfy H, Besheer T, Eldeib D, Eladl A‐H, El‐Setouhy M, El‐Gilany A‐H. 2016. Associations of human leucocyte antigen class II‐DQB 1 alleles with hepatitis C virus infection in Egyptian population: a multicentre family‐based study. J Viral Hepat. 23:961–70.
  • Elsayed HM, Nabiel Y, Sheta T. 2017. IL12 gene polymorphism in association with hepatocellular carcinoma in HCV-infected Egyptian Patients. Immunol Invest. 46:123–33.
  • Gomes, ACMB Torres, N, Leite, LV Tureck, ACK Titski, GE Milano-Gai, L Lazarotto, and LF Alle. 2018. ‘Association between Toll-like receptors (TLR) and NOD-like receptor (NLR) polymorphisms and lipid and glucose metabolism’, Gene. 685:211–221.
  • Guo J, Loke J, Zheng F, Hong F, Yea S, Fukata M, Tarocchi M, Abar OT, Huang H, Sninsky JJ. 2009. Functional linkage of cirrhosis‐predictive single nucleotide polymorphisms of Toll‐like receptor 4 to hepatic stellate cell responses. Hepatology. 49:960–68.
  • Hanafiah KM, Groeger J, Flaxman AD, Wiersma ST. 2013. Global epidemiology of hepatitis C virus infection: new estimates of age‐specific antibody to HCV seroprevalence. Hepatology. 57:1333–42.
  • He Q, Graham CS, Mangoni ED, Koziel MJ. 2006. Differential expression of toll‐like receptor mRNA in treatment non‐responders and sustained virologic responders at baseline in patients with chronic hepatitis C. Liver Int. 26:1100–10.
  • Hernandez–Gea V, Toffanin S, Friedman SL, Llovet JM. 2013. Role of the microenvironment in the pathogenesis and treatment of hepatocellular carcinoma. Gastroenterology. 144:512–27.
  • Huo Z, Wang X, Shu X, Fan C, Zhou X. 2017. Association of genetic polymorphisms in toll-like receptor 2 (TLR2) and susceptibility to hepatocellular carcinoma. Biomed Res. 28:269–273.
  • Junjie X, Songyao J, Minmin S, Yanyan S, Baiyong S, Xiaxing D, Jiabin J, Zhan X, Hao C. 2012. The association between Toll-like receptor 2 single-nucleotide polymorphisms and hepatocellular carcinoma susceptibility. BMC Cancer. 12:57.
  • Koike K, Tsutsumi T, Fujie H, Shintani Y, Moriya K. 2002. Molecular mechanism of viral hepatocarcinogenesis. Oncology. 62:29.
  • Liu W-T, Jing -Y-Y, Guo-feng Y, Han Z-P, Dan-dan Y, Fan Q-M, Fei Y, Rong L, Gao L, Zhao Q-D. 2015. Toll like receptor 4 facilitates invasion and migration as a cancer stem cell marker in hepatocellular carcinoma. Cancer Lett. 358:136–43.
  • Medvedev AE. 2013. Toll-like receptor polymorphisms, inflammatory and infectious diseases, allergies, and cancer. J Interferon Cytokine Res. 33:467–84.
  • Mei ZA, Wang Y, Xia X, Song Y. 2019. Genetic polymorphisms of the IFNLR1 gene correlate with HCV infection and biochemical features of chronic HCV patients in Yunnan, China. Immunol Invest. 1–9. https://doi.org/10.1080/08820139.2019.1642914.
  • Mersha TB, Ding L, He H, Alexander ES, Zhang X, Kurowski BG, Pilipenko V, Kottyan L, Martin LJ, Fardo DW. 2015. Impact of population stratification on family-based association in an admixed population. Int J Genomics. doi:10.1155/2015/501617
  • Minmin S, Xiaoqian X, Hao C, Baiyong S, Xiaxing D, Junjie X, Zhan X, Jianquan Z, Songyao J. 2011. Single nucleotide polymorphisms of Toll-like receptor 4 decrease the risk of development of hepatocellular carcinoma. PLoS One. 6:e19466–e66.
  • Miura K, Ishioka M, Minami S, Horie Y, Ohshima S, Goto T, Ohnishi H. 2016. Toll-like receptor 4 on macrophage promotes the development of steatohepatitis-related hepatocellular carcinoma in mice. J Biol Chem. M115:709048.
  • Mosaad YM, Metwally SS, Farag RE, Lotfy ZF, AbdelTwab HE. 2019. Association between toll-like receptor 3 (TLR3) rs3775290, TLR7 rs179008, TLR9 rs352140 and chronic HCV. Immunol Invest. 48:321–32.
  • Paik Y-H, Lee KS, Lee HJ, Yang KM, Lee SJ, Lee DK, Han K-H, Chon CY, Lee SI, Moon YM. 2006. Hepatic stellate cells primed with cytokines upregulate inflammation in response to peptidoglycan or lipoteichoic acid. Lab Inves. 86:676.
  • Pham TNQ, Lin DMH, Mulrooney‐Cousins PM, Churchill ND, Kowala‐Piaskowska A, Mozer‐Lisewska I, Machaj A, Pazgan‐Simon M, Zalewska M, Simon K. 2013. Hepatitis C virus load and expression of a unique subset of cellular genes in circulating lymphoid cells differentiate non‐responders from responders to pegylated interferon alpha–ribavirin treatment. J Med Virol. 85:441–48.
  • Pires-Neto ODS, de Sá KSG, Santana BB, Gomes TM, Da Silva Graça S, Amoras E, Da Silva Conde SR, Demachki S, Azevedo VN, Martins-Feitosa RN, et al. 2015. Lack of association between polymorphisms of the TLR4 gene and infection with the hepatitis B and C viruses. Mediators Inflamm. 7:1–7.
  • Rausell A, Telenti A. 2014. Genomics of host–pathogen interactions. Curr Opin Immunol. 30:32–38.
  • Sadik N, Hamid A, Shaker OG, Ghanem HZ, Hassan HA, Abdel-Hamid A-HZ. 2015. Single-nucleotide polymorphism of Toll-like receptor 4 and interleukin-10 in response to interferon-based therapy in Egyptian chronic hepatitis C patients. Arch Virol. 160:2181–95.
  • Seki E, Brenner DA. 2008. Toll‐like receptors and adaptor molecules in liver disease: update. Hepatology. 48:322–35.
  • Soylu A, Ates H, Cingoz S, Turkmen M, Demir BK, Tunca M, Sakizli M, Cirit M, Ersoy R, Ulgenalp A, et al. 2011. TLR polymorphisms in FMF: association of TLR-2 (Arg753Gln) and TLR-4 (Asp299Gly, Thre399Ile) polymorphisms and myeloid cell TLR-2 and TLR-4 expression with the development of secondary amyloidosis in FMF. Inflammation. 34:379–87.
  • Tamura R, Kanda T, Imazeki F, Shuang W, Nakamoto S, Tanaka T, Arai M, Fujiwara K, Saito K, Roger T. 2011. Hepatitis C Virus nonstructural 5A protein inhibits lipopolysaccharide-mediated apoptosis of hepatocytes by decreasing expression of Toll-like receptor 4ʹ. Int J Infect Dis. 204:793–801.
  • Tharwat E, Gad GFM, Nazmy MH, Mohamed HI, Hamza N, Wahid A, Ibrahim ARN. 2019. Impact of IL-27p28 (rs153109) and TNF-alpha (rs1800629) genetic polymorphisms on the progression of HCV infection in Egyptian patients. Immunol Invest. 48:255–67.
  • Uraki S, Tameda M, Sugimoto K, Shiraki K, Takei Y, Nobori T, Ito M. 2015. Substitution in amino acid 70 of hepatitis C virus core protein changes the adipokine profile via toll-like receptor 2/4 signaling. PLoS One. 10:e0131346.
  • Wahid A, Hamzawy MA, Mohamad MA, Khalifa GFM, Gad AB, Abdelwahab SF. 2019. RNA protein kinase SNP at −226 C<T is a biomarker for the clearance of HCV among Egyptian patients. Immunol Invest. 48:211–21.
  • Yang J, Min L, Zheng QC. 2015. Emerging role of Toll-like receptor 4 in hepatocellular carcinoma. J Hepatocell Carcinoma. 2:11–17.
  • Yang L, Xiao-Gang X, Zhang J-G, Qiu-Ran X, Huang D-S. 2016. Accumulating evidence: TLR signaling facilitates the development of hepatocellular carcinoma. Int J Clin Exp Med. 9:4107–12.
  • Yee LJ. 2004. Host genetic determinants in hepatitis C virus infection. Genes Immun. 5:237–45.
  • Yong YONG, Lin HE. 2005. SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res. 15:97.
  • Zhu L, Yuan H, Jiang T, Wang R, Hongxia M, Zhang S. 2013. Association of TLR2 and TLR4 Polymorphisms with risk of cancer: A meta-analysis. PLoS One. 8:e82858.

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