Publication Cover
Immunological Investigations
A Journal of Molecular and Cellular Immunology
Volume 50, 2021 - Issue 1
246
Views
4
CrossRef citations to date
0
Altmetric
Original Articles

Infection of Epstein–Barr Virus is Associated with the Decrease of Helios+FoxP3+Regulatory T Cells in Active Ulcerative Colitis Patients

, , , , &

References

  • Ciccocioppo R, Racca F, Paolucci S, Campanini G, Pozzi L, Betti E, Riboni R, Vanoli A, Baldanti F, Corazza GR. 2015. Human cytomegalovirus and Epstein–Barr virus infection in inflammatory bowel disease: need for mucosal viral load measurement. World J Gastroenterol. 21(6):1915–26. doi:10.3748/wjg.v21.i6.1915
  • Cohen JI. 2009. Optimal treatment for chronic active Epstein–Barr virus disease. Pediatr Transplant. 13(4):393–96.
  • Cui H, Cai Y, Wang L, Jia B, Li J, Zhao S, Chu X, Lin J, Zhang X, Bian Y, et al. 2018. Berberine regulates Treg/Th17 balance to treat ulcerative colitis through modulating the gut microbiota in the colon. Front Pharmacol. 9:571.
  • D’Haens G, Sandborn WJ, Feagan BG, Geboes K, Hanauer SB, Irvine EJ, Lémann M, Marteau P, Rutgeerts P, Schölmerich J, et al. 2007. A review of activity indices and efficacy end points for clinical trials of medical therapy in adults with ulcerative colitis. Gastroenterology 132(2):763–86. PMID: 17258735.
  • da Silva BC, Lyra AC, Rocha R, Santana GO. 2014. Epidemiology, demographic characteristics and prognostic predictors of ulcerative colitis. World J Gastroenterol. 20(28):9458–67.
  • Danese S, Fiocchi C. 2011. Ulcerative colitis. N Engl J Med. 365(18):1713–25.
  • Ebrahimi Daryani N, Saghazadeh A, Moossavi S, Sadr M, Shahkarami S, Soltani S, Farhadi E, Rezaei N. 2017. Interleukin-4 and interleukin-10 gene polymorphisms in patients with inflammatory bowel disease. Immunol Invest. 46(7):714–29.
  • Fukaura K, Iboshi Y, Ogino H, Ihara E, Nakamura K, Nishihara Y, Nishioka K, Chinen T, Iwasa T, Aso A, et al. 2018. Mucosal profiles of immune molecules related to T helper and regulatory T cells predict future relapse in patients with quiescent ulcerative colitis. Inflamm Bowel Dis. 25(6):1019–27. doi:10.1093/ibd/izy395
  • Getnet D, Grosso JF, Goldberg MV, Harris TJ, Yen H-R, Bruno TC, Durham NM, Hipkiss EL, Pyle KJ, Wada S, et al. 2010. A role for the transcription factor Helios in human CD4+CD25+ regulatory T cells. Mol Immunol. 47(7–8):1595–600. doi:10.1016/j.molimm.2010.02.001
  • Golding A, Hasni S, Illei G, Shevach EM. 2013. The percentage of FoxP3+Helios+ Treg cells correlates positively with disease activity in systemic lupus erythematosus. Arthritis Rheum. 65(11):2898–906.
  • Harrison OJ, Powrie FM. 2013. Regulatory T cells and immune tolerance in the intestine. Cold Spring Harb Perspect Biol 5(7) pii:a018341–a018341. doi:10.1101/cshperspect.a018341.
  • Hu Y, Zhang L, Chen H, Liu X, Zheng X, Shi H, Jiang L, Cui D. 2019. Analysis of regulatory T cell subsets and their expression of Helios and PD-1 in patients with Hashimoto thyroiditis. Int J Endocrinol. 2019:5368473.
  • Iranshahi N, Assar S, Amiri SM, Zafari P, Fekri A, Taghadosi M. 2019. Decreased gene expression of Epstein–Barr Virus-Induced Gene 3 (EBI-3) may contribute to the pathogenesis of rheumatoid arthritis. Immunol Invest. 48(4):367–77.
  • Keyhanmehr N, Motedayyen H, Eskandari N. 2019. The effects of silymarin and cyclosporine A on the proliferation and cytokine production of regulatory T cells. Immunol Invest. 48(5):533–48.
  • Li X, Chen N, You P, Peng T, Chen G, Wang J, Li J, Liu Y. 2019. The status of Epstein–Barr virus infection in intestinal mucosa of chinese patients with inflammatory bowel disease. Digestion. 99(2):126–32.
  • Liu C, Guan Z, Zhao L, Song Y, Wang H. 2017. Elevated level of circulating CD4+Helios+FoxP3+ cells in primary Sjogren’s syndrome patients. Mod Rheumatol. 27(4):630–37.
  • Lopes S, Andrade P, Conde S, Liberal R, Dias CC, Fernandes S, Pinheiro J, Simões JS, Carneiro F, Magro F, et al. 2017. Looking into enteric virome in patients with IBD: defining guilty or innocence? Inflamm Bowel Dis. 23(8):1278–84. doi:10.1097/MIB.0000000000001167
  • Magro F, Santos-Antunes J, Albuquerque A, Vilas-Boas F, Macedo GN, Nazareth N, Lopes S, Sobrinho-Simões J, Teixeira S, Dias CC, et al. 2013. Epstein–Barr virus in inflammatory bowel disease-correlation with different therapeutic regimens. Inflamm Bowel Dis. 19(8):1710–16. doi:10.1097/MIB.0b013e318281f31c
  • Maloy KJ, Powrie F. 2011. Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature. 474(7351):298–306.
  • Mitchell JL, Seng A, Yankee TM. 2016. Expression patterns of Ikaros family members during positive selection and lineage commitment of human thymocytes. Immunology. 149(4):400–12.
  • Ohkusa T, Koido S. 2015. Intestinal microbiota and ulcerative colitis. J Infect Chemother. 21(11):761–68.
  • Ohto U, Shibata T, Tanji H, Ishida H, Krayukhina E, Uchiyama S, Miyake K, Shimizu T. 2015. Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9. Nature. 520(7549):702–05.
  • Paul WE. 1991. Interleukin-4: a prototypic immunoregulatory lymphokine. Blood 77(9):1859–70. PMID: 2018830.
  • Pezhouh MK, Miller JA, Sharma R, Borzik D, Eze O, Waters K, Westerhoff MA, Parian AM, Lazarev MG, Voltaggio L, et al. 2018. Refractory inflammatory bowel disease: is there a role for Epstein–Barr virus? A case-controlled study using highly sensitive Epstein–Barr virus-encoded small RNA1 in situ hybridization. Hum Pathol. 82:187–92.
  • Pisetsky DS. 2018. Role of Epstein–Barr virus infection in SLE: gene-environment interactions at the molecular level. Ann Rheum Dis. 77(9):1249–50.
  • Rizzo AG, Orlando A, Gallo E, Bisanti A, Sferrazza S, Montalbano LM, Macaluso FS, Cottone M. 2017. Is Epstein–Barr virus infection associated with the pathogenesis of microscopic colitis? J Clin Virol. 97:1–3.
  • Round JL, Mazmanian SK. 2009. The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol. 9(5):313–23.
  • Ryan JL, Shen Y-J, Morgan DR, Thorne LB, Kenney SC, Dominguez RL, Gulley ML. 2012. Epstein–Barr virus infection is common in inflamed gastrointestinal mucosa. Dig Dis Sci. 57(7):1887–98.
  • Sartor RB. 2006. Mechanisms of disease: pathogenesis of Crohn’s disease and ulcerative colitis. Nat Clin Pract Gastroenterol Hepatol 3(7):390–407. PMID: 16819502.
  • Shohan M, Sabzevary-Ghahfarokhi M, Bagheri N, Shirzad H, Rahimian G, Soltani A, Ghatreh-Samani M, Deris F, Tahmasbi K, Shahverdi E, et al. 2018. Intensified Th9 response is associated with the immunopathogenesis of active ulcerative colitis. Immunol Invest. 47(7):700–11. doi:10.1080/08820139.2018.1486411
  • Smith PM, Howitt MR, Panikov N, Michaud M, Gallini CA, Bohlooly-Y M, Glickman JN, Garrett WS. 2013. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science. 341(6145):569–73.
  • Takatori H, Kawashima H, Matsuki A, Meguro K, Tanaka S, Iwamoto T, Sanayama Y, Nishikawa N, Tamachi T, Ikeda K, et al. 2015. Helios enhances treg cell function in cooperation with FoxP3. Arthritis Rheumatol. 67(6):1491–502. doi:10.1002/art.39091
  • Tanoue T, Atarashi K, Honda K. 2016. Development and maintenance of intestinal regulatory T cells. Nat Rev Immunol. 16(5):295–309.
  • Trier JS. 2002. Mucosal flora in inflammatory bowel disease: intraepithelial bacteria or endocrine epithelial cell secretory granules? Gastroenterology 123(3):955. PMID: 12198731.
  • Wyss A, Raselli T, Perkins N, Ruiz F, Schmelczer G, Klinke G, Moncsek A, Roth R, Spalinger MR, Hering L, et al. 2019. The EBI2-oxysterol axis promotes the development of intestinal lymphoid structures and colitis. Mucosal Immunol. 12(3):733–45. doi:10.1038/s41385-019-0140-x
  • Xavier RJ, Podolsky DK. 2007. Unravelling the pathogenesis of inflammatory bowel disease. Nature 448(7152):427–34. PMID: 17653185.
  • Zafari P, Yari K, Mostafaei S, Iranshahi N, Assar S, Fekri A, Taghadosi M. 2018. Analysis of Helios gene expression and Foxp3 TSDR methylation in the newly diagnosed rheumatoid arthritis patients. Immunol Invest. 47(6):632–42.
  • Zagórowicz E, Bugajski M, Wieszczy P, Pietrzak A, Magdziak A, Mróz A. 2016. Cytomegalovirus infection in ulcerative colitis is related to severe inflammation and a high count of cytomegalovirus-positive cells in biopsy is a risk factor for colectomy. J Crohns Colitis. 10(10):1205–11.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.