The Association between Interleukin-6 Gene Polymorphisms and Risk of Systemic Lupus Erythematosus: A Meta-analysis with Trial Sequential Analysis

References

• Abbas D, Hamdy E, Helal MM. 2011. Promoter region polymorphism (− 174 G/C) of interleukin-6 gene and SLE; are they associated? Egyptian Rheumatol. 33:69–75.
   Google Scholar
• Amirghofran Z, Moazemi Godarzi E, Kamali Sarvestani E, Aflaki E. 2009. IL-6 gene polymorphisms in iranian patients with systemic lupus erythematosus. Eur J Immunol. 39:S234.
   PubMed Web of Science ®Google Scholar
• Asano NM, Angelo HD, da Silva HA, Maia MM, Lins OG, Souza PE. 2013. Interleukin-6 promoter polymorphisms −174 G/C in Brazilian patients with systemic lupus erythematosus. Hum Immunol. 74:1153–56.
   PubMed Web of Science ®Google Scholar
• Brull DJ, Montgomery HE, Sanders J, Dhamrait S, Luong L, Rumley A, Lowe GDO, Humphries SE. 2001. Interleukin-6 gene -174G>C and -572G>C promoter polymorphisms are strong predictors of plasma interleukin-6 levels after coronary artery bypass surgery. Arterioscler Thromb Vasc Biol. 21:1458–63.
   PubMed Web of Science ®Google Scholar
• Button KS, Ioannidis JP, Mokrysz C, Nosek BA, Flint J, Robinson ESJ, Munafò MR. 2013. Power failure: why small sample size undermines the reliability of neuroscience. Nat Rev Neurosci. 14:365–76.
   PubMed Web of Science ®Google Scholar
• Chua KH, Kee BP, Tan SY, Lian LH. 2009. Interleukin-6 promoter polymorphisms (−174 G/C) in Malaysian patients with systemic lupus erythematosus. Braz J Med Biol Res. 42:551–55.
   PubMed Web of Science ®Google Scholar
• Cui YX, Fu CW, Jiang F, Ye LX, Meng W. 2015. Association of the interleukin-6 polymorphisms with systemic lupus erythematosus: a meta-analysis. Lupus. 24:1308–17.
   PubMed Web of Science ®Google Scholar
• D’Cruz DP, Khamashta MA, Hughes GR. 2007. Systemic lupus erythematosus. Lancet. 369:587–96.
   PubMed Web of Science ®Google Scholar
• DerSimonian R, Laird N. 1986. Meta-analysis in clinical trials. Control Clin Trials. 7:177–88.
   PubMed Web of Science ®Google Scholar
• Egger M, Davey Smith G, Schneider M, Minder C. 1997. Bias in meta-analysis detected by a simple, graphical test. BMJ. 315:629–34.
   PubMed Web of Science ®Google Scholar
• Fishman D, Faulds G, Jeffery R, Mohamed-Ali V, Yudkin JS, Humphries S, Woo P. 1998. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest. 102:1369–76.
   PubMed Web of Science ®Google Scholar
• Godarzi EM, Sarvestani EK, Aflaki E, Amirghofran Z. 2011. Interleukin-6 gene polymorphism in Iranian patients with systemic lupus erythematosus. Clin Rheumatol. 30:179–84.
   PubMed Web of Science ®Google Scholar
• Guarnizo-Zuccardi P, Lopez Y, Giraldo M, Garcia N, Rodriguez L, Ramirez L, Uribe O, Garcia L, Vasquez G. 2007. Cytokine gene polymorphisms in Colombian patients with systemic lupus erythematosus. Tissue Antigens. 70:376–82.
   PubMed Web of Science ®Google Scholar
• Hamdy E, Afify RA, Kamal A, Abass D, Mahmoud M. 2012. IL-6 promoter polymorphism (−174G/C) and systemic lupus erythematosus. Comp Clin Pathol. 21:975.
   Google Scholar
• Hristova M, Dourmishev L, Kamenarska Z, Nikolova S, Kaneva R, Vinkov A, Baleva M, Monova D, Mitev V. 2013. Role of the promoter polymorphism IL-6-174G/C in dermatomyositis and systemic lupus erythematosus. Biomed Res Int. 2013:315365.
   PubMed Web of Science ®Google Scholar
• Hrycek A, Siekiera U, Cieslik P, Szkrobka W. 2005. HLA-DRB1 and -DQB1 alleles and gene polymorphisms of selected cytokines in systemic lupus erythematosus. Rheumatol Int. 26:1–6.
   PubMed Web of Science ®Google Scholar
• Huang CM, Huo AP, Tsai CH, Chen C-L, Tsai F-J. 2006. Lack of association of interleukin-6 and interleukin-8 gene polymorphisms in Chinese patients with systemic lupus erythematosus. J Clin Lab Anal. 20:255–59.
   PubMed Web of Science ®Google Scholar
• Jeon JY, Kim HA, Kim SH, PARK H-S, SUH C-H. 2010. Interleukin 6 gene polymorphisms are associated with systemic lupus erythematosus in Koreans. J Rheumatol. 37:2251–58.
   PubMed Web of Science ®Google Scholar
• Jeon JY, Kim HA, Kim SH, Suh CH. 2011. Association between variable number tandem repeats within the 3 ‘ flanking region of the interleukin-6 gene and systemic lupus erythematosus in Korean patients. Lupus. 20:1161–65.
   PubMed Web of Science ®Google Scholar
• Jeon JY, Kim KY, Kim HA, Suh CH. 2013. The interleukin 6 receptor alpha gene polymorphisms are associated with clinical manifestations of systemic lupus erythematosus in Koreans. Int J Immunogenet. 40:356–60.
   PubMed Web of Science ®Google Scholar
• Katkam SK, Rajasekhar L, Kumaraswami K, Kutala VK. 2017. Association of IL −6-174 G>C polymorphism with the risk of SLE among south Indians: evidence from case-control study and meta-analysis. Lupus. 26:1491–501.
   PubMed Web of Science ®Google Scholar
• Lee YH. 2018. An overview of meta-analysis for clinicians. Korean J Intern Med. 33:277–83.
   PubMed Web of Science ®Google Scholar
• Linker-Israeli M, Wallace DJ, Prehn J, Michael D, Honda M, Taylor KD, Paul-Labrador M, Fischel-Ghodsian N, Fraser PA, Klinenberg JR. 1999. Association of IL-6 gene alleles with systemic lupus erythematosus (SLE) and with elevated IL-6 expression. Genes Immun. 1(1):45–52.
   PubMed Web of Science ®Google Scholar
• Lisnevskaia L, Murphy G, Isenberg D. 2014. Systemic lupus erythematosus. Lancet. 384:1878–88.
   PubMed Web of Science ®Google Scholar
• Moher D, Liberati A, Tetzlaff J, Altman DG. 2009. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 6:e1000097.
   PubMed Web of Science ®Google Scholar
• Paradowska-Gorycka A, Roszak M, Stypinska B, Lutkowska A, Walczyk M, Olesinska M, Wajda A, Piotrowski P, Puszczewicz M, Majewski D, et al. 2019. IL-6 and TGF-beta gene polymorphisms, their serum levels, as well as HLA profile, in patients with systemic lupus erythematosus. Clin Exp Rheumatol. 37:963–75.
   PubMed Web of Science ®Google Scholar
• Riley RD, Higgins JP, Deeks JJ. 2011. Interpretation of random effects meta-analyses. BMJ. 342:d549.
   PubMed Web of Science ®Google Scholar
• Santos MJ, Fernandes D, Capela S, da Silva JC, Fonseca JE. 2011. Interleukin-6 promoter polymorphism −174 G/C is associated with nephritis in Portuguese Caucasian systemic lupus erythematosus patients. Clin Rheumatol. 30:409–13.
   PubMed Web of Science ®Google Scholar
• Schotte H, Schluter B, Rust S, Assmann G, Domschke W, Gaubitz M. 2001. Interleukin-6 promoter polymorphism (–174 G/C) in Caucasian German patients with systemic lupus erythematosus. Rheumatology (Oxford). 40:393–400.
   PubMed Web of Science ®Google Scholar
• Shi L, Yang X, Dong X, Zhang B. 2016. Polymorphism of HSD17B1 Ser312Gly with cancer risk: evidence from 66,147 Subjects. Twin Res Hum Genet. 19:136–45.
   PubMed Web of Science ®Google Scholar
• Shirota Y, Yarboro C, Fischer R, Pham T-H, Lipsky P, Illei GG. 2013. Impact of anti-interleukin-6 receptor blockade on circulating T and B cell subsets in patients with systemic lupus erythematosus. Ann Rheum Dis. 72(1):118–28.
   PubMed Web of Science ®Google Scholar
• Solus JF, Chung CP, Oeser A, Li C, Rho YH, Bradley KM, Kawai VK, Smith JR, Stein CM. 2015. Genetics of serum concentration of IL-6 and TNF alpha in systemic lupus erythematosus and rheumatoid arthritis: a candidate gene analysis. Clin Rheumatol. 34:1375–82.
   PubMed Web of Science ®Google Scholar
• Tackey E, Lipsky PE, Illei GG. 2004. Rationale for interleukin-6 blockade in systemic lupus erythematosus. Lupus. 13:339–43.
   PubMed Web of Science ®Google Scholar
• Talaat RM, Alrefaey SA, Bassyouni IH, Ashour ME, Raouf AA. 2016. Genetic polymorphisms of interleukin 6 and interleukin 10 in Egyptian patients with systemic lupus eythematosus. Lupus. 25(3):255–64.
   PubMed Web of Science ®Google Scholar
• Thakkinstian A, McElduff P, D’Este C, Duffy D, Attia J. 2005. A method for meta-analysis of molecular association studies. Stat Med. 24(9):1291–306.
   PubMed Web of Science ®Google Scholar
• Thakkinstian A, McKay GJ, McEvoy M, Chakravarthy U, Chakrabarti S, Silvestri G, Kaur I, Li X, Attia J. 2011. Systematic review and meta-analysis of the association between complement component 3 and age-related macular degeneration: a HuGE review and meta-analysis. Am J Epidemiol. 173(12):1365–79.
   PubMed Web of Science ®Google Scholar
• Tobias A. 1999. Assessing the influence of a single study in the meta-analysis estimate. Stata Tech Bull. 8:15–17.
   Google Scholar
• Wen PF, Wang XS, Zhang M, Li R, Qiu LJ, Ni J, Pan HF, Ye DQ. 2016. Association study of single nucleotide polymorphism of IL-6 and systemic lupus erythematosus. Chin J Dis Control Prev. 18:277–80.
   Google Scholar
• Wetterslev J, Thorlund K, Brok J, Gluud C. 2008. Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis. J Clin Epidemiol. 61:64–75.
   PubMed Web of Science ®Google Scholar
• Wu YK, Cai B, Zhang JL, Shen B, Huang Z, Tan C, Baan CC, Wang L. 2017. IL-1 beta and IL-6 are highly expressed in RF plus IgE plus systemic lupus erythematous subtype. J Immunol Res. 2017:5096741.
   PubMed Web of Science ®Google Scholar
• Xu WD, Zhang YJ, Pan HF, Ye DQ. 2012. Targeting IL-6 promoter polymorphism −174G/C should be dependent on ethnicity. Clin Rheumatol. 31:191–92.
   PubMed Web of Science ®Google Scholar
• Ziaee V, Tahghighi F, Moradinejad MH, Harsini S, Mahmoudi M, Rezaei A, Soltani S, Sadr M, Aghighi Y, Rezaei N. 2014. Interleukin-6, interleukin-1 gene cluster and interleukin-1 receptor polymorphisms in Iranian patients with juvenile systemic lupus erythematosus. Eur Cytokine Netw. 25:35–40.
   PubMed Web of Science ®Google Scholar
• Zucchi D, Elefante E, Calabresi E, Signorini V, Bortoluzzi A, Tani C. 2019. One year in review 2019: systemic lupus erythematosus. Clin Exp Rheumatol. 37:715–22.
   PubMed Web of Science ®Google Scholar