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Immunological Investigations
A Journal of Molecular and Cellular Immunology
Volume 50, 2021 - Issue 5
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Research Article

Intranodal Administration of Neoantigen Peptide-loaded Dendritic Cell Vaccine Elicits Epitope-specific T Cell Responses and Clinical Effects in a Patient with Chemorefractory Ovarian Cancer with Malignant Ascites

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References

  • Acton SE, Farrugia AJ, Astarita J, Mourão-Sá D, Jenkins RP, Nye E, Hooper S, van Blijswijk J, Rogers NC, Snelgrove KJ, et al. 2014. Dendritic cells control fibroblastic reticular network tension and lymph node expansion. Nature. 514(7523):498–502. doi:10.1038/nature13814.
  • Bedrosian I, Mick R, Xu S, Nisenbaum H, Faries M, Zhang P, Cohen PA, Koski G, Czerniecki BJ. 2003. Intranodal administration of peptide-pulsed mature dendritic cell vaccines results in superior CD8 + T-cell function in melanoma patients. J Clin Oncol. 21(20):3826–35.
  • Blaeschke F, Paul MC, Schuhmann MU, Rabsteyn A, Schroeder C, Casadei N, Matthes J, Mohr C, Lotfi R, Wagner B, et al. 2019. Low mutational load in pediatric medulloblastoma still translates into neoantigens as targets for specific T-cell immunotherapy. Cytotherapy. 21(9):973–86. doi:10.1016/j.jcyt.2019.06.009.
  • Choudhury NJ, Kiyotani K, Yap KL, Campanile A, Antic T, Yew PY, Steinberg G, Park JH, Nakamura Y, O’Donnell PH, et al. 2016. Low T-cell receptor diversity, high somatic mutation burden, and high neoantigen load as predictors of clinical outcome in muscle-invasive bladder cancer. Eur Urol Focus. 2(4):445–52. doi:10.1016/j.euf.2015.09.007.
  • Drerup JM, Liu Y, Padron AS, Murthy K, Hurez V, Zhang B, Curiel TJ. 2015. Immunotherapy for ovarian cancer. Curr Treat Options Oncol. 16(1):317. doi:10.1007/s11864-014-0317-1.
  • Durgeau A, Virk Y, Corgnac S, Mami-Chouaib F. 2018. Recent advances in targeting CD8 T-cell immunity for more effective cancer immunotherapy. Front Immunol. 9:14. doi:10.1007/s11864-014-0317-1.
  • Garg AD, Vara Perez M, Schaaf M, Agostinis P, Zitvogel L, Kroemer G, Galluzzi L. 2017. Trial watch: dendritic cell-based anticancer immunotherapy. Oncoimmunology. 6(7):e1328341.
  • Gilliet M, Kleinhans M, Lantelme E, Schadendorf D, Burg G, Nestle FO. 2003. Intranodal injection of semimature monocyte-derived dendritic cells induces T helper type 1 responses to protein neoantigen. Blood. 102(1):36–42.
  • Giudicelli V, Chaume D, Lefranc MP. 2005. IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes. Nucleic Acids Res. 33:D256–D261.
  • Johanns TM, Miller CA, Liu CJ, Perrin RJ, Bender D, Kobayashi DK, Campian JL, Chicoine MR, Dacey RG, Huang J, et al. 2019. Detection of neoantigen-specific T cells following a personalized vaccine in a patient with glioblastoma. Oncoimmunol. 8(4):e1561106. doi:10.1080/2162402X.2018.1561106.
  • Keskin DB, Anandappa AJ, Sun J, Tirosh I, Mathewson ND, Li S, Oliveira G, Giobbie-Hurder A, Felt K, Gjini E, et al. 2019. Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial. Nature. 565(7738):234–39. doi:10.1038/s41586-018-0792-9.
  • Kissick HT. 2018. Is it possible to develop cancer vaccines to neoantigens, what are the major challenges, and how can these be overcome? Neoantigens as vaccine targets for cancer. Cold Spring Harb Perspect Biol. 10(11):a033704.
  • Kiyotani K, Chan HT, Nakamura Y. 2018. Immunopharmacogenomics towards personalized cancer immunotherapy targeting neoantigens. Cancer Sci. 109(3):542–49.
  • Kiyotani K, Park J-H, Inoue H, Husain A, Olugbile S, Zewde M, Nakamura Y, Vigneswaran WT. 2017. Integrated analysis of somatic mutations and immune microenvironment in malignant pleural mesothelioma. Oncoimmunol. 6(2):e1278330.
  • Lambert LA, Gibson GR, Maloney M, Durell B, Noelle RJ, Barth RJ. 2001. Intranodal immunization with tumor lysate-pulsed dendritic cells enhances protective antitumor immunity. Cancer Res. 61(2):641–46.
  • Liu XS, Mardis ER. 2017. Applications of immunogenomics to cancer. Cell. 168(4):600–12. doi:10.1016/j.cell.2017.01.014.
  • Martin SD, Brown SD, Wick DA, Nielsen JS, Kroeger DR, Twumasi-Boateng K, Holt RA, Nelson BH. 2016. Low mutation burden in ovarian cancer may limit the utility of neoantigen-targeted vaccines. PLoS One. 11(5):e0155189.
  • McGranahan N, Furness AJS, Rosenthal R, Ramskov S, Lyngaa R, Saini SK, Jamal-Hanjani M, Wilson GA, Birkbak NJ, Hiley CT, et al. 2016. Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade. Science. 351(6280):1463–69. doi:10.1126/science.aaf1490.
  • Morse MA, Coleman RE, Akabani G, Niehaus N, Coleman D, Lyerly HK. 1999. Migration of human dendritic cells after injection in patients with metastatic malignancies. Cancer Res. 59(1):56–58.
  • Nestle FO, Alijagic S, Gilliet M, Sun Y, Grabbe S, Dummer R, Burg G, Schadendorf D. 1998. Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells. Nat Med. 4(3):328–32.
  • Ott PA, Hu Z, Keskin DB, Shukla SA, Sun J, Bozym DJ, Zhang W, Luoma A, Giobbie-Hurder A, Peter L, et al. 2017. An immunogenic personal neoantigen vaccine for patients with melanoma. Nature. 547(7662):217–21. doi:10.1038/nature22991.
  • Pokhriyal R, Hariprasad R, Kumar L, Hariprasad G. 2019. Chemotherapy resistance in advanced ovarian cancer patients. Biomark Cancer. 11:1179299X1986081.
  • Ridolfi R, Riccobon A, Galassi R, Giorgetti G, Petrini M, Fiammenghi L, Stefanelli M, Ridolfi L, Moretti A, Migliori G, et al. 2004. Evaluation of in vivo labelled dendritic cell migration in cancer patients. J Transl Med. 2(1):27. doi:10.1186/1479-5876-2-27.
  • Sahin U, Derhovanessian E, Miller M, Kloke B-P, Simon P, Löwer M, Bukur V, Tadmor AD, Luxemburger U, Schrörs B, et al. 2017. Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer. Nature. 547(7662):222–26. doi:10.1038/nature23003.
  • Saxena M, Bhardwaj N. 2018. Re-emergence of dendritic cell vaccines for cancer treatment. Trend Cancer. 4(2):119–37.
  • Szolek A, Schubert B, Mohr C, Sturm M, Feldhahn M, Kohlbacher O. 2014. OptiType: precision HLA typing from next-generation sequencing data. Bioinformatics. 30(23):3310–16.
  • Yarchoan M, Johnson BA III, Lutz ER, Laheru DA, Jaffee EM. 2017. Targeting neoantigens to augment antitumor immunity. Nat Rev Cancer. 17(4):209–22. doi:10.1038/nrc.2016.154.
  • Yoshimura S, Tsunoda T, Osawa R, Harada M, Watanabe T, Hikichi T, Katsuda M, Miyazawa M, Tani M, Iwahashi M, et al. 2014. Identification of an HLA-A2-restricted epitope peptide derived from hypoxia-inducible protein 2 (HIG2). PLoS One. 9(1):e85267. doi:10.1371/journal.pone.0085267.
  • Zacharakis N, Chinnasamy H, Black M, Xu H, Lu Y-C, Zheng Z, Pasetto A, Langhan M, Shelton T, Prickett T, et al. 2018. Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer. Nat Med. 24(6):724–30. doi:10.1038/s41591-018-0040-8.
  • Zamora AE, Crawford JC, Allen EK, Guo XZJ, Bakke J, Carter RA, Abdelsamed HA, Moustaki A, Li Y, Chang T-C, et al. 2019. Pediatric patients with acute lymphoblastic leukemia generate abundant and functional neoantigen-specific CD8 + T cell responses. Sci Transl Med. 11(498):eaat8549. doi:10.1126/scitranslmed.aat8549.