Publication Cover
Immunological Investigations
A Journal of Molecular and Cellular Immunology
Volume 50, 2021 - Issue 6
437
Views
9
CrossRef citations to date
0
Altmetric
Research Article

Effects of Teriflunomide on B Cell Subsets in MuSK-Induced Experimental Autoimmune Myasthenia Gravis and Multiple Sclerosis

ORCID Icon, ORCID Icon, , ORCID Icon, , , & ORCID Icon show all

References

  • Allman W, Qi H, Saini SS, Li J, Tuzun E, Christadoss P. 2012. CD4 costimulation is not required in a novel LPS-enhanced model of myasthenia gravis. J Neuroimmunol. 249(1–2):1–7.
  • Baggi F, Nicolle M, Vincent A, Matsuo H, Willcox N, Newsom-Davis J. 1993. Presentation of endogenous acetylcholine receptor epitope by an MHC class II-transfected human muscle cell line to a specific CD4+ T cell clone from a myasthenia gravis patient. J Neuroimmunol. 46:57–65.
  • Bruneau JM, Yea CM, Spinella-Jaegle S, Fudali C, Woodward K, Robson PA, Sautès C, Westwood R, Kuo EA, Williamson RA, et al. 1998. Purification of human dihydro-orotate dehydrogenase and its inhibition by A77 1726, the active metabolite of leflunomide. Biochem J. 336:299–303.
  • Cetin H, Pathogenic Mechanisms VA. 2018. Clinical correlations in autoimmune myasthenic syndromes. Semin Neurol. 38:344–54.
  • Cheng Y, Sun L, Xie Z, Fan X, Cao Q, Han J, Zhu J, Jin T. 2017. Diversity of immune cell types in multiple sclerosis and its animal model: pathological and therapeutic implications. J Neurosci Res. 95:1973–83.
  • Cherwinski HM, Cohn RG, Cheung P, Webster DJ, Xu YZ, Caulfield JP, Young JM, Nakano G, Ransom JT. 1995. The immunosuppressant leflunomide inhibits lymphocyte proliferation by inhibiting pyrimidine biosynthesis. J Pharmacol Exp Ther. 275:1043–49.
  • Comi G, Miller AE, Benamor M, Truffinet P, Poole EM, Freedman MS. 2019. Characterizing lymphocyte counts and infection rates with long-term teriflunomide treatment: pooled analysis of clinical trials. Mult Scler. 1352458519851981. doi:https://doi.org/10.1177/1352458519851981
  • Evoli A, Alboini PE, Damato V, Iorio R, Provenzano C, Bartoccioni E, Marino M. 2018. Myasthenia gravis with antibodies to MuSK: an update. Ann N Y Acad Sci. 1412:82–89.
  • Fuentealba RA, Marasa J, Diamond MI, Piwnica-Worms D, Weihl CC. 2012. An aggregation sensing reporter identifies leflunomide and teriflunomide as polyglutamine aggregate inhibitors. Hum Mol Genet. 21:664–80.
  • Gandoglia I, Ivaldi F, Laroni A, Benvenuto F, Solaro C, Mancardi G, Kerlero de Rosbo N, Uccelli A. 2017. Teriflunomide treatment reduces B cells in patients with MS. Neurol Neuroimmunol Neuroinflamm. 4:e403.
  • Guptill JT, Yi JS, Sanders DB, Guidon AC, Juel VC, Massey JM, Howard JF Jr, Scuderi F, Bartoccioni E, Evoli A, et al. 2015. Characterization of B cells in muscle-specific kinase antibody myasthenia gravis. Neurol Neuroimmunol Neuroinflamm. 2:e77.
  • Kraan MC, Reece RJ, Barg EC, Smeets TJ, Farnell J, Rosenburg R, Veale DJ, Breedveld FC, Emery P, Tak PP. 2000. Modulation of inflammation and metalloproteinase expression in synovial tissue by leflunomide and methotrexate in patients with active rheumatoid arthritis. Findings in a prospective, randomized, double-blind, parallel-design clinical trial in thirty-nine patients at two centers. Arthritis Rheum. 43:1820–30.
  • Lebrun C, Bourg V, Bresch S, Cohen M, Rosenthal-Allieri MA, Desnuelle C, Ticchioni M. 2016. Therapeutic target of memory B cells depletion helps to tailor administration frequency of rituximab in myasthenia gravis. J Neuroimmunol. 298:79–81.
  • Mandola AB, Levy J, Nahum A, Hadad N, Levy R, Rylova A, Simon AJ, Lev A, Somech R, Broides A. 2019. Neutrophil functions in immunodeficiency due to DOCK8 deficiency. Immunol Invest. 48:431–39.
  • Medina S, Sainz de la Maza S, Villarrubia N, Álvarez-Lafuente R, Costa-Frossard L, Arroyo R, Monreal E, Tejeda-Velarde A, Rodríguez-Martín E, Roldán E, et al. 2019. Teriflunomide induces a tolerogenic bias in blood immune cells of MS patients. Ann Clin Transl Neurol. 6:355–63.
  • Merrill JE, Hanak S, Pu SF, Liang J, Dang C, Iglesias-Bregna D, Harvey B, Zhu B, McMonagle-Strucko K. 2009. Teriflunomide reduces behavioral, electrophysiological, and histopathological deficits in the Dark Agouti rat model of experimental autoimmune encephalomyelitis. J Neurol. 256:89–103.
  • Muto K, Matsui N, Unai Y, Sakai W, Haji S, Udaka K, Miki H, Furukawa T, Abe M, Kaji R. 2017. Memory B cell resurgence requires repeated rituximab in myasthenia gravis. Neuromuscul Disord. 27:918–22.
  • Rahmati M, Ghannadian SM, Kasiri N, Ahmadi L, Motedayyen H, Shaygannejad V, Pourazar A, Alsahebfosoul F, Ganjalikhani Hakemi M, Eskandari N. 2020. Modulation of Th17 proliferation and IL-17A gene expression by acetylated form of apigenin in patients with multiple sclerosis. Immunol Invest. 1–14. doi:https://doi.org/10.1080/08820139.2020.1726381
  • Shiraishi H, Motomura M, Yoshimura T, Fukudome T, Fukuda T, Nakao Y, Tsujihata M, Vincent A, Eguchi K. 2005. Acetylcholine receptors loss and postsynaptic damage in MuSK antibody-positive myasthenia gravis. Ann Neurol. 57:289–93.
  • Si R, Zhao P, Yu Z, Qu Z, Sun W, Li T, Jiang Y. 2020. Increased non-switched memory B cells are associated with plasmablasts, serum IL-6 levels and renal functional impairments in IgAN patients. Immunol Invest. 49:178–90.
  • Solovjov DA, Pluskota E, Plow EF. 2005. Distinct roles for the alpha and beta subunits in the functions of integrin alphaMbeta2. J Biol Chem. 280:1336–45.
  • Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, Correale J, Fazekas F, Filippi M, Freedman MS, et al. 2018 Feb. Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. Lancet Neurol. 17(2):162–73. doi:https://doi.org/10.1016/S1474-4422(17)30470-2.
  • Trakas N, Zisimopoulou P, Tzartos SJ. 2011. Development of a highly sensitive diagnostic assay for muscle-specific tyrosine kinase (MuSK) autoantibodies in myasthenia gravis. J Neuroimmunol. 240–241:79–86.
  • Trapp BD, Nave KA. 2008. Multiple sclerosis: an immune or neurodegenerative disorder? Annu Rev Neurosci. 31:247–69.
  • Tuzun E, Berrih-Aknin S, Brenner T, Kusner LL, Le Panse R, Yang H, Tzartos S, Christadoss P. 2015. Guidelines for standard preclinical experiments in the mouse model of myasthenia gravis induced by acetylcholine receptor immunization. Exp Neurol. 270:11–17. doi:https://doi.org/10.1016/j.expneurol.2015.02.009
  • Tuzun E, Christadoss P. 2013. Complement associated pathogenic mechanisms in myasthenia gravis. Autoimmun Rev. 12:904–11.
  • Ulusoy C, Kim E, Tüzün E, Huda R, Yılmaz V, Poulas K, Trakas N, Skriapa L, Niarchos A, Strait RT, et al. 2014. Preferential production of IgG1, IL-4 and IL-10 in MuSK-immunized mice. Clin Immunol. 151:155–63.
  • Wu B, Goluszko E, Christadoss P. 2001 May. Experimental autoimmune myasthenia gravis in the mouse. Curr Protoc Immunol. 15(8):1–26.
  • Yilmaz V, Oflazer P, Aysal F, Durmus H, Poulas K, Yentur SP, Gulsen-Parman Y, Tzartos S, Marx A, Tuzun E, et al. 2015. Differential cytokine changes in patients with myasthenia gravis with antibodies against AChR and MuSK. PLoS One. 10:e0123546.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.