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Immunological Investigations
A Journal of Molecular and Cellular Immunology
Volume 51, 2022 - Issue 2
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Research Article

Higher Peripheral Blood IFN-γ-/IL-4+ Th2 Lymphocytes Are Associated with Lower Rate of Relapse in Patients with Lymphoma

Mehdi Dehghania Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;b Department of Hematology and Medical Oncology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, IranView further author information
,
Mani Ramzia Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;b Department of Hematology and Medical Oncology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, IranView further author information
,
Mehdi Kalanic Department of Immunology, Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, IranView further author information
,
Hossein Golmoghaddamd Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranView further author information
&
Nargess Arandia Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, IranCorrespondence[email protected]
View further author information
Pages 452-463 | Published online: 05 Nov 2020

References

  • Chraa D, Naim A, Olive D, Badou A. 2019. T lymphocyte subsets in cancer immunity: friends or foes. J Leukoc Biol. 105:243–55.
  • de Lima CA, Jammal MP, Etchebehere RM, Murta EFC, Nomelini RS. 2020. Lymphocytes in peritumoral stroma: evaluation in epithelial ovarian neoplasms. Immunol Invest. 49:397–405.
  • Dehghani M, Kalani M, Golmoghaddam H, Ramzi M, Arandi N. 2020. Aberrant peripheral blood CD4 (+) CD25 (+) FOXP3 (+) regulatory T cells/T helper-17 number is associated with the outcome of patients with lymphoma. Cancer Immunol Immunother. 69:1917–28.
  • Dobrzanski MJ. 2013. Expanding roles for CD4 T cells and their subpopulations in tumor immunity and therapy. Front Oncol. 3:63.
  • Ellyard JI, Simson L, Parish CR. 2007. Th2‐mediated anti‐tumour immunity: friend or foe? Tissue Antigens. 70:1–11.
  • Fridman WH, Pagès F, Sautès-Fridman C, Galon J. 2012. The immune contexture in human tumours: impact on clinical outcome. Nat Rev Cancer. 12:298–306.
  • Greaves P, Clear A, Owen A, Iqbal S, Lee A, Matthews J, Wilson A, Calaminici M, Gribben JG. 2013. Defining characteristics of classical Hodgkin lymphoma microenvironment T-helper cells. Blood. 122:2856–63.
  • Haabeth OAW, Bogen B, Corthay A. 2012. A model for cancer-suppressive inflammation. Oncoimmunology. 1:1146–55.
  • Jones E, Pringle J, Angel C, Rees R. 2002. Th1/Th2 cytokine expression and its relationship with tumor growth in B cell non-Hodgkin’s lymphoma (NHL). Leuk Lymphoma. 43:1313–21.
  • Kurtz DM, Tschetter LK, Allred JB, Geyer SM, Kurtin PJ, Putnam WD, Rowland KM Jr, Wiesenfeld M, Soori GS, Tenglin RC. 2007. Subcutaneous interleukin-4 (IL-4) for relapsed and resistant non-Hodgkin lymphoma: A phase II trial in the North Central Cancer Treatment Group, NCCTG 91-78-51. Leuk Lymphoma. 48:1290–98.
  • Liu J-Q, Li X-Y, Yu H-Q, Yang G, Liu Z-Q, Geng X-R, Wang S, Mo L-H, Zeng L, Zhao M. 2015. Tumor-specific Th2 responses inhibit growth of CT26 colon-cancer cells in mice via converting intratumor regulatory T cells to Th9 cells. Sci Rep. 5:10665.
  • Lorvik KB, Hammarström C, Fauskanger M, Haabeth OAW, Zangani M, Haraldsen G, Bogen B, Corthay A. 2016. Adoptive transfer of tumor-specific Th2 cells eradicates tumors by triggering an in situ inflammatory immune response. Cancer Res. 76:6864–76.
  • Mori T, Takada R, Watanabe R, Okamoto S, Ikeda Y. 2001. T-helper (Th) 1/Th2 imbalance in patients with previously untreated B-cell diffuse large cell lymphoma. Cancer Immunol Immunother. 50:566–68.
  • Purwar R, Schlapbach C, Xiao S, Kang HS, Elyaman W, Jiang X, Jetten AM, Khoury SJ, Fuhlbrigge RC, Kuchroo VK. 2012. Robust tumor immunity to melanoma mediated by interleukin-9–producing T cells. Nat Med. 18:1248.
  • Schreck S, Friebel D, Buettner M, Distel L, Grabenbauer G, Young LS, Niedobitek G. 2009. Prognostic impact of tumour‐infiltrating Th2 and regulatory T cells in classical Hodgkin lymphoma. Hematol Oncol. 27:31–39.
  • Shen Y, Fujimoto S. 1996. A tumor-specific Th2 clone initiating tumor rejection via primed CD8+ cytotoxic T-lymphocyte activation in mice. Cancer Res. 56:5005–11.
  • Spacek J, Vocka M, Netikova I, Skalova H, Dundr P, Konopasek B, Zavadova E, Lubos P. 2018. Immunological examination of peripheral blood in patients with colorectal cancer compared to healthy controls. Immunol Invest. 47:643–53.
  • Yin Q, Chen L, Li Q, Mi R, Li Y, Wei X, Song Y. 2014. Changes of T-lymphocyte subpopulation and differential expression pattern of the T-bet and GATA-3 genes in diffuse large B-cell lymphoma patients after chemotherapy. Cancer Cell Int. 14:85.

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