Fibroblast-like Synoviocytes-derived Exosomal PCGEM1 Accelerates IL-1β-induced Apoptosis and Cartilage Matrix Degradation by miR-142-5p/RUNX2 in Chondrocytes

References

• Batshon G, Elayyan J, Qiq O, Reich E, Ben-Aderet L, Kandel L, Haze A, Steinmeyer J, Lefebvre V, Zhang H, et al. 2020. Serum NT/CT SIRT1 ratio reflects early osteoarthritis and chondrosenescence. Ann Rheum Dis. 79(10):1370–80. doi:https://doi.org/10.1136/annrheumdis-2020-217072.
   PubMedGoogle Scholar
• Cao J, Han X, Qi X, Jin X, Li X. 2018. miR‑204‑5p inhibits the occurrence and development of osteoarthritis by targeting Runx2. Int J Mol Med. 42(5):2560–68.
   PubMed Web of Science ®Google Scholar
• Catheline SE, Hoak D, Chang M, Ketz JP, Hilton MJ, Zuscik MJ, Jonason JH. 2019. Chondrocyte-specific RUNX2 overexpression accelerates post-traumatic osteoarthritis progression in adult mice. J Bone Miner Res. 34(9):1676–89.
   PubMed Web of Science ®Google Scholar
• Chen D, Kim DJ, Shen J, Zou Z, O’Keefe RJ. 2020. Runx2 plays a central role in osteoarthritis development. J Orthop Translat. 23:132–39.
   PubMed Web of Science ®Google Scholar
• Coutinho de Almeida R, Ramos YFM, Mahfouz A, Den Hollander W, Lakenberg N, Houtman E, Van Hoolwerff M, Suchiman HED, Rodríguez Ruiz A, Slagboom PE, et al. 2019. RNA sequencing data integration reveals an miRNA interactome of osteoarthritis cartilage. Ann Rheum Dis. 78(2):270–77. doi:https://doi.org/10.1136/annrheumdis-2018-213882.
   PubMed Web of Science ®Google Scholar
• De Palma A, Cheleschi S, Pascarelli NA, Tenti S, Galeazzi M, Fioravanti A. 2017. Do MicroRNAs have a key epigenetic role in osteoarthritis and in mechanotransduction? Clin Exp Rheumatol. 35(3):518–26.
   PubMed Web of Science ®Google Scholar
• Endisha H, Datta P, Sharma A, Nakamura S, Rossomacha E, Younan C, Ali SA, Tavallaee G, Lively S, Potla P, et al. 2021. MicroRNA-34a-5p promotes joint destruction during osteoarthritis. Arthritis Rheumatol. 73(3):426–39. doi:https://doi.org/10.1002/art.41552.
   PubMedGoogle Scholar
• Gossan N, Boot-Handford R, Meng QJ. 2015. Ageing and osteoarthritis: a circadian rhythm connection. Biogerontology. 16(2):209–19.
   PubMed Web of Science ®Google Scholar
• Huang J, Zhao L. 2019. The microRNAs miR-204 and miR-211 maintain joint homeostasis and protect against osteoarthritis progression. Nat Commun. 10(1):2876.
   PubMedGoogle Scholar
• Hwang HS, Kim HA. 2015. Chondrocyte apoptosis in the pathogenesis of osteoarthritis. Int J Mol Sci. 16(11):26035–54.
   PubMed Web of Science ®Google Scholar
• Ji Y, Fang QY, Wang SN, Zhang Z-W, Hou Z-J, Li J-N, Fu S-Q. 2020. Lnc-RNA BLACAT1 regulates differentiation of bone marrow stromal stem cells by targeting miR-142-5p in osteoarthritis. Eur Rev Med Pharmacol Sci. 24(6):2893–901.
   PubMed Web of Science ®Google Scholar
• Kang Y, Song J, Kim D, Ahn C, Park S, Chun C-H, Jin E-J. 2016. PCGEM1 stimulates proliferation of osteoarthritic synoviocytes by acting as a sponge for miR-770. J Orthop Res. 34(3):412–18.
   PubMed Web of Science ®Google Scholar
• Karouzakis E, Gay RE, Gay S, Neidhart M. 2009. Epigenetic control in rheumatoid arthritis synovial fibroblasts. Nat Rev Rheumatol. 5(5):266–72.
   PubMed Web of Science ®Google Scholar
• Kolhe R, Hunter M, Liu S, Jadeja RN. 2017. Gender-specific differential expression of exosomal miRNA in synovial fluid of patients with osteoarthritis. Sci Rep. 7(1):2029.
   PubMed Web of Science ®Google Scholar
• Komori T. 2018. Runx2, an inducer of osteoblast and chondrocyte differentiation. Histochem Cell Biol. 149(4):313–23.
   PubMed Web of Science ®Google Scholar
• Li L, Lv G, Wang B, Kuang L. 2018. The role of lncRNA XIST/miR-211 axis in modulating the proliferation and apoptosis of osteoarthritis chondrocytes through CXCR4 and MAPK signaling. Biochem Biophys Res Commun. 503(4):2555–62.
   PubMed Web of Science ®Google Scholar
• Li Y, Li S, Luo Y, Liu Y, Yu N. 2017. LncRNA PVT1 regulates chondrocyte apoptosis in osteoarthritis by acting as a sponge for miR-488-3p. DNA Cell Biol. 36(7):571–80.
   PubMed Web of Science ®Google Scholar
• Liu S, Xiao Z, Ai F, Liu F, Chen X, Cao K, Ren W, Zhang X, Shu P, Zhang D, et al. 2017. miR-142-5p promotes development of colorectal cancer through targeting SDHB and facilitating generation of aerobic glycolysis. Biomed Pharmacother. 92:1119–27.
   PubMed Web of Science ®Google Scholar
• Malemud CJ. 2018. MicroRNAs and osteoarthritis. Cells. 7:8.
   Web of Science ®Google Scholar
• Meldolesi J. 2018. Exosomes and ectosomes in intercellular communication. Curr Biol. 28(8):R435–R444.
   PubMed Web of Science ®Google Scholar
• Olivotto E, Otero M, Astolfi A, Platano D, Facchini A, Pagani S, Flamigni F, Facchini A, Goldring MB, Borzì RM, et al. 2013. IKKα/CHUK regulates extracellular matrix remodeling independent of its kinase activity to facilitate articular chondrocyte differentiation. PloS One. 8(9):e73024. doi:https://doi.org/10.1371/journal.pone.0073024.
   PubMed Web of Science ®Google Scholar
• Pan L, Zhang Y, Chen N, Yang L. 2017. Icariin regulates cellular functions and gene expression of osteoarthritis patient-derived human fibroblast-like synoviocytes. Int J Mol Sci. 18(12):2656.
   Web of Science ®Google Scholar
• Pegtel DM, Gould SJ. 2019. Exosomes. Annu Rev Biochem. 88:487–514.
   PubMed Web of Science ®Google Scholar
• Piao S, Du W, Wei Y, Yang Y, Feng X, Bai L. 2020. Protectin DX attenuates IL-1β-induced inflammation via the AMPK/NF-κB pathway in chondrocytes and ameliorates osteoarthritis progression in a rat model. Int Immunopharmacol. 78:106043.
   PubMed Web of Science ®Google Scholar
• Primorac D, Molnar V. 2020. Knee osteoarthritis: a review of pathogenesis and state-of-the-art non-operative therapeutic considerations. Genes (Basel). 11(8):854.
   PubMed Web of Science ®Google Scholar
• Reynard LN, Barter MJ. 2020. Osteoarthritis year in review 2019: genetics, genomics and epigenetics. Osteoarthritis Cartilage. 28(3):275–84.
   PubMed Web of Science ®Google Scholar
• Salmena L, Poliseno L, Tay Y, Kats L, Pandolfi PP. 2011. A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language? Cell. 146(3):353–58.
   PubMed Web of Science ®Google Scholar
• Shakibaei M, John T, Seifarth C, Mobasheri A. 2007. Resveratrol inhibits IL-1 beta-induced stimulation of caspase-3 and cleavage of PARP in human articular chondrocytes in vitro. Ann N Y Acad Sci. 1095:554–63.
   PubMed Web of Science ®Google Scholar
• Simion V, Haemmig S, Feinberg MW. 2019. LncRNAs in vascular biology and disease. Vascul Pharmacol. 114:145–56.
   PubMed Web of Science ®Google Scholar
• Song C, Xu X, Wu Y, Ji B, Zhou X, Qin L. 2019. Study of the mechanism underlying hsa-miR338-3p downregulation to promote fibrosis of the synovial tissue in osteoarthritis patients. Mol Biol Rep. 46(1):627–37.
   PubMed Web of Science ®Google Scholar
• Sun P, Wu Y, Li X, Jia Y. 2020. miR-142-5p protects against osteoarthritis through competing with lncRNA XIST. J Gene Med. 22(4):e3158.
   PubMed Web of Science ®Google Scholar
• Tan F, Wang D, Yuan Z. 2020. The fibroblast-like synoviocyte derived exosomal long non-coding RNA H19 alleviates osteoarthritis progression through the miR-106b-5p/TIMP2 axis. Inflammation. 43(4):1498–509.
   PubMed Web of Science ®Google Scholar
• Tu J, Huang W, Zhang W, Mei J, Zhu C. 2020. The emerging role of lncRNAs in chondrocytes from osteoarthritis patients. Biomed Pharmacother. 131:110642.
   PubMed Web of Science ®Google Scholar
• Tu M, Tang J, He H, Cheng P, Chen C. 2017. MiR-142-5p promotes bone repair by maintaining osteoblast activity. J Bone Miner Metab. 35(3):255–64.
   PubMed Web of Science ®Google Scholar
• Vincent TL. 2020. Peripheral pain mechanisms in osteoarthritis. Pain. 161(Suppl 1(1)):S138–s146.
   PubMedGoogle Scholar
• Wang BW, Jiang Y, Yao ZL, Chen P-S, Yu B, Wang S-N. 2019. Aucubin protects chondrocytes against IL-1β-induced apoptosis in vitro and inhibits osteoarthritis in mice model. Drug Des Devel Ther. 13:3529–38.
   PubMed Web of Science ®Google Scholar
• Xiang Y, Li Y, Yang L, He Y, Jia D, Hu X. 2020. miR-142-5p as a CXCR4-targeted microRNA attenuates SDF-1-induced chondrocyte apoptosis and cartilage degradation via inactivating MAPK signaling pathway. Biochem Res Int. 2020:4508108.
   PubMed Web of Science ®Google Scholar
• Xie F, Liu YL, Chen XY, Li Q, Zhong J, Dai B-Y, Shao X-F, Wu G-B. 2020. Role of microRNA, LncRNA, and exosomes in the progression of osteoarthritis: a review of recent literature. Orthop Surg. 12(3):708–16.
   PubMed Web of Science ®Google Scholar
• Xu Y, Xu S, Gao Z, Xiao L, Xiao F, Xu H, Zhang X. 2018. Degree of endplate chondrocyte degeneration in different tension regions during mechanical stimulation. Mol Med Rep. 17(3):4415–21.
   PubMed Web of Science ®Google Scholar
• Yan J, Yang B, Lin S, Xing R, Lu Y. 2019. Downregulation of miR-142-5p promotes tumor metastasis through directly regulating CYR61 expression in gastric cancer. Gastric Cancer. 22(2):302–13.
   PubMed Web of Science ®Google Scholar
• Zhang Q, Zheng J, Liu L. 2019. The long noncoding RNA PCGEM1 promotes cell proliferation, migration and invasion via targeting the miR-182/FBXW11 axis in cervical cancer. Cancer Cell Int. 19:304.
   PubMed Web of Science ®Google Scholar
• Zhang T, Piao H-Y, Guo S, Zhao Y, Wang Y, Zheng Z-C, Zhang J. 2020. LncRNA PCGEM1 enhances metastasis and gastric cancer invasion through targeting of miR-129-5p to regulate P4HA2 expression. Exp Mol Pathol. 116:104487.
   PubMed Web of Science ®Google Scholar
• Zhao Y, Xu J. 2018. Synovial fluid-derived exosomal lncRNA PCGEM1 as biomarker for the different stages of osteoarthritis. Int Orthop. 42(12):2865–72.
   PubMed Web of Science ®Google Scholar