Advanced search
Publication Cover
Immunological Investigations
A Journal of Molecular and Cellular Immunology
Volume 52, 2023 - Issue 5
Submit an article Journal homepage
86
Views
0
CrossRef citations to date
0
Altmetric
Research Article

C5a Serum Levels in Patients with Endometriosis: A Cross-Sectional Study

Danilo Rahala Post Graduate Program in Gynecology and Obstetrics, Federal University of Paraná, Curitiba, Brazil;b Department of Medicine, UNIPAR – Parana University, Umuarama, BrazilView further author information
,
Carlos Bezerra Sobrinhoc Department of Medicine, Mackenzie Evangelical School of Medicine Paraná, Curitiba, BrazilView further author information
,
Laura Vilas Boasc Department of Medicine, Mackenzie Evangelical School of Medicine Paraná, Curitiba, BrazilView further author information
,
Cesar Augusto Capellaria Post Graduate Program in Gynecology and Obstetrics, Federal University of Paraná, Curitiba, BrazilView further author information
,
Fabiana Antunes Andradea Post Graduate Program in Gynecology and Obstetrics, Federal University of Paraná, Curitiba, BrazilView further author information
&
Renato Nisiharaa Post Graduate Program in Gynecology and Obstetrics, Federal University of Paraná, Curitiba, Brazil;c Department of Medicine, Mackenzie Evangelical School of Medicine Paraná, Curitiba, BrazilCorrespondence[email protected] [email protected]
View further author information
Pages 561-566 | Published online: 02 May 2023

References

  • Agostinis C, Balduit A, Mangogna A, Zito G, Romano F, Ricci G, Kishore U, Bulla R. 2021. Immunological basis of the endometriosis: the complement system as a potential therapeutic target. Front Immunol. 11:1–16.
  • Ajona D, Ortiz-Espinosa S, Pio R. 2019. Complement anaphylatoxins C3a and C5a: emerging roles in cancer progression and treatment. Semin Cell Dev Biol. 85:153–63.
  • Allegretti M, Moriconi A, Beccari A, Bitondo R, Bizzarri C, Bertini R, Colotta F. 2012. Targeting C5a: recent advances in drug discovery. Curr Med Chem. 12(2):217–36.
  • American Society for Reproductive. 1997. Revised American Society for Reproductive Medicine classification of endometriosis: 1996. Fertil Steril. 67(5):817–21.
  • Diurno F, Numis FG, Porta G, Cirillo F, Maddaluno S, Ragozzino A, De Negri P, Di Gennaro C, Pagano A, Allegorico E, et al. 2020. Eculizumab treatment in patients with COVID-19: preliminary results from real life ASL Napoli 2 Nord experience. Eur Rev Med Pharmacol Sci. 24(7):40.
  • Fassbender A, D’Hooghe T, Mihalyi A, Kyama C, Simsa P, Lessey BA. 2009. Plasma C3a-des-Arg levels in women with and without endometriosis. Am J Reprod Immunol. 62(3):187–95.
  • Guo R-F, Ward PA. 2005. Role of C5a in inflammatory responses. Annu Rev Immunol. 23(1):821–52.
  • Hawksworth OA, Li XX, Coulthard LG, Wolvetang EJ, Woodruff TM. 2017. New concepts on the therapeutic control of complement anaphylatoxin receptors. Mol Immunol. 89:36–43.
  • Karadadas E, Hortu I, Ak H, Ergenoglu AM, Karadadas N, Aydin HH. 2020. Evaluation of complement system proteins C3a, C5a and C6 in patients of endometriosis. Clin Biochem. 81:15–19.
  • Králíčková M, Fiala L, Losan P, Tomes P, Vetvicka V. 2018. Altered immunity in endometriosis: what came first? Immunol Invest. 47(6):569–82.
  • Nothnick WB. 2001. Treating endometriosis as an autoimmune disease. Fertil Steril. 76(2):223–31.
  • Quadros AU, Cunha TM. 2016. C5a and pain development: an old molecule, a new target. Pharmacol Res. 112:58–67.
  • Rahal D, Andrade F, Nisihara R. 2021. Insights into the role of complement system in the pathophysiology of endometriosis. Immunol Lett. 231:43–48.
  • Vitiello A, La Porta R, D’Aiuto V, Ferrara F. 2021. Pharmacological approach for the reduction of inflammatory and prothrombotic hyperactive state in COVID-19 positive patients by acting on complement cascade. Hum Immunol. 82(4):264–69.
  • Vlaar APJ, de Bruin S, Busch M, Timmermans SAMEG, van Zeggeren IE, Koning R, Ter Horst L, Bulle EB, van Baarle FEHP, van de Poll MCG, et al. 2020. Anti-C5a antibody IFX-1 (vilobelimab) treatment versus best supportive care for patients with severe COVID-19 (PANAMO): an exploratory, open-label, phase 2 randomised controlled trial. Lancet Rheumatol. 2(12):e764–73.
  • Zelek WM, Morgan BP. 2020. Monoclonal antibodies capable of inhibiting complement downstream of C5 in multiple species. Front Immunol. 11:1–14.
  • Zondervan KT, Becker CM, Koga K, Missmer SA, Taylor RN, Viganò P. 2018. Endometriosis. Nat Rev Dis Prim. 4(1):9.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.