Intracranial Hypertension Associated With Testosterone Therapy In Female-To-Male Transgender Patients: A Case Report And Literature Review

REFERENCES

• Durcan FJ, Corbett JJ, Wall M. The incidence of pseudotumor cerebri Population studies in Iowa and Louisiana. Arch Neurol. 1988;45:875–877.
   PubMed Web of Science ®Google Scholar
• Radhakrishnan K, et al. Idiopathic intracranial hypertension (pseudotumor cerebri). Descriptive epidemiology in rochester, minn, 1976 to 1990. Arch Neurol. 1993;50(1):78–80. doi:10.1001/archneur.1993.00540010072020.
   PubMedGoogle Scholar
• Rigi M, Almarzouqi SJ, Morgan ML, Lee AG. Papilledema: epidemiology, etiology, and clinical management. Eye and Brain. 2015;7:47–57. doi:10.2147/EB.S69174.
   PubMed Web of Science ®Google Scholar
• Grech O, Mollan SP, Wakerley BR, et al. Emerging themes in idiopathic intracranial hypertension. J Neurol. 2020;267(12):3776–3784. doi:10.1007/s00415-020-10090-4.
   PubMed Web of Science ®Google Scholar
• Goodwin J. Recent developments in idiopathic intracranial hypertension (IIH). Semin Ophthalmol. 2003;18(4):181–189. doi:10.1080/08820530390895181.
   PubMedGoogle Scholar
• Klein A, Stern N, Osher E, et al. Hyperandrogenism is associated with earlier age of onset of idiopathic intracranial hypertension in women. Curr Eye Res. 2013;38(9):972–976. doi:10.3109/02713683.2013.799214.
   PubMed Web of Science ®Google Scholar
• Avisar I, Gaton DD, Dania H, Stiebel-Kalish H. The prevalence of polycystic ovary syndrome in women with idiopathic intracranial hypertension. Scientifica (Cairo). 2012;2012:1–4. doi:10.6064/2012/708042.
   Google Scholar
• Mehta Y, Seal LJ, Angus-Leppan H. Idiopathic intracranial hypertension in transgender people. Journal of Neuro-Ophthalmology. 2021;Publish Ahead of Print. Online Ahead of Print. doi:10.1097/WNO.0000000000001458.
   Google Scholar
• Nayman T, Hébert M, Ospina LH. Idiopathic intracranial hypertension in a pediatric transgender patient. Am J Ophthalmol Case Rep. 2021;24:101208. doi:10.1016/j.ajoc.2021.101208.
   PubMedGoogle Scholar
• Ronan GP, Sweeney B. Asymptomatic idiopathic intracranial hypertension post female to male gender transition. BMJ Case Rep. 2021;14(12):e246454. doi:10.1136/bcr-2021-246454.
   PubMedGoogle Scholar
• Nguyen HV, Gilbert AL, Fortin E, et al. Elevated intracranial pressure associated with exogenous hormonal therapy used for gender affirmation. J Neuroophthalmol. 2021;41(2):217–223. doi:10.1097/WNO.0000000000000926.
   PubMed Web of Science ®Google Scholar
• Lin GC, Paz M, Porrmann JW, et al. Spontaneous cerebrospinal fluid leak in a transgender man: is testosterone therapy a risk factor? JAMA Otolaryngol Neck Surg. 2020;146(10):973–975. doi:10.1001/jamaoto.2020.2394.
   PubMed Web of Science ®Google Scholar
• Margolin EA, Mason RH. Female-to-male transgender patient with idiopathic intracranial hypertention. J Neurol Sci. 2020;415:116970. doi:10.1016/j.jns.2020.116970.
   PubMed Web of Science ®Google Scholar
• Qureshi S, Qureshi K, Hassan A, Antonio A. Recurrent intracranial hypertension in a transgender female-to-male on testosterone therapy: a case report. Neurology. 2020;94(15 supplement).
   Web of Science ®Google Scholar
• Kogachi K, Konstas A, Karanjia R, Sadun AA. Endovascular stenting in a transgender patient with idiopathic intracranial hypertension. J Neuroophthalmol. 2019;39(2):247–248. doi:10.1097/WNO.0000000000000752.
   PubMed Web of Science ®Google Scholar
• Weinlander E, Derani T, Cornblath WT, De Lott LB. Intracranial hypertension in transgender patients. J Neuroophthalmol. 2019;39(2):232–233. doi:10.1097/WNO.0000000000000736.
   PubMed Web of Science ®Google Scholar
• Hornby C, Mollan SP, Mitchell J, et al. What do transgender patients teach us about idiopathic intracranial hypertension? Neuroophthalmology. 2017;41(6):326–329. doi:10.1080/01658107.2017.1316744.
   PubMed Web of Science ®Google Scholar
• Buchanan I, Hansen K, Bedolla J. Idiopathic intracranial hypertension in a transgender male on hormone therapy. Arch Emerg Med Crit Care. 2017;2:1019.
   Google Scholar
• Park S, Cheng CP, Lim LT, Gerber D. Secondary intracranial hypertension from testosterone therapy in a transgender patient. Semin Ophthalmol. 2014;29(3):156–158. doi:10.3109/08820538.2013.788678.
   PubMed Web of Science ®Google Scholar
• Mowl AD, Grogg JA, Klein J. Secondary pseudotumour cerebri in a patient undergoing sexual reassignment therapy. Clin Exp Optom. 2009;92(5):449–453. doi:10.1111/j.1444-0938.2009.00404.x.
   PubMed Web of Science ®Google Scholar
• Sheets C, Peden M, Guy J. Idiopathic intracranial hypertension in a transgender man. J Neuroophthalmol. 2007;27(4):313–315. doi:10.1097/WNO.0b013e31815c431e.
   PubMed Web of Science ®Google Scholar
• O’Reilly MW, Westgate CS, Hornby C, et al. A unique androgen excess signature in idiopathic intracranial hypertension is linked to cerebrospinal fluid dynamics. JCI Insight. 2019;4(6):e125348. doi:10.1172/jci.insight.125348.
   PubMed Web of Science ®Google Scholar
• Wall M, Kupersmith MJ, Kieburtz KD, et al. The idiopathic intracranial hypertension treatment trial: clinical profile at baseline. JAMA Neurol. 2014;71(6):693–701. doi:10.1001/jamaneurol.2014.133.
   PubMed Web of Science ®Google Scholar
• Wall M, McDermott MP, Kieburtz KD, et al. Effect of Acetazolamide on visual function in patients with idiopathic intracranial hypertension and mild visual loss: the idiopathic intracranial hypertension treatment trial. JAMA. 2014;311(16):1641–1651. doi:10.1001/jama.2014.3312.
   PubMed Web of Science ®Google Scholar
• Wall M. Update on idiopathic intracranial hypertension. Neurol Clin. 2017;35(1):45–57. doi:10.1016/j.ncl.2016.08.004.
   PubMed Web of Science ®Google Scholar
• Lai LT, Danesh-Meyer HV, Kaye AH. Visual outcomes and headache following interventions for idiopathic intracranial hypertension. J Clin Neurosci. 2014;21(10):1670–1678. doi:10.1016/j.jocn.2014.02.025.
   PubMed Web of Science ®Google Scholar
• Green AE, DeChants JP, Price MN, Davis CK. Association of gender-affirming hormone therapy with depression, thoughts of suicide, and attempted suicide among transgender and nonbinary youth. J Adolesc Heal. 2022;70(4):643–649. doi:10.1016/j.jadohealth.2021.10.036.
   PubMed Web of Science ®Google Scholar