Etiology, Pathogens, Clinical Features and Treatment of Bacterial Scleritis

REFERENCES

• Ramenaden ER, Raiji VR. Clinical characteristics and visual outcomes in infectious scleritis: a review. Clin Ophthalmol. 2013;7:2113–2122. doi:10.2147/OPTH.S37809.
   PubMedGoogle Scholar
• Meallet MA. Subpalpebral lavage antibiotic treatment for severe infectious scleritis and keratitis. Cornea. 2006;25(2):159–163. doi:10.1097/01.ico.0000177837.31249.19.
   PubMed Web of Science ®Google Scholar
• Rush RB. Contact lens-associated nocardial necrotizing scleritis. Korean J Ophthalmol. 2013;27(4):291–293. doi:10.3341/kjo.2013.27.4.291.
   PubMedGoogle Scholar
• Arora R, Shroff D, Narula R, et al. Inverse hypopyon as the presenting feature of infectious scleritis in a case of tropical pyomyositis. Can J Ophthalmol. 2006;41(6):769–771. doi:10.3129/i06-075.
   PubMed Web of Science ®Google Scholar
• Wirth MG, Helbig H. Can eyelashes migrate? Klin Monbl Augenheilkd. 2005;222(3):238–240. doi:10.1055/s-2005-858106.
   PubMed Web of Science ®Google Scholar
• Jin XH, Namba K, Saito W, et al. Bacterial endophthalmitis caused by an intraocular cilium in a patient under treatment with infliximab. J Ophthalmic Inflamm Infect. 2013;3(1):50. doi:10.1186/1869-5760-3-50.
   PubMedGoogle Scholar
• Hwang YS, Chen Y-F, Lai -C-C, et al. Infectious scleritis after use of immunomodulators. Arch Ophthalmol. 2002;120(8):1093–1094.
   PubMedGoogle Scholar
• Chao DL, Albini TA, McKeown CA, et al. Infectious Pseudomonas scleritis after strabismus surgery. J Aapos. 2013;17(4):423–425. doi:10.1016/j.jaapos.2013.03.018.
   PubMed Web of Science ®Google Scholar
• Fahim K, Houghton O, Dastjerdi M, et al. Posterior scleritis secondary to Pseudomonas aeruginosa keratitis. Cornea. 2005;24(7):879–881. doi:10.1097/01.ico.0000154403.78838.90.
   PubMed Web of Science ®Google Scholar
• Rich RM, Smiddy WE, Davis JL. Infectious scleritis after retinal surgery. Am J Ophthalmol. 2008;145(4):695–699. doi:10.1016/j.ajo.2007.11.024.
   PubMed Web of Science ®Google Scholar
• Smith TC, Lee GA. Conservative management of Pseudomonal infectious sclerokeratitis. Clin Exp Optom. 2008;91(3):319–321. doi:10.1111/j.1444-0938.2007.00185.x.
   PubMed Web of Science ®Google Scholar
• Coussa RG, Wakil SM, Saheb H, et al. Anterior infectious necrotizing scleritis secondary to Pseudomonas aeruginosa infection following intravitreal ranibizumab injection. Am J Ophthalmol Case Rep. 2017;5:16–19. doi:10.1016/j.ajoc.2016.10.009.
   PubMedGoogle Scholar
• Moreno Honrado M, Del Campo Z, Buil JA. A case of necrotizing scleritis resulting from Pseudomonas aeruginosa. Cornea. 2009;28(9):1065–1066. doi:10.1097/ICO.0b013e3181971213.
   PubMed Web of Science ®Google Scholar
• De Wit D, Newman D. Novel antibiotic regime for pseudomonal scleritis complicating scleral buckling surgery. BMJ Case Rep. 2010;2010(apr29 1):bcr0120091514–bcr0120091514. doi:10.1136/bcr.01.2009.1514.
   Google Scholar
• Zheng X, Kodama T, Goto T, et al. Autologous fascia lata grafts for scleral repair in eyes with infectious necrotizing scleritis. Arch Ophthalmol. 2011;129(9):1225–1227. doi:10.1001/archophthalmol.2011.260.
   PubMedGoogle Scholar
• Moussa K, Shantha J, Schallhorn JM. Blurry vision and eye pain after pterygium surgery. JAMA Ophthalmol. 2018;136(7):827–828. doi:10.1001/jamaophthalmol.2017.6054.
   PubMed Web of Science ®Google Scholar
• Siatiri H, Mirzaee-Rad N, Aggarwal S, et al. combined tenonplasty and scleral graft for refractory pseudomonas scleritis following pterygium removal with mitomycin c application. J Ophthalmic Vis Res. 2018;13(2):200–202. doi:10.4103/jovr.jovr_122_16.
   PubMed Web of Science ®Google Scholar
• Murthy SI, Sati A, Sangwan V. Infectious scleritis mimicking severe ocular inflammation: atypical initial presentation. BMJ Case Rep. 2013;2013(feb20 1):bcr-2013-008686-bcr-2013–008686. doi:10.1136/bcr-2013-008686.
   PubMedGoogle Scholar
• Nguyen P, Yiu SC. Imaging studies in a case of infectious scleritis after pterygium excision. Middle East Afr J Ophthalmol. 2012;19(3):337–339. doi:10.4103/0974-9233.97953.
   PubMedGoogle Scholar
• Meyer JJ, Espandar L, Marx DP, et al. Pseudomonas scleritis resistant to fourth-generation fluoroquinolones in a patient without prior trauma or surgery. Ocul Immunol Inflamm. 2008;16(3):127–129. doi:10.1080/09273940801947662.
   PubMed Web of Science ®Google Scholar
• Radford R, Brahma A, Armstrong M, et al. Severe sclerokeratitis due to Pseudomonas aeruginosa in noncontact-lens wearers. Eye (Lond). 2000;14(Pt 1):3–7. doi:10.1038/eye.2000.2.
   PubMedGoogle Scholar
• Agarwal S, Majumder PD. Pseudomonas aeruginosa scleritis initially presenting as idiopathic diffuse anterior scleritis. Oman J Ophthalmol. 2020;13(1):51–52. doi:10.4103/ojo.OJO_256_2018.
   PubMedGoogle Scholar
• Chansangpetch S, Manassakorn A, Laksanaphuk P, et al. Case report: atypical presentation of Mycobacterium tuberculosis uveitis preceding nodular scleritis. BMC Infect Dis. 2015;15(1):476. doi:10.1186/s12879-015-1221-4.
   PubMedGoogle Scholar
• Gupta N, Chawla B, Venkatesh P, et al. Necrotizing scleritis and peripheral ulcerative keratitis in a case of Sweet’s syndrome found culture-positive for Mycobacterium tuberculosis. Ann Trop Med Parasitol. 2008;102(6):557–560. doi:10.1179/136485908X311812.
   PubMed Web of Science ®Google Scholar
• Taki W, Keino H, Watanabe T. Interferon-gamma release assay in tuberculous scleritis. Arch Ophthalmol. 2011;129(3):368–371. doi:10.1001/archophthalmol.2011.27.
   PubMedGoogle Scholar
• Kesen MR, Edward DP, Rao NP. Atypical infectious nodular scleritis. Arch Ophthalmol. 2009;127(8):1079–1080. doi:10.1001/archophthalmol.2009.197.
   PubMedGoogle Scholar
• Biswas J, Aparna AC, Radha A, et al. Tuberculous scleritis in a patient with rheumatoid arthritis. Ocul Immunol Inflamm. 2012;20(1):49–52. doi:10.3109/09273948.2011.628195.
   PubMed Web of Science ®Google Scholar
• Parchand SM, Kumar AS, Kaliaperumal S, et al. Tuberculous scleral abscess with choroidal detachment. BMJ Case Rep. 2017;2017.
   Google Scholar
• Gupta A, Gupta V, Pandav SS, et al. Posterior scleritis associated with systemic tuberculosis. Indian J Ophthalmol. 2003;51(4):347–349.
   PubMedGoogle Scholar
• Sharma R, Marasini S, Nepal BP. Tubercular scleritis. Kathmandu Univ Med J (KUMJ). 2010;8(31):352–356. doi:10.3126/kumj.v8i3.6228.
   PubMedGoogle Scholar
• Dutta Majumder P. Presumed tuberculous sclerokeratitis presenting with hypopyon. Ocul Immunol Inflamm. 2019;27(7):1121–1123. doi:10.1080/09273948.2018.1511812.
   PubMed Web of Science ®Google Scholar
• Agarwal AM, Dutta Majumder P. Tubercular posterior scleritis: a case report and review of literature. Indian J Ophthalmol. 2019;67(8):1362–1365. doi:10.4103/ijo.IJO_1942_18.
   PubMed Web of Science ®Google Scholar
• Damodaran K, George AE, Goel S, et al. Tubercular sclerouveitis masquerading as an ocular tumor: a case report. Ocul Immunol Inflamm. 2012;20(5):368–371. doi:10.3109/09273948.2012.708957.
   PubMed Web of Science ®Google Scholar
• Kurup SK, Chan CC. Mycobacterium-related ocular inflammatory disease: diagnosis and management. Ann Acad Med Singapore. 2006;35:203–209.
   PubMed Web of Science ®Google Scholar
• Thomas M, Lim JI. Painful Red Eye in a Woman in Her 70s. JAMA Ophthalmol. 2016;134(2):233–234. doi:10.1001/jamaophthalmol.2015.2152.
   PubMed Web of Science ®Google Scholar
• Pappuru RR, Dave VP. An unusual case of ocular tuberculosis presenting as subretinal abscess with posterior scleritis. Int Ophthalmol. 2017;37(1):285–289. doi:10.1007/s10792-016-0254-z.
   PubMed Web of Science ®Google Scholar
• Mittal V, Fernandes M. Cotrimoxazole-resistant Nocardia sclerokeratitis: effective therapy with fourth-generation fluoroquinolones. Can J Ophthalmol. 2012;47(6):e58–60. doi:10.1016/j.jcjo.2012.07.007.
   PubMed Web of Science ®Google Scholar
• Das S, Saunders M, Cheng AC, et al. Nodular non-necrotising anterior scleritis due to Nocardia nova infection. Eye (Lond). 2007;21(2):276–278. doi:10.1038/sj.eye.6702524.
   PubMed Web of Science ®Google Scholar
• Choudhry S, Rao SK, Biswas J, et al. Necrotizing nocardial scleritis with intraocular extension: a case report. Cornea. 2000;19(2):246–248. doi:10.1097/00003226-200003000-00023.
   PubMed Web of Science ®Google Scholar
• Cunha LPD, Juncal V, Carvalhaes CG, et al. Nocardial scleritis: a case report and a suggested algorithm for disease management based on a literature review. Am J Ophthalmol Case Rep. 2018;10:1–5. doi:10.1016/j.ajoc.2018.01.018.
   PubMedGoogle Scholar
• Maruo H, Shiraishi A, Hara Y, et al. Necrotizing nocardial scleritis successfully treated with surgical debridement and topical polyvinyl alcohol iodine and antibiotics. J Ocul Pharmacol Ther. 2011;27(4):415–418. doi:10.1089/jop.2011.0043.
   PubMed Web of Science ®Google Scholar
• Gonzalez A, Fakhar K, Gubernick D, et al. Scleritis caused by in vitro linezolid-resistant nocardia asteroides. Case Rep Ophthalmol Med. 2014;2014:326957. doi:10.1155/2014/326957.
   PubMedGoogle Scholar
• Gonzalez A, Jennings E, Vaziri S, et al. Second report of a Nocardia beijingensis infection in the United States: nodular scleritis with in vitro imipenem resistance. Digit J Ophthalmol. 2016;22(3):62–66. doi:10.5693/djo.02.2016.01.003.
   PubMedGoogle Scholar
• Seth RK, Gaudio PA. Nocardia asteroides necrotizing scleritis associated with subtenon triamcinolone acetonide injection. Ocul Immunol Inflamm. 2008;16(4):139–140. doi:10.1080/09273940802140804.
   PubMed Web of Science ®Google Scholar
• Ramos-Esteban JC, Servat JJ, Silva RSD, et al. Necrotizing nocardial scleritis after combined penetrating keratoplasty and phacoemulsification with intraocular lens implantation: a case report and review of the literature. Arq Bras Oftalmol. 2007;70(2):355–359. doi:10.1590/S0004-27492007000200031.
   PubMedGoogle Scholar
• Kim SJ, Schwent BJ, Srivastava SK. Methicillin-resistant Staphylococcus aureus infectious scleritis after vitrectomy for endophthalmitis. Retin Cases Brief Rep. 2009;3(4):407–408. doi:10.1097/ICB.0b013e31818ba958.
   PubMedGoogle Scholar
• Lee JE, Oum BS, Choi HY, et al. Methicillin-resistant Staphylococcus aureus sclerokeratitis after pterygium excision. Cornea. 2007;26(6):744–746. doi:10.1097/ICO.0b013e31804e45ba.
   PubMed Web of Science ®Google Scholar
• Kearney FM, Blaikie AJ, Gole GA. Anterior necrotizing scleritis after strabismus surgery in a child. J Aapos. 2007;11(2):197–198. doi:10.1016/j.jaapos.2006.09.002.
   PubMed Web of Science ®Google Scholar
• Lin HC, Ma DH-K, Chen Y-F, et al. Late-onset intrascleral dissemination of Stenotrophomonas maltophilia scleritis after pterygium excision. Cornea. 2011;30(6):712–715. doi:10.1097/ICO.0b013e31820007ed.
   PubMed Web of Science ®Google Scholar
• Ramos-Esteban JC, Jeng BH. Posttraumatic Stenotrophomonas maltophilia infectious scleritis. Cornea. 2008;27(2):232–235. doi:10.1097/ICO.0b013e318159a968.
   PubMed Web of Science ®Google Scholar
• Chen YF, Chung PC, Hsiao CH. Stenotrophomonas maltophilia keratitis and scleritis. Chang Gung Med J. 2005;28:142–150.
   PubMedGoogle Scholar
• Gharaee H, Khalife M, Sagheb Hossein Poor S, et al. Infectious scleritis after subtenon triamcinolone acetonide injection. Ocul Immunol Inflamm. 2011;19(4):284–285. doi:10.3109/09273948.2011.584010.
   PubMed Web of Science ®Google Scholar
• Etienne M, Gueudry J, Chapuzet C, et al. Post-streptococcal scleritis: corticosteroids avoid visual acuity loss. J Infect. 2012;65(6):575–577. doi:10.1016/j.jinf.2012.08.009.
   PubMed Web of Science ®Google Scholar
• Rabina G, Leibovitch I, Abumanhal M, et al. Orbital inflammatory syndrome post group A streptococcal infection - case series and review of literature. Ocul Immunol Inflamm. 2019;27(1):162–167. doi:10.1080/09273948.2017.1367408.
   PubMed Web of Science ®Google Scholar
• Cunningham MA, Alexander JK, Matoba AY, et al. Management and outcome of microbial anterior scleritis. Cornea. 2011;30(9):1020–1023. doi:10.1097/ICO.0b013e31820967bd.
   PubMed Web of Science ®Google Scholar
• Paula JS, Simão MLH, Rocha EM, et al. Atypical pneumococcal scleritis after pterygium excision: case report and literature review. Cornea. 2006;25(1):115–117. doi:10.1097/01.ico.0000164784.18290.45.
   PubMed Web of Science ®Google Scholar
• Ang M, Chee SP. Propionibacterium acnes endogenous endophthalmitis presenting with bilateral scleritis and uveitis. Eye (Lond). 2010;24(5):944–945. doi:10.1038/eye.2009.194.
   PubMed Web of Science ®Google Scholar
• Tay E, Rajan M, Tuft S. Listeria monocytogenes sclerokeratitis: a case report and literature review. Cornea. 2008;27(8):947–949. doi:10.1097/ICO.0b013e31816c4078.
   PubMed Web of Science ®Google Scholar
• Margo CE, Pavan PR. Mycobacterium chelonae conjunctivitis and scleritis following vitrectomy. Arch Ophthalmol. 2000;118(8):1125–1128. doi:10.1001/archopht.118.8.1125.
   PubMedGoogle Scholar
• Oz O, Lee DH, Smetana SM, et al. A case of infected scleral buckle with Mycobacterium chelonae associated with chronic intraocular inflammation. Ocul Immunol Inflamm. 2004;12(1):65–67. doi:10.1076/ocii.12.1.65.28069.
   PubMed Web of Science ®Google Scholar
• Nielsen JS, Blatt S, Perlman J, et al. Clinicopathologic case report: scleral buckle associated nontuberculous mycobacterial scleritis. Semin Ophthalmol. 2004;19(3–4):101–104. doi:10.1080/08820530490882517.
   PubMedGoogle Scholar
• Metta H, Corti M, Brunzini R. Disseminated infection due to Mycobacterium chelonae with scleritis, spondylodiscitis and spinal epidural abscess. Braz J Infect Dis. 2008;12(3):260–262. doi:10.1590/S1413-86702008000300019.
   PubMed Web of Science ®Google Scholar
• Clare G, Mitchell S. Iris root abscess and necrotizing sclerokeratitis caused by Mycobacterium abscessus and presenting as hemorrhagic anterior uveitis. Cornea. 2008;27(2):255–257. doi:10.1097/ICO.0b013e31815bd1ed.
   PubMed Web of Science ®Google Scholar
• AlKheraiji NF, AlKheraiji AF, Stone DU. Mycobacterium abscessus scleritis after a Baerveldt glaucoma implant. Clin Exp Ophthalmol. 2017;45(3):306–308. doi:10.1111/ceo.12824.
   PubMed Web of Science ®Google Scholar
• Pisitpayat P, Sirikul T, Hongmanee P, et al. Mycobacterium haemophilum scleritis: two case reports and review of literature. BMC Ophthalmol. 2020;20(1):378. doi:10.1186/s12886-020-01649-w.
   PubMedGoogle Scholar
• Shaikh SI, Biswas J, Rishi P. Nodular syphilitic scleritis masquerading as an ocular tumor. J Ophthalmic Inflamm Infect. 2015;5(1):8. doi:10.1186/s12348-015-0040-5.
   PubMedGoogle Scholar
• Escott SM, Pyatetsky D. Unilateral nodular scleritis secondary to latent syphilis. Clin Med Res. 2015;13(2):94–95. doi:10.3121/cmr.2015.1279.
   PubMedGoogle Scholar
• Fenolland JR, Bonnel S, Rambaud C, et al. Syphilitic Scleritis. Ocul Immunol Inflamm. 2016;24(1):93–95. doi:10.3109/09273948.2014.916307.
   PubMed Web of Science ®Google Scholar
• Moloney G, Branley M, Kotsiou G, et al. Syphilis presenting as scleritis in an HIV-positive man undergoing immune reconstitution. Clin Exp Ophthalmol. 2004;32(5):526–528. doi:10.1111/j.1442-9071.2004.00871.x.
   PubMed Web of Science ®Google Scholar
• Win PH, Gonzales CR, Young T, et al. Syphilitic scleritis and choroidal malignant melanoma of the same eye. Semin Ophthalmol. 2007;22(3):193–195. doi:10.1080/08820530701522325.
   PubMedGoogle Scholar
• Yoo WS, Kim CR, Kim BJ, et al. Successful treatment of infectious scleritis by Pseudomonas aeruginosa with autologous perichondrium graft of conchal cartilage. Yonsei Med J. 2015;56(6):1738–1741. doi:10.3349/ymj.2015.56.6.1738.
   PubMed Web of Science ®Google Scholar