Viral Keratitis, Surgical Intervention in Viral Keratitis, Challenges in Diagnosis and Treatment of Viral Keratitis, HSV, HZV

REFERENCES

• Koganti R, Yadavalli T, Naqvi RA, Shukla D, Naqvi AR. Pathobiology and treatment of viral keratitis. Exp Eye Res. 2021;205:108483. doi:10.1016/j.exer.2021.108483.
   PubMed Web of Science ®Google Scholar
• Ting DSJ, Ho CS, Deshmukh R, Said DG, Dua HS. Infectious keratitis: an update on epidemiology, causative microorganisms, risk factors, and antimicrobial resistance. Eye (Lond). 2021;35(4):1084–1101. doi:10.1038/s41433-020-01339-3.
   PubMed Web of Science ®Google Scholar
• Labib BA, Chigbu DI. Clinical Management of Herpes Simplex Virus Keratitis. Diagnostics (Basel). 2022;12(10):2368. doi:10.3390/diagnostics12102368.
   PubMedGoogle Scholar
• Labetoulle M, Boutolleau D, Burrel S, Haigh O, Rousseau A. Herpes simplex virus, varicella-zoster virus and cytomegalovirus keratitis: facts for the clinician. Ocul Surf. 2023;28:336–350. doi:10.1016/j.jtos.2021.07.002.
   PubMed Web of Science ®Google Scholar
• Chodosh J, Ung L. Adoption of innovation in herpes simplex virus keratitis. Cornea. 2020;1(1):S7–S18. doi:10.1097/ICO.0000000000002425.
   Google Scholar
• Yadavalli T, Agelidis A, Jaishankar D, Mangano K, Thakkar N, Penmetcha K, et al. Targeting herpes simplex virus-1 gD by a DNA aptamer can be an effective new strategy to curb viral infection. Mol Ther Nucleic Acids. 2017;9:365–378. doi:10.1016/j.omtn.2017.10.009.
   PubMedGoogle Scholar
• Laing KJ, Ouwendijk WJD, Koelle DM, GMGM V. Immunobiology of varicella-zoster virus infection. J Infect Dis. 2018;218(suppl_2):S68–S74. doi:10.1093/infdis/jiy403.
   PubMedGoogle Scholar
• Feder RS. Infectious diseases of the cornea and external eye: viral infections. In: Feder RS, Berdy JG, Luorno JD, Marcovich AL, Milan SI, Reilly CD, Trief D, Verdier DD, eds. Basic and Clinical Science Course, Section 08: External Disease and Cornea 2021-2022. San Francisco, CA: American Academy of Ophthalmology; 2021:pp. 281–316.
   Google Scholar
• Holland EJ, Schwartz GS Herpes simplex keratitis. In: Krachmer J, Mannis MJ, Holland EJ. eds. Cornea. 3rd ed. Louis: Mosby Elsevier; 2011: pp. 953–984.
   Google Scholar
• Lobo AM, Agelidis AM, Shukla D. Pathogenesis of herpes simplex keratitis: the host cell response and ocular surface sequelae to infection and inflammation Ocul Surf. 2019;17(1):40–49. doi:10.1016/j.jtos.2018.10.002.
   PubMed Web of Science ®Google Scholar
• Kaye S, Choudhary A. Herpes simplex keratitis Prog Retin Eye Res. 2006;25(4):355–380. doi:10.1016/j.preteyeres.2006.05.001.
   PubMed Web of Science ®Google Scholar
• Arduino PG, Porter SR. Herpes simplex virus type 1 infection: overview on relevant clinico-pathological features J Oral Pathol Med. 2008;37(2):107–121. doi:10.1111/j.1600-0714.2007.00586.x.
   PubMed Web of Science ®Google Scholar
• Kuo YC, Lin CY. Recurrent herpes simplex virus type 1 infection precipitated by the impaired production of interleukin-2, alpha-interferon, and cell-mediated cytotoxicity J Med Virol. 1990;31(3):183–189. doi:10.1002/jmv.1890310303.
   PubMed Web of Science ®Google Scholar
• Stock C, Guillén-Grima F, de Mendoza JH, Marin-Fernandez B, Aguinaga-Ontoso I, Krämer A. Risk factors of herpes simplex type 1 (HSV-1) infection and lifestyle factors associated with HSV-1 manifestations Eur J Epidemiol. 2001;17(9):885–890. doi:10.1023/a:1015652713971.
   PubMed Web of Science ®Google Scholar
• Zerboni L, Sen N, Oliver SL, Arvin AM. Molecular mechanisms of varicella zoster virus pathogenesis. Nat Rev Microbiol. 2014;12(3):197–210. doi:10.1038/nrmicro3215.
   PubMed Web of Science ®Google Scholar
• Jastrzebski A, Brownstein S, Ziai S, Saleh S, Lam K, Jackson WB. Reactivation of herpes zoster keratitis with corneal perforation after zoster vaccination. Cornea. 2017;36(6):740–742. doi:10.1097/ICO.0000000000001203.
   PubMed Web of Science ®Google Scholar
• Reijo A, Antti V, Jukka M. Endothelial cell loss in herpes zoster keratouveitis Br J Ophthalmol. 1983;67(11):751–754. doi:10.1136/bjo.67.11.751.
   PubMed Web of Science ®Google Scholar
• Dworkin RH, Johnson RW, Breuer J, Gnann JW, Levin MJ, Backonja M, et al. Recommendations for the management of herpes zoster. Clin Infect Dis. 2007;44(Suppl 1):S1–26. doi:10.1086/510206.
   PubMed Web of Science ®Google Scholar
• Jain NJF A rare presentation of Herpes zoster Ophthalmicus. University Journal of Surgery and Surgical Specialities. 2019;5(2). http://ejournal-tnmgrmu.ac.in/index.php/surgery/article/view/10513
   Google Scholar
• Weinberg A, Zhang JH, Oxman MN, Johnson GR, Hayward AR, Caulfield MJ, et al. Varicella-zoster virus-specific immune responses to herpes zoster in elderly participants in a trial of a clinically effective zoster vaccine. J Infect Dis. 2009;200(7):1068–1077. doi:10.1086/605611.
   PubMed Web of Science ®Google Scholar
• Gopinath SCB, Hayashi K, Kumar PKR. Aptamer that binds to the gD protein of herpes simplex virus 1 and efficiently inhibits viral entry. J Virol. 2012;86(12):6732–6744. doi:10.1128/JVI.00377-12.
   PubMed Web of Science ®Google Scholar
• Alkatan HM, Al-Essa RS. Challenges in the diagnosis of microbial keratitis: a detailed review with update and general guidelines Saudi J Ophthalmol. 2019;33(3):268–276. doi:10.1016/j.sjopt.2019.09.002.
   PubMed Web of Science ®Google Scholar
• Azher TN, Yin XT, Tajfirouz D, Huang AJ, Stuart PM. Herpes simplex keratitis: challenges in diagnosis and clinical management. Clin Ophthalmol. 2017;11:185–191. doi:10.2147/OPTH.S80475.
   PubMed Web of Science ®Google Scholar
• Chranioti A, Malamas A, Metallidis S, Mataftsi A, Chalvatzis N, Ziakas N. Bilateral herpes simplex virus-related peripheral ulcerative keratitis leading to corneal perforation in a patient with primary herpes simplex virus infection J Ophthalmic Vis Res. 2019;14(1):93–96. doi:10.4103/jovr.jovr_3_17.
   PubMed Web of Science ®Google Scholar
• Shin J, Ra H, Rho CR. Herpes simplex virus linear endotheliitis in a post-keratoplasty patient: a case report. Medicine. 2019;98(3):e14191. doi:10.1097/MD.0000000000014191.
   PubMed Web of Science ®Google Scholar
• Erdem E, Harbiyeli İİ, Öztürk G, Oruz O, Açıkalın A, Yağmur M, et al. Atypical herpes simplex keratitis: frequency, clinical presentations and treatment results. Int Ophthalmol. 2020;40(3):659–665. doi:10.1007/s10792-019-01226-1.
   PubMed Web of Science ®Google Scholar
• Garg P. Microsporidia infection of the cornea–a unique and challenging disease. Cornea. 2013;32(1):S33–38. doi:10.1097/ICO.0b013e3182a2c91f.
   PubMedGoogle Scholar
• Toriyama K, Inoue T, Suzuki T, Kobayashi T, Ohashi Y. Necrotizing keratitis caused by acyclovir-resistant herpes simplex virus. Case Rep Ophthalmol. 2014;5(3):325–328. doi:10.1159/000368297.
   PubMedGoogle Scholar
• Goldschmidt P, Rostane H, Saint-Jean C, Batellier L, Alouch C, Zito E, et al. Effects of topical anaesthetics and fluorescein on the real-time PCR used for the diagnosis of herpesviruses and acanthamoeba keratitis. Br J Ophthalmol. 2006;90(11):1354–1356. doi:10.1136/bjo.2006.098830.
   PubMed Web of Science ®Google Scholar
• Shoji J, Sakimoto T, Inada N, Kamei Y, Matsubara M, Takamura E, et al. A diagnostic method for herpes simplex keratitis by simultaneous measurement of viral DNA and virus-specific secretory IgA in tears: an evaluation. Jpn J Ophthalmol. 2016;60(4):294–301. doi:10.1007/s10384-016-0448-y.
   PubMed Web of Science ®Google Scholar
• Wagstaff AJ, Faulds D, Goa KA. A reappraisal of its antiviral activity, pharmacokinetic properties and therapeutic efficacy Drugs. 1994;47(1):153–205. doi:10.2165/00003495-199447010-00009.
   PubMed Web of Science ®Google Scholar
• Kuffova L, Knickelbein JE, Yu T, Medina C, Amescua G, Rowe AM, et al. High-risk corneal graft rejection in the setting of previous corneal herpes simplex virus (HSV)-1 infection. Invest Ophthalmol Vis Sci. 2016;57(4):1578–1587. doi:10.1167/iovs.15-17894.
   PubMed Web of Science ®Google Scholar
• van Velzen M, van de Vijver DAMC, van Loenen FB, ADME O, Remeijer L, GMGM V. Acyclovir prophylaxis predisposes to antiviral-resistant recurrent herpetic keratitis. J Infect Dis. 2013;208(9):1359–1365. doi:10.1093/infdis/jit350.
   PubMed Web of Science ®Google Scholar
• Yokogawa H, Kobayashi A, Mori N, Sugiyama K. Mapping of dendritic lesions in patients with herpes simplex keratitis using in vivo confocal microscopy. Clin Ophthalmol. 2015;9:1771–1777. doi:10.2147/OPTH.S92517.
   PubMedGoogle Scholar
• Mocan MC, Irkec M, Mikropoulos DG, Bozkurt B, Orhan M, Konstas AGP. In vivo confocal microscopic evaluation of the inflammatory response in non-epithelial herpes simplex keratitis Curr Eye Res. 2012;37(12):1099–1106. doi:10.3109/02713683.2012.707270.
   PubMed Web of Science ®Google Scholar
• Soliman W, Nassr MA, Abdelazeem K, Al-Hussaini AK. Appearance of herpes simplex keratitis on anterior segment optical coherence tomography. Int Ophthalmol. 2019;39(12):2923–2928. doi:10.1007/s10792-019-01142-4.
   PubMed Web of Science ®Google Scholar
• Satpathy G, Mishra AK, Tandon R, Sharma MK, Sharma A, Nayak N, et al. Evaluation of tear samples for herpes simplex virus 1 (HSV) detection in suspected cases of viral keratitis using PCR assay and conventional laboratory diagnostic tools. Br J Ophthalmol. 2011;95(3):415–418. doi:10.1136/bjo.2010.191049.
   PubMed Web of Science ®Google Scholar
• Hidalgo F, Melón S, de Oña M, Do Santos V, Martínez A, Cimadevilla R, et al. Diagnosis of herpetic keratoconjunctivitis by nested polymerase chain reaction in human tear film. Eur J Clin Microbiol Infect Dis. 1998;17(2):120–123. doi:10.1007/BF01682169.
   PubMed Web of Science ®Google Scholar
• Farhatullah S, Kaza S, Athmanathan S, Garg P, Reddy SB, Sharma S. Diagnosis of herpes simplex virus-1 keratitis using Giemsa stain, immunofluorescence assay, and polymerase chain reaction assay on corneal scrapings Br J Ophthalmol. 2004;88(1):142–144. doi:10.1136/bjo.88.1.142.
   PubMed Web of Science ®Google Scholar
• Ruben JJ, Guda JM, Sontam B, Bagga B, Konduri R, Sharma S. Evaluation of multiplex real-time polymerase chain reaction for the detection of HSV-1 & 2 and VZV in the diagnosis of viral keratitis. Invest Ophthalmol Vis Sci. 2017;58:3604.
   Google Scholar
• Hoarau G, Haigh O, Vauloup-Fellous C, et al. Diagnostic performance of real-time quantitative PCR in tear samples in various subtypes of herpes simplex keratitis. J Clin Microbiol. 2023;61(12):e0088523. doi:10.1128/jcm.00885-23.
   PubMed Web of Science ®Google Scholar
• Huang F, Wang Z, Cao W, Liu C, Zhang C. Analysis of prophylactic parameters and the relative cut-off values for predicting stromal herpes simplex keratitis recurrence. Published online 2022. doi:10.21203/rs.3.rs-1159580/v1.
   Google Scholar
• Granato PA, Alkins BR, Yen-Lieberman B, et al. Comparative evaluation of AmpliVue HSV 1+2 assay with ELVIS culture for detecting herpes simplex virus 1 (HSV-1) and HSV-2 in clinical specimens. J Clin Microbiol. 2015;53(12):3922–3925. doi:10.1128/JCM.01905-15.
   PubMed Web of Science ®Google Scholar
• Kuo MT, Fang PC, Yu HJ, Chao TL, Chien CC, Chen SH, et al. A multiplex dot hybridization assay for detection and differentiation of acanthamoeba and herpes keratitis. Invest Ophthalmol Vis Sci. 2016;57(4):2158–2163. doi:10.1167/iovs.15-17741.
   PubMed Web of Science ®Google Scholar
• Morishige N, Jester JV, Naito J, Osorio N, Wahlert A, Jones C, et al. Herpes simplex virus type 1 ICP0 localizes in the stromal layer of infected rabbit corneas and resides predominantly in the cytoplasm and/or perinuclear region of rabbit keratocytes. J Gen Virol. 2006;87(Pt 10):2817–2825. doi:10.1099/vir.0.82076-0.
   PubMedGoogle Scholar
• Austin A, Lietman T, Rose-Nussbaumer J. Update on the management of infectious keratitis. Ophthalmology. 2017;124(11):1678–1689. doi:10.1016/j.ophtha.2017.05.012.
   PubMed Web of Science ®Google Scholar
• Wilhelmus KR, Gee L, Hauck WW, Kurinij N, Dawson CR, Jones DB, et al. Herpetic eye disease study. A controlled trial of topical corticosteroids for herpes simplex stromal keratitis. Ophthalmology. 1994;101(12):1883–1895. discussion 1895-1896. doi:10.1016/s0161-6420(94)31087-6.
   PubMed Web of Science ®Google Scholar
• Wilhelmus KR. Diagnosis and management of herpes simplex stromal keratitis. Cornea. 1987;6(4):286–291. doi:10.1097/00003226-198706040-00011.
   PubMed Web of Science ®Google Scholar
• Wilhelmus KR. Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis. Cochrane Database Syst Rev. 2015;1(1). doi:10.1002/14651858.CD002898.pub5.
   PubMedGoogle Scholar
• Tsatsos M, MacGregor C, Athanasiadis I, Moschos MM, Hossain P, Anderson D. Herpes simplex virus keratitis: an update of the pathogenesis and current treatment with oral and topical antiviral agents Clin Exp Ophthalmol. 2016;44(9):824–837. doi:10.1111/ceo.12785.
   PubMed Web of Science ®Google Scholar
• Virók DP, Eszik I, Mosolygó T, Önder K, Endrész V, Burián K. A direct quantitative PCR-based measurement of herpes simplex virus susceptibility to antiviral drugs and neutralizing antibodies. J Virol Methods. 2017;242:46–52. doi:10.1016/j.jviromet.2017.01.007.
   PubMed Web of Science ®Google Scholar
• Gateley A, Gander RM, Johnson PC, Kit S, Otsuka H, Kohl S. Herpes simplex virus type 2 meningoencephalitis resistant to acyclovir in a patient with AIDS. J Infect Dis. 1990;161(4):711–715. doi:10.1093/infdis/161.4.711.
   PubMed Web of Science ®Google Scholar
• Jiang YC, Feng H, Lin YC, Guo XR. New strategies against drug resistance to herpes simplex virus. Int J Oral Sci. 2016;8(1):1–6. doi:10.1038/ijos.2016.3.
   PubMed Web of Science ®Google Scholar
• Piret J, Boivin G. Resistance of herpes simplex viruses to nucleoside analogues: mechanisms, prevalence, and management. Antimicrob Agents Chemother. 2011;55(2):459–472. doi:10.1128/AAC.00615-10.
   PubMed Web of Science ®Google Scholar
• Pottage JC, Kessler HA. Herpes simplex virus resistance to acyclovir: clinical relevance. Infect Agents Dis. 1995;4:115–124.
   PubMedGoogle Scholar
• Pisitpayat P, Jongkhajornpong P, Lekhanont K, Nonpassopon M. Role of intravenous acyclovir in treatment of herpes simplex virus stromal keratitis with ulceration: a review of 2 cases. Am J Case Rep. 2021;22:e930467. doi:10.12659/AJCR.930467.
   PubMed Web of Science ®Google Scholar
• Minkovitz JB, Pepose JS. Topical interferon alpha-2a treatment of herpes simplex keratitis resistant to multiple antiviral medications in an immunosuppressed patient. Cornea. 1995;14(3):326–330. doi:10.1097/00003226-199505000-00017.
   PubMed Web of Science ®Google Scholar
• Wang J, Quake SR. RNA-guided endonuclease provides a therapeutic strategy to cure latent herpesviridae infection. Proc Natl Acad Sci USA. 2014;111(36):13157–13162. doi:10.1073/pnas.1410785111.
   PubMed Web of Science ®Google Scholar
• Jaishankar D, Yakoub AM, Yadavalli T, Agelidis A, Thakkar N, Hadigal S, et al. An off-target effect of BX795 blocks herpes simplex virus type 1 infection of the eye. Sci Transl Med. 2018;10(428):eaan5861. doi:10.1126/scitranslmed.aan5861.
   PubMed Web of Science ®Google Scholar
• Tuli S, Gray M, Shah A. Surgical management of herpetic keratitis Curr Opin Ophthalmol. 2018;29(4):347–354. doi:10.1097/ICU.0000000000000484.
   PubMed Web of Science ®Google Scholar
• White ML, Chodosh J Herpes simplex virus keratitis: A treatment guideline - 2014. American Academy Of Ophthalmology. Published June 27, 2014. https://www.aao.org/education/clinical-statement/herpes-simplex-virus-keratitis-treatment-guideline. Accessed December 21, 2023
   Google Scholar
• Herpes simplex virus (HSV) keratitis treatment & management: approach considerations, infectious epithelial keratitis, stromal keratitis. Published online June 13, 2023. https://emedicine.medscape.com/article/1194268-treatment?form=fpf. Accessed December 21, 2023
   Google Scholar
• NaPier E, Camacho M, McDevitt TF, Sweeney AR. Neurotrophic keratopathy: current challenges and future prospects. Ann Med. 2022;54(1):666–673. doi:10.1080/07853890.2022.2045035.
   PubMed Web of Science ®Google Scholar
• Heiligenhaus A, Li H, Hernandez Galindo EE, Koch JM, Steuhl KP, Meller D. Management of acute ulcerative and necrotising herpes simplex and zoster keratitis with amniotic membrane transplantation. Br J Ophthalmol. 2003;87(10):1215–1219. doi:10.1136/bjo.87.10.1215.
   PubMed Web of Science ®Google Scholar
• Yoganathan P, Udell I. Treatment of presumed herpes simplex keratitis with long term Antivirals; can we refine the treatment paradigm? Invest Ophthalmol Vis Sci. 2006;47:3043.
   Google Scholar
• Barney NP, Foster CS. A prospective randomized trial of oral acyclovir after penetrating keratoplasty for herpes simplex keratitis. Cornea. 1994;13(3):232–236. doi:10.1097/00003226-199405000-00007.
   PubMed Web of Science ®Google Scholar
• Sibley D, Larkin DFP. Update on Herpes simplex keratitis management. Eye (Lond). 2020;34(12):2219–2226. doi:10.1038/s41433-020-01153-x.
   PubMed Web of Science ®Google Scholar
• Tambasco FP, Cohen EJ, Nguyen LH, Rapuano CJ, Laibson PR. Oral acyclovir after penetrating keratoplasty for herpes simplex keratitis. Arch Ophthalmol. 1999;117(4):445–449. doi:10.1001/archopht.117.4.445.
   PubMedGoogle Scholar
• Goodfellow JF, Nabili S, Jones MN, et al. Antiviral treatment following penetrating keratoplasty for herpetic keratitis. Eye (Lond). 2011;25(4):470–474. doi:10.1038/eye.2010.237.
   PubMed Web of Science ®Google Scholar
• Jabbehdari S, Rafii AB, Yazdanpanah G, Hamrah P, Holland EJ, Djalilian AR. Update on the management of high-risk penetrating keratoplasty. Curr Ophthalmol Rep. 2017;5(1):38–48. doi:10.1007/s40135-017-0119-2.
   PubMedGoogle Scholar
• Miserocchi E, Modorati G, Galli L, Rama P. Efficacy of valacyclovir vs acyclovir for the prevention of recurrent herpes simplex virus eye disease: a pilot study. Am J Ophthalmol. 2007;144(4):547–551. doi:10.1016/j.ajo.2007.06.001.
   PubMed Web of Science ®Google Scholar
• Higaki S, Itahashi M, Deai T, Fukuda M, Shimomura Y. Effect of oral valaciclovir on herpetic keratitis. Cornea. 2006;25(10 Suppl 1):S64–67. doi:10.1097/01.ico.0000247216.08886.9d.
   PubMed Web of Science ®Google Scholar
• Gonzalez A, Price MO, Feng MT, Lee C, Arbelaez JG, Price FW. Immunologic rejection episodes after deep anterior lamellar keratoplasty: incidence and risk factors. Cornea. 2017;36(9):1076–1082. doi:10.1097/ICO.0000000000001223.
   PubMed Web of Science ®Google Scholar
• Koganti R, Yadavalli T, Shukla D. Current and emerging therapies for ocular herpes simplex virus type-1 infections. Microorganisms. 2019;7(10):429. doi:10.3390/microorganisms7100429.
   PubMed Web of Science ®Google Scholar
• Samii M. Operative reconstruction of injured nerves Langenbecks Arch Chir. 1972;332(1):355–362. doi:10.1007/BF01282653.
   PubMedGoogle Scholar
• Terzis JK, Dryer MM, Bodner BI. Corneal neurotization: a novel solution to neurotrophic keratopathy Plast Reconstr Surg. 2009;123(1):112–120. doi:10.1097/PRS.0b013e3181904d3a.
   PubMed Web of Science ®Google Scholar
• Park JK, Charlson ES, Leyngold I, Kossler AL. Corneal neurotization: a review of pathophysiology and outcomes Ophthalmic Plast Reconstr Surg. 2020;36(5):431–437. doi:10.1097/IOP.0000000000001583.
   PubMed Web of Science ®Google Scholar
• Fogagnolo P, Giannaccare G, Bolognesi F, Digiuni M, Tranchina L, Rossetti L, et al. Direct versus indirect corneal neurotization for the treatment of neurotrophic keratopathy: a multicenter prospective comparative study. Am J Ophthalmol. 2020;220:203–214. doi:10.1016/j.ajo.2020.07.003.
   PubMed Web of Science ®Google Scholar
• Kim JS, Rafailov L, Leyngold IM. Corneal neurotization for postherpetic neurotrophic keratopathy: initial experience and clinical outcomes Ophthalmic Plast Reconstr Surg. 2021;37(1):42–50. doi:10.1097/IOP.0000000000001676.
   PubMed Web of Science ®Google Scholar
• Chang JH, Garg NK, Lunde E, Han KY, Jain S, Azar DT. Corneal neovascularization: an anti-VEGF therapy review Surv Ophthalmol. 2012;57(5):415–429. doi:10.1016/j.survophthal.2012.01.007.
   PubMed Web of Science ®Google Scholar
• Hosseini H, Khalili MR. Therapeutic potential of bevacizumab (avastin) in herpetic stromal keratitis (HSK). Med Hypotheses. 2007;69(3):568–570. doi:10.1016/j.mehy.2007.01.032.
   PubMed Web of Science ®Google Scholar
• Manzano RPA, Peyman GA, Khan P, Carvounis PE, Kivilcim M, Ren M, et al. Inhibition of experimental corneal neovascularisation by bevacizumab (Avastin). Br J Ophthalmol. 2007;91(6):804–807. doi:10.1136/bjo.2006.107912.
   PubMed Web of Science ®Google Scholar
• Bahar I, Kaiserman I, McAllum P, Rootman D, Slomovic A. Subconjunctival bevacizumab injection for corneal neovascularization. Cornea. 2008;27(2):142–147. doi:10.1097/ICO.0b013e318159019f.
   PubMed Web of Science ®Google Scholar
• Koenig Y, Bock F, Horn F, Kruse F, Straub K, Cursiefen C. Short- and long-term safety profile and efficacy of topical bevacizumab (avastin) eye drops against corneal neovascularization. Graefes Arch Clin Exp Ophthalmol. 2009;247(10):1375–1382. doi:10.1007/s00417-009-1099-1.
   PubMed Web of Science ®Google Scholar
• Koenig Y, Bock F, Kruse FE, Stock K, Cursiefen C. Angioregressive pretreatment of mature corneal blood vessels before keratoplasty: fine-needle vessel coagulation combined with anti-VEGFs. Cornea. 2012;31(8):887–892. doi:10.1097/ICO.0b013e31823f8f7a.
   PubMed Web of Science ®Google Scholar