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Research Article

Anti-β 2 -Glycoprotein I Autoantibodies and Atherosclerosis

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Pages 51-66 | Published online: 03 Aug 2009

  • M.L. Boey, C.B. Colaco, A.E. Gharavi, K.B. Elkon, S. Loizou and G.R. V. Hughes, Thrombosis in systemic lupus erythematosus: Striking association with the presence of circulation lupus anticoagulant. Br. Med. J., 287: 1021-1023, 1983.
  • E.N. Harris, A.E. Gharavi, M.L. Boey, B.M. Patel, C.G. Mackworth-Young, S. Loizou and G.R. V. Hughes, Anticardiolipin antibodies: Detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus. Lancet, 2: 1211-1214, 1983.
  • G.R. V. Hughes, E.N. Harris and A.E. Gharavi, The anticardiolipin syndrome. J. Rheumatol., 13: 486-489, 1986.
  • M. Galli, P. Comfurius, C. Maassen, H.C. Hemker, M.H. de Baets, P.J. C. van BredaVriesman, T. Barbui, R.F. A. Zwaal and E.M. Bevers, Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor. Lancet, 335: 1544-1547, 1990.
  • H.P. McNeil, R.J. Simpson, C.N. Chesterman and S.A. Krilis, Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: ß2-glycoprotein I (apolipoprotein H). Proc. Natl. Acad. Sci. USA, 87: 4120-4124, 1990.
  • E. Matsuura, Y. Igarashi, M. Fujimoto, K. Ichikawa and T. Koike, Anticardiolipin cofactorts) and differential diagnosis of autoimmune disease. Lancet, 336: 177-178, 1990.
  • A. Tsutsumi, E. Matsuura, K. Ichikawa, A. Fujisaku, M. Mukai, S. Kobayashi and T. Koike, Antibodies to ß2-glycoprotein I and clinical manifestations in patients with systemic lupus erythematosus. Arthritis Rheum., 39: 1466-1474, 1996.
  • D. Alarcon-Segovia and A.R. Cabrai, The concept and classification of antiphospholipid/cofactor syndromes. Lupus, 5: 364-367, 1996.
  • E. Matsuura, Y. Igarashi, T. Yasuda, D.A. Triplett and T. Koike, Anticardiolipin antibodies recognize ß2-glycoprotein I structure altered by interacting with an oxygen modified solid phase surface. J. Exp. Med., 179: 457-462, 1994.
  • M.S. Brown and J.L. Goldstein, The hyperlipoproteinemias and other disorders of lipid metabolism. Harrison's Principles of Internal Medicine, 13th edition. In: K.D. Isselbacher, ed. New York: McGraw-Hill, Inc. 2058-2069, 1994.
  • J.L. Witztum and D. Steinberg, Role of oxidized low density lipoprotein in atherogenesis. J. Clin. Invest. 88: 1785-1792, 1991.
  • J.L. Goldstein, Y.K. Ho, S.K. Basu and M.S. Brown, Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition. Proc. Natl. Acad. Sci., USA, 76: 333-337, 1979.
  • K.D. O'Brien, C.E. Alpers, J.E. Hokanson, S. Wang and A. Chait, Oxidation-specific epitopes in human coronary atherosclerosis are not limited to oxidized low-density lipoprotein. Circulation, 94: 1216-1225, 1996.
  • O. Vaarala, G. Alfthan, M. Jauhiainen, M. Leirisalo-Repo, K. Aho and T. Palosuo, Crossreaction between antibodies to oxidised low-density lipoprotein and to cardiolipin in systemic lupus erythematosus. Lancet, 341: 923-925, 1993.
  • F.J. Tinahones, M.J. Cuadrado, M.A. Khamashta, F. Mujic, J.M. Gomez-Zumaquero, E. Collantes and G.R. V. Hughes, Lack of cross-reaction between antibodies to ß2-glycoprotein-I and oxidized low-density lipoprotein in patients with antiphospholipid syndrome. Br. J. Rheumatol., 37: 746-749, 1998.
  • F.I. Romero, O. Amengual, T. Atsumi, M.A. Khamashta, F.J. Tinahones and G.R. V. Hughes, Arterial disease in lupus and secondary antiphospholipid syndrome: Association with anti-ß2glycoprotein I antibodies but not with antibodies against oxidized low-density lipoprotein. Br. J. Rheumatol., 37: 883-888, 1998.
  • Y. Hasunuma, E. Matsuura, Z. Makita, T. Katahira, S. Nishi and T. Koike, Involvement of ß22-glycoprotein I and anticardiolipin antibodies in oxidatively modified low-density lipoprotein uptake by macrophages. Clin. Exp. Immunol., 107: 569-573, 1997.
  • S. HU+00F6rkko, E. Miller, E. Dudl, P. Reaven, L.K. Curtiss, N.J. Zvaifler, R. Terkeltaub, S.S. Pierangeli, D.W. Branch, W. Palinski and J.L. Witztum, Antiphospholipid antibodies are directed against epitopes of oxidized phospholipids. Recognition of cardiolipin by monoclonal antibodies to epitopes on oxidized low-density lipoprotein. J. Clin. Invest., 98: 815-825, 1996.
  • S. Hörkko, E. Miller, D.W. Branch, W. Palinski and J.L. Witztum, The epitopes for some antiphospholipid antibodies are adducts of oxidized phospholipid and ß2 glycoprotein 1 (and other proteins). Proc. Natl. Acad. Sci. USA, 94: 10356-10361, 1997.
  • S. Hörrko, D.A. Bird, E. Miller, H. Itabe, N. Leitinger, G. Subbanagounder, J.A. Berliner, P. Friedman, E.A. Dennis, L.K. Curtiss, W. Palinski and J.L. Witztum, Monoclonal autoantibodies specific for oxidized phospholipids or oxidized phospholipid-protein adducts inhibit macrophage uptake of oxidized low-density lipoproteins. J. Clin. Invest., 103: 117-128, 1999.
  • A.D. Watson, N. Leitinger, M. Navab, K.F. Faull, S. Hörkko, J.L. Witztum, W. Palinski, D. Schwenke, R.G. Salomon, W. Sha, G. Subbanagounder, A.M. Fogelman and J.A. Berliner, Structural identification by mass spectrometry of oxidized phospholipids in minimally oxidized low density lipoprotein that induce monocyte/endothelial interactions and evidence for their presence in vivo. J. Biol. Chem., 272: 13597-13607, 1997.
  • K. Kobayashi, E. Matsuura, Q. Liu, J. Furukawa, K. Kaihara, J. Inagaki, T. Asumi, N. Sakairi, T. Yasuda, D.V. Voelker and T. Koike, A specific ligand for ß2-glycoprotein I mediates autoantibody-dependent uptake of oxidized low density lipoprotein by macrophages, J. Lipid Res., 42: 697-709, 2001.
  • J. Frostegard, R. Wu, A. Haegerstrand, M. Patarroyo, A.K. Lefvert and J. Nilsson, Mononuclear leukocytes exposed to oxidized low density lipoprotein secrete a factor that stimulates endothelial cells to express adhesion molecules. Atherosclerosis, 103: 213-219, 1993.
  • S.D. Gushing, J.A. Berliner, A.J. Valente, M.C. Territo, M. Navab, F. Parhami, R. Gerrity, C.J. Schwartz and A.M. Fogelman, Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells. Proc. Natl. Acad. Sci. USA, 87: 5134-5138, 1990.
  • T.B. Rajavashisth, A. Andalibi, M.C. Territo, J.A. Berliner, M. Navab, A.M. Fogelman and A.J. Lusis, Induction of endothelial cell expression of granulocyte and macrophage colony-stimulating factors by modified low-density lipoproteins. Nature, 344: 254-257, 1990.
  • A. Nakata, J. Miyagawa, S. Yamashita, M. Nishida, R. Tamura, K. Yamamori, T. Nakamura, S. Nozaki, K. Kameda-Takemura, S. Kawata, N. Taniguchi, S Higashiyama and Y. Matsuzawa, Localization of heparin-binding epidermal growth factor-like growth factor in human coronary arteries. Possible roles of HB-EGF in the formation of coronary atherosclerosis. Circulation, 94: 2778-2786, 1996.
  • N. Watanabe, M. Kurabayashi, Y. Shimomura, K. Kawai-Kowase, Y. Hoshino, I. Manabe, M. Watanabe, M. Aikawa, M. Kuro-o, T. Suzuki, Y. Yazaki and R. Nagai, BTEB2 Nagai, a Kruppel-like transcription factor, regulates expression of the SMemb/nonmuscle myosin heavy chain B (SMemb/NMHC-B) gene. Cric. Res., 85: 182-191, 1999.
  • F.S. Santiago, H.C. Lowe, M.M. Kavurma, C.N. Chesterman, A. Baker, D.G. Atkins and L.M. Khachigian, New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury. Nature Med., 5: 1438, 1999.
  • F. Mach, U. Schonbeck, G.K. Sukhova, E. Atkinson and P. Libby, Reduction of athrosclerosis in mice by inhibition of CD40 signalling. Nature, 394: 200-203, 1998.
  • W. Jessup, Oxidized lipoproteins and nitric oxide. Curr. Opin. Lipidol., 7: 274-280, 1996.
  • D. Steinberg, Low density lipoprotein oxidation and its pathobiological significance. J. Biol. Chem., 272: 20963-20966, 1997.
  • L.G. Fong, S. Parthasarathy, J.L. Witztum and D. Steinberg, Nonenzymatic oxidative cleavage of peptide bonds in apoprotein B-100. J. Lipid Res., 28: 1466-1477, 1987.
  • H. Esterbauer, G. Jurgens, O. Quehenberger and E. Koller, Autoxidation of human low density lipoprotein: Loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes. J. Lipid Res., 28: 495-509, 1987.
  • L. Nagy, P. Tontonoz, J.G. Alvarez, H. Chen and R.M. Evans, Oxidized LDL regulates macrophage gene expression through ligand activation of PPARy. Cell 93: 229-240, 1998.
  • A. Weidtmann, R. Scheithe, N. Hrboticky, A. Pietsch, R. Lorenz and W. Siess, Mildly oxidized LDL induces platelet aggregation through activation of phospholipase A2. Arterioscler. Thromb. Vase. Biol., 15: 1131-1138, 1995.
  • L. Kritharides, W. Jessup, J. Gifford and R.T. Dean, A method for defining the stages of low density lipoprotein oxidation by the separation of cholesterol- and cholesteryl ester-oxidation products using HPLC. Anal. Biochem., 213: 79-89, 1993.
  • M. van Heek, D. Schmitt, P. Toren, M.K. Cathcart and P.E. DiCorleto, Cholesteryl hydroperoxyoctadecadienoate from oxidized low density lipoprotein inactivated platelet-derived growth factor. J. Biol. Chem., 273: 19405-19410, 1998.
  • A.J. Brown, S.L. Leong, R.T. Dean and W. Jessup, 7-Hydroperoxycholesterol and its products in oxidized low density lipoprotein and human atherosclerotic plaque. J. Lipid Res., 38: 1730-1745, 1997.
  • A.J. Brown and W. Jessup, Oxysterols and atherosclerosis. Atherosclerosis, 142: 1-28, 1999.
  • H. Kamido, A. Kuksis, L. Marai and J.J. Myher, Identification of cholesterol-bound aldehydes in copper-oxidized low density lipoprotein. FEBS Lett., 304: 269-272, 1992.
  • H. Kamido, A. Kuksis, L. Marai and J.J. Myher, Lipid ester-bound aldehydes among copper-catalyzed peroxidation products of human plasma lipoproteins. J. Lipid Res., 36: 1876-1886, 1995.
  • G. Hoppe, A. Ravandi, D. Herrera, A. Kuksis and H.F. Hoff, Oxidation products of cholesteryl linoleate are resistant to hydrolysis in macrophages, form complexes with proteins, and are present in human atherosclerotic lesions. J. Lipid Res., 38: 1347-1360, 1997.
  • H.A. Kleinveld, H.L. M. Hak-Lemmers, A.F. H. Stalenhoef and P.N. M. Demacker, Improved measurement of low-density-lipoprotein susceptibility to copper-induced oxidation: Application of a short procedure for isolating low-density lipoprotein. Clin. Chem., 38: 2066-2072, 1992.
  • S. Parthasarathy, L.G. Fong, M.T. Quinn and D. Steinberg, Oxidative modification of LDL: Comparison between cell-mediated and copper-mediated modification. Ear. Heart J., 11: (Suppl.) E: 83-87, 1990.
  • S. Yla-Herttuala, W. Palinski, M.E. Rosenfeld, S. Parthasarathy, TE. Carew, S. Butler, J.L. Witztum and D. Steinberg, Evidence for presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man. J. Clin. Invest., 85: 1086-1095, 1989.
  • E. Ehrenwald, G.M. Chisolm and RL. Fox, Intact ceruloplasmin oxidatively modifies low density lipoprotein. J. Clin. Invest., 93: 1493-1501, 1994.
  • D. Lamb and D.S. Leake, Acidic pH enables caeruloplasmin to catalyse the modification of low-density lipoprotein. FEBS Lett., 338: 122-126, 1994.
  • H.E. Schultze, K. Heide and H. Haupt, Uber ein bisher ubekanntes niedermolekulare ß2globulin des humanserums. Naturwissenschaften, 48: 719-724, 1961.
  • H. Wurm, ß2-glycoprotein I (apolipoprotein H) interactions with phospholipid vesicles. Int. J. Biochem., 16: 511-515, 1984.
  • E. Polz, Isolation of a specific lipid-binding protein from human serum by affinity chromatography using heparin-Sepharose. In: H. Peelers, ed., Properties of biological fluids. Pergamon: Oxford Press, 817-820, 1979.
  • E. Polz and G.M. Kostner, The binding of ß2glycoprotein I to human serum lipoproteins: Distribution among density fraction. FEBS lett., 102: 183-186, 1979.
  • J. Nimpf, E.M. Bevers, RH. Bomans, U. Till, H. Wurm, G.M. Kostner and R.F. Zwaal, Prothrombinase activity of human platelets is inhibited by ß2-glycoprotein I. Biochim. Biophys. Acta, 884: 142-149, 1986.
  • I. Schousboe, ß2-Glycoprotein I: A plasma inhibitor of the contact activation of the intrinsic blood coagulation pathway. Blood, 66: 1086-1091, 1985.
  • J. Nimpf, H. Wrum and G.M. Kostner, ß2-Glycoprotein I (apo-H) inhibits the release reaction of human platelets during ADP-induced aggregation. Atherosclerosis, 63: 109-114, 1987.
  • M. Ieko, K. Ichikawa, D.A. Triplett, E. Matsuura, T. Atsumi, K. Sawada and T. Koike, ß2-Glycoprotein I is necessary to inhibit protein C activity by monoclonal anticardiolipin antibodies. Arthritis Rheum., 42: 167-174, 1999.
  • E. Matsuura, Y. Igarashi, T. Yasuda, D.A. Triplett and T. Koike, Anticardiolipin antibodies recognize ß2glycoprotein I structure altered by interacting with an oxygen modified solid phase surface. J. Exp. Med., 179: 457-462, 1994.
  • D. Steinberg, Low density lipoprotein oxidation and its pathobiological significance. J. Biol. Chem., 272: 20963-20966, 1997.
  • K. Nishikawa, H. Arai and K. Inoue, Scavenger receptor-mediated uptake and metabolism of lipid vesicles containing acidic phospholipids by mouse peritoneal macrophages. J. Biol. Chem., 265: 5226-5231, 1990.
  • R.L. Griffith, G.T. Virella, H.C. Stevenson and M.F. Lopes-Virella, Low density lipoprotein metabolism by human macrophages activated with low density lipoprotein immune complexes; a possible mechanism of foam cell formation. J. Exp. Med., 168: 1041-1059, 1988.
  • M.F. Lopes-Virella, N. Binzafar, S. Rackley, A. Takei, M. La Via and G. Virella, The uptake of LDL-IC by human macrophages: Predominant involvement of the FcyRI receptor. Atherosclerosis, 135: 161-170, 1997.
  • J.C. Khoo, E. Miller, F. Pio, D. Steinberg and J.L. Witztum, Monoclonal antibodies against LDL further enhance macrophage uptake of LDL aggregates. Arterioscler. Thromb., 12: 1258-1266, 1992.
  • P.A. Kiener, B.M. Rankin, P.M. Davis, S.A. Yocum, G.A. Warr and R.I. Grove, Immune complexes of LDL induce atherogenic responses in human monocytic cells. Arterioscler. Thromb. Vase. Biol., 15: 990-999, 1995.
  • P.M. Morganelli, R.A. Rogers, T.J. Kitzmiller and A. Bergeron, Enhanced metabolism of LDL aggregates mediated by specific human monocyte IgG Fc receptors. J. Lipid Res., 36: 714-724, 1995.
  • J.E. Hunt and S.A. Krilis, The fifth domain of ß2-glycoprotein I contains a phospholipid binding site (Cys281-Cys288) and a region recognized by anticardiolipin antibodies. J. Immunol., 152: 653-659, 1994.
  • B. Bouma, RG. de Groot, J.M. H. van den Elsen, R.B. G. Ravelli, A. Scheuten, M.J. A. Simmelink, R.H. W.M. Derksen, J. Kroon and R Gros, Adhension mechanism of human ß2-glycoprotein I to phospholipids based on its crystal structure. EMBO J., 18: 5166-5174, 1999.
  • M. Igarashi, E. Matsuura, Y. Igarashi, H. Nagae, K. Ichikawa, D.A. Triplett and T. Koike, Human ß2-glycoprotein I as an anticardiolipin cofactor determined using deleted mutants expressed by a baculovirus system. Blood, 87: 3262-3270, 1996.
  • G.M. Iverson, E.J. Victoria and D.M. Marquis, Anti-ß2-glycoprotein I (ß2GPI) autoantibodies recognize an epitope on the first domain of ß2GPI. Proc. Natl. Acad. Sci., USA, 95: 15542-15546, 1998.
  • W. Palinski, M.E. Rosenfeld, S. Yla-Herttuala, G.C. Gumer, S.S. Socher, S.W. Butler, S. Parathasarathy, T.E. Carew, D. Steinberg and J.L. Witztum, Low density lipoprotein undergoes oxidative modification in vivo. Proc. Natl. Acad. Sci., USA, 86: 1372-1376, 1989.
  • W. Palinski, S. Yla-Harttuala, M.E. Rosenfeld, S.W. Butler, S.A. Socher, S. Parathasarathy, L.K. Curtiss and J.L. Witztum, Antisera and monoclonal antibodies specific for epitopes generated during oxidative modification of low density lipoprotein. Atherosderosis, 10: 325-335, 1990.
  • J.T. Salonen, S. Yla-Herttuala, R. Yamamoto, S. Butler, H. Korpela, R. Salonen, K. Nyyssonen, W. Palinski and J.L. Witztum, Autoantibody against oxidized LDL and progression of carotide atherosclerosis. Lancet, 339: 883-887, 1992.
  • M. Puurunen, O. Vaarala, H. Julkunen, K. Aho and T. Palosuo, Antibodies to phospholipid binding proteins and occurrence of thrombosis in patients with systemic lupus erythematosus. Clin. Immunol. Immunopathol., 80: 16-22, 1996.
  • J. George, A. Afek, B. Gilburd, M. Blank, Y. Levy, A. Aron-Maor, H. Levkovitz, A. Shaish, I. Goldberg, J. Kopolovic, D. Harats and Y. Shoenfeld, Induction of early atherosclerosis in LDL-receptor-deficient mice immunized with ß2-glycoprotein I, Circulation, 98: 1108-1115, 1988.
  • J. George, D. Harats, B. Gilburd, A. Afek, Y. Levy, J. Schneiderman, I. Barshack, J. Kopolovic and Y. Shoenfeld, Immunolocalization of ß2-glycoprotein I (apolipoprotein H) to human atherosclerotic plaques: Potential implications for lesion progression. Circulation, 9: 2227-2230, 1999.

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