93
Views
12
CrossRef citations to date
0
Altmetric
Research Article

IMAGING OCULAR IMMUNE RESPONSES BY INTRAVITAL MICROSCOPY

, , , , &
Pages 255-273 | Published online: 03 Aug 2009

  • H.J. Kaplan, Z. Wang, N. Bora, J. Sohn, H. Shao, and T.J. McCarthy, In vivo imaging with a micro-PET in experimental autoimmune anterior uveitis (EAAU). Abstract, Invest. Ophthalmol. Vis. Sci., 42: S912, 2001.
  • M.R. Sandora, G.L. Costa, J.M. Benson, K. Lejon, A.J. Slavin, C.H. Contag, and G.G. Fathman, Real time in vivo imaging of T cell trafficking in autoimmune disease. Abstract. FASEB J., 14: A1148, 2000.
  • U.H. VonAndrian, P. Hansell, J.D. Chambers, E.M. Berger, I. Torres Filho, E.G. Butcher, and K.E. Arfors, L-selectin function is required for beta 2-integrinmediated neutrophil adhesion at physiological shear rates in vivo. Am. J. Physiol., 263: H1034-H1044, 1992.
  • E. Svensjo., The hamster cheek pouch as a model in microcirculation research. Eur. Respir. J. Suppl., 12: 595s-600s, 600s-601s, 1990.
  • K. Ozer, G. Adanali, J. Zins, and M. Siemionow, In vivo microscopic assessment of cremasteric microcirculation during hindlimb allograft rejection in rats. Plast. Reconstr. Surg., 103: 1949-1956, 1999.
  • U.H. vonAndrian, Intravital microscopy of the peripheral lymph node microcirculation in mice. Microcirculation, 3: 287-300, 1996.
  • I.B. Mazoand U.H. vonAndrian, Adhesion and homing of blood-borne cells in bone marrow microvessels. J. Leukoc. Biol., 66: 25-32, 1999.
  • M.D. Becker, R. Nobiling, S.R. Planck, and J.T. Rosenbaum, Digital video-imaging of leukocyte migration in the iris: Intravital microscopy in a physiological model during the onset of endotoxin- induced uveitis. J. Immunol. Meth., 240:23-37,2000.
  • I. Gery and J.W. Streilein, Autoimmunity in the eye and its regulation. Curr. Opin. Immunol., 6: 938-945, 1994.
  • V. Panoutsakopoulou, M.E. Sanchirico, K.M. Huster, M. Jansson, F. Granucci, D.J. Shim, K.W. Wucherpfennig, and H. Cantor, Analysis of the relationship between viral infection and autoimmune disease. Immunity, 15: 137-147, 2001.
  • J.V. Forresterand R.G. McMenamin, Immunopathogenic mechanisms in intraocular inflammation. Chem. Immunol., 73: 159-185, 1999.
  • R.R. Caspi, F.G. Roberge, C.G. McAllister, M. el-Saied, T. Kuwabara, I. Gery, E. Hanna, and R.B. Nussenblatt, Tcell lines mediating experimental autoimmune uveoretinities (EAU) in the rat. J. Immunol., 136: 928-933, 1986.
  • R.R. Caspi, C.C. Chan, Y. Fujino, F. Najafian, S. Grover, C.T. Hansen, and R.L. Wilder, Recruitment of antigen-nonspecific cells plays a pivotal role in the pathogenesis of a T cell-mediated organ-specific autoimmune disease, experimental autoimmune uveoretinitis. J. Neuroimmunol., 47: 177-188, 1993.
  • S. Savion, S. Oddo, S. Grover, and R.R. Caspi, Uveitogenic T lymphocytes in the rat: Pathogenicity vs. lymphokine production, adhesion molecules and surface antigen expression. J. Neuroimmunol., 55: 35-44, 1994.
  • T. Kezuka, J. Sakai, H. Yokoi, M. Takeuchi, A. Okada, O. Taguchi, M. Usui, and J. Mizuguchi, Peptide-mediated suppression of experimental autoimmune uveoretinities in mice: Development of a peptide vaccine. Internat. Immunol., 8: 1229-1235, 1996.
  • R.L. Ufret-Vincenty, L. Quigley, N. Tresser, S.H. Pak, A. Gado, S. Hausmann, K.W. Wucherpfennig, and S. Brocke, In vivo survival of viral antigen-specific T cells that induce experimental autoimmune encephalomyelitis. J. Exp. Med., 188: 1725-1738, 1998.
  • J. Bauer, H. Wekerle, and H. Lassmann, Apoptosis in brain-specific autoimmune disease. Curr. Opin. Immunol., 7: 839-843, 1995.
  • A. Flugel, M. Willem, T. Berkowicz, and H. Wekerle, Gene transfer into CD4+ T lymphocytes: Green fluorescent protein-engineered, encephalitogenic T cells illuminate brain autoimmune responses. Nat. Med., 5: 843-847, 1999.
  • A. Flugel, T. Berkowicz, T. Ritter, M. Labeur, D.E. Jenne, Z. Li, J.W. Ellwart, M. Willem, H. Lassmann, and H. Wekerle, Migratory activity and functional changes of green fluorescent effector cells before and during experimental autoimmune encephalomyelitis. Immunity, 14: 547-560, 2001.
  • J.T. Rosenbaum, H.O. McDevitt, R.B. Guss, and P.R. Egbert, Endotoxininduced uveitis in rats as a model for human disease. Nature., 286: 611-613, 1980.
  • Q. Li, B. Peng, S.M. Whitcup, S.U. Jang, and C.-C. Chan, Endotoxin induced uveitis in the mouse: Susceptibility and genetic control. Exp. Eye Res., 61: 629-632, 1995.
  • M.D. Becker, R. Nobiling, S.R. Planck, and J.T. Rosenbaum, Digital video-imaging of leukocyte migration in the iris: Intravital microscopy in a physiological model during the onset of endotoxin-induced uveitis. J. Immunol. Meth., 240: 23-37, 2000.
  • H. Baatz, U. Pleyer, H.J. Thiel, and C. Hammer, In vivo study of leukocyte-endothelium interaction in endotoxin-induced uveitis. Invest. Opthalmol. Vis. Sei., 36: 1960-1967, 1995.
  • K. Yamashiro, J. Kiryu, A. Tsujikawa, M. Honjo, A. Nonaka, K. Miyamoto, Y. Honda, H. Tanihara, and Y. Ogura, Inhibitory effects of antithrombin III against leukocyte rolling and infiltration during endotoxin-induced uveitis in rats. Invest. Opthalmol. Vis. Sci., 42: 1553-1560, 2001.
  • M.D. Becker, L.M. O'Rourke, W.S. Blackman, S.R. Planck, and J.T. Rosenbaum, Reduced leukocyte migration, but normal rolling and arrest, in interleukin-8 receptor homologue knockout mice. Invest. Ophthalmol. Vis. Sci., 41: 1812-1817, 2000.
  • J.R. Smith, L.M. O'Rourke, M.D. Becker, M. Cao, K.A. Williams, S.R. Planck, and J.T. Rosenbaum, Anti-rat ICAM-1 antibody does not influence the course of experimental melanin-induced uveitis. Curr. Eye Res., 21: 906-912, 2000.
  • G. Adamus, D. Amundson, M. Vainiene, K. Ariail, M. Machnicki, and A. Weinberg, Myelin basic protein specific T-helper cells induce experimental anterior uveitis. J. Neurosci. Res., 44: 513-518, 1996.
  • D. Avichezer, P.B., Silver, C.C. Chan, B. Wiggert, and R.R. Caspi, Identification of a new epitope of human IRBP that induces autoimmune uveoretinitis in mice of the H-2B haplotype. Invest. Ophthalmol. Vis. Sci., 41: 127-131, 2000.
  • P.B. Silver, L.V. Rizzo, C.C. Chan, L.A. Donoso, B. Wiggert, and R.R. Caspi, Identification of a major pathogenic epitope in the human IRBP molecule recognized by mice of the H-2r haplotype. Invest. Ophthalmol. Vis. Sci., 36: 946-954, 1995.
  • R.A. Prendergast, C.E. Iliff, N.M. Coskuncan, R.R. Caspi, G. Sartani, T.K. Tarrant, G.A. Lutty, and D.S. McLeod, T cell traffic and the inflammatory response in experimental autoimmune uveoretinitis. Invest. Opthalmol. Vis. Sci. 1., 39: 754-762, 1998.
  • M.D. Becker, S. Crespo, T.M. Martin, S.R. Planck, M. Naramura, and J.T. Rosenbaum, Intraocular in vivo imaging of activated T-lymphocytes expressing green-fluorescent protein after stimulation with endotoxin. Graefe's Arch. Clin. Exp. Ophthalmol., 239: 609-612, 2001.
  • K. Miyamoto, Y. Ogura, M. Hamada, H. Nishiwaki, N. Hiroshiba, A. Tsujikawa, M. Mandai, K. Suzuma, S.J. Tojo, and Y. Honda, In vivo neutralization of Pselectin inhibits leukocyte-endothelial interactions in retinal microcirculation during ocular inflammation. Microvasc. Res., 55: 230-240, 1998.
  • M. Hamada, Y. Ogura, K. Miyamoto, H. Nishiwaki, N. Hiroshiba, and Y. Honda, Retinal leukocyte behavior in experimental autoimmune uveoretinitis of rats. Exp. Eye Res., 65: 445-450, 1997.
  • A. Parnaby-Price, M.R. Stanford, J. Biggerstaff, L. Howe, R.A. Whitson, J. Marshall, and G.R. Wallace, Leukocyte trafficking in experimental autoimmune uveitis in vivo. J. Leuk. Biol., 64: 434-440, 1998.
  • P. Hossain, J. Liversidge, M.J. Crée, et al., In vivo cell tracking by scanning laser ophthalmoscopy: Quantification of leukocyte kinetics. Invest. Ophthalmol. Vis. Sci., 39: 1879-1887, 1998.
  • R.B. Silver, C.C. Chan, B. Wiggert, and R.R. Caspi, The requirement for pertusis to induce EAU is strain-dependent: B10.RIII, but not B10.A mice, develop EAU and Th1 responses to IRBP without pertussis treatment. Invest. Ophthalmol. Vis. Sci., 40: 2898-2905, 1999.
  • T.K. Tarrant, R.B. Silver, C.C. Chan, B. Wiggert, and R.R. Caspi, Endogenous IL12 is required for induction and expression of experimental autoimmune uveitis. J. Immunol., 161: 122-127, 1998.
  • H. Xu, A. Manivannan, D. Carry, J. Liversidge, R.F. Sharp, J.V. Forrester, and L.J. Crane, Evaluation of leukocyte dynamic in mouse retinal circulation with scanning laser ophthalmoloscopy (Video report). Br. J. Ophthalmol., Available at: http//bjo.bmjjournals.com/cgi/content/full/85/7/DCI, 2001.
  • H. Xu, A. Manivannan, K. Goatman, J. Liversidge, P.F. Sharp, J.V. Forrester, and LJ. Crane. (2002) Improved Leukocyte tracking in mouse retinal and choroidal circulation. Exp. Eye Res. In press.
  • T.M. Martin, G. Allada, M.D. Becker, S.R. Planck, and J.T. Rosenbaum, Imaging of normal and inflamed conjunctival microvasculature in rats using real-time fluorescence intravital microscopy. Abstract. Invest. Ophthalmol. Vis. Sci., 41: S670, 2000.
  • C. Robert, R.C. Fuhlbrigge, J.D. Kieffer, S. Ayehunie, R.O. Hynes, G. Cheng, S. Grabbe, U. H. von Andrian, and T.S. Kupper, Interaction of dendritic cells with skin endothelium: A new perspective on immunosurveillance. J. Exp. Med., 189: 627-636, 1999.
  • G. Allada, T.M. Martin, C.M. Suing, M.D. Becker, S.R. Planck, and J.T. Rosenbaum, Real-time fluorescence intravital microscopy of conjunctival leukocyte migration induced by C48/80 ± eotoxin. Abstract. FASEB J., 14: A1154, 2000.
  • J. Kirveskari, M.H. Vesaluoma, J.A. Moilanen, T.M. Tervo, M.W Petroll, E. Linnolahti, and R. Renkonen, A novel non-invasive, in vivo technique for the quantification of leukocyte rolling and extravasation at sites of inflammation in human patients. Nat. Med., 7: 376-379, 2001.
  • M. Paques, B. Boval, S. Richard, R. Tadayoni, P. Massin, O. Mundler, A. Gaudric, and A. Vicaut, Evaluation of fluorescein-labeled autologous leukocytes for examination of retinal circulation in humans. Curr. Eye Res., 21: 560-565, 2000.
  • A. Manivannan, J. Van der Hoek, P. Vieira, A. Farrow, J. Olson, P.F. Sharp, and J.V. Forrester, Clinical investigation of a true color scanning laser ophthalmoscope. Arch. Ophthalmol., 119: 819-824, 2001.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.