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International Reviews of Immunology Volume 21, 2002 - Issue 4-5
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Research Article

ROLES OF IFN-γ ON STAGE CONVERSION OF AN OBLIGATE INTRACELLULAR PROTOZOAN PARASITE, Toxoplasma Gondii

AKIHIKO YANO Department of Infection and Host Defence, Graduate School of Medicine, Chiba University, Chiba, Japan
,
HYE-SEONG MUN Department of Infection and Host Defence, Graduate School of Medicine, Chiba University, Chiba, Japan
,
MEI CHIN Department of Infection and Host Defence, Graduate School of Medicine, Chiba University, Chiba, Japan
,
KAZUMI NOROSE Department of Infection and Host Defence, Graduate School of Medicine, Chiba University, Chiba, Japan
,
KAZUYUKI HATA Department of Infection and Host Defence, Graduate School of Medicine, Chiba University, Chiba, Japan
,
MASASHI KOBAYASHI Department of Infection and Host Defence, Graduate School of Medicine, Chiba University, Chiba, Japan
,
FUMEI AOSAI Department of Infection and Host Defence, Graduate School of Medicine, Chiba University, Chiba, Japan
&
YOICHIRO IWAKURA Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
 show all
Pages 405-421 | Published online: 03 Aug 2009

  • B.J. Luft and J.S. Remington, Toxoplasmic encephalitis in AIDS. Clin. Infect. Dis., 15: 211-222, 1992.
  • P. Ambroise-Thomas and H. Pelloux, Toxopasmosis-congenital and in immuno-compromised patients: A parallel. Parasitai. Today., 9: 61-62, 1993.
  • J.K. Frenkel, Biology of Toxoplasma gondii, in Congenital Toxplasmosis, P.A. Thomas and P.E. Petersen, (eds.), Paris: Springer, 2000.
  • M.A. Slavin, J.D. Meyers, J.S. Remington and R.C. Hackman, Toxoplasma gondii infection in marrow transplant recipients: A 20 year experience. Bone Marrow Transplant, 13: 549-557, 1994.
  • J.K. Frenkel, Pathogenesis of toxoplasmosis and of infections with organisms resembling Toxoplasma. Ann. NY Acad. Sciences, 64: 215-251, 1956.
  • RH. Chandrasekar and F. Momin, Disseminated toxoplasmosis in marrow re-cipients: A report of three cases and a review of the literature. Bone Marrow Transplant Team. Bone Marrow Transplant, 19: 685-689, 1997.
  • K.E. Orr, F.K. Gould, G. Short, J.H. Dark, C.J. Hilton, P.A. Corris and R. Freeman, Outcome of Toxoplasma gondii mismatches in heart transplant recipients over a period of 8 years. J. Infect., 29: 249-253, 1994.
  • TG. Wreghitt, M. Hakim, J.J. Gray, A.H. Balfour, RG. Stovin, S. Stewart, J. Scott, TA. English and J. Wallwork, Toxoplasmosis in heart and heart and lung trans-plant recipients. J. Clin. Pathol., 42: 194-199, 1989.
  • G. Michel, I. Thuret, H. Chambost, C. Scheiner, C. Mary and H. Perrimond, Lung toxoplasmosis after HLA mismatched bone marrow transplantation. Bone Marrow Transplant, 14: 455-457, 1994.
  • Y. Suzuki, M.A. Orellana, R.D. Schreiber and J.S. Remington, Interferon-gamma: The major mediator of resistance against Toxoplasma gondii. Science, 240: 516-518, 1988.
  • I.A. Khan, K.H. Ely and L.H. Kasper, A purified parasite antigen (p30) mediates CDS+ T cell immunity against fatal Toxoplasma gondii infection in mice. J. Immunol., 147: 3501-3506, 1991.
  • R. Gazzinelli, Y. Xu, S. Hieny, A. Cheever and A. Sher, Simultaneous depletion of CD4+ and CDS+ T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii. J. Immunol., 149: 175-180, 1992.
  • E.Y. Denkers, R.T. Gazzinelli, D. Martin and A. Sher, Emergence of NK1.1+ cells as effectors of IFN-gamma dependent immunity to Toxoplasma gondii in MHC class I- deficient mice. J. Exp. Med., 178: 1465-1472, 1993.
  • C.A. Hunter, E. Candolfi, C. Subauste, V. Van Cleave and J.S. Remington, Studies on the role of interleukin-12 in acute murine toxoplasmosis. Immunology, 84: 16-20, 1995.
  • M. Deckert-Schluter, A. Rang, D. Weiner, S. Huang, O.D. Wiestier, H. Hof and D. Schluter, Interferon-gamma receptor-deficiency renders mice highly susceptible to toxoplasmosis by decreased macrophage activation. Lab. Inwest., 75: 827-841, 1996.
  • T Scharton-Kersten, H. Nakajima, G. Yap, A. Sher and W.J. Leonard, Infection of mice lacking the common cytokine receptor gamma-chain (gamma(c)) reveals an unexpected role for CD4 ' T lymphocytes in early IFN-gamma-dependent resistance to Toxoplasma gondii. J. Immunol., 160: 2565-2569, 1998.
  • W. Bohne, U. Gross, D.J. Ferguson and J. Heesemann, Cloning and characterization of a bradyzoite-specifically expressed gene (hsp30/bag1) of Toxoplasmagondii, related to genes encoding small heat-shock proteins of plants. MoI. Microbiol., 16: 1221-1230, 1995.
  • U. Gross, M.C. Kempf, F. Seeber, C.G. Luder, R. Lugert and W. Bohne, Reactivation of chronic toxoplasmosis: Is there a link to strain-specific differences in the parasite? Behring Inst. Mitt., 97-106, 1997.
  • J.P. Dubey, G.V. Swan and J.K. Frenkel, A simplified method for isolation of Toxoplasma gondii from the feces of cats. J. Parasitol., 58: 1005-1006, 1972.
  • K. Lingelbach and K.A. Joiner, The parasitophorous vacuole membrane surrounding Plasmodium and Toxoplasma: An unusual compartment in infected cells. J. Cell. Sci., Ill: 1467-1475, 1998.
  • V.B. Carruthers and L.D. Sibley, Sequential protein secretion from three distinct organelles of Toxoplasma gondii accompanies invasion of human fibroblasts. Eur. J. Cell. Biol., 73: 114-123, 1997.
  • P.M. Sasono and J.E. Smith, Toxoplasma gondii: An ultrastructural study of hostcell invasion by the bradyzoite stage. Parasitol. Res., 84: 640-645, 1998.
  • L. Jacobs, J.S. Remington and M.L. Melton, The resistance of the encysted form of Toxoplasma gondii. J. Parasitol., 46: 11-21, 1960.
  • L. Jacobs, J.S. Remington and M.L. Melton, A survey of meat samples from swine, cattle, and sheep for the presence of Toxoplasma. J. Parasitol., 46: 23-28, 1960.
  • J.K. Frenkel, The stage-conversion time of Toxoplasma gondii: Interpretation of chemical-biologic data out of parasitologic or host context. Parasitol. Res., 82: 656-658, 1996.
  • U. Gross, W. Bohnern, M. Soete and J.F. Dubremetz, Developmental differentiation between tachyzoites and bradyzoites of Toxoplasma gondii. Parasitai. Today, 12: 30-33, 1996.
  • J.P. Dubey, C.A. Speer, S.K. Shen, O.G. H. Kwok and J.A. Blixt, Oocyst-induced murine toxoplasmosis: Life cycle, pathogenicity, and stage conversion in mice fed Toxoplasma gondii oocysts. J. Parasitai. Today, 83: 870-882, 1997.
  • J.S. Remington and E.N. Cavanaugh, Isolation of encysted form of Toxoplasma gondii from human skeletal muscle and brain. New Engl. J. Med., 273: 1303-1310, 1965.
  • W. Luo, F. Aosai, M. Ueda, K. Yamashita, K. Shimizu, S. Sekiya and A. Yano, Kinetics in parasite abundance in susceptible and resistant mice infected with an avirulent strain of Toxoplasma gondii by using quantitative competitive PCR. J. Parasitol., 83: 1070-1074, 1997.
  • H. Hata, F. Aosai, H.S. Mun, M. Chen, M. Kobayashi, A.A. Khairul, H. Kubosawa and A. Yano, Identification of Toxoplasma gondii tachyzoites and bradyzoites by a quantitative competitive polymerase chain reaction method after the acid treatment. Jpn. J. Trap. Med. Hyg., 28: 189-192, 2000.
  • J.K. Frenkel, J.P. Dubey and R.L. Hoff, Loss of stages after continuous passage of Toxoplasma gondii and Besnoitia jellisoni. J. Protozool., 23: 421-424, 1976.
  • J.P. Dubey and J.K. Frenkel, Toxoplasmosis of rats: A review, with considerations of their value as an animal model and their possible role in epidemiology. Vet. Parasitol., 77: 1-32, 1998.
  • R.T. Gazzinelli, F.T. Hakim, S. Hieny, G.M. Shearer and A. Sher, Synergistic role of CD4+' and CDS+ T lymphocytes in IFN-gamma production and protective immunity induced by an attenuated Toxoplasma gondii vaccine. J. Immunol., 146: 286-292, 1991.
  • G. Trinchieri, Interleukin-12 and its role in the generation of TH1 cells. Immunol. Today, 14: 335-338, 1993.
  • J.G. Montoya, K.E. Lowe, C. Clayberger, D. Moody, D. Do, J.S. Remington, S. Talib and C.S. Subauste, Human CD4+ and CDS+ T lymphocytes are both cytotoxic to Toxoplasma gondii-infected cells. Infect. Immun., 64: 176-181 1996.
  • J. Alexander and C.A. Hunter, Immunoregulation during toxoplasmosis. Chem. Immunol., 70:81-102, 1998.
  • T.H. Yang, F. Aosai, K. Norose, M. Ueda and A. Yano, Enhanced cytotoxicity of IFN-gamma-producing CD4+ cytotoxic T lymphocytes specific for T. gondii-infected human melanoma cells. J. Immunol., 154: 290-298, 1995.
  • A. Yano, F. Aosai, M. Ohta, H. Hasekura, K. Sugane and S. Hayashi, Antigen presentation by Toxoplasma gondii-infected cells to CD4+ proliferative T cells and CDS' cytotoxic cells. J. Parasitol., 75: 411-416, 1989.
  • F. Aosai, T.H. Yang, M. Ueda and A. Yano, Isolation of naturally processed peptides from a Toxoplasma gondii-infected human B lymphoma cell line that are recognized by cytotoxic T lymphocytes. J. Parasitol., 80: 260-266, 1994.
  • A. Yano, S. Ohno, K. Norose, T. Baba, K. Yamashita, F. Aosai and K. Segawa, Antigen presentation by Toxoplasma -infected cells: Antigen entry through cell membrane fusion. Int. Arch. Allergy Immunol, 98: 13-17, 1992.
  • T.H. Yang, F. Aosai, K. Norose, H.S. Mun and A. Yano, Heat shock cognate protein 71-associated peptides function as an epitope for Toxoplasma gondii-specific CD4+ CTL. Microbiol. Immunol, 41: 553-561, 1997.
  • H.S. Mun, F. Aosai, K. Norose, M. Chen, H. Hata, Y.I. Tagawa, Y. Iwakura, D.S. Byun and A. Yano, Toxoplasma gondii Hsp70 as a danger signal in Toxoplasma gondii-infected mice. Cell Stress. Chaperones, 5: 328-335, 2000.
  • R.T. Gazzinelli, S. Hieny, TA. Wynn, S. Wolf and A. Sher, Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intra-cellular parasite and induces resistance in T-cell-deficient hosts. Proc. Natl. Acad. Sci. USA, 90: 6115-6119, 1993.
  • C.D. Jun, S.H. Kim, C.T. Soh, S.S. Kang and H.T. Chung, Nitric oxide mediates the toxoplasmastatic activity of murine microglial cells in vitro. Immunol. Invest., 22: 487-501, 1993.
  • J.A. Langermans, M.E. Van der Hulst, P.H. Nibbering, P.S. Hiemstra, L. Fransen and R. Van Furth, IFN-gamma-induced L-arginine-dependent toxoplasmastatic activity in murine peritoneal macrophages is mediated by endogenous tumor necrosis factor-alpha. J. Immunol, 148: 568-574, 1992.
  • W. Bohne, J. Heesemann and U. Gross, Reduced replication of Toxoplasma gondii is necessary for induction of bradyzoite-specific antigens: A possible role for nitric oxide in triggering stage conversion. Infect Immun, 62: 1761-1767, 1994.
  • M. Kobayashi, F. Aosai, H. Hata, H.S. Mun, Y. Tagawa, Y. Iwakura and A. Yano, Toxoplasma gondii: Difference of invasion into tissue of digestive organs between susceptible and resistant strain and influence of IFN-gamma in mice inoculated with the cysts perorally. J. Parasitol., 85: 973-975, 1999.
  • K. Norose, H.S. Mun, F. Aosai, M. Chen, H. Hata, Y. Tagawa, Y. Iwakura and A. Yano, Organ infectivity of Toxoplasma gondii in interferon-gamma knockout mice. J. Parasitol., 87: 447-452, 2001.
  • L.H. Kasper, I.A. Khan, K.H. Ely, R. Buelow and J.C. Boothroyd, Antigen-specific (p30) mouse CDS+ T cells are cytotoxic against Toxoplasma gondii-infected peritoneal macrophages. J. Immunol., 148: 1493-1498, 1992.
  • E.Y. Denkers, R.T. Gazzinelli, S. Hieny, P. Caspar and A. Sher, Bone marrow macrophages process exogenous Toxoplasma gondii polypeptides for recognition by parasite-specific cytolytic T lymphocytes. J. Immunol., 150: 517-526, 1993.
  • Y. Suzuki and J.S. Remington, The effect of anti-IFN-gamma antibody on the protective effect of Lyt-2+ immune T cells against toxoplasmosis in mice. J. Immunol., 144: 1954-1956, 1990.
  • E.Y. Denkers, A. Sher and R.T. Gazzinelli, CD8+ T-cell interactions with Toxoplasma gondii: Implications for processing of antigen for class-I-restricted recognition. Res. Immunol., 144: 51-57, 1993.
  • K. Yamashita, K. Yui, M. Ueda and A. Yano, Cytotoxic T-lymphocyte-mediated lysis of Toxoplasma gondii-infected target cells does not lead to death of intracellular parasites. Infect. Immun., 66: 4651-4655, 1998.
  • S.J. Parker, C.W. Roberts and J. Alexander, CDS+ T cells are the major lymphocyte subpopulation involved in the protective immune response to Toxoplasma gondii in mice. Clin. Exp. Immunol., 84: 207-212, 1991.
  • M.B. Purner, R.L. Berens, P.B. Nash, A. van Linden, E. Ross, C. Kruse, E.C. Krug and T.J. Curiel, CD4-mediated and CDS-mediated cytotoxic and proliferative immune responses to Toxoplasma gondii in seropositive humans. Infect. Immun., 64: 4330-4338, 1996.
  • J.L. Burg, D. Perelman, L.H. Kasper, RL. Ware and J.C. Boothroyd, Molecular analysis of the gene encoding the major surface antigen of Toxoplasma gondii. J. Immunol., 141: 3584-3591, 1988.
  • A. Yano, H.S. Mun, T.H. Yang, H. Hata, M. Kobayashi, K. Norose, S. Hayakawa, Y. Tagawa, Y. Iwakura, S. Nakazaki, Y. Nakazaki, S. Sekiya, A. Yamaura, H. Kubosawa, N. Yumoto and F. Aosai, Roles of lFN-? in Effector Mechanisms and Pathogenicity of HSPs in Mice and Human Infected with Toxoplasma gondii. I. Tada, S. Kojima and M. Tsuji, (eds.), ICOPA IX. International Proceedings Division, Chiba, 1998.
  • H.S. Mun, F. Aosai and A. Yano, Role of Toxoplasma gondii HSP70 and Toxoplasma gondii HSP30/bagl in antibody formation and prophylactic immunity in mice experimentally infected with Toxoplasma gondii. Microbiol. Immunol., 43: 471-479, 1999.
  • L.M. Weiss, Y.F. Ma, P.M. Takvorian, H.B. Tanowitz and M. Wittner, Bradyzoite development in Toxoplasma gondii and the HSP70 stress response. Infect. Immun., 66: 3295-3302, 1998.
  • N.M. Suva, R.T. Gazzinelli, D.A. Suva, E.A. Ferro, L.H. Kasper and J.R. Mineo, Expression of Toxoplasma gondii-specific heat shock protein 70 during in vivo conversion of bradyzoites to tachyzoites. Infect. Immun., 66: 3959-3963, 1998.
  • E. Konishi, Monoclonal antibodies multireactive with parasite antigens produced by hybridomas generated from naive mice. Parasitology, 115: 387-393, 1997.
  • M. Chen, F. Aosai, H.S. Mun, K. Norose, H. Hata and A. Yano, Anti-HSP70 autoantibody formation by B-1 cells in Toxoplasma gondii-infected mice. Infect. Immun., 68: 4893-4899, 2000.
  • X.F. Qin, S. Schwers, W. Yu, F. Papavasiliou, H. Suh, A. Nussenzweig, K. Rajewsky and M.C. Nussenzweig, Secondary V(D) J recombination in B-1 cells. Nature, 397: 355-359, 1999.
  • [64) K. Hayakawa, R.R. Hardy and L.A. Herzenberg, Peritoneal Ly-I B cells: Genetic control, autoantibody production, increased lambda light chain expression. Ear. J. Immunol., 16: 450-456, 1986.
  • R.R. Hardy, C.E. Carmack, Y.S. Li and K. Hayakawa, Distinctive developmental origins and specificities of murine CDS' B cells. Immunol. Rev., 137:91-118, 1994.

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