Redox-sensitive transcription factors play a significant role in the development of rheumatoid arthritis

References

• Alamanos Y, Drosos AA. Epidemiology of adult rheumatoid arthritis. Autoimmun Rev. 2005;4(3):130–6. https://doi.org/10.1016/j.autrev.2004.09.002
   PubMed Web of Science ®Google Scholar
• Alamanos Y, Voulgari PV, Drosos AA. Incidence and prevalence of rheumatoid arthritis, based on the 1987 American college of rheumatology criteria: A systematic review. Semin Arthritis Rheum. 2006;36(3):182–8. https://doi.org/10.1016/j.semarthrit.2006.08.006
   PubMed Web of Science ®Google Scholar
• Sokka T, Abelson B, Pincus T. Mortality in rheumatoid arthritis: 2008 update. Clin Exp Rheumatol. 2008;26(5 Suppl 51):S35–61.
   PubMed Web of Science ®Google Scholar
• Innala L, Sjöberg C, Möller B, et al. Co-morbidity in patients with early rheumatoid arthritis – inflammation matters. Arthritis Res Ther. 2016;18:33. https://doi.org/10.1186/s13075-016-0928-y. PubMed PMID: PMC4730785.
   PubMed Web of Science ®Google Scholar
• Hazes JMW. Determinants of physical function in rheumatoid arthritis: association with the disease process. Rheumatology. 2003;42(suppl 2):ii17–ii21. https://doi.org/10.1093/rheumatology/keg328.
   PubMed Web of Science ®Google Scholar
• Feitsma AL, Worthington J, van der Helm-van AH, et al. Protective effect of noninherited maternal HLA-DR antigens on rheumatoid arthritis development. Proceedings of the National Academy of Sciences. 2007;104(50):19966–70.
   PubMed Web of Science ®Google Scholar
• Di Sante G, Tolusso B, Fedele AL, et al. Collagen Specific T-Cell Repertoire and HLA-DR Alleles: Biomarkers of Active Refractory Rheumatoid Arthritis. EBioMedicine. 2015;2(12):2037–45.
   PubMed Web of Science ®Google Scholar
• Louthrenoo W, Kasitanon N, Wangkaew S, et al. Distribution of HLA-DR alleles among Thai patients with rheumatoid arthritis. Hum Immunol. 2015;76(2):113–7.
   PubMed Web of Science ®Google Scholar
• De Rosa MC, Giardina B, Bianchi C, et al. Modeling the ternary complex TCR-Vβ/collagenII (261–273)/HLA-DR4 associated with rheumatoid arthritis. PLoS One. 2010;5(7):e11550.
   PubMed Web of Science ®Google Scholar
• Araújo VMA, Melo IM, Lima V. Relationship between periodontitis and rheumatoid arthritis: Review of the literature. Mediators Inflamm. 2015;1–15. 259074. doi:10.1155/2015/259074.
   Web of Science ®Google Scholar
• Hitchon CA, El-Gabalawy HS. Oxidation in rheumatoid arthritis. Arthritis Res Ther. 2004;6:265–78.
   PubMed Web of Science ®Google Scholar
• Li G, Zhang Y, Qian Y, et al. Interleukin-17 A promotes rheumatoid arthritis synoviocytes migration and invasion under hypoxia by increasing MMP2 and MMP9 expression through NF-κB/HIF-1α pathway. Mol Immunol. 2013;53(3):227–36. https://doi.org/10.1016/j.molimm.2012.08.018
   PubMed Web of Science ®Google Scholar
• Li G-Q, Zhang Y, Liu D, et al. PI3 kinase/Akt/HIF-1α pathway is associated with hypoxia-induced epithelial–mesenchymal transition in fibroblast-like synoviocytes of rheumatoid arthritis. Mol Cell Biochem. 2013;372(1–2):221–31.
   PubMed Web of Science ®Google Scholar
• Lee J, Koh K, Kim Y-E, et al. Upregulation of Nrf2 expression by human cytomegalovirus infection protects host cells from oxidative stress. J Gen Virol. 2013;94(7):1658–68. https://doi.org/10.1099/vir.0.052142-0.
   PubMed Web of Science ®Google Scholar
• Lee EK, Kim JA, Park SJ, et al. Low-dose radiation activates Nrf1/2 through reactive species and the Ca(2+)/ERK1/2 signaling pathway in human skin fibroblast cells. BMB Rep. 2013;46(5):258–63. https://doi.org/10.5483/BMBRep.2013.46.5.199. PubMed PMID: PMC4133890.
   PubMed Web of Science ®Google Scholar
• Kawasaki H, Komai K, Nakamura M, et al. Human wee1 kinase is directly transactivated by and increased in association with c-Fos/AP-1: rheumatoid synovial cells overexpressing these genes go into aberrant mitosis. Oncogene. 2003;22(44):6839–44.
   PubMed Web of Science ®Google Scholar
• Jawed H, Jamall S, Shah S, et al. N-(2-hydroxy phenyl) acetamide produces profound inhibition of c-Fos protein and mRNA expression in the brain of adjuvant-induced arthritic rats. Mol Cell Biochem. 2014;387(1–2):81–90. https://doi.org/10.1007/s11010-013-1873-6.
   PubMed Web of Science ®Google Scholar
• Hot A, Zrioual S, Lenief V, et al. IL-17 and tumour necrosis factor α combination induces a HIF-1α-dependent invasive phenotype in synoviocytes. Ann Rheum Dis. 2012;71(8):1393–401. https://doi.org/10.1136/annrheumdis-2011-200867.
   PubMed Web of Science ®Google Scholar
• Han H, Lee K-S, Rong W, et al. Different roles of peripheral mitogen-activated protein kinases in carrageenan-induced arthritic pain and arthritis in rats. Curr Res Anesth Analg. 2012;115(5):1221–7.
   Google Scholar
• Granet C, Maslinski W, Miossec P. Increased AP-1 and NF-κB activation and recruitment with the combination of the proinflammatory cytokines IL-1β, tumor necrosis factor alpha and IL-17 in rheumatoid synoviocytes. Arthritis Res Ther. 2004;6(3):1–9. https://doi.org/10.1186/ar1159.
   Web of Science ®Google Scholar
• Fourtounis J, Wang IM, Mathieu M-C, et al. Gene expression profiling following NRF2 and KEAP1 siRNA knockdown in human lung fibroblasts identifies CCL11/Eotaxin-1 as a novel NRF2 regulated gene. Respir Res. 2012;13(1):92–. https://doi.org/10.1186/1465-9921-13-92. PubMed PMID: PMC3546844.
   PubMed Web of Science ®Google Scholar
• Albina JE, Mastrofrancesco B, Vessella JA, et al. HIF-1 expression in healing wounds: HIF-1α induction in primary inflammatory cells by TNF-α. Am J Physiol Cell Physiol. 2001;281(6):C1971–C7.
   PubMed Web of Science ®Google Scholar
• Cho M-L, Jung YO, Moon Y-M, et al. Interleukin-18 induces the production of vascular endothelial growth factor (VEGF) in rheumatoid arthritis synovial fibroblasts via AP-1-dependent pathways. Immunol Lett. 2006;103(2):159–66. https://doi.org/10.1016/j.imlet.2005.10.020
   PubMed Web of Science ®Google Scholar
• BelAiba RS, Bonello S, Zähringer C, et al. Hypoxia up-regulates hypoxia-inducible factor-1α transcription by involving phosphatidylinositol 3-kinase and nuclear factor κB in pulmonary artery smooth muscle cells. Mol Biol Cell. 2007;18(12):4691–7.
   PubMed Web of Science ®Google Scholar
• Ahn JK, Koh EM, Cha HS, et al. Role of hypoxia-inducible factor-1α in hypoxia-induced expressions of IL-8, MMP-1 and MMP-3 in rheumatoid fibroblast-like synoviocytes. Rheumatology. 2008;47(6):834–9. https://doi.org/10.1093/rheumatology/ken086.
   PubMed Web of Science ®Google Scholar
• Aikawa Y, Morimoto K, Yamamoto T, et al. Treatment of arthritis with a selective inhibitor of c-Fos/activator protein-1. Nat Biotechnol. 2008;26(7):817–23.
   PubMed Web of Science ®Google Scholar
• Brouwer E, Gouw A, Posthumus M, et al. Hypoxia inducible factor-1-alpha (HIF-1alpha) is related to both angiogenesis and inflammation in rheumatoid arthritis. Clin Exp Rheumatol. 2009;27(6):945–51.
   PubMed Web of Science ®Google Scholar
• Noort AR, Tak PP, Tas SW. Non-canonical NF-κB signaling in rheumatoid arthritis: Dr Jekyll and Mr Hyde? Arthritis Res Ther. 2015;17(1):15. https://doi.org/10.1186/s13075-015-0527-3.
   PubMed Web of Science ®Google Scholar
• Asahara H, Fujisawa K, Kobata T, et al. Direct evidence of high DNA binding activity of transcription factor AP‐1 in rheumatoid arthritis synovium. Arthritis Rheum. 1997;40(5):912–8.
   PubMedGoogle Scholar
• Maicas N, Ferrándiz ML, Brines R, et al. Deficiency of Nrf2 accelerates the effector phase of arthritis and aggravates joint disease. Antioxid Redox Signal. 2011;15(4):889–901.
   PubMed Web of Science ®Google Scholar
• Jia T, Pan Y, Li J, et al. Strategies for active TNF-α vaccination in rheumatoid arthritis treatment. Vaccine. 2013;31(38):4063–8.
   PubMed Web of Science ®Google Scholar
• Konisti S, Kiriakidis S, Paleolog EM. Hypoxia—a key regulator of angiogenesis and inflammation in rheumatoid arthritis. Nature Reviews Rheumatology. 2012;8(3):153–62.
   PubMed Web of Science ®Google Scholar
• Henrotin Y, Bruckner P, Pujol J-P. The role of reactive oxygen species in homeostasis and degradation of cartilage. Osteoarthritis Cartilage. 2003;11(10):747–55.
   PubMed Web of Science ®Google Scholar
• Schett G. Cells of the synovium in rheumatoid arthritis. Osteoclasts. Arthritis Res Ther. 2007;9(1):1–6. https://doi.org/10.1186/ar2110.
   Google Scholar
• Kim H-R, Kim K-W, Jung HG, Yoon K-S, Oh H-J, Cho M-L, et al. Macrophage migration inhibitory factor enhances osteoclastogenesis through upregulation of RANKL expression from fibroblast-like synoviocytes in patients with rheumatoid arthritis. Arthritis Res Ther. 2011;13(2):1–13. https://doi.org/10.1186/ar3279.
   Web of Science ®Google Scholar
• Cho M-L, Ju J-H, Kim H-R, et al. Toll-like receptor 2 ligand mediates the upregulation of angiogenic factor, vascular endothelial growth factor and interleukin-8/CXCL8 in human rheumatoid synovial fibroblasts. Immunol Lett. 2007;108(2):121–8.
   PubMed Web of Science ®Google Scholar
• Kennedy A, Ng CT, Biniecka M, et al. Angiogenesis and blood vessel stability in inflammatory arthritis. Arthritis Rheumatol. 2010;62(3):711–21.
   Google Scholar
• Chen Y, Donnelly E, Kobayashi H, et al. Gene therapy targeting the Tie2 function ameliorates collagen‐induced arthritis and protects against bone destruction. Arthritis Rheumatol. 2005;52(5):1585–94.
   Google Scholar
• Biniecka M, Canavan M, McGarry T, et al. Dysregulated bioenergetics: a key regulator of joint inflammation. Ann Rheum Dis. 2016;75(12):2192–200.
   PubMed Web of Science ®Google Scholar
• Shiozawa S, Tsumiyama K. Pathogenesis of rheumatoid arthritis and c-Fos/AP-1. Cell Cycle. 2009;8(10):1539–43. https://doi.org/10.4161/cc.8.10.8411.
   PubMed Web of Science ®Google Scholar
• Lefèvre S, Knedla A, Tennie C, et al. Synovial fibroblasts spread rheumatoid arthritis to unaffected joints. Nat Med. 2009;15(12):1414–20.
   PubMed Web of Science ®Google Scholar
• Lefèvre S, Schwarz M, Meier FM, et al. Disease-Specific Effects of Matrix and Growth Factors on Adhesion and Migration of Rheumatoid Synovial Fibroblasts. J Immunol. 2017;198(12):4588–95.
   PubMed Web of Science ®Google Scholar
• Frank-Bertoncelj M, Trenkmann M, Klein K, et al. Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions. Nature Communications. 2017;8:14852.
   PubMed Web of Science ®Google Scholar
• Ai R, Hammaker D, Boyle DL, Morgan R, Walsh AM, Fan S, et al. Joint-specific DNA methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processes. Nature communications. 10;7:11849. doi:10.1038/ncomms11849
   Web of Science ®Google Scholar
• Kato M, Ospelt C, Gay RE, et al. Dual role of autophagy in stress‐induced cell death in rheumatoid arthritis synovial fibroblasts. Arthritis Rheumatol. 2014;66(1):40–8.
   PubMed Web of Science ®Google Scholar
• Buckland J. Rheumatoid arthritis: Autophagy: a dual role in the life and death of RASFs. Nature Reviews Rheumatology. 2013;9(11):637.
   PubMedGoogle Scholar
• Taylor PC, Sivakumar B. Hypoxia and angiogenesis in rheumatoid arthritis. Curr Opin Rheumatol. 2005;17(3):293–8.
   PubMed Web of Science ®Google Scholar
• Akhavani MA, Madden L, Buysschaert I, et al. Hypoxia upregulates angiogenesis and synovial cell migration in rheumatoid arthritis. Arthritis Res Ther. 2009;11(3):R64.
   PubMed Web of Science ®Google Scholar
• Yang Z, Fujii H, Mohan SV, Goronzy JJ, Weyand CM. Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells. J Exp Med. 2013:210(10):2119–34. 20130252.
   PubMed Web of Science ®Google Scholar
• Park SY, Lee SW, Kim HY, et al. HMGB1 induces angiogenesis in rheumatoid arthritis via HIF‐1α activation. Eur J Immunol. 2015;45(4):1216–27.
   PubMed Web of Science ®Google Scholar
• Biniecka M, Fox E, Gao W, et al. Hypoxia induces mitochondrial mutagenesis and dysfunction in inflammatory arthritis. Arthritis Rheumatol. 2011;63(8):2172–82.
   Google Scholar
• McGarry T, Biniecka M, Gao W, Cluxton D, Canavan M, Wade S, et al. Resolution of TLR2-induced inflammation through manipulation of metabolic pathways in Rheumatoid Arthritis. Sci Rep. 2017;7(43165):1–13. doi:10.1038/srep43165
   PubMed Web of Science ®Google Scholar
• Zhou R, Yazdi AS, Menu P, et al. A role for mitochondria in NLRP3 inflammasome activation. Nature. 2011;469(7329):221–5.
   PubMed Web of Science ®Google Scholar
• Chen S-Y, Shiau A-L, Li Y-T, et al. Transcription Factor Snail Regulates Tumor Necrosis Factor α–Mediated Synovial Fibroblast Activation in the Rheumatoid Joint. Arthritis Rheumatol. 2015;67(1):39–50. https://doi.org/10.1002/art.38899.
   PubMed Web of Science ®Google Scholar
• Kovac S, Angelova PR, Holmström KM, et al. Nrf2 regulates ROS production by mitochondria and NADPH oxidase. Biochimica et Biophysica Acta (BBA)-General Subjects. 2015;1850(4):794–801.
   PubMed Web of Science ®Google Scholar
• Qin Z, Robichaud P, He T, et al. Oxidant exposure induces cysteine-rich protein 61 (CCN1) via c-Jun/AP-1 to reduce collagen expression in human dermal fibroblasts. PLoS One. 2014;9(12).
   Web of Science ®Google Scholar
• McMorrow JP, Crean D, Gogarty M, et al. Tumor Necrosis Factor Inhibition Modulates Thrombospondin-1 Expression in Human Inflammatory Joint Disease through Altered NR4A2 Activity. Am J Pathol. 2013;183(4):1243–57. https://doi.org/10.1016/j.ajpath.2013.06.029
   PubMed Web of Science ®Google Scholar
• Berg A, Baldwin A. The Ikb proteins: multifunctional regulators of rel/NFk-B transcription. Genes Dev. 1993;7:2064–70.
   PubMed Web of Science ®Google Scholar
• Chen DP, Wong CK, Leung PC, et al. Anti-inflammatory activities of Chinese herbal medicine sinomenine and Liang Miao San on tumor necrosis factor-α-activated human fibroblast-like synoviocytes in rheumatoid arthritis. J Ethnopharmacol. 2011;137(1):457–68. https://doi.org/10.1016/j.jep.2011.05.048
   PubMed Web of Science ®Google Scholar
• Ivanov S, Dragoi A-M, Wang X, et al. A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA. Blood. 2007;110(6):1970–81.
   PubMed Web of Science ®Google Scholar
• Lawrence T, Bebien M, Liu GY, et al. IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation. Nature. 2005;434(7037):1138–43.
   PubMed Web of Science ®Google Scholar
• Amin MA, Mansfield PJ, Pakozdi A, et al. Interleukin-18 induces angiogenic factors in rheumatoid arthritis synovial tissue fibroblasts via distinct signaling pathways. Arthritis Rheum. 2007;56(6):1787–97. https://doi.org/10.1002/art.22705.
   PubMed Web of Science ®Google Scholar
• Kim Sj, Chen Z, Chamberlain ND, et al. Ligation of TLR5 promotes myeloid cell infiltration and differentiation into mature osteoclasts in rheumatoid arthritis and experimental arthritis. J Immunol. 2014;193(8):3902–13. https://doi.org/10.4049/jimmunol.1302998.
   PubMed Web of Science ®Google Scholar
• Oliver KM, Garvey JF, Ng CT, et al. Hypoxia activates NF-κB–Dependent gene expression through the canonical signaling pathway. Antioxid Redox Signal. 2009;11(9):2057–64.
   PubMed Web of Science ®Google Scholar
• Elshabrawy HA, Chen Z, Volin MV, et al. The pathogenic role of angiogenesis in rheumatoid arthritis. Angiogenesis. 2015;18(4):433–48.
   PubMed Web of Science ®Google Scholar
• Hong C, Shen C, Ding H, et al. An involvement of SR-B1 mediated p38 MAPK signaling pathway in serum amyloid A-induced angiogenesis in rheumatoid arthritis. Mol Immunol. 2015;66(2):340–5. https://doi.org/10.1016/j.molimm.2015.03.254
   PubMed Web of Science ®Google Scholar
• Coste E, Greig IR, Mollat P, et al. Identification of small molecule inhibitors of RANKL and TNF signalling as anti-inflammatory and antiresorptive agents in mice. Ann Rheum Dis. 2015;74(1):220–6. https://doi.org/10.1136/annrheumdis-2013-203700.
   PubMed Web of Science ®Google Scholar
• Chi PL, Chen YW, Hsiao LD, et al. Heme oxygenase 1 attenuates interleukin‐1β–induced cytosolic phospholipase A2 expression via a decrease in NADPH oxidase/reactive oxygen species/activator protein 1 activation in rheumatoid arthritis synovial fibroblasts. Arthritis Rheum. 2012;64(7):2114–25.
   PubMedGoogle Scholar
• Dhar SK, Lynn BC, Daosukho C, et al. Identification of nucleophosmin as an NF-κB co-activator for the induction of the human SOD2 gene. J Biol Chem. 2004;279(27):28209–19.
   PubMed Web of Science ®Google Scholar
• Gossye V, Elewaut D, Bougarne N, et al. Differential mechanism of NF-kappaB inhibition by two glucocorticoid receptor modulators in rheumatoid arthritis synovial fibroblasts. Arthritis Rheum. 2009;60(11):3241–50. https://doi.org/10.1002/art.24963. PubMed PMID: 19877072.
   PubMed Web of Science ®Google Scholar
• Li J, Li J, Chen R, et al. Targeting NF-kappaB and TNF-alpha Activation by Electroacupuncture to Suppress Collagen-induced Rheumatoid Arthritis in Model Rats. Altern Ther Health Med. 2015;21(4):26–34. PubMed PMID: 26030114.
   PubMed Web of Science ®Google Scholar
• Lin H, Xiao Y, Chen G, et al. HMG-CoA reductase inhibitor simvastatin suppresses Toll-like receptor 2 ligand-induced activation of nuclear factor kappa B by preventing RhoA activation in monocytes from rheumatoid arthritis patients. Rheumatol Int. 2011;31(11):1451–8. https://doi.org/10.1007/s00296-010-1510-6. PubMed PMID: 20473500.
   PubMed Web of Science ®Google Scholar
• Menghini R, Campia U, Tesauro M, et al. Toll-like receptor 4 mediates endothelial cell activation through NF-kappaB but is not associated with endothelial dysfunction in patients with rheumatoid arthritis. PLoS ONE [Electronic Resource]. 2014;9(6):e99053. https://doi.org/10.1371/journal.pone.0099053. PubMed PMID: 124918924; PubMed Central PMCID: PMCPMC4053330.
   PubMedGoogle Scholar
• Okamoto H, Yoshio T, Kaneko H, et al. Inhibition of NF-kappaB signaling by fasudil as a potential therapeutic strategy for rheumatoid arthritis. Arthritis Rheum. 2010;62(1):82–92. https://doi.org/10.1002/art.25063. PubMed PMID: 20039418.
   PubMed Web of Science ®Google Scholar
• Onuora S. Rheumatoid arthritis: Novel NFkappaB inhibitor associated with RA severity. Nature Reviews Rheumatology. 2015;11(12):684. https://doi.org/10.1038/nrrheum.2015.152. PubMed PMID: 26553605.
   PubMedGoogle Scholar
• Torices S, Alvarez-Rodriguez L, Grande L, et al. A truncated variant of ASCC1, a novel inhibitor of NF-kappaB, is associated with disease severity in patients with rheumatoid arthritis. J Immunol. 2015;195(11):5415–20. https://doi.org/10.4049/jimmunol.1501532. PubMed PMID: 26503956.
   PubMed Web of Science ®Google Scholar
• Westra J, Brouwer E, Bos R, et al. Regulation of Cytokine-Induced HIF-1α Expression in Rheumatoid Synovial Fibroblasts. Ann N Y Acad Sci. 2007;1108(1):340–8. https://doi.org/10.1196/annals.1422.035.
   PubMed Web of Science ®Google Scholar
• Muz B, Larsen H, Madden L, et al. Prolyl hydroxylase domain enzyme 2 is the major player in regulating hypoxic responses in rheumatoid arthritis. Arthritis Rheum. 2012;64(9):2856–67. https://doi.org/10.1002/art.34479.
   PubMed Web of Science ®Google Scholar
• Pugh CW, Ratcliffe PJ. The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis. Semin Cancer Biol. 2003;13(1):83–9. Epub 2003/01/01. PubMed PMID: 12507560.
   PubMed Web of Science ®Google Scholar
• Semenza GL. Targeting HIF-1 for cancer therapy. Nature Reviews Cancer. 2003;3(10):721–32.
   PubMed Web of Science ®Google Scholar
• Wang Ch, Yao H, Chen Ln, et al. CD147 induces angiogenesis through a vascular endothelial growth factor and hypoxia‐inducible transcription factor 1α–mediated pathway in rheumatoid arthritis. Arthritis Rheum. 2012;64(6):1818–27.
   PubMedGoogle Scholar
• Izquierdo E, Canete JD, Celis R, et al. Immature blood vessels in rheumatoid synovium are selectively depleted in response to anti-TNF therapy. PLoS One. 2009;4(12):e8131.
   PubMed Web of Science ®Google Scholar
• Gao W, McCormick J, Connolly M, Balogh E, Veale DJ, Fearon U. Hypoxia and STAT3 signalling interactions regulate pro-inflammatory pathways in rheumatoid arthritis. Ann Rheum Dis. 2014;74:1275–83. doi:10.1136/annrheumdis-2013-204105
   PubMed Web of Science ®Google Scholar
• Demaria M, Poli V. PKM2, STAT3 and HIF-1α: The Warburg's vicious circle. Jak-Stat. 2012;1(3):194–6.
   PubMedGoogle Scholar
• Lau TT, Wang DA. Stromal cell-derived factor-1 (SDF-1): homing factor for engineered regenerative medicine. Expert Opin Biol Ther. 2011;11(2):189–97.
   PubMed Web of Science ®Google Scholar
• Amin MA, Rabquer BJ, Mansfield PJ, et al. Interleukin 18 induces angiogenesis in vitro and in vivo via Src and Jnk kinases. Ann Rheum Dis. 2010;69(12):2204–12. https://doi.org/10.1136/ard.2009.127241.
   PubMed Web of Science ®Google Scholar
• Wang J, Li C, Liu Y, et al. JAB1 determines the response of rheumatoid arthritis synovial fibroblasts to tumor necrosis factor-α. Am J Pathol. 2006;169(3):889–902.
   PubMed Web of Science ®Google Scholar
• Thiel G, Rössler OG. Resveratrol stimulates AP‐1‐regulated gene transcription. Mol Nutr Food Res. 2014;58(7):1402–13.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Dong J, He P, et al. Genistein inhibit cytokines or growth factor-induced proliferation and transformation phenotype in fibroblast-like synoviocytes of rheumatoid arthritis. Inflammation. 2012;35(1):377–87. https://doi.org/10.1007/s10753-011-9365-x.
   PubMed Web of Science ®Google Scholar
• Park SY, Lee SW, Shin HK, et al. Cilostazol enhances apoptosis of synovial cells from rheumatoid arthritis patients with inhibition of cytokine formation via Nrf2‐linked heme oxygenase 1 induction. Arthritis Rheum. 2010;62(3):732–41.
   PubMedGoogle Scholar
• Cutolo M. Rheumatoid arthritis: circadian and circannual rhythms in RA. Nature Reviews Rheumatology. 2011;7(9):500–2.
   PubMed Web of Science ®Google Scholar
• Chin Y-T, Liao Y-W, Fu M, et al. Nrf-2 regulates cyclosporine-stimulated HO-1 expression in gingiva. J Dent Res. 2011;90(8):995–1000.
   PubMed Web of Science ®Google Scholar
• Fragoulis A, Laufs J, Muller S, et al. Sulforaphane has opposing effects on TNF-alpha stimulated and unstimulated synoviocytes. Arthritis Res Ther. 2012;14(5):R220.
   PubMed Web of Science ®Google Scholar
• Lau A, Wang XJ, Zhao F, et al. A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62. Mol Cell Biol. 2010;30(13):3275–85.
   PubMed Web of Science ®Google Scholar
• Wruck CJ, Fragoulis A, Gurzynski A, et al. Role of oxidative stress in rheumatoid arthritis: insights from the Nrf2-knockout mice. Ann Rheum Dis. 2011;70(5):844–50. https://doi.org/10.1136/ard.2010.132720.
   PubMed Web of Science ®Google Scholar
• Onodera Y, Teramura T, Takehara T, et al. Hyaluronic acid regulates a key redox control factor Nrf2 via phosphorylation of Akt in bovine articular chondrocytes. FEBS Open Bio. 2015;5(1):476–84.
   PubMedGoogle Scholar
• Hinoi E, Takarada T, Fujimori S, et al. Nuclear factor E2 p45-related factor 2 negatively regulates chondrogenesis. Bone. 2007;40(2):337–44.
   PubMed Web of Science ®Google Scholar
• Kim KM, Song JD, Chung HT, et al. Protein kinase CK2 mediates peroxynitrite-induced heme oxygenase-1 expression in articular chondrocytes. Int J Mol Med. 2012;29(6):1039.
   PubMed Web of Science ®Google Scholar
• Rubio N, Verrax J, Dewaele M, et al. p38MAPK-regulated induction of p62 and NBR1 after photodynamic therapy promotes autophagic clearance of ubiquitin aggregates and reduces reactive oxygen species levels by supporting Nrf2–antioxidant signaling. Free Radic Biol Med. 2014;67:292–303. https://doi.org/10.1016/j.freeradbiomed.2013.11.010
   PubMed Web of Science ®Google Scholar
• Hawkins KE, Joy S, Delhove JM, et al. NRF2 orchestrates the metabolic shift during induced pluripotent stem cell reprogramming. Cell reports. 2016;14(8):1883–91.
   PubMed Web of Science ®Google Scholar
• Garcia‐Carbonell R, Divakaruni AS, Lodi A, et al. Critical Role of Glucose Metabolism in Rheumatoid Arthritis Fibroblast‐like Synoviocytes. Arthritis Rheumatol. 2016;68(7):1614–26.
   PubMed Web of Science ®Google Scholar
• Jimi E, Phillips RJ, Rincon M, et al. Activation of NF-κB promotes the transition of large, CD43+ pre-B cells to small, CD43− pre-B cells. Int Immunol. 2005;17(6):815–25.
   PubMed Web of Science ®Google Scholar
• Kaileh M, Sen R. NF‐κB function in B lymphocytes. Immunol Rev. 2012;246(1):254–71.
   PubMedGoogle Scholar
• Hu H, Wu X, Jin W, et al. Noncanonical NF-κB regulates inducible costimulator (ICOS) ligand expression and T follicular helper cell development. Proceedings of the National Academy of Sciences. 2011;108(31):12827–32.
   PubMed Web of Science ®Google Scholar
• Li T, Morgan MJ, Choksi S, et al. MicroRNAs modulate the noncanonical transcription factor NF-[kappa] B pathway by regulating expression of the kinase IKK [alpha] during macrophage differentiation. Nat Immunol. 2010;11(9):799–805.
   PubMed Web of Science ®Google Scholar
• Kew RR, Penzo M, Habiel DM, et al. The IKKα-Dependent NF-κB p52/RelB Noncanonical Pathway Is Essential To Sustain a CXCL12 Autocrine Loop in Cells Migrating in Response to HMGB1. J Immunol. 2012;188(5):2380–6. https://doi.org/10.4049/jimmunol.1102454.
   PubMed Web of Science ®Google Scholar
• Maddur MS, Miossec P, Kaveri SV, et al. Th17 cells: biology, pathogenesis of autoimmune and inflammatory diseases, and therapeutic strategies. The American journal of Pathology. 2012;181(1):8–18.
   PubMed Web of Science ®Google Scholar
• Li L, Ruan Q, Hilliard B, et al. Transcriptional regulation of the Th17 immune response by IKKα. The Journal of Experimental Medicine. 2011;208(4):787–96.
   PubMed Web of Science ®Google Scholar
• Lind EF, Ahonen CL, Wasiuk A, et al. Dendritic cells require the NF-κB2 pathway for cross-presentation of soluble antigens. J Immunol. 2008;181(1):354–63.
   PubMed Web of Science ®Google Scholar
• Schett G, Stach C, Zwerina J, et al. How antirheumatic drugs protect joints from damage in rheumatoid arthritis. Arthritis Rheum. 2008;58(10):2936–48.
   PubMedGoogle Scholar
• Ventura J-J, Kennedy NJ, Lamb JA, et al. c-Jun NH2-terminal kinase is essential for the regulation of AP-1 by tumor necrosis factor. Mol Cell Biol. 2003;23(8):2871–82.
   PubMed Web of Science ®Google Scholar
• Sirum-Connolly K, Brinckerhoff CE. lnterleukin-1 or phorbol induction of the stromelysin promoter requires an element that cooperates with AP-1. Nucleic Acids Res. 1991;19(2):335–41.
   PubMed Web of Science ®Google Scholar
• Morel JC, Park CC, Zhu K, et al. Signal transduction pathways involved in rheumatoid arthritis synovial fibroblast interleukin-18-induced vascular cell adhesion molecule-1 expression. J Biol Chem. 2002;277(38):34679–91.
   PubMed Web of Science ®Google Scholar
• Chen M, Boilard E, Nigrovic PA, et al. Predominance of cyclooxygenase 1 over cyclooxygenase 2 in the generation of proinflammatory prostaglandins in autoantibody‐driven K/BxN serum–transfer arthritis. Arthritis Rheum. 2008;58(5):1354–65.
   PubMedGoogle Scholar
• Jain A, Lamark T, Sjøttem E, et al. p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription. J Biol Chem. 2010;285(29):22576–91.
   PubMed Web of Science ®Google Scholar
• Ichihara S, Yamada Y, Liu F, et al. Ablation of the transcription factor Nrf2 promotes ischemia-induced neovascularization by enhancing the inflammatory response. Arterioscler Thromb Vasc Biol. 2010;30(8): 1553–61.
   PubMed Web of Science ®Google Scholar