Expanding horizons in breast and prostate cancer prevention and early detection

References

• Miller , BA , Ries , LAG , Hankey , BF , Kosary , CL and Edwards , BK , eds. 1992 . Cancer Statistics Review: 1973‐1989 , NIH Pub. No.92‐2789 Bethesda, MD : National Cancer Institute .
   Google Scholar
• Rutqvist , LE , Miller , AB Andersson , I . 19901 . Reduced breast‐cancer mortality with mammography screening —an assessment of currently available data . Int J Cancer , 5 : 76 – 84 .
   Google Scholar
• Rose , DP , Boyar , AP and Wynder , EL . 1986 . International comparisons of mortality rates for cancer of the breast, ovary, prostate, and colon and per capita food consumption . Cancer , 58 : 2363 – 2371 .
   PubMed Web of Science ®Google Scholar
• Muir , CS , Waterhouse , J Mack , TM . 1987 . Cancer In‐’ cidence in Five Continents , Volume V. , Lyon, , France : WHO International Agency for Research in Cancer .
   Google Scholar
• Kurihara , M , Aoki , K and Tominaga , S . 1984 . Cancer Mortality Statistics in the World , Nagoya, , Japan : University of Nagoya Press .
   Google Scholar
• National Academy of Sciences, National Research Council, Commission on Life Sciences . 1989 . Diet and Health. Implications for Reducing Chronic Disease Risk , Washington, DC : National Academy Press .
   Google Scholar
• Prentice , RL , Kakar , F Hursting , SD . 1988 . Aspects of the rationale for the Womens’ Health Trial . J Natl Cancer Inst , 80 : 802 – 814 .
   PubMed Web of Science ®Google Scholar
• Albanes , D . 1990 . Energy balance, body size, and cancer . Crit Rev Oncol Hematol , 10 : 283 – 303 .
   PubMedGoogle Scholar
• Steinmetz , KA and Potter , JD . 1991 . Vegetables, fruit, and cancer. I. Epidemiology . Cancer Causes Control , 2 : 325 – 357 .
   PubMed Web of Science ®Google Scholar
• Rose , DP . 1992 . Dietary fiber, phytoestrogens, and breast cancer . Nutrition , 8 : 47 – 51 .
   PubMed Web of Science ®Google Scholar
• Adlercreutz , H , Mousavi , Y and Hockerstedt , K . 1992 . Diet and breast cancer . Acta Oncologica , 31 : 175 – 181 .
   PubMed Web of Science ®Google Scholar
• Block , G . 1991 . Vitamin C and cancer prevention: The epidemiologic evidence . Am J Clin Nutr , 53 : 270s – 282s .
   PubMed Web of Science ®Google Scholar
• Albanes , D , Blair , A and Taylor , PR . 1989 . Physical activity and risk of cancer in the NHANES I population . Am J Public Health , 79 : 744 – 750 .
   PubMed Web of Science ®Google Scholar
• Bernstein , L , Ross , RK Lobo , RA . 1987 . The effects of moderate physical activity on menstrual cycle patterns in adolescence: Implications for breast cancer prevention . Br J Cancer , 55 : 681 – 685 .
   PubMed Web of Science ®Google Scholar
• Hiatt , RA . 1990 . Alcohol consumption and breast cancer . Med Oncol Tumor Pharmacother , 7 : 143 – 151 .
   PubMedGoogle Scholar
• Longnecker , MP , Berlin , JA Orza , MJ . 1988 . A meta‐analysis of alcohol consumption in relation to risk of breast cancer . JAMA , 260 : 652 – 656 .
   PubMed Web of Science ®Google Scholar
• Boring , CC , Squires , TS and Tong , T . 1992 . Cancer statistics, 1992 . CA , 42 : 19 – 38 .
   Google Scholar
• Hursting , SD , Thornquist , M and Henderson , MM . 1990 . Types of dietary fat and the incidence of cancer at five sites . Prev Med , 19 : 242 – 253 .
   PubMed Web of Science ®Google Scholar
• Rose , DP . 1990 . Dietary fiber and breast cancer . Nutr Cancer , 13 : 1 – 8 .
   PubMed Web of Science ®Google Scholar
• Howe , GR , Hirohata , T Hislop , TG . 1990 . Dietary factors and risk of breast cancer: Combined analysis of 12 case‐control studies . J Natl Cancer Inst , 82 : 561 – 569 .
   PubMed Web of Science ®Google Scholar
• Schatzkin , A , Greenwald , P Byar , DP . 1989 . The dietary fat‐breast cancer hypothesis is alive . JAMA , 261 : 3284 – 3287 .
   PubMed Web of Science ®Google Scholar
• Willett , WC , Stampfer , MJ Colditz , GA . 1987 . Dietary fat and the risk of breast cancer . N Engl J Med , 316 : 22 – 28 .
   PubMed Web of Science ®Google Scholar
• Willett , WC , Hunter , DJ Stampfer , MJ . 1992 . Dietary fat and fiber in relation to risk of breast cancer—an 8‐year follow‐up . JAMA , 268 : 2037 – 2044 .
   PubMed Web of Science ®Google Scholar
• Howe , GR , Friedenreich , CM Jain , M . 1991 . A cohort study of fat intake and risk of breast cancer . J Natl Cancer Inst , 83 : 336 – 340 .
   PubMed Web of Science ®Google Scholar
• Kushi , LH , Sellers , TA Potter , JD . 1992 . Dietary fat and postmenopausal breast cancer . J Natl Cancer Inst , 84 : 1092 – 1099 .
   PubMedGoogle Scholar
• Knekt , P , Albanes , D Seppanen , R . 1990 . Dietary fat Breast and prostate cancer prevention and early detection and risk of breast cancer . Am J Clin Nutr , 52 : 903 – 908 .
   PubMed Web of Science ®Google Scholar
• Jones , DY , Schatzkin , A Green , SB . 1987 . Dietary fat and breast cancer in the National Health and Nutrition Examination Survey I Epidemiologic Follow‐up Study . J Natl Cancer Inst , 79 : 465 – 171 .
   PubMed Web of Science ®Google Scholar
• Howe , GR . 1992 . High‐fat diets and breast cancer risk: The epidemiologic evidence . JAMA , 268 : 2080 – 2081 .
   PubMed Web of Science ®Google Scholar
• Rose , DP and Connolly , JM . 1990 . Dietary prevention of breast cancer . Med Oncol Tumor Pharmacother , 7 : 121 – 130 .
   Google Scholar
• Bang , HO , Dyerberg , J and Hjorne , N . 1976 . The composition of food consumed by Greenland Eskimos . Acta Med Scand , 200 : 69 – 73 .
   PubMed Web of Science ®Google Scholar
• Kromann , N and Green , A . 1980 . Epidemiological studies in the Upemavik District, Greenland: Incidence of some chronic diseases 1950‐1974 . Acta Med Scand , 208 : 401 – 406 .
   PubMed Web of Science ®Google Scholar
• Kaizer , N , Boyd , NF and Tritchler , D . 1989 . Fish consumption and breast cancer risk: An ecological study . Nutr Cancer , 12 : 61 – 68 .
   PubMed Web of Science ®Google Scholar
• Taioli , E , Nicolosi , A and Wynder , EL . 1991 . Dietary habits and breast cancer: A comparative study of United States and Italian data . Nutr Cancer , 16 : 259 – 265 .
   PubMed Web of Science ®Google Scholar
• Cohen , LA , Thompson , DO Maeura , Y . 1986 . Dietary fat and mammary cancer. I. Promoting effects of different dietary fats on n‐nitrosomethylurea‐induced rat mammary tumorigenesis . J Natl Cancer Inst , 77 : 33 – 42 .
   PubMed Web of Science ®Google Scholar
• Willett , WC . 1990 . Epidemiologic studies of diet and cancer . Med Oncol Tumor Pharmacother , 7 : 93 – 97 .
   PubMedGoogle Scholar
• Willett , WC , Stampfer , MJ Colditz , GA . 1990 . Relation of meat, fat, and their fiber intake to the risk of colon cancer in a prospective study among women . N Engl J Med , 323 : 1664 – 1672 .
   PubMed Web of Science ®Google Scholar
• Kesteloot , H , Lesaffre , E and Joossens , JV . 1991 . Dairy fat, saturated animal fat, and cancer risk . Prev Med , 20 : 226 – 236 .
   PubMed Web of Science ®Google Scholar
• Goodwin , PJ and Boyd , NF . 1987 . Critical appraisal of the evidence that dietary fat intake is related to breast cancer risk in humans . J Natl Cancer Inst , 79 : 473 – 485 .
   PubMed Web of Science ®Google Scholar
• 1986 . Diet, Nutrition, and Cancer: A Critical Evaluation, Volume I Macronutrients and Cancer , Boca Raton : CRC Press, Inc. .
   Google Scholar
• Welsch , CW . 1987 . Enhancement of mammary tumorigenesis by dietary fat: Review of potential mechanisms . Am J Clin Nutr , 45 : 192 – 202 .
   PubMed Web of Science ®Google Scholar
• Longcope , C , Gorbach , S Goldin , B . 1987 . The effect of a low fat diet on estrogen metabolism . J Clin En‐docrinol Metab , 64 : 1246 – 1250 .
   PubMed Web of Science ®Google Scholar
• Musey , PI , Collins , DC Bradlow , HL . 1987 . Effect of diet on oxidation of 17 beta‐estradiol in vivo . J Clin Endocrinol Metab , 65 : 792 – 795 .
   PubMed Web of Science ®Google Scholar
• Shankar , S and Lanza , E . 1991 . Dietary fiber and cancer prevention . Hematol Oncol Clin North Am , 5 : 25 – 41 .
   PubMed Web of Science ®Google Scholar
• Willett , WC , Stampfer , MJ Colditz , GA . 1987 . Moderate alcohol consumption and the risk of breast cancer . N Engl J Med , 316 : 1174 – 1180 .
   PubMed Web of Science ®Google Scholar
• Howe , G , Rohan , T Decarli , A . 1991 . The association between alcohol and breast cancer risk: Evidence from the combined analysis of six dietary case‐control studies . Int J Cancer , 47 : 707 – 710 .
   PubMed Web of Science ®Google Scholar
• Morabia , A and Wynder , EL . 1990 . Epidemiology and natural history of breast cancer . Surg Clin North Am , 70 : 739 – 752 .
   PubMed Web of Science ®Google Scholar
• Frisch , RE , Wyshak , G Albright , NL . 1985 . Lower prevalence of breast cancer and cancers of the reproductive system among former college athletes compared to non‐athletes . Br J Cancer , 52 : 885 – 891 .
   PubMed Web of Science ®Google Scholar
• Boone , CW , Kelloff , GJ and Malone , WF . 1990 . Identification of candidate cancer chemopreventive agents and their evaluation in animal models and human clinical trials: A review . Cancer Res , 50 : 2 – 9 .
   PubMed Web of Science ®Google Scholar
• Ratko , TA , Detrisac , CJ Dinger , NM . 1989 . Chemopreventive efficacy of combined retinoid and tamoxifen treatment following surgical excision of a primary mammary cancer in female rats . Cancer Res , 49 : 4472 – 4476 .
   PubMed Web of Science ®Google Scholar
• Early Breast Cancer Trialists’ Collaborative Group . 1988 . Effects of adjuvant tamoxifen and of cytotoxic therapy on mortality in early breast cancer . N Engl J Med , 319 : 1681 – 1692 .
   PubMed Web of Science ®Google Scholar
• Vanchieri , C . 1992 . Breast cancer prevention study initiated in Italy . J Natl Cancer Inst , 84 : 1555 – 1556 .
   PubMed Web of Science ®Google Scholar
• Costa , A , Veronesi , U , De Palo , G , Chiesa , F , Formelli , F , Marubini , E , Del Vecchio , M and Nava , M . 1992 . “ Chemoprevention of cancer with the synthetic retinoid fen‐retinide clinical trials in progress at the Milan Cancer Institute ” . In Cancer Chemoprevention , Edited by: Wattenberg , L , Lipkin , M , Boone , CW and Kelloff , GJ . 95 – 112 . Boca Raton : CRC Press, Inc. .
   Google Scholar
• Seidman , H , Gelb , SK Silverberg , E . 1987 . Survival experience in the Breast Cancer Detection Demonstration Project . 37 : 258 – 290 .
   Google Scholar
• Tabar , L , Gad , A Holmberg , LH . 1985 . Reduction in mortality from breast cancer after mass screening with mammography . Lancet , 1 : 829 – 832 .
   PubMed Web of Science ®Google Scholar
• Tabor , L , Fagerberg , G Duffy , SW . 1989 . The Swedish two‐county trial of mammographic screening for breast cancer: Recent results and calculation of benefit . J Epidemiol Community Health , 43 : 107 – 114 .
   PubMed Web of Science ®Google Scholar
• Tabar , L , Fagerberg , G Duffy , SW . 1992 . Update of the Swedish two‐county program of mammographic screening for breast cancer . Radiol Clin North Am , 30 : 187 – 210 .
   PubMed Web of Science ®Google Scholar
• Duffy , SW , Tabar , L Fagerberg , G . 1991 . Breast screening, prognostic factors and survival—results from the Swedish two‐county study . Br J Cancer , 64 : 1133 – 1138 .
   PubMed Web of Science ®Google Scholar
• Andersson , I , Aspergren , K Janzon , L . 1988 . Mammographic screening and mortality from breast cancer; The Malmo mammographic screening trial . Br Med , 7297 : 943 – 948 .
   Google Scholar
• Frisell , J , Eklund , G Hellstrom , L . 1991 . Randomized study of mammography screening—preliminary report on mortality in the Stockholm trial . Breast Cancer Res Treat , 18 : 49 – 56 .
   PubMed Web of Science ®Google Scholar
• Chamberlain , J , Coleman , D Ellman , R . 1988 . First results on mortality reduction in the UK trial of early detection of breast cancer . Lancet , II : 411 – 416 .
   Google Scholar
• Roberts , MM , Alexander , FE Anderson , TJ . 1990 . Edinburgh trial of screening for breast cancer: Mortality at seven years . Lancet , 335 : 241 – 246 .
   PubMed Web of Science ®Google Scholar
• Nattinger , AB and Goodwin , JS . 1992 . Screening mammogra‐phy for older women . Arch Intern Med , 152 : 922 – 925 .
   PubMed Web of Science ®Google Scholar
• Costanza , ME . 1992 . Breast cancer screening in older women—synopsis of a forum . Cancer , 69 : 1925 – 1931 .
   PubMed Web of Science ®Google Scholar
• Chu , KC , Smart , CR and Tarone , RE . 1988 . Analysis of breast cancer mortality and stage distribution by age for the Health Insurance Plan Clinical Trial . J Natl Cancer Inst , 80 : 1125 – 1132 .
   PubMed Web of Science ®Google Scholar
• Miller , AB , Baines , CJ To , T . 1992 . Canadian National Breast Screening Study: 1. Breast cancer detection and death rates among women aged 40 to 49 years . Can Med Assoc J , 147 : 1459 – 1476 .
   PubMedGoogle Scholar
• Miller , AB , Baines , CJ To , T . 1992 . Canadian National Breast Screening Study: 2. Breast cancer detection and death rates among women aged 50 to 59 years . Can Med Assoc J , 147 : 1477 – 1488 .
   PubMedGoogle Scholar
• Baines , CJ , Miller , AB Kopans , DB . 1990 . Canadian National Breast Screening Study: Assessment of technical quality by external review . Am J Roentgenol , 155 : 743 – 747 .
   PubMed Web of Science ®Google Scholar
• Miller , AB , Warren , L Kopans , DB . 1992 . Re: Author of Canadian breast cancer study retracts warnings . J Natl Cancer Inst , 84 : 1365 – 1371 .
   Google Scholar
• Grumbach , Y and Nguyen , HT . 1991 . Mammography in younger women . Curr Opin Radiol , 3 : 602 – 610 .
   Google Scholar
• Hendrick , RE . 1991 . What primary care physicians should know about radiation exposure, image quality, and accreditation of mammography providers . Women's Health Issues , 1 : 79 – 85 .
   Google Scholar
• Miller , AB , Howe , GR Sherman , GJ . 1989 . Mortality from breast cancer after irradiation during fluoro‐scopic examinations in patients being treated for tuberculosis . N Engl J Med , 321 : 1285 – 1289 .
   PubMed Web of Science ®Google Scholar
• Boice , JD , Monson , RR and Rosenstein , M . 1981 . Cancer mortality in women after repeated fluoroscopic examinations of the chest . J Natl Cancer Inst , 66 : 863 – 867 .
   PubMed Web of Science ®Google Scholar
• Shore , RE , Hildreth , N Woodard , E . 1986 . Breast cancer among women given x‐ray therapy for acute post‐partum mastitis . J Natl Cancer Inst , 77 : 689 – 696 .
   PubMed Web of Science ®Google Scholar
• Tokunaga , M , Land , CE and Tokuoka , S . 1991 . Follow‐up studies of breast cancer incidence among atomic bomb survivors . J Radiat Res , : 201 – 211 .
   Google Scholar
• Feig , SA and Ehrlich , SM . 1990 . Estimation of radiation risk from screening mammography: Recent trends and comparison with expected benefits . Radiology , 174 : 638 – 647 .
   Google Scholar
• Alcorn , FS . 1990 . Value of mammographic screening: Assessment of studies and opinion . Radiographics , 10 : 1133 – 1139 .
   Google Scholar
• Peeters , PHM , Verbeek , ALM Zielhuis , GA . 1990 . Breast cancer screening in women over age 50 . Acta Radiol , 31 : 225 – 231 .
   Google Scholar
• Liff , JM , Sung , JFC Chow , W‐H . 1991 . Does increased detection account for the rising incidence of breast cancer? . Am J Public Health , 81 : 462 – 465 .
   Google Scholar
• White , E , Lee , CY and Kristal , AR . 1990 . Evaluation of the increase in breast cancer incidence in relation to mammography use . J Natl Cancer Inst , 82 : 1546 – 1552 .
   PubMed Web of Science ®Google Scholar
• Kessler , LG . 1992 . The relationship between age and incidence of breast cancer . Cancer , 69 : 1896 – 1903 .
   Google Scholar
• Kessler , LG , Feuer , EJ and Brown , ML . 1991 . projections of the breast cancer burden to U.S. women: 1990‐2000 . Prev Med , 20 : 170 – 182 .
   PubMed Web of Science ®Google Scholar
• Centers for Disease Control (CDC) . 1989 . Trends in screening mammograms for women 50 years of age and older—Behavioral Risk Factor Surveillance System, 1987 . MMWR , 38 : 137 – 140 .
   Google Scholar
• Bailar , JC . 1976 . Mammography. A contrary view . Ann Intern Med , 84 : 77
   PubMed Web of Science ®Google Scholar
• Breen , N and Kessler , L . 1992 . Increases in screening mammography: U.S. women 40 and older . J Natl Cancer Inst , 84 : 1549
   Google Scholar
• Romans , MC , Marchant , DJ Pearse , Wh . 1991 . Utilization of screening mammography—1990 . Women's Health Issues , 1 : 68 – 73 .
   PubMedGoogle Scholar
• Centers for Disease Control (CDC) . 1990 . Use of mammography‐United States, 1990 . Morb Mortal Wkly Rep , 39 : 621 – 630 .
   Google Scholar
• Howe , HL . 1992 . Repeat mammography among women over 50 years of age . Am J Prev Med , 8 : 182 – 185 .
   Google Scholar
• Grady , KE , Lemkau , JP McVay , JM . 1992 . The importance of physician encouragement in breast cancer screening in older women . Prev Med , 21 : 766 – 780 .
   PubMed Web of Science ®Google Scholar
• American Cancer Society . 1990 . 1989 Survey of physicians’ attitudes and practices in early cancer detection . CA , 40 : 77 – 101 .
   Google Scholar
• Moskowitz , M . 1992 . Guidelines for screening for breast cancer . Radiol Clin North Am , 30 : 221 – 233 .
   PubMedGoogle Scholar
• Costanza , ME , Stoddard , AM Zapka , JG . 1992 . Physician compliance with mammography guidelines: Barriers and enhancers . J Am Board Fam. Pract , 5 : 143 – 152 .
   PubMedGoogle Scholar
• Kozlowski , JM , Ellis , WJ and Grayhack , JT . 1991 . Advanced prostatic carcinoma: Early versus late endocrine therapy . Urol Clin North Am , 18 : 15 – 24 .
   PubMed Web of Science ®Google Scholar
• Bracken , G and Geller , J . 1991 . Imperato‐McGinley J, et al: One‐year experience in the treatment of benign prostatic hyperplasia with finasteride . J Androl , 12 : 372 – 375 .
   PubMed Web of Science ®Google Scholar
• Imperato‐McGinley , J , Shackleton , C Orlic , S . 1990 . C19 and C21 5B/5a metabolite ratios in subjects treated with the 5a‐reductase inhibitor finasteride: Comparison of male pseudohermaphrodites with inherited 5a‐reductase deficiency . J Clin Endocrinol Metab , 70 : 777 – 782 .
   PubMed Web of Science ®Google Scholar
• Stoner , E , Bracken , RB Stein , E . 1992 . The clinical effects of a 5α‐reductase inhibitor, finasteride, on benign prostatic hyperplasia . J Urol , 147 : 1298 – 1302 .
   PubMed Web of Science ®Google Scholar
• Gormley , GJ , Stoner , E Bruskewitz , RC . 1992 . The effect of finasteride in men with benign prostate hyperplasia . N Engl J Med , 327 : 1185 – 1191 .
   PubMed Web of Science ®Google Scholar
• Fair , WR , Presti , JC Jr. Sogani , P . 1991 . Multicen‐ter, randomized, double‐blind, placebo controlled study to investigate the effect of finasteride (MK‐906) on stage D prostate cancer . J Urol , 145 : 317A
   Google Scholar
• Stoner , E . 1990 . The clinical development of a 5a‐reduc‐tase inhibitor, finasteride . J Steroid Biochem Mol Biol , 37 : 375 – 378 .
   PubMed Web of Science ®Google Scholar
• Littrup , PJ , Lee , F and Mettlin , C . 1992 . Prostate cancer screening: Current trends and future implications . CA , 42 : 198 – 211 .
   Google Scholar
• Optenberg , SA and Thompson , IM . 1990 . Economics of screening for carcinoma of the prostate . Urol Clin North Am , 17 : 719 – 737 .
   PubMed Web of Science ®Google Scholar
• Epstein , BE and Hanks , GE . 1992 . Prostate cancer: Evaluation and radiotherapeutic management . CA , 42 : 223 – 240 .
   Google Scholar
• Lee , F and Littrup , PJ . 1988 . Torp‐Pedersen ST, et al: Prostate cancer: Comparison of transrectal US and digital rectal examination for screening . Radiology , 168 : 389 – 394 .
   PubMed Web of Science ®Google Scholar
• Oesterling , JE . 1992 . Prostate‐specific antigen—Improving its ability to diagnose early prostate cancer . JAMA , 267 : 2236 – 2238 .
   PubMed Web of Science ®Google Scholar
• Catalona , WJ , Smith , DS Ratliff , TL . 1991 . Measurement of prostate‐specific antigen in serum as a screening test for prostate cancer . N Engl J Med , 324 : 1156 – 1161 .
   PubMed Web of Science ®Google Scholar
• Brawer , MK , Chetner , MP Beatie , J . 1992 . Screening for prostatic carcinoma with prostate specific antigen . J Urol , 147 : 841 – 845 .
   PubMed Web of Science ®Google Scholar
• Cooner , WH , Mosley , RB Rutherford , CL Jr. 1990 . Prostate cancer detection in a clinical urological practice by ultrasonography, digital rectal examination and prostate specific antigen . J Urol , 143 : 1146 – 1152 .
   PubMed Web of Science ®Google Scholar
• Mettlin , C , Lee , F Drago , J . 1991 . The American Cancer Society National Prostate Cancer Detection Project—Findings on the detection of early prostate cancer in 2,425 men . Cancer , 67 : 2949 – 2958 .
   PubMed Web of Science ®Google Scholar
• Babaian , RJ , Mettlin , C Kane , R . 1992 . The relationship of prostate‐specific antigen to digital rectal examination and transrectal ultrasonography . Cancer , 69 : 1195 – 1200 .
   PubMed Web of Science ®Google Scholar
• Gerber , GS and Chodak , GW . 1991 . Routine screening for cancer of the prostate . J Natl Cancer Inst , 83 : 329 – 335 .
   PubMedGoogle Scholar
• Meyskens , FL Jr. 1988 . Evolution of cancer prevention and control program at the Arizona Cancer Center . J Natl Cancer Inst , 80 : 1595 – 1598 .
   Google Scholar
• Delivered October 2, 1992 at the 26th Annual Meeting of the AACE in Buffalo, New York.
   Google Scholar
• Director, Division of Cancer Prevention and Control, National Cancer Institute.
   Google Scholar
• Division of Cancer Prevention and Control, National Cancer Institute.
   Google Scholar