904
Views
23
CrossRef citations to date
0
Altmetric
Laboratory Studies

L-Carnitine Ameliorates Glycerol-Induced Myoglobinuric Acute Renal Failure in Rats

, , , , &
Pages 124-133 | Received 26 Aug 2008, Accepted 04 Nov 2008, Published online: 07 Jul 2009

REFERENCES

  • Zager RA. Rhabdomyolysis and myohemoglobinuric acute renal failure. Kidney Int. 1996; 49: 314–326
  • Vanholder R, Sever MS, Erek E, Lameire N. Rhabdomyolysis. J Am Soc Nephrol. 2000; 11: 1553–1561
  • Abassi ZA, Hoffman A, Better OS. Acute renal failure complicating muscle crush injury. Semin Nephrol. 1998; 18: 558–565
  • Ustundag S, Yalcin O, Sen S, Cukur Z, Ciftci S, Demirkan B. Ren Fail. 2008; 30: 727–735
  • Stefanovic V, Savic V, Vlahovic P, Cvetkovic T, Najman S, Mitic-Zlatkovic M. Reversal of experimental myoglobinuric acute renal failure with bioflavonoids from seeds of grape. Ren Fail. 2000; 22: 255–266
  • Chander V, Chopra K. Molsidomine, a nitric oxide donor and L-arginine protects against rhabdomyolysis-induced myoglobinuric acute renal failure. Biochim Biophys Acta. 2005; 1723: 208–214
  • Paller MS, Hoidal JR, Ferris TF. Oxygen free radicals in ischemic acute renal failure in the rat. J Clin Invest. 1984; 74: 1156–1164
  • Emerit J, Beaumont C, Trivin F. Iron metabolism, free radicals, and oxidative injury. Biomed Pharmacother. 2001; 55: 333–339
  • Paller MS, Hedlund BE. Role of iron in postischemic renal injury in the rat. Kidney Int. 1988; 34: 474–480
  • Galaris D, Korantzopoulos P. On the molecular mechanism of metmyoglobin-catalyzed reduction of hydrogen peroxide by ascorbate. Free Radic Biol Med. 1997; 22: 657–667
  • Di Lisa F, Barbato R, Manebo R, Siliprandi N. Carnitine and carnitine esters in mitochondrial metabolism and function. The carnitine system. A new therapeutical approach to cardiovascular diseases, JW De Jong, R Ferrari. Kluwer Academic Publishers, Dordrecth 1995; 21–38
  • Mayes PA. Lipids of physiologic significance. Harper's Biochemistry, RK Murray, DK Granner, PA Mayes, VW Rodwell. Stamford, Appleton and Lange 2000; 160–171
  • Arduini A. Carnitine and its acyl esters as secondary antioxidants?. Am Heart J. 1992; 123: 1726–1727
  • Gülç I. Antioxidant and antiradical activities of L-carnitine. Life Sci. 2006; 78: 803–811
  • Sener G, Ekşioğlu-Demiralp E, Cetiner M, et al. L-Carnitine ameliorates methotrexate-induced oxidative organ injury and inhibits leukocyte death. Cell Biol Toxicol. 2006; 22: 47–60
  • Boonsanit D, Kanchanapangka S, Buranakarl C. L-carnitine ameliorates doxorubicin-induced nephrotic syndrome in rats. Nephrology. 2006; 11: 313–320
  • Origlia N, Migliori M, Panichi V, et al. Protective effect of L-propionylcarnitine in chronic cyclosporine-a induced nephrotoxicity. Biomed Pharmacother. 2006; 60: 77–81
  • Görür S, Bağdatoğlu OT, Polat G. Protective effect of L-carnitine on renal ischaemia-reperfusion injury in the rat. Cell Biochem Funct. 2005; 23: 151–155
  • Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979; 95: 351–358
  • Aebi H. Catalase in vitro. Methods Enzymol. 1984; 105: 121–126
  • Shah SV, Walker PD. Evidence suggesting a role for hydroxyl radical in glycerol-induced acute renal failure. Am J Physiol. 1988; 255: F438–F443
  • McHowat J, Yamada KA, Saffitz JE, Corr PB. Subcellular distribution of endogenous long chain acylcarnitines during hypoxia in adult canine myocytes. Cardiovasc Res. 1993; 27: 1237–1243
  • Vanella A, Russo A, Acquaviva R, et al. L -propionyl-carnitine as superoxide scavenger, antioxidant, and DNA cleavage protector. Cell Biol Toxicol. 2000; 16: 99–104
  • Rubanyi GM, Vanhoutte PM. Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor. Am J Physiol. 1986; 250: H822–H827
  • Valdivielso JM, López-Novoa JM, Eleno N, Pérez Barriocanal F. Role of glomerular nitric oxide in glycerol-induced acute renal failure. Can J Physiol Pharmacol. 2000; 78: 476–482
  • Alvarez de Sotomayor M, Bueno R, Pérez-Guerrero C, Herrera MD. Effect of L-carnitine and propionyl-L-carnitine on endothelial function of small mesenteric arteries from SHR. J Vasc Res. 2007; 44: 354–364
  • Paller MS. Hemoglobin- and myoglobin-induced acute renal failure in rats: Role of iron in nephrotoxicity. Am J Physiol. 1988; 255: F539–F544
  • Calò LA, Davis PA, Pagnin E, et al. Carnitine-mediated improved response to erythropoietin involves induction of haem oxygenase-1: Studies in humans and in an animal model. Nephrol Dial Transplant. 2008; 23: 890–895
  • Sever MS. The basic concepts. The crush syndrome, MS Sever. Karger, Basel 2005; 15–35
  • Rosenberger C, Goldfarb M, Shina A, et al. Evidence for sustained renal hypoxia and transient hypoxia adaptation in experimental rhabdomyolysis-induced acute kidney injury. Nephrol Dial Transplant. 2008; 23: 1135–1143
  • Evans AM, Fornasini G. Pharmacokinetics of L-carnitine. Clin Pharmacokinet. 2003; 42: 941–967
  • Bain MA, Faull R, Milne RW, Evans AM. Oral L-carnitine: metabolite formation and hemodialysis. Curr Drug Metab. 2006; 7: 811–816
  • Reuter SE, Faull RJ, Evans AM. L-carnitine supplementation in the dialysis population: Are Australian patients missing out?. Nephrology (Carlton). 2008; 13: 3–16
  • Ohshima H, Kawabata T. Mechanism of N-nitrosodimethylamine formation from trimethylamine and trimethylaminoxide. IARC Sci Publ. 1978; 19: 143–153
  • Simenhoff ML, Burke JF, Saukkonen JJ, Ordinario AT, Doty R. Biochemical profile or uremic breath. N Engl J Med. 1977; 297: 132–135
  • Rebouche CJ. Kinetics, pharmacokinetics, and regulation of L-carnitine and acetyl-L-carnitine metabolism. Ann N Y Acad Sci. 2004; 1033: 30–41
  • Moretti S, Alesse E, Di Marzio L, et al. Effect of L-carnitine on human immunodeficiency virus-1 infection-associated apoptosis: A pilot study. Blood. 1998; 91: 3817–3824
  • Moretti S, Famularo G, Marcellini S, et al. L-carnitine reduces lymphocyte apoptosis and oxidant stress in HIV-1-infected subjects treated with zidovudine and didanosine. Antioxid Redox Signal. 2002; 4: 391–403

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.