miR-136 improves renal fibrosis in diabetic rats by targeting down-regulation of tyrosine kinase SYK and inhibition of TGF-β1/Smad3 signaling pathway

References

• Hu J, Ye M, Zhou Z. Aptamers: novel diagnostic and therapeutic tools for diabetes mellitus and metabolic diseases. J Mol Med. 2017;95(3):249–256.
   PubMed Web of Science ®Google Scholar
• Sun X-Y, Qin H-J, Zhang ZE, et al. Valproate attenuates diabetic nephropathy through inhibition of endoplasmic reticulum stress induced apoptosis. Mol Med Rep. 2016;13(1):661–668.
   PubMed Web of Science ®Google Scholar
• Xu B-H, Sheng J, You Y-K, et al. Deletion of Smad3 prevents renal fibrosis and inflammation in type 2 diabetic nephropathy. Metab Clin Exp. 2020;103:154013.
   PubMed Web of Science ®Google Scholar
• Van Krieken R, Krepinsky JC. Caveolin-1 in the pathogenesis of diabetic nephropathy: potential therapeutic target? Curr Diab Rep. 2017;17(3):19.
   PubMed Web of Science ®Google Scholar
• Sender V, Lang L, Stamme C. Surfactant protein-A modulates LPS-induced TLR4 localization and signaling via beta-arrestin 2. PLoS One. 2013;8(3):e59896.
   PubMed Web of Science ®Google Scholar
• Wang S, Meng X-M, Ng Y-Y, et al. TGF-beta/Smad3 signalling regulates the transition of bone marrow-derived macrophages into myofibroblasts during tissue fibrosis. Oncotarget. 2016;7(8):8809–8822.
   PubMedGoogle Scholar
• Black LM, Lever JM, Agarwal A. Renal inflammation and fibrosis: a double-edged sword. J Histochem Cytochem. 2019;67(9):663–681.
   PubMed Web of Science ®Google Scholar
• Liu D, Mamorska-Dyga A. Syk inhibitors in clinical development for hematological malignancies. J Hematol Oncol. 2017;10(1):145.
   PubMedGoogle Scholar
• Bijli KM, Fazal F, Minhajuddin M, et al. Activation of Syk by protein kinase C-delta regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via tyrosine phosphorylation of RelA/p65. J Biol Chem. 2008;283(21):14674–14684.
   PubMed Web of Science ®Google Scholar
• Nemeth T, Virtic O, Sitaru C, et al. The Syk tyrosine kinase is required for skin inflammation in an in vivo mouse model of epidermolysis bullosa acquisita. J Invest Dermatol. 2017;137(10):2131–2139.
   PubMed Web of Science ®Google Scholar
• Yang WS, Chang JW, Han NJ, et al. Spleen tyrosine kinase mediates high glucose-induced transforming growth factor-beta1 up-regulation in proximal tubular epithelial cells. Exp Cell Res. 2012;318(15):1867–1876.
   PubMed Web of Science ®Google Scholar
• Tang PM-K, Zhang Y-Y, Mak TS-K, et al. Transforming growth factor-beta signalling in renal fibrosis: from Smads to non-coding RNAs. J Physiol (Lond). 2018;596(16):3493–3503.
   Google Scholar
• Li X-W, Feng L-X, Zhu X-J, et al. Human umbilical cord blood mononuclear cells protect against renal tubulointerstitial fibrosis in cisplatin-treated rats. Biomed Pharmacother. 2020;121:109310.
   PubMedGoogle Scholar
• Maity S, Muhamed J, Sarikhani M, et al. Sirtuin 6 deficiency transcriptionally up-regulates TGF-beta signaling and induces fibrosis in mice. J Biol Chem. 2020;10(25):1–35.
   Web of Science ®Google Scholar
• Fan Y, Chen H, Huang Z, et al. Emerging role of miRNAs in renal fibrosis. RNA Biol. 2020;17(1):1–12.
   PubMed Web of Science ®Google Scholar
• Liu L, Wang Y, Yan R, et al. BMP-7 inhibits renal fibrosis in diabetic nephropathy via miR-21 downregulation. Life Sci. 2019;238:116957.
   PubMed Web of Science ®Google Scholar
• Liu Y, Liu B, Liu Y, et al. MicroRNA expression profile by next-generation sequencing in a novel rat model of contrast-induced acute kidney injury. Ann Transl Med. 2019;7(8):178–178.
   PubMed Web of Science ®Google Scholar
• Metzinger-Le Meuth V, Metzinger L. miR-223 and other miRNA’s evaluation in chronic kidney disease: Innovative biomarkers and therapeutic tools. Noncoding RNA Res. 2019;4(1):30–35.
   PubMed Web of Science ®Google Scholar
• Harvey SJ, Jarad G, Cunningham J, et al. Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease. JASN. 2008;19(11):2150–2158.
   Web of Science ®Google Scholar
• Ho J, Ng KH, Rosen S, et al. Podocyte-specific loss of functional microRNAs leads to rapid glomerular and tubular injury. JASN. 2008;19(11):2069–2075.
   Web of Science ®Google Scholar
• Shi S, Yu L, Chiu C, et al. Podocyte-selective deletion of dicer induces proteinuria and glomerulosclerosis. JASN. 2008;19(11):2159–2169.
   Web of Science ®Google Scholar
• Chen P, Zhao L, Pan X, et al. Tumor suppressor microRNA-136-5p regulates the cellular function of renal cell carcinoma. Oncol Lett. 2018;15(4):5995–6002.
   PubMed Web of Science ®Google Scholar
• Joyce E, Glasner P, Ranganathan S, et al. Tubulointerstitial nephritis: diagnosis, treatment, and monitoring. Pediatr Nephrol. 2017;32(4):577–587.
   PubMed Web of Science ®Google Scholar
• Hewitson TD, Holt SG, Smith ER, et al. Progression of tubulointerstitial fibrosis and the chronic kidney disease phenotype - role of risk factors and epigenetics. Front Pharmacol. 2017;8:520.
   PubMed Web of Science ®Google Scholar
• Biernacka A, Dobaczewski M, Frangogiannis NG, et al. TGF-β signaling in fibrosis. Growth Factors. 2011;29(5):196–202.
   PubMed Web of Science ®Google Scholar
• Nakerakanti S. The role of TGF-β receptors in fibrosis. Open Rheumatol J. 2012;6(1):156–162.
   PubMedGoogle Scholar
• Yang WS, Kim J-S, Han NJ, et al. Toll-like receptor 4/spleen tyrosine kinase complex in high glucose signal transduction of proximal tubular epithelial cells. Cell Physiol Biochem. 2015;35(6):2309–2319.
   PubMedGoogle Scholar
• Zhang D, Wang J, Wang Z, et al. miR-136 modulates TGF-β1-induced proliferation arrest by targeting PPP2R2A in keratinocytes. Biomed Res Int. 2015;2015:1–8.
   Web of Science ®Google Scholar
• Yang Y, Liu L, Cai J, et al. Targeting Smad2 and Smad3 by miR-136 suppresses metastasis-associated traits of lung adenocarcinoma cells. Oncol Res. 2014;21(6):345–352.
   Web of Science ®Google Scholar