Glomerular C4 deposition and glomerulosclerosis predict worse renal outcomes in Chinese patients with IgA nephropathy

References

• Wyatt RJ, Julian BA. IgA nephropathy. N Engl J Med. 2013;368(25):2402–2414.
   PubMed Web of Science ®Google Scholar
• Goto M, Wakai K, Kawamura T, et al. A scoring system to predict renal outcome in IgA nephropathy: a nationwide 10-year prospective cohort study. Nephrol Dial Transplant. 2009;24(10):3068–3074.
   PubMed Web of Science ®Google Scholar
• Kawamura T, Joh K, Okonogi H, et al. A histologic classification of IgA nephropathy for predicting long-term prognosis: emphasis on end-stage renal disease. J Nephrol. 2013;26(2):350–357.
   PubMed Web of Science ®Google Scholar
• Magistroni R, D’Agati VD, Appel GB, et al. New developments in the genetics, pathogenesis, and therapy of IgA nephropathy. Kidney Int. 2015;88(5):974–989.
   PubMed Web of Science ®Google Scholar
• Lv J, Zhang H, Zhou Y, et al. Natural history of immunoglobulin A nephropathy and predictive factors of prognosis: a long-term follow up of 204 cases in China. Nephrology. 2008;13(3):242–246.
   PubMed Web of Science ®Google Scholar
• Berthoux F, Mohey H, Laurent B, et al. Predicting the risk for dialysis or death in IgA nephropathy. J Am Soc Nephrol. 2011;22(4):752–761.
   PubMed Web of Science ®Google Scholar
• Trimarchi H, Barratt J, Cattran DC, et al. Oxford Classification of IgA nephropathy 2016: an update from the IgA Nephropathy Classification Working Group. Kidney Int. 2017;91(5):1014–1021.
   PubMed Web of Science ®Google Scholar
• Suzuki H, Kiryluk K, Novak J, et al. The pathophysiology of IgA nephropathy. J Am Soc Nephrol. 2011;22(10):1795–1803.
   PubMed Web of Science ®Google Scholar
• Maillard N, Wyatt RJ, Julian BA, et al. Current understanding of the role of complement in IgA nephropathy. J Am Soc Nephrol. 2015;26(7):1503–1512.
   PubMed Web of Science ®Google Scholar
• Kiryluk K, Novak J, Gharavi AG. Pathogenesis of immunoglobulin A nephropathy: recent insight from genetic studies. Annu Rev Med. 2013;64(1):339–356.
   PubMedGoogle Scholar
• Pan M, Zhang J, Li Z, et al. Increased C4 and decreased C3 levels are associated with a poor prognosis in patients with immunoglobulin A nephropathy: a retrospective study. BMC Nephrol. 2017;18(1):231.
   PubMedGoogle Scholar
• Kim SJ, Koo HM, Lim BJ, et al. Decreased circulating C3 levels and mesangial C3 deposition predict renal outcome in patients with IgA nephropathy. PLoS One. 2012;7(7):e40495.
   PubMed Web of Science ®Google Scholar
• Espinosa M, Ortega RM, Sanchez M, et al. Association of C4d deposition with clinical outcomes in IgA nephropathy. Clin J Am Soc Nephrol. 2014;9(5):897–904.
   PubMed Web of Science ®Google Scholar
• Stevens LA, Claybon MA, Schmid CH, et al. Evaluation of the Chronic Kidney Disease Epidemiology Collaboration equation for estimating the glomerular filtration rate in multiple ethnicities. Kidney Int. 2011;79(5):555–562.
   PubMed Web of Science ®Google Scholar
• Smith SM, Hoy WE, Cobb L. Low incidence of glomerulosclerosis in normal kidneys. Arch Pathol Lab Med. 1989;113(11):1253–1255.
   PubMed Web of Science ®Google Scholar
• Xie J, Kiryluk K, Wang W, et al. Predicting progression of IgA nephropathy: new clinical progression risk score. PLoS One. 2012;7(6):e38904.
   PubMed Web of Science ®Google Scholar
• Le W, Liang S, Hu Y, et al. Long-term renal survival and related risk factors in patients with IgA nephropathy: results from a cohort of 1155 cases in a Chinese adult population. Nephrol Dial Transplant. 2012;27(4):1479–1485.
   PubMed Web of Science ®Google Scholar
• Zhu B, Zhu C, Lin Y, et al. Clinical characteristics of IgA nephropathy associated with low complement 4 levels. Ren Fail. 2015;37(3):424–432.
   PubMed Web of Science ®Google Scholar
• Bi TD, Zheng JN, Zhang JX, et al. Serum complement C4 is an important prognostic factor for IgA nephropathy: a retrospective study. BMC Nephrol. 2019;20(1):244.
   PubMedGoogle Scholar
• Min P, Qiongxiu Z, Shubei Z, et al. Serum C3/C4 ratio is a novel predictor of renal prognosis in patients with IgA nephropathy: a retrospective study. Immunol Res. 2018;66:381–391.
   PubMed Web of Science ®Google Scholar
• Komatsu H, Fujimoto S, Hara S, et al. Relationship between serum IgA/C3 ratio and progression of IgA nephropathy. Intern Med. 2004;43(11):1023–1028.
   PubMed Web of Science ®Google Scholar
• Maeng Y, Kim M, Park J, et al. Glomerular and tubular C4d depositions in IgA nephropathy: relations with histopathology and with albuminuria. Int J Clin Exp Pathol. 2013;6(5):904–910.
   PubMed Web of Science ®Google Scholar
• Pilely K, Skjoedt MO, Nielsen C, et al. A specific assay for quantification of human C4c by use of an anti-C4c monoclonal antibody. J Immunol Methods. 2014;405:87–96.
   PubMed Web of Science ®Google Scholar
• Roos A, Rastaldi MP, Calvaresi N, et al. Glomerular activation of the lectin pathway of complement in IgA nephropathy is associated with more severe renal disease. J Am Soc Nephrol. 2006;17(6):1724–1734.
   PubMed Web of Science ®Google Scholar
• Liu LL, Liu N, Chen Y, et al. Glomerular mannose-binding lectin deposition is a useful prognostic predictor in immunoglobulin A nephropathy. Clin Exp Immunol. 2013;174(1):152–160.
   PubMed Web of Science ®Google Scholar
• Lee HJ, Choi SY, Jeong KH, et al. Association of C1q deposition with renal outcomes in IgA nephropathy. Clin Nephrol. 2013;80(2):98–104.
   PubMed Web of Science ®Google Scholar
• Berger SP, Roos A, Daha MR. Complement and the kidney: what the nephrologist needs to know in 2006? Nephrol Dial Transplant. 2005;20(12):2613–2619.
   PubMed Web of Science ®Google Scholar
• Liu Y, Zhang Y, Liu D, et al. Prediction of ESRD in IgA nephropathy patients from an Asian cohort: a random forest model. Kidney Blood Press Res. 2018;43(6):1852–1864.
   PubMed Web of Science ®Google Scholar
• Chen T, Li X, Li Y, et al. Prediction and risk stratification of kidney outcomes in IgA nephropathy. Am J Kidney Dis. 2019;74(3):300–309.
   PubMed Web of Science ®Google Scholar
• Cattran DC, Coppo R, Cook HT, et al. The Oxford classification of IgA nephropathy: rationale, clinicopathological correlations, and classification. Kidney Int. 2009;76(5):534–545.
   PubMed Web of Science ®Google Scholar
• Haas M, Verhave JC, Liu ZH, et al. A multicenter study of the predictive value of crescents in IgA nephropathy. J Am Soc Nephrol. 2017;28(2):691–701.
   PubMed Web of Science ®Google Scholar
• Walsh M, Sar A, Lee D, et al. Histopathologic features aid in predicting risk for progression of IgA nephropathy. Clin J Am Soc Nephrol. 2010;5(3):425–430.
   PubMed Web of Science ®Google Scholar