LncTUG1 ameliorates renal tubular fibrosis in experimental diabetic nephropathy through the miR-145-5p/dual-specificity phosphatase 6 axis

References

• Zheng W, Guo J, Liu ZS. Effects of metabolic memory on inflammation and fibrosis associated with diabetic kidney disease: an epigenetic perspective. Clin Epigenetics. 2021;13(1):87.
   PubMed Web of Science ®Google Scholar
• Flyvbjerg A. The role of the complement system in diabetic nephropathy. Nat Rev Nephrol. 2017;13(5):311–318.
   PubMed Web of Science ®Google Scholar
• Sabatino A, Regolisti G, Cosola C, et al. Intestinal microbiota in type 2 diabetes and chronic kidney disease. Curr Diab Rep. 2017;17(3):16.
   PubMed Web of Science ®Google Scholar
• Khemais-Benkhiat S, Belcastro E, Idris-Khodja N, et al. Angiotensin II-induced redox-sensitive SGLT1 and 2 expression promotes high glucose-induced endothelial cell senescence. J Cell Mol Med. 2020;24(3):2109–2122.
   PubMed Web of Science ®Google Scholar
• Isono M, Chen S, Hong SW, et al. Smad pathway is activated in the diabetic mouse kidney and Smad3 mediates TGF-beta-induced fibronectin in mesangial cells. Biochem Biophys Res Commun. 2002;296(5):1356–1365.
   PubMed Web of Science ®Google Scholar
• Zhang S, Yang J, Li H, et al. Skimmin, a coumarin, suppresses the streptozotocin-induced diabetic nephropathy in Wistar rats. Eur J Pharmacol. 2012;692(1–3):78–83.
   PubMed Web of Science ®Google Scholar
• Chung JY, Chan MK, Li JS, et al. TGF-beta signaling: from tissue fibrosis to tumor microenvironment. Int J Mol Sci. 2021;22(14):7575.
   Web of Science ®Google Scholar
• Sen Z, Weida W, Jie M, et al. Coumarin glycosides from hydrangea paniculata slow down the progression of diabetic nephropathy by targeting Nrf2 anti-oxidation and smad2/3-mediated profibrosis. Phytomedicine. 2019;57:385–395.
   PubMed Web of Science ®Google Scholar
• Chen Y, Li Z, Chen X, et al. Long non-coding RNAs: from disease code to drug role. Acta Pharm Sin B. 2021;11(2):340–354.
   PubMed Web of Science ®Google Scholar
• Kim Y, Hwang SD, Lim JH, et al. Attenuated Lymphatic proliferation ameliorates diabetic nephropathy and High-Fat Diet-Induced renal lipotoxicity. Sci Rep. 2019;9(1):1994.
   PubMedGoogle Scholar
• Yiu WH, Li RX, Wong DWL, et al. Complement C5a inhibition moderates lipid metabolism and reduces tubulointerstitial fibrosis in diabetic nephropathy. Nephrol Dial Transplant. 2018;33(8):1323–1332.
   PubMed Web of Science ®Google Scholar
• Chen Y-y, Chen X-G, Zhang S. Druggability of lipid metabolism modulation against renal fibrosis. Acta Pharmacol Sin. 2022;43(3):505–519.
   PubMed Web of Science ®Google Scholar
• Meng XM, Nikolic-Paterson DJ, Lan HY. TGF-beta: the master regulator of fibrosis. Nat Rev Nephrol. 2016;12(6):325–338.
   PubMed Web of Science ®Google Scholar
• Zhang L, Zhang J, Liu X, et al. Tribbles 3 regulates the fibrosis cytokine TGF- beta 1 through ERK1/2-MAPK signaling pathway in diabetic nephropathy. J Immunol Res. 2014;2014:240396.
   PubMed Web of Science ®Google Scholar
• Ramkissoon A, Chaney KE, Milewski D, et al. Targeted Inhibition of the dual specificity phosphatases DUSP1 and DUSP6 suppress MPNST growth via JNK. Clin Cancer Res. 2019;25(13):4117–4127.
   PubMed Web of Science ®Google Scholar
• Maillet M, Purcell NH, Sargent MA, et al. DUSP6 (MKP3) null mice show enhanced ERK1/2 phosphorylation at baseline and increased myocyte proliferation in the heart affecting disease susceptibility. J Biol Chem. 2008;283(45):31246–31255.
   PubMed Web of Science ®Google Scholar
• Chen L, Wang Y, Luan H, et al. DUSP6 protects murine podocytes from high glucose‑induced inflammation and apoptosis. Mol Med Rep. 2020;22(3):2273–2282.
   PubMed Web of Science ®Google Scholar
• Wu H, Jia B, Zhao X, et al. Pathophysiology and system biology of rat c-BSA induced immune complex glomerulonephritis and pathway comparison with human gene sequencing data. Int Immunopharmacol. 2022;109:108891.
   PubMedGoogle Scholar
• Zhang Y, Huang X, Liu J, et al. New insight into long non-coding RNAs associated with bone metastasis of breast cancer based on an integrated analysis. Cancer Cell Int. 2021;21(1):372.
   PubMed Web of Science ®Google Scholar
• Zhang Y, He W, Zhang S. Seeking for correlative genes and signaling pathways with bone metastasis from breast cancer by integrated analysis. Front Oncol. 2019;9:138.
   PubMed Web of Science ®Google Scholar
• Xu Y, Ge Z, Zhang E, et al. The lncRNA TUG1 modulates proliferation in trophoblast cells via epigenetic suppression of RND3. Cell Death Dis. 2017;8(10):e3104.
   PubMed Web of Science ®Google Scholar
• Mirza AH, Kaur S, Pociot F. Long non-coding RNAs as novel players in beta cell function and type 1 diabetes. Hum Genomics. 2017;11(1):17.
   PubMedGoogle Scholar
• Zhang S, Xin H, Li Y, et al. Skimmin, a coumarin from hydrangea paniculata, slows down the progression of membranous glomerulonephritis by anti-Inflammatory effects and inhibiting immune complex deposition. Evid Based Complement Alternat Med. 2013;2013:819296.
   PubMed Web of Science ®Google Scholar
• Wang W, Sheng L, Chen Y, et al. Total coumarin derivates from hydrangea paniculata attenuate renal injuries in cationized-BSA induced membranous nephropathy by inhibiting complement activation and interleukin 10-mediated interstitial fibrosis. Phytomedicine. 2022;96:153886.
   PubMed Web of Science ®Google Scholar
• Tesch GH, Allen TJ. Rodent models of streptozotocin-induced diabetic nephropathy. Nephrology. 2007;12(3):261–266.
   PubMed Web of Science ®Google Scholar
• Tang PM, Zhang YY, Xiao J, et al. Neural transcription factor Pou4f1 promotes renal fibrosis via macrophage-myofibroblast transition. Proc Natl Acad Sci USA. 2020;117(34):20741–20752.
   PubMed Web of Science ®Google Scholar
• Long J, Badal SS, Ye Z, et al. Long noncoding RNA Tug1 regulates mitochondrial bioenergetics in diabetic nephropathy. J Clin Invest. 2016;126(11):4205–4218.
   PubMed Web of Science ®Google Scholar
• Jiang N, Xia J, Jiang B, et al. TUG1 alleviates hypoxia injury by targeting miR-124 in H9c2 cells. Biomed Pharmacother. 2018;103:1669–1677.
   PubMed Web of Science ®Google Scholar
• Zheng Z, Ma T, Lian X, et al. Clopidogrel reduces fibronectin accumulation and improves diabetes-induced renal fibrosis. Int J Biol Sci. 2019;15(1):239–252.
   PubMed Web of Science ®Google Scholar
• Du Q, Fu YX, Shu AM, et al. Loganin alleviates macrophage infiltration and activation by inhibiting the MCP-1/CCR2 axis in diabetic nephropathy. Life Sci. 2021;272:118808.
   PubMed Web of Science ®Google Scholar
• Pfuhlmann K, Pfluger PT, Schriever SC, et al. Dual specificity phosphatase 6 deficiency is associated with impaired systemic glucose tolerance and reversible weight retardation in mice. PLOS One. 2017;12(9):e0183488.
   PubMed Web of Science ®Google Scholar
• Zhang J, Cui C, Xu H. Downregulation of miR-145-5p elevates retinal ganglion cell survival to delay diabetic retinopathy progress by targeting FGF5. Biosci Biotechnol Biochem. 2019;83(9):1655–1662.
   PubMed Web of Science ®Google Scholar
• Shahrokhi SZ, Saeidi L, Sadatamini M, et al. Can miR-145-5p be used as a marker in diabetic patients? Arch Physiol Biochem. 2022;128(5):1175–1180.
   PubMed Web of Science ®Google Scholar
• Zamanian Azodi M, Rezaei-Tavirani M, Rezaei-Tavirani M, et al. Gestational Diabetes mellitus regulatory network identifies hsa-miR-145-5p and hsa-miR-875-5p as potential biomarkers. Int J Endocrinol Metab. 2019;17(3):e86640.
   PubMed Web of Science ®Google Scholar