ABT-263 exerts a protective effect on upper urinary tract damage by alleviating neurogenic bladder fibrosis

References

• Liao L. Evaluation and management of neurogenic bladder: what is new in China? IJMS. 2015;16(8):18580–18600.
   Google Scholar
• Stein R, Bogaert G, Dogan HS, et al. EAU/ESPU guidelines on the management of neurogenic bladder in children and adolescent part I diagnostics and conservative treatment. Neurourol Urodyn. 2020;39(1):45–57.
   PubMed Web of Science ®Google Scholar
• Panicker JN, Fowler CJ, Kessler TM. Lower urinary tract dysfunction in the neurological patient: clinical assessment and management. Lancet Neurol. 2015;14(7):720–732.
   PubMed Web of Science ®Google Scholar
• Gajewski JB, Schurch B, Hamid R, et al. An international continence society (ICS) report on the terminology for adult neurogenic lower urinary tract dysfunction (ANLUTD). Neurourol Urodyn. 2018;37(3):1152–1161.
   PubMed Web of Science ®Google Scholar
• Peyronnet B, Richard C, Bendavid C, et al. Urinary TIMP-2 and MMP-2 are significantly associated with poor bladder compliance in adult patients with spina bifida. Neurourol Urodyn. 2019;38(8):2151–2158.
   PubMed Web of Science ®Google Scholar
• Tiryaki S, Yagmur I, Parlar Y, et al. Botulinum injection is useless on fibrotic neuropathic bladders. J Pediatr Urol. 2015;11(1):27.e1–27.e4.
   PubMed Web of Science ®Google Scholar
• Li P, Liao L, Chen G, et al. Early low-frequency stimulation of the pudendal nerve can inhibit detrusor overactivity and delay progress of bladder fibrosis in dogs with spinal cord injuries. Spinal Cord. 2013;51(9):668–672.
   PubMed Web of Science ®Google Scholar
• Anumanthan G, Tanaka ST, Adams CM, et al. Bladder stromal loss of transforming growth factor receptor II decreases fibrosis after bladder obstruction. J Urol. 2009;182(4S):1775–1780.
   PubMed Web of Science ®Google Scholar
• Kim KK, Sheppard D, Chapman HA. TGF-β1 signaling and tissue fibrosis. Cold Spring Harb Perspect Biol. 2018;10(4):a022293.
   PubMed Web of Science ®Google Scholar
• Massagué J. TGFβ signalling in context. Nat Rev Mol Cell Biol. 2012;13(10):616–630.
   PubMed Web of Science ®Google Scholar
• Schultz GS, Wysocki A. Interactions between extracellular matrix and growth factors in wound healing. Wound Repair Regen. 2009;17(2):153–162.
   PubMed Web of Science ®Google Scholar
• Fry CH, Kitney DG, Paniker J, et al. Fibrosis and the bladder, implications for function ICI-RS 2017. Neurourol Urodyn. 2018;37(S4):S7–S12.
   PubMedGoogle Scholar
• Larson SA, Dolivo DM, Dominko T. Artesunate inhibits myofibroblast formation via induction of apoptosis and antagonism of pro-fibrotic gene expression in human dermal fibroblasts. Cell Biol Int. 2019;43(11):1317–1322.
   PubMed Web of Science ®Google Scholar
• Wang W, Zhou PH, Xu CG, et al. Baicalein ameliorates renal interstitial fibrosis by inducing myofibroblast apoptosis invivo and invitro. BJU Int. 2016;118(1):145–152.
   PubMed Web of Science ®Google Scholar
• Lee JW, Oh JE, Rhee KJ, et al. Co-treatment with interferon-γ and 1-methyl tryptophan ameliorates cardiac fibrosis through cardiac myofibroblasts apoptosis. Mol Cell Biochem. 2019;458(1-2):197–205.
   PubMed Web of Science ®Google Scholar
• Li S, Wu P, Han B, et al. Deltamethrin induces apoptosis in cerebrum neurons of quail via promoting endoplasmic reticulum stress and mitochondrial dysfunction. Environ Toxicol. 2022;37(8):2033–2043.
   PubMed Web of Science ®Google Scholar
• Lagares D, Santos A, Grasberger PE, et al. Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis. Sci Transl Med. 2017;9(420):eaal3765.
   PubMed Web of Science ®Google Scholar
• Pan J, Li D, Xu Y, et al. Inhibition of bcl-2/xl with ABT-263 selectively kills senescent type II pneumocytes and reverses persistent pulmonary fibrosis induced by ionizing radiation in mice. Int J Radiat Oncol Biol Phys. 2017;99(2):353–361.
   PubMed Web of Science ®Google Scholar
• Ackler S, Mitten MJ, Chen J, et al. Navitoclax (ABT-263) and bendamustine ± rituximab induce enhanced killing of non-Hodgkin’s lymphoma tumours in vivo. Br J Pharmacol. 2012;167(4):881–891.
   PubMed Web of Science ®Google Scholar
• Walaszczyk A, Dookun E, Redgrave R, et al. Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction. Aging Cell. 2019;18(3):e12945.
   PubMed Web of Science ®Google Scholar
• Li YL, Wen JJ, Wen YB, et al. Reconstruction of bladder function and prevention of renal deterioration by means of end-to-side neurorrhaphy in rats with neurogenic bladder. Neurourol Urodyn. 2018;37(4):1272–1280.
   PubMed Web of Science ®Google Scholar
• Chen J, Jin S, Abraham V, et al. The bcl-2/Bcl-X(L)/bcl-w inhibitor, navitoclax, enhances the activity of chemotherapeutic agents in vitro and in vivo. Mol Cancer Ther. 2011;10(12):2340–2349.
   PubMed Web of Science ®Google Scholar
• Chang HY, Havton LA. Differential effects of urethane and isoflurane on external urethral sphincter electromyography and cystometry in rats. Am J Physiol Renal Physiol. 2008;295(4):F1248–F1253.
   PubMed Web of Science ®Google Scholar
• He YL, Wen JG, Pu QS, et al. Losartan prevents bladder fibrosis and protects renal function in rat with neurogenic paralysis bladder. Neurourol Urodyn. 2021;40(1):137–146.
   PubMed Web of Science ®Google Scholar
• Zhao MT, Chen H, Liu Q, et al. Molecular and functional resemblance of differentiated cells derived from isogenic human iPSCs and SCNT-derived ESCs. Proc Natl Acad Sci USA. 2017;114(52):E11111–E11120.
   PubMed Web of Science ®Google Scholar
• Fang H, Lu B, Wang X, et al. Application of data mining techniques to explore predictors of upper urinary tract damage in patients with neurogenic bladder. Braz J Med Biol Res. 2017;50(10):e6638.
   PubMed Web of Science ®Google Scholar
• Madero-Morales PA, Robles-Torres JI, Vizcarra-Mata G, et al. Randomized clinical trial using sterile single use and reused polyvinylchloride catheters for intermittent catheterization with a clean technique in spina bifida cases: short-term urinary tract infection outcomes. J Urol. 2019;202(1):153–158.
   PubMed Web of Science ®Google Scholar
• Wang J, Chen Y, Gu D, et al. Ketamine-induced bladder fibrosis involves epithelial-to-mesenchymal transition mediated by transforming growth factor-β1. Am J Physiol Renal Physiol. 2017;313(4):F961–F972.
   PubMed Web of Science ®Google Scholar
• Lu YT, Tingskov SJ, Djurhuus JC, et al. Can bladder fibrosis in congenital urinary tract obstruction be reversed? J Pediatr Urol. 2017;13(6):574–580.
   PubMed Web of Science ®Google Scholar
• Wang QW, Wen JG, Song DK, et al. Is it possible to use urodynamic variables to predict upper urinary tract dilatation in children with neurogenic bladder-sphincter dysfunction? BJU Int. 2006;98(6):1295–1300.
   PubMed Web of Science ®Google Scholar
• Chen Y, Ma Y, He Y, et al. The TGF-β1 pathway is early involved in neurogenic bladder fibrosis of juvenile rats. Pediatr Res. 2021;90(4):759–767.
   PubMed Web of Science ®Google Scholar
• Tse C, Shoemaker AR, Adickes J, et al. ABT-263: a potent and orally bioavailable bcl-2 family inhibitor. Cancer Res. 2008;68(9):3421–3428.
   PubMed Web of Science ®Google Scholar
• Mérino D, Khaw SL, Glaser SP, et al. Bcl-2, bcl-x(L), and bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells. Blood. 2012;119(24):5807–5816.
   PubMed Web of Science ®Google Scholar
• Islam SS, Mokhtari RB, El Hout Y, et al. TGF-β1 induces EMT reprogramming of porcine bladder urothelial cells into collagen producing fibroblasts-like cells in a Smad2/Smad3-dependent manner. J. Cell Commun. Signal. 2014;8(1):39–58.
   PubMed Web of Science ®Google Scholar
• Hinz B, Lagares D. Evasion of apoptosis by myofibroblasts: a hallmark of fibrotic diseases. Nat Rev Rheumatol. 2020;16(1):11–31.
   PubMed Web of Science ®Google Scholar
• Shoemaker AR, Mitten MJ, Adickes J, et al. Activity of the bcl-2 family inhibitor ABT-263 in a panel of small cell lung cancer xenograft models. Clin Cancer Res. 2008;14(11):3268–3277.
   PubMed Web of Science ®Google Scholar
• Lock R, Carol H, Houghton PJ, et al. Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program. Pediatr. Blood Cancer. 2008;50(6):1181–1189.
   PubMed Web of Science ®Google Scholar
• Pullarkat VA, Lacayo NJ, Jabbour E, et al. Venetoclax and navitoclax in combination with chemotherapy in patientswith relapsed or refractory acute lymphoblastic leukemia and LymphoblasticLymphoma. Cancer Discov. 2021;11(6):1440–1453.
   PubMed Web of Science ®Google Scholar
• Abate M, Festa A, Falco M, et al. Mitochondria as playmakers of apoptosis, autophagy and senescence. Semin Cell Dev Biol. 2020;98:139–153.
   PubMed Web of Science ®Google Scholar