Advanced search
Publication Cover
Renal Failure Volume 45, 2023 - Issue 1
Submit an article Journal homepage
1,520
Views
1
CrossRef citations to date
0
Altmetric
Research Article

Periosteum-derived mesenchymal stem cell alleviates renal fibrosis through mTOR-mediated Treg differentiation

Yongsheng Luoa Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China;b Shanghai Key Laboratory of Organ Transplantation, Shanghai, ChinaView further author information
,
Kuanxin Zhangc Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaView further author information
,
Jiaheng Wua Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China;b Shanghai Key Laboratory of Organ Transplantation, Shanghai, ChinaView further author information
,
Hao Zengd Shanghai Medical College, Fudan University, Shanghai, ChinaView further author information
,
Juntao Chena Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China;b Shanghai Key Laboratory of Organ Transplantation, Shanghai, ChinaView further author information
,
Pingbao Zhanga Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China;b Shanghai Key Laboratory of Organ Transplantation, Shanghai, ChinaView further author information
,
Jingjing Guoa Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China;b Shanghai Key Laboratory of Organ Transplantation, Shanghai, ChinaView further author information
,
Cuidi Xua Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China;b Shanghai Key Laboratory of Organ Transplantation, Shanghai, ChinaView further author information
,
Xinhao Niua Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China;b Shanghai Key Laboratory of Organ Transplantation, Shanghai, ChinaView further author information
,
Yin Celeste Cheuka Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China;b Shanghai Key Laboratory of Organ Transplantation, Shanghai, ChinaView further author information
,
Shihao Xua Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China;b Shanghai Key Laboratory of Organ Transplantation, Shanghai, ChinaView further author information
,
Yirui Caoa Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China;b Shanghai Key Laboratory of Organ Transplantation, Shanghai, ChinaView further author information
,
Yufeng Zhaoa Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China;b Shanghai Key Laboratory of Organ Transplantation, Shanghai, ChinaView further author information
,
Dong Zhua Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China;b Shanghai Key Laboratory of Organ Transplantation, Shanghai, ChinaCorrespondence[email protected]
View further author information
,
Xuanchuan Wanga Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China;b Shanghai Key Laboratory of Organ Transplantation, Shanghai, ChinaCorrespondence[email protected]
View further author information
&
Ruiming Ronga Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China;b Shanghai Key Laboratory of Organ Transplantation, Shanghai, ChinaCorrespondence[email protected]
View further author information
 show all
Article: 2212079 | Received 12 Dec 2022, Accepted 05 May 2023, Published online: 23 May 2023

References

  • Bon D, Chatauret N, Giraud S, et al. New strategies to optimize kidney recovery and preservation in transplantation. Nat Rev Nephrol. 2012;8(6):1–14.
  • Chawla LS, Kimmel PL. Acute kidney injury and chronic kidney disease: an integrated clinical syndrome. Kidney Int. 2012;82(5):516–524.
  • Nieuwenhuijs-Moeke GJ, Pischke SE, Berger SP, et al. Ischemia and reperfusion injury in kidney transplantation: relevant mechanisms in injury and repair. J Clin Med. 2020;9(1):253.
  • Eltzschig HK, Eckle T. Ischemia and reperfusion – from mechanism to translation. Nat Med. 2011;17(11):1391–1401.
  • Zhuang Q, Ma R, Yin Y, et al. Mesenchymal stem cells in renal fibrosis: the flame of cytotherapy. Stem Cells Int. 2019;2019:8387350.
  • Fu X, Liu G, Halim A, et al. Mesenchymal stem cell migration and tissue repair. Cells. 2019;8(8):784.
  • Andrzejewska A, Lukomska B, Janowski M. Concise review: mesenchymal stem cells: from roots to boost. Stem Cells. 2019;37(7):855–864.
  • Song N, Scholtemeijer M, Shah K. Mesenchymal stem cell immunomodulation: mechanisms and therapeutic potential. Trends Pharmacol Sci. 2020;41(9):653–664.
  • Luo Y, Guo J, Zhang P, et al. Mesenchymal stem cell protects injured renal tubular epithelial cells by regulating mTOR-mediated Th17/Treg axis. Front Immunol. 2021;12:684197.
  • Mittal SK, Cho W, Elbasiony E, et al. Mesenchymal stem cells augment regulatory T cell function via CD80-mediated interactions and promote allograft survival. Am J Transplant. 2022;22(6):1564–1577.
  • Brown C, McKee C, Bakshi S, et al. Mesenchymal stem cells: cell therapy and regeneration potential. J Tissue Eng Regen Med. 2019;13(9):1738–1755.
  • Derubeis AR, Cancedda R. Bone marrow stromal cells (BMSCs) in bone engineering: limitations and recent advances. Ann Biomed Eng. 2004;32(1):160–165.
  • Stolzing A, Jones E, McGonagle D, et al. Age-related changes in human bone marrow-derived mesenchymal stem cells: consequences for cell therapies. Mech Ageing Dev. 2008;129(3):163–173.
  • Choi YS, Noh SE, Lim SM, et al. Multipotency and growth characteristic of periosteum-derived progenitor cells for chondrogenic, osteogenic, and adipogenic differentiation. Biotechnol Lett. 2008;30(4):593–601.
  • Ringe J, Leinhase I, Stich S, et al. Human mastoid periosteum-derived stem cells: promising candidates for skeletal tissue engineering. J Tissue Eng Regen Med. 2008;2(2–3):136–146.
  • Ribeiro FV, Suaid FF, Ruiz KG, et al. Periosteum-derived cells as an alternative to bone marrow cells for bone tissue engineering around dental implants. A histomorphometric study in beagle dogs. J Periodontol. 2010;81(6):907–916.
  • Jaquiery C, Schaeren S, Farhadi J, et al. In vitro osteogenic differentiation and in vivo bone-forming capacity of human isogenic jaw periosteal cells and bone marrow stromal cells. Ann Surg. 2005;242(6):859.
  • Boregowda SV, Krishnappa V, Haga CL, et al. A clinical indications prediction scale based on TWIST1 for human mesenchymal stem cells. EBioMedicine. 2016;4:62–73.
  • Mezey E. Human mesenchymal stem/stromal cells in immune regulation and therapy. Stem Cells Transl Med. 2022;11(2):114–134.
  • Li J, Chen J, Zhang M, et al. The mTOR deficiency in monocytic myeloid-derived suppressor cells protects mouse cardiac allografts by inducing allograft tolerance. Front Immunol. 2021;12:661338.
  • Cheuk YC, Xu S, Zhu D, et al. Monocytic myeloid-derived suppressor cells inhibit myofibroblastic differentiation in mesenchymal stem cells through IL-15 secretion. Front Cell Dev Biol. 2022;10:817402.
  • Gazdic M, Markovic BS, Arsenijevic A, et al. Crosstalk between mesenchymal stem cells and T regulatory cells is crucially important for the attenuation of acute liver injury. Liver Transpl. 2018;24(5):687–702.
  • Mushahary D, Spittler A, Kasper C, et al. Isolation, cultivation, and characterization of human mesenchymal stem cells. Cytometry A. 2018;93(1):19–31.
  • Jang HR, Park JH, Kwon GY, et al. Effect of preemptive treatment with human umbilical cord blood-derived mesenchymal stem cells on the development of renal ischemia–reperfusion injury in mice. Am J Physiol Renal Physiol. 2014;307(10):F1149–F1161.
  • Bai M, Zhang L, Fu B, et al. IL-17A improves the efficacy of mesenchymal stem cells in ischemic–reperfusion renal injury by increasing Treg percentages by the COX-2/PGE2 pathway. Kidney Int. 2018;93(4):814–825.
  • Cai J, Jiao X, Zhao S, et al. Transforming growth factor-beta1-overexpressing mesenchymal stromal cells induced local tolerance in rat renal ischemia/reperfusion injury. Cytotherapy. 2019;21(5):535–545.
  • Eggenhofer E, Benseler V, Kroemer A, et al. Mesenchymal stem cells are short-lived and do not migrate beyond the lungs after intravenous infusion. Front Immunol. 2012;3:297.
  • Nowacki M, Nazarewski Ł, Pokrywczyńska M, et al. Long-term influence of bone marrow-derived mesenchymal stem cells on liver ischemia–reperfusion injury in a rat model. Ann Transplant. 2015;20:132–140.
  • Schubert R, Sann J, Frueh JT, et al. Tracking of adipose-derived mesenchymal stromal/stem cells in a model of cisplatin-induced acute kidney injury: comparison of bioluminescence imaging versus qRT-PCR. Int J Mol Sci. 2018;19(9):2564.
  • Zhu Z, Han C, Xian S, et al. Placental mesenchymal stromal cells (PMSCs) and PMSC-derived extracellular vesicles (PMSC-EVs) attenuated renal fibrosis in rats with unilateral ureteral obstruction (UUO) by regulating CD4(+) T cell polarization. Stem Cells Int. 2020;2020:2685820.
  • Duffy MM, Ritter T, Ceredig R, et al. Mesenchymal stem cell effects on T-cell effector pathways. Stem Cell Res Ther. 2011;2(4):34.
  • Bottcher M, Hofmann AD, Bruns H, et al. Mesenchymal stromal cells disrupt mTOR-signaling and aerobic glycolysis during T-cell activation. Stem Cells. 2016;34(2):516–521.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.