Bushen Huoxue formula protects against renal fibrosis and pyroptosis in chronic kidney disease by inhibiting ROS/NLRP3-mediated inflammasome activation

References

• Franco ML, Beyerstedt S, Rangel ÉB. Klotho and mesenchymal stem cells: a review on cell and gene therapy for chronic kidney disease and acute kidney disease. Pharmaceutics. 2021;14(1):11. Epub 2022/01/22.
   PubMed Web of Science ®Google Scholar
• Lau WL, Savoj J, Nakata MB, et al. Altered microbiome in chronic kidney disease: systemic effects of gut-derived uremic toxins. Clin Sci (Lond). 2018;132(5):509–522. PubMed PMID: WOS:000428013500001. doi: 10.1042/cs20171107.
   PubMed Web of Science ®Google Scholar
• Gao Y, Yuan D, Gai L, et al. Saponins from panax japonicus ameliorate age-related renal fibrosis by inhibition of inflammation mediated by NF-κB and TGF-β1/smad signaling and suppression of oxidative stress via activation of Nrf2-ARE signaling. J Ginseng Res. 2021;45(3):408–419. Epub 2021/05/25.
   PubMed Web of Science ®Google Scholar
• Chaves LD, McSkimming DI, Bryniarski MA, et al. Chronic kidney disease, uremic milieu, and its effects on gut bacterial microbiota dysbiosis. Am J Physiol Renal Physiol. 2018;315(3):F487–F502. PubMed PMID: WOS:000442357700009. doi: 10.1152/ajprenal.00092.2018.
   PubMed Web of Science ®Google Scholar
• Lin J, Jiang Z, Liu C, et al. Emerging roles of long non-coding RNAs in renal fibrosis. Life (Basel). 2020;10(8):2020. Epub 2020/08/06.
   Web of Science ®Google Scholar
• Du R, Xia L, Ning X, et al. Hypoxia-induced Bmi1 promotes renal tubular epithelial cell-mesenchymal transition and renal fibrosis via PI3K/akt signal. Mol Biol Cell. 2014;25(17):2650–2659. Epub 2014/07/11.
   PubMed Web of Science ®Google Scholar
• Guo H, Bi X, Zhou P, et al. NLRP3 deficiency attenuates renal fibrosis and ameliorates mitochondrial dysfunction in a mouse unilateral ureteral obstruction model of chronic kidney disease. Mediators Inflamm. 2017;2017:8316560–8316510. Epub 2017/03/30.
   Web of Science ®Google Scholar
• Higgins DF, Ewart LM, Masterson E, et al. BMP7-induced-Pten inhibits akt and prevents renal fibrosis. Biochim Biophys Acta Mol Basis Dis. 2017;1863(12):3095–3104. Epub 2017/09/20.
   PubMed Web of Science ®Google Scholar
• Bian X, Bai Y, Su X, et al. Knockdown of periostin attenuates 5/6 nephrectomy-induced intrarenal renin-angiotensin system activation, fibrosis, and inflammation in rats. J Cell Physiol. 2019;234(12):22857–22873. Epub 2019/05/28.
   PubMed Web of Science ®Google Scholar
• Ishigaki S, Ohashi N, Matsuyama T, et al. Melatonin ameliorates intrarenal renin-angiotensin system in a 5/6 nephrectomy rat model. Clin Exp Nephrol. 2018;22(3):539–549. Epub 2017/11/22.
   PubMed Web of Science ®Google Scholar
• Benetti A, Martins FL, Sene LB, et al. Urinary DPP4 correlates with renal dysfunction, and DPP4 inhibition protects against the reduction in megalin and podocin expression in experimental CKD. Am J Physiol Renal Physiol. 2021;320(3):F285–F296. Epub 2020/12/22.
   PubMed Web of Science ®Google Scholar
• Zhong J, Guo D, Chen CB, et al. Prevention of angiotensin II-mediated renal oxidative stress, inflammation, and fibrosis by angiotensin-converting enzyme 2. Hypertension. 2011;57(2):314–322. Epub 2010/12/30.
   PubMed Web of Science ®Google Scholar
• Jiang M, Yang Z, Lyu L, et al. Dapagliflozin attenuates renal fibrosis by suppressing angiotensin II/TGFβ signaling in diabetic mice. J Diabetes Complications. 2024;38(2):108687. Epub 2024/01/25
   PubMed Web of Science ®Google Scholar
• Lu J-R, Han H-Y, Chen J, et al. Protective effects of Bu-Shen-Huo-Xue formula against 5/6 nephrectomy-induced chronic renal failure in rats. Evid Based Complement Alternat Med. 2014;2014:589846–589849. Epub 2014/05/28.
   PubMed Web of Science ®Google Scholar
• Lu J-R, Han H-Y, Hu J, et al. Mechanism research of Bu-Shen-Huo-Xue formula against renal fibrosis in rats with 5/6 nephrectomy via E-cadherin, α-SMA, and TGF-β1. Clin Nephrol. 2018;90(1):53–58. Epub 2018/05/12.
   PubMed Web of Science ®Google Scholar
• Shi J, Gao W, Shao F. Pyroptosis: gasdermin-mediated programmed necrotic cell death. Trends Biochem Sci. 2017;42(4):245–254. Epub 2016/12/10.
   PubMed Web of Science ®Google Scholar
• He Y, Hara H, Núñez G. Mechanism and regulation of NLRP3 inflammasome activation. Trends Biochem Sci. 2016;41(12):1012–1021. Epub 2016/09/28.
   PubMed Web of Science ®Google Scholar
• Fusco R, Siracusa R, Genovese T, et al. Focus on the role of NLRP3 inflammasome in diseases. Int J Mol Sci. 2020;21(12):2020. Epub 2020/06/18.
   PubMed Web of Science ®Google Scholar
• Suetomi T, Willeford A, Brand CS, et al. Inflammation and NLRP3 inflammasome activation initiated in response to pressure overload by Ca(2+)/calmodulin-dependent protein kinase II δ signaling in cardiomyocytes are essential for adverse cardiac remodeling. Circulation. 2018;138(22):2530–2544. Epub 2018/12/21.
   PubMed Web of Science ®Google Scholar
• Wen S, Deng F, Li L, et al. VX-765 ameliorates renal ­injury and fibrosis in diabetes by regulating caspase-1-mediated pyroptosis and inflammation. J Diabetes Investig. 2022;13(1):22–33. Epub 2021/09/09.
   PubMed Web of Science ®Google Scholar
• Derangère V, Chevriaux A, Courtaut F, et al. Liver X ­receptor β activation induces pyroptosis of human and murine Colon cancer cells. Cell Death Differ. 2014;21(12):1914–1924. Epub 2014/08/16.
   PubMed Web of Science ®Google Scholar
• Hou Y, Lin S, Qiu J, et al. NLRP3 inflammasome negatively regulates podocyte autophagy in diabetic ­nephropathy. Biochem Biophys Res Commun. 2020;521(3):791–798. Epub 2019/11/11.
   PubMed Web of Science ®Google Scholar
• Wang C, Wu C, Yan Z, et al. Ameliorative effect of xiaoyao-jieyu-san on post-stroke depression and its ­potential mechanisms. J Nat Med. 2019;73(1):76–84. Epub 2018/09/09.
   PubMed Web of Science ®Google Scholar
• Zhang W-W, Zheng R-H, Bai F, et al. Steroidogenic acute regulatory protein/aldosterone synthase mediates ­angiotensin II-induced cardiac fibrosis and ­hypertrophy. Mol Biol Rep. 2020;47(2):1207–1222. Epub 2019/12/11
   PubMed Web of Science ®Google Scholar
• Cheng Z, Limbu MH, Wang Z, et al. MMP-2 and 9 in chronic kidney disease. Int J Mol Sci. 2017;18(4):776. Epub 2017/04/12.
   PubMed Web of Science ®Google Scholar
• Sachse A, Wolf G. Angiotensin II-induced reactive oxygen species and the kidney. J Am Soc Nephrol. 2007;18(9):2439–2446. Epub 2007/08/10.
   PubMed Web of Science ®Google Scholar
• Tobar N, Villar V, Santibanez JF. ROS-NFkappaB mediates TGF-beta1-induced expression of urokinase-type plasminogen activator, matrix metalloproteinase-9 and cell invasion. Mol Cell Biochem. 2010;340(1-2):195–202. Epub 2010/03/06.
   PubMed Web of Science ®Google Scholar
• Valentin F, Bueb JL, Kieffer P, et al. Oxidative stress activates MMP-2 in cultured human coronary smooth muscle cells. Fundam Clin Pharmacol. 2005;19(6):661–667. Epub 2005/11/30.
   PubMed Web of Science ®Google Scholar
• Song M, Wang J, Sun Y, et al. Inhibition of gasdermin D-dependent pyroptosis attenuates the progression of silica-induced pulmonary inflammation and fibrosis. Acta Pharm Sin B. 2022;12(3):1213–1224. Epub 2022/05/10.
   PubMed Web of Science ®Google Scholar
• Samarakoon R, Overstreet JM, Higgins SP, et al. TGF-β1 → SMAD/p53/USF2 → PAI-1 transcriptional axis in ureteral obstruction-induced renal fibrosis. Cell Tissue Res. 2012;347(1):117–128. Epub 2011/06/04.
   PubMed Web of Science ®Google Scholar
• Bai R, Lang Y, Shao J, et al. The role of NLRP3 inflammasome in cerebrovascular diseases pathology and possible therapeutic targets. ASN Neuro. 2021;13:17590914211018100. Epub 2021/06/01.
   Web of Science ®Google Scholar
• Yang M, Wang X, Han Y, et al. Targeting the NLRP3 ­inflammasome in diabetic nephropathy. Curr Med Chem. 2021;28(42):8810–8824. Epub 2021/07/07.
   PubMed Web of Science ®Google Scholar
• Li Y, Yuan Y, Huang Z-X, et al. GSDME-mediated ­pyroptosis promotes inflammation and fibrosis in ­obstructive ­nephropathy. Cell Death Differ. 2021;28(8):2333–2350. Epub 2021/03/06.
   PubMed Web of Science ®Google Scholar
• Zhang K-J, Wu Q, Jiang S-M, et al. Pyroptosis: a new frontier in kidney diseases. Oxid Med Cell Longev. 2021;2021:6686617. Epub 2021/05/20
   PubMed Web of Science ®Google Scholar
• Vilaysane A, Chun J, Seamone ME, et al. The NLRP3 ­inflammasome promotes renal inflammation and contributes to CKD. J Am Soc Nephrol. 2010;21(10):1732–1744. Epub 2010/08/07.
   PubMed Web of Science ®Google Scholar