384
Views
0
CrossRef citations to date
0
Altmetric
Basic Sciences Investigations

Hyperactivation of p53 contributes to mitotic catastrophe in podocytes through regulation of the Wee1/CDK1/cyclin B1 axis

, , , , , & show all
Article: 2365408 | Received 29 Jan 2024, Accepted 03 Jun 2024, Published online: 14 Jun 2024

References

  • Collaboration GBDCKD. Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2020;395(10225):709–733. doi: 10.1016/S0140-6736(20)30045-3.
  • Torban E, Braun F, Wanner N, et al. From podocyte biology to novel cures for glomerular disease. Kidney Int. 2019;96(4):850–861. doi: 10.1016/j.kint.2019.05.015.
  • Assady S, Wanner N, Skorecki KL, et al. New insights into podocyte biology in glomerular health and disease. J Am Soc Nephrol. 2017;28:1707–1715.
  • Yin L, Yu L, He JC, et al. Controversies in podocyte loss: death or detachment? Front Cell Dev Biol. 2021;9:771931. doi: 10.3389/fcell.2021.771931.
  • Wharram BL, Goyal M, Wiggins JE, et al. Podocyte depletion causes glomerulosclerosis: diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene. J Am Soc Nephrol. 2005;16(10):2941–2952. doi: 10.1681/ASN.2005010055.
  • Vitale I, Galluzzi L, Castedo M, et al. Mitotic catastrophe: a mechanism for avoiding genomic instability. Nat Rev Mol Cell Biol. 2011;12(6):385–392. doi: 10.1038/nrm3115.
  • Kimura M, Yoshioka T, Saio M, et al. Mitotic catastrophe and cell death induced by depletion of centrosomal proteins. Cell Death Dis. 2013;4(4):e603. doi: 10.1038/cddis.2013.108.
  • Timofeev O, Cizmecioglu O, Settele F, et al. Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition. J Biol Chem. 2010;285(22):16978–16990. doi: 10.1074/jbc.M109.096552.
  • Parker LL, Piwnica-Worms H. Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase. Science. 1992;257(5078):1955–1957. doi: 10.1126/science.1384126.
  • Solomon MJ, Lee T, Kirschner MW. Role of phosphorylation in p34cdc2 activation: identification of an activating kinase. Mol Biol Cell. 1992;3(1):13–27. doi: 10.1091/mbc.3.1.13.
  • Coulonval K, Kooken H, Roger PP. Coupling of T161 and T14 phosphorylations protects cyclin B-CDK1 from premature activation. Mol Biol Cell. 2011;22(21):3971–3985. doi: 10.1091/mbc.E11-02-0136.
  • Heald R, McLoughlin M, McKeon F. Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase. Cell. 1993;74(3):463–474. doi: 10.1016/0092-8674(93)80048-j.
  • Chow JP, Poon RY, Ma HT. Inhibitory phosphorylation of cyclin-dependent kinase 1 as a compensatory mechanism for mitosis exit. Mol Cell Biol. 2011;31(7):1478–1491. doi: 10.1128/MCB.00891-10.
  • Mak JP, Man WY, Chow JP, et al. Pharmacological inactivation of CHK1 and WEE1 induces mitotic catastrophe in nasopharyngeal carcinoma cells. Oncotarget. 2015;6(25):21074–21084. doi: 10.18632/oncotarget.4020.
  • Jiang A, Song A, Zhang C. Modes of podocyte death in diabetic kidney disease: an update. J Nephrol. 2022;35(6):1571–1584. doi: 10.1007/s40620-022-01269-1.
  • Liapis H, Romagnani P, Anders HJ. New insights into the pathology of podocyte loss: mitotic catastrophe. Am J Pathol. 2013;183(5):1364–1374. doi: 10.1016/j.ajpath.2013.06.033.
  • Lasagni L, Lazzeri E, Shankland SJ, et al. Podocyte mitosis - a catastrophe. Curr Mol Med. 2013;13(1):13–23. doi: 10.2174/1566524011307010013.
  • Hara M, Oohara K, Dai DF, et al. Mitotic catastrophe causes podocyte loss in the urine of human diabetics. Am J Pathol. 2019;189(2):248–257. doi: 10.1016/j.ajpath.2018.10.016.
  • Mulay SR, Thomasova D, Ryu M, et al. Podocyte loss involves MDM2-driven mitotic catastrophe. J Pathol. 2013;230(3):322–335. doi: 10.1002/path.4193.
  • Tang H, Lei CT, Ye C, et al. MDM2 is implicated in high-glucose-induced podocyte mitotic catastrophe via Notch1 signalling. J Cell Mol Med. 2017;21(12):3435–3444. doi: 10.1111/jcmm.13253.
  • Zhan P, Zhang Y, Shi W, et al. Myeloid-derived growth factor deficiency exacerbates mitotic catastrophe of podocytes in glomerular disease. Kidney Int. 2022;102(3):546–559. doi: 10.1016/j.kint.2022.1004.1027.
  • Wang Z, Chang Y, Liu Y, et al. Inhibition of the lncRNA MIAT prevents podocyte injury and mitotic catastrophe in diabetic nephropathy. Mol Ther Nucleic Acids. 2022;28:136–153. doi: 10.1016/j.omtn.2022.03.001.
  • Ranjan A, Iwakuma T. Non-canonical cell death induced by p53. Int J Mol Sci. 2016;17(12):2068. doi: 10.3390/ijms17122068.
  • Jeansson M, Björck K, Tenstad O, et al. Adriamycin alters glomerular endothelium to induce proteinuria. J Am Soc Nephrol. 2009;20(1):114–122. doi: 10.1681/ASN.2007111205.
  • Macconi D, Bonomelli M, Benigni A, et al. Pathophysiologic implications of reduced podocyte number in a rat model of progressive glomerular injury. Am J Pathol. 2006;168:42–54.
  • Lee VW, Harris DC. Adriamycin nephropathy: a model of focal segmental glomerulosclerosis. Nephrology (Carlton). 2011;16(1):30–38. doi: 10.1111/j.1440-1797.2010.01383.x.
  • Lasagni L, Ballerini L, Angelotti ML, et al. Notch activation differentially regulates renal progenitors proliferation and differentiation toward the podocyte lineage in glomerular disorders. Stem Cells. 2010;28(9):1674–1685. doi: 10.1002/stem.492.
  • Zhang Y, Chen Y, Yang F, et al. HBx transfection limits proliferative capacity of podocytes through cell cycle regulation. Acta Biochim Biophys Sin (Shanghai). 2014;46(12):1016–1023. doi: 10.1093/abbs/gmu102.
  • Estrada CC, Paladugu P, Guo Y, et al. Kruppel-like factor 4 is a negative regulator of STAT3-induced glomerular epithelial cell proliferation. JCI Insight. 2018;3(12):e98214. doi: 10.1172/jci.insight.98214.
  • Nishad R, Mukhi D, Singh AK, et al. Growth hormone induces mitotic catastrophe of glomerular podocytes and contributes to proteinuria. Cell Death Dis. 2021;12(4):342. doi: 10.1038/s41419-021-03643-6.
  • Tian X, Pedigo CE, Li K, et al. Profilin1 is required for prevention of mitotic catastrophe in murine and human glomerular diseases. J Clin Invest. 2023;133(24):e171237. doi: 10.1172/JCI171237.
  • Feng J, Bao L, Wang X, et al. Low expression of HIV genes in podocytes accelerates the progression of diabetic kidney disease in mice. Kidney Int. 2021;99:914–925.
  • Thomasova D, Bruns HA, Kretschmer V, et al. Murine double minute-2 prevents p53-overactivation-related cell death (pdoptosis) of podocytes. J Am Soc Nephrol. 2015;26(7):1513–1523. doi: 10.1681/ASN.2014040345.
  • Lewis CW, Bukhari AB, Xiao EJ, et al. Upregulation of Myt1 promotes acquired resistance of cancer cells to Wee1 inhibition. Cancer Res. 2019;79(23):5971–5985. doi: 10.1158/0008-5472.CAN-19-1961.