Clinical impact of Wnt5a expression on persistence of acute kidney injury in patients with urosepsis

References

• Seymour CW, Liu VX, Iwashyna TJ, et al. Assessment of clinical criteria for sepsis: for the third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8):1–9. doi: 10.1001/jama.2016.0288.
   Web of Science ®Google Scholar
• Zarbock A, Nadim MK, Pickkers P, et al. Sepsis-associated acute kidney injury: consensus report of the 28th Acute Disease Quality Initiative workgroup. Nat Rev Nephrol. 2023;19(6):401–417. doi: 10.1038/s41581-023-00683-3.
   PubMed Web of Science ®Google Scholar
• Godin M, Murray P, Mehta RL. Clinical approach to the patient with AKI and sepsis. Semin Nephrol. 2015;35(1):12–22. doi: 10.1016/j.semnephrol.2015.01.003.
   PubMed Web of Science ®Google Scholar
• Kellum JA, Sileanu FE, Murugan R, et al. Classifying AKI by urine output versus serum creatinine level. J Am Soc Nephrol. 2015;26(9):2231–2238. doi: 10.1681/ASN.2014070724.
   PubMed Web of Science ®Google Scholar
• Kellum JA, Sileanu FE, Bihorac A, et al. Recovery after acute kidney injury. Am J Respir Crit Care Med. 2017;195(6):784–791. doi: 10.1164/rccm.201604-0799OC.
   PubMed Web of Science ®Google Scholar
• Kellum JA, Chawla LS, Keener C, et al. The effects of alternative resuscitation strategies on acute kidney injury in patients with septic shock. Am J Respir Crit Care Med. 2016;193(3):281–287. doi: 10.1164/rccm.201505-0995OC.
   PubMed Web of Science ®Google Scholar
• Chawla LS, Bellomo R, Bihorac A, et al. Acute kidney disease and renal recovery: consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup. Nat Rev Nephrol. 2017;13(4):241–257. doi: 10.1038/nrneph.2017.2.
   PubMed Web of Science ®Google Scholar
• Logan CY, Nusse R. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol. 2004;20(1):781–810. doi: 10.1146/annurev.cellbio.20.010403.113126.
   PubMedGoogle Scholar
• Bhatt PM, Malgor R. Wnt5a: a player in the pathogenesis of atherosclerosis and other inflammatory disorders. Atherosclerosis. 2014;237(1):155–162. doi: 10.1016/j.atherosclerosis.2014.08.027.
   PubMed Web of Science ®Google Scholar
• Pashirzad M, Shafiee M, Rahmani F, et al. Role of Wnt5a in the pathogenesis of inflammatory diseases. J Cell Physiol. 2017;232(7):1611–1616. doi: 10.1002/jcp.25687.
   PubMed Web of Science ®Google Scholar
• Akoumianakis I, Polkinghorne M, Antoniades C. Non-canonical WNT signalling in cardiovascular disease: mechanisms and therapeutic implications. Nat Rev Cardiol. 2022;19(12):783–797. doi: 10.1038/s41569-022-00718-5.
   PubMed Web of Science ®Google Scholar
• Zhao Y, Wang CL, Li RM, et al. Wnt5a promotes inflammatory responses via nuclear factor kappaB (NF-kappaB) and mitogen-activated protein kinase (MAPK) pathways in human dental pulp cells. J Biol Chem. 2014;289(30):21028–21039. doi: 10.1074/jbc.M113.546523.
   PubMed Web of Science ®Google Scholar
• Kim J, Kim J, Kim DW, et al. Wnt5a induces endothelial inflammation via beta-catenin-independent signaling. J Immunol. 2010;185(2):1274–1282. doi: 10.4049/jimmunol.1000181.
   PubMed Web of Science ®Google Scholar
• Pereira C, Schaer DJ, Bachli EB, et al. Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10. Arterioscler Thromb Vasc Biol. 2008;28(3):504–510. doi: 10.1161/ATVBAHA.107.157438.
   PubMed Web of Science ®Google Scholar
• Schulte DM, Kragelund D, Müller N, et al. The wingless-related integration site-5a/secreted frizzled-related protein-5 system is dysregulated in human sepsis. Clin Exp Immunol. 2015;180(1):90–97. doi: 10.1111/cei.12484.
   PubMed Web of Science ®Google Scholar
• Shin J, Yoon Y, Oh DJ. Evaluation of the Wnt signaling pathway as a prognostic marker in patients with urosepsis. Mol Cell Biochem. 2020;473(1-2):15–23. doi: 10.1007/s11010-020-03804-9.
   PubMed Web of Science ®Google Scholar
• Singer M, Deutschman CS, Seymour CW, et al. The Third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8):801–810. doi: 10.1001/jama.2016.0287.
   PubMed Web of Science ®Google Scholar
• Wetzels JF, Kiemeney LA, Swinkels DW, et al. Age- and gender-specific reference values of estimated GFR in Caucasians: the Nijmegen Biomedical Study. Kidney Int. 2007;72(5):632–637. doi: 10.1038/sj.ki.5002374.
   PubMed Web of Science ®Google Scholar
• Levey AS, Coresh J, Greene T, Chronic Kidney Disease Epidemiology C., et al. Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate. Ann Intern Med. 2006;145(4):247–254. doi: 10.7326/0003-4819-145-4-200608150-00004.
   PubMed Web of Science ®Google Scholar
• Kellum JA, Lameire N, Aspelin P, et al. Kidney Disease: improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group: kdigo clinical practice guideline for acute kidney injury. Kidney Int Suppl. 2012;2:138.
   Google Scholar
• Perinel S, Vincent F, Lautrette A, et al. Transient and persistent acute kidney injury and the risk of hospital mortality in critically Ill patients: results of a multicenter cohort study. Crit Care Med. 2015;43(8):e269-275–e275. doi: 10.1097/CCM.0000000000001077.
   Web of Science ®Google Scholar
• Koyner JL, Mackey RH, Rosenthal NA, et al. Clinical outcomes of persistent severe acute kidney injury among patients with kidney disease improving global outcomes stage 2 or 3 acute kidney injury. Am J Nephrol. 2022;53(11-12):816–825. doi: 10.1159/000528158.
   PubMed Web of Science ®Google Scholar
• Landi A, Branca M, Leonardi S, et al. Transient vs in-hospital persistent acute kidney injury in patients with acute coronary syndrome. JACC Cardiovasc Interv. 2023;16(2):193–205. doi: 10.1016/j.jcin.2022.10.009.
   PubMed Web of Science ®Google Scholar
• Ostermann M, Zarbock A, Goldstein S, et al. Recommendations on acute kidney injury biomarkers from the acute disease quality initiative consensus conference: a consensus statement. JAMA Netw Open. 2020;3(10):e2019209. doi: 10.1001/jamanetworkopen.2020.19209.
   PubMed Web of Science ®Google Scholar
• Caironi P, Latini R, Struck J, et al. Circulating proenkephalin, acute kidney injury, and its improvement in patients with severe sepsis or shock. Clin Chem. 2018;64(9):1361–1369. doi: 10.1373/clinchem.2018.288068.
   PubMed Web of Science ®Google Scholar
• Hollinger A, Wittebole X, François B, et al. Proenkephalin A 119-159 (Penkid) is an early biomarker of septic acute kidney injury: the Kidney in Sepsis and Septic Shock (Kid-SSS) study. Kidney Int Rep. 2018;3(6):1424–1433. doi: 10.1016/j.ekir.2018.08.006.
   PubMed Web of Science ®Google Scholar
• Schunk SJ, Zarbock A, Meersch M, et al. Association between urinary dickkopf-3, acute kidney injury, and subsequent loss of kidney function in patients undergoing cardiac surgery: an observational cohort study. Lancet. 2019;394(10197):488–496. doi: 10.1016/S0140-6736(19)30769-X.
   PubMed Web of Science ®Google Scholar
• Hoste E, Bihorac A, Al-Khafaji A, et al. Identification and validation of biomarkers of persistent acute kidney injury: the RUBY study. Intensive Care Med. 2020;46(5):943–953. doi: 10.1007/s00134-019-05919-0.
   PubMed Web of Science ®Google Scholar
• Choi EY, Park HH, Kim H, et al. Wnt5a and Wnt11 as acute respiratory distress syndrome biomarkers for severe acute respiratory syndrome coronavirus 2 patients. Eur Respir J. 2020;56DOI(5):2001531. doi: 10.1183/13993003.01531-2020.
   PubMed Web of Science ®Google Scholar
• Chi S, Xue J, Chen X, et al. Correlation of plasma and urine Wnt5A with the disease activity and cutaneous lesion severity in patients with systemic lupus erythematosus. Immunol Res. 2022;70(2):174–184. doi: 10.1007/s12026-021-09253-w.
   PubMed Web of Science ®Google Scholar
• Yu M, Guo Y, Zhang P, et al. Increased circulating Wnt5a protein in patients with rheumatoid arthritis-associated interstitial pneumonia (RA-ILD). Immunobiology. 2019;224(4):551–559. doi: 10.1016/j.imbio.2019.04.006.
   PubMed Web of Science ®Google Scholar
• Xiao L, Zhou D, Tan RJ, et al. Sustained activation of wnt/beta-catenin signaling drives AKI to CKD progression. J Am Soc Nephrol. 2016;27(6):1727–1740. doi: 10.1681/ASN.2015040449.
   PubMed Web of Science ®Google Scholar
• Feng Y, Liang Y, Zhu X, et al. The signaling protein Wnt5a promotes TGFbeta1-mediated macrophage polarization and kidney fibrosis by inducing the transcriptional regulators Yap/Taz. J Biol Chem. 2018;293(50):19290–19302. doi: 10.1074/jbc.RA118.005457.
   PubMed Web of Science ®Google Scholar
• Rashid ST, Humphries JD, Byron A, et al. Proteomic analysis of extracellular matrix from the hepatic stellate cell line LX-2 identifies CYR61 and Wnt-5a as novel constituents of fibrotic liver. J Proteome Res. 2012;11(8):4052–4064. doi: 10.1021/pr3000927.
   PubMed Web of Science ®Google Scholar
• Rydell-Törmänen K, Zhou X-H, Hallgren O, et al. Aberrant nonfibrotic parenchyma in idiopathic pulmonary fibrosis is correlated with decreased beta-catenin inhibition and increased Wnt5a/b interaction. Physiol Rep. 2016;4DOI(5):e12727. doi: 10.14814/phy2.12727.
   PubMedGoogle Scholar
• Abraityte A, Vinge LE, Askevold ET, et al. Wnt5a is elevated in heart failure and affects cardiac fibroblast function. J Mol Med (Berl). 2017;95(7):767–777. doi: 10.1007/s00109-017-1529-1.
   PubMed Web of Science ®Google Scholar
• van Amerongen R, Fuerer C, Mizutani M, et al. Wnt5a can both activate and repress Wnt/beta-catenin signaling during mouse embryonic development. Dev Biol. 2012;369(1):101–114. doi: 10.1016/j.ydbio.2012.06.020.
   PubMed Web of Science ®Google Scholar
• Cooper DJ, Plewes K, Grigg MJ, et al. An evaluation of commonly used surrogate baseline creatinine values to classify AKI during acute infection. Kidney Int Rep. 2021;6(3):645–656. doi: 10.1016/j.ekir.2020.12.020.
   PubMed Web of Science ®Google Scholar
• Bouchard J. Estimating baseline serum creatinine for assessing acute kidney injury: not a one size fits all approach. Kidney Int Rep. 2021;6(3):562–564. doi: 10.1016/j.ekir.2021.01.030.
   PubMed Web of Science ®Google Scholar