Causal relationship between Helicobacter pylori infection and IgA nephropathy: a bidirectional two-sample mendelian randomization study

References

• Jones NL, Koletzko S, Goodman K, et al. Joint ESPGHAN/NASPGHAN Guidelines for the management of Helicobacter pylori in children and adolescents (Update 2016). J Pediatr Gastroenterol Nutr. 2017;64(6):1–11. doi: 10.1097/MPG.0000000000001594.
   PubMed Web of Science ®Google Scholar
• Niknam R, Barfei M, Mahmoudi L. Helicobacter pylori, ­endoscopic, and histologic features among kidney transplant candidates in Southern Iran. Infect Drug Resist. 2019;12:3687–3693.
   PubMed Web of Science ®Google Scholar
• Pan W, Zhang H, Wang L, et al. Association between Helicobacter pylori infection and kidney damage in patients with peptic ulcer. Ren Fail. 2019;41(1):1028–1034. doi: 10.1080/0886022X.2019.1683029.
   PubMed Web of Science ®Google Scholar
• Shin SP, Bang CS, Lee JJ, et al. Helicobacter pylori ­infection in patients with chronic kidney disease: a ­systematic review and meta-analysis. Gut Liver. 2019;13(6):628–641. doi: 10.5009/gnl18517.
   PubMed Web of Science ®Google Scholar
• Pattrapornpisut P, Avila-Casado C, Reich HN. IgA nephropathy: core Curriculum 2021. Am J Kidney Dis. 2021;78(3):429–441. doi: 10.1053/j.ajkd.2021.01.024.
   PubMed Web of Science ®Google Scholar
• Schena FP, Nistor I. Epidemiology of IgA nephropathy: a global perspective. Semin Nephrol. 2018;38(5):435–442. doi: 10.1016/j.semnephrol.2018.05.013.
   PubMed Web of Science ®Google Scholar
• Galla JH. IgA nephropathy. Kidney Int. 1995;47(2):377–387. doi: 10.1038/ki.1995.50.
   PubMed Web of Science ®Google Scholar
• Reich HN, Troyanov S, Scholey JW, et al. Remission of proteinuria improves prognosis in IgA nephropathy. J Am Soc Nephrol. 2007;18(12):3177–3183. doi: 10.1681/ASN.2007050526.
   PubMed Web of Science ®Google Scholar
• D’Amico G, Colasanti G, Belgioioso GBd, et al. Long-term follow-up of IgA mesangial nephropathy: clinico-histological study in 374 patients. Semin Nephrol. 1987;7(4):355–358.
   PubMed Web of Science ®Google Scholar
• Moriyama T, Tanaka K, Iwasaki C, et al. Prognosis in IgA nephropathy: 30-year analysis of 1,012 patients at a single center in Japan. PLOS One. 2014;9(3):e91756. doi: 10.1371/journal.pone.0091756.
   PubMed Web of Science ®Google Scholar
• Kusano K, Inokuchi A, Fujimoto K, et al. Coccoid Helicobacter pylori exists in the palatine tonsils of patients with IgA nephropathy. J Gastroenterol. 2010;45(4):406–412. doi: 10.1007/s00535-009-0169-9.
   PubMed Web of Science ®Google Scholar
• Kong X, Xu D, Li F, et al. Association of H. pylori infection with chronic kidney disease among Chinese adults. Int Urol Nephrol. 2017;49(5):845–850. doi: 10.1007/s11255-016-1498-2.
   PubMed Web of Science ®Google Scholar
• Liu XZ, Zhang YM, Jia NY, et al. Helicobacter pylori infection is associated with elevated galactose-deficient IgA1 in IgA nephropathy. Ren Fail. 2020;42(1):539–546. doi: 10.1080/0886022X.2020.1772295.
   PubMed Web of Science ®Google Scholar
• Ueda J, Okuda M, Nishiyama T, et al. Diagnostic accuracy of the E-plate serum antibody test kit in detecting Helicobacter pylori infection among Japanese children. J Epidemiol. 2014;24(1):47–51. doi: 10.2188/jea.JE20130078.
   PubMed Web of Science ®Google Scholar
• Zhu TT, Wang L, Wang HL, et al. Helicobacter pylori participates in the pathogenesis of IgA nephropathy. Ren Fail. 2016;38(9):1398–1404. doi: 10.1080/0886022X.2016.1216713.
   PubMed Web of Science ®Google Scholar
• Wang L, Tan RZ, Chen Y, et al. CagA promotes proliferation and secretion of extracellular matrix by inhibiting signaling pathway of apoptosis in rat glomerular mesangial cells. Ren Fail. 2016;38(3):458–464. doi: 10.3109/0886022X.2016.1138831.
   PubMed Web of Science ®Google Scholar
• Chmiela M, Kupcinskas J. Review: pathogenesis of Helicobacter pylori infection. Helicobacter. 2019;24(S1):e12638. doi: 10.1111/hel.12638.
   PubMedGoogle Scholar
• Galmiche A, Rassow J, Doye A, et al. The N-terminal 34 kDa fragment of Helicobacter pylori vacuolating cytotoxin targets mitochondria and induces cytochrome c release. Embo j. 2000;19(23):6361–6370. doi: 10.1093/emboj/19.23.6361.
   PubMed Web of Science ®Google Scholar
• Molinari M, Salio M, Galli C, et al. Selective inhibition of Ii-dependent antigen presentation by Helicobacter pylori toxin VacA. J Exp Med. 1998;187(1):135–140. doi: 10.1084/jem.187.1.135.
   PubMed Web of Science ®Google Scholar
• Fernández-de-Larrea N, Michel A, Romero B, et al. Antibody reactivity against Helicobacter pylori proteins in a sample of the Spanish adult population in 2008–2013. Helicobacter. 2017;22(5):e12401. doi: 10.1111/hel.12401.
   PubMed Web of Science ®Google Scholar
• Michel A, Pawlita M, Boeing H, et al. Helicobacter pylori antibody patterns in Germany: a cross-sectional population study. Gut Pathog. 2014;6(1):10. doi: 10.1186/1757-4749-6-10.
   PubMedGoogle Scholar
• Barratt J, Bailey EM, Buck KS, et al. Exaggerated systemic antibody response to mucosal Helicobacter pylori infection in IgA nephropathy. Am J Kidney Dis. 1999;33(6):1049–1057. doi: 10.1016/S0272-6386(99)70141-1.
   PubMed Web of Science ®Google Scholar
• Kanbay M, Kasapoglu B, Akcay A. An occult risk factor for proteinuria: helicobacter pylori infection. Med Hypotheses. 2007;69(3):709–710. doi: 10.1016/j.mehy.2007.01.010.
   PubMed Web of Science ®Google Scholar
• Rahmani A, Moradkhani A, Hafezi Ahmadi MR, et al. Association between serum levels of high sensitive C-reactive protein and inflammation activity in chronic gastritis patients. Scand J Gastroenterol. 2016;51(5):531–537. doi: 10.3109/00365521.2015.1102318.
   PubMed Web of Science ®Google Scholar
• Testerman TL, Morris J. Beyond the stomach: an updated view of Helicobacter pylori pathogenesis, diagnosis, and treatment. WJG. 2014;20(36):12781–12808. doi: 10.3748/wjg.v20.i36.12781.
   PubMed Web of Science ®Google Scholar
• Umit H, Umit EG. Helicobacter pylori and mean platelet volume: a relation way before ımmune thrombocytopenia? Eur Rev Med Pharmacol Sci. 2015;19(15):2818–2823.
   PubMed Web of Science ®Google Scholar
• Sulikowska B, Rutkowski B, Marszałek A, et al. The role of interstitial changes in the progression of chronic kidney disease. Postepy Hig Med Dosw. 2015;69:830–837. doi: 10.5604/17322693.1162570.
   Web of Science ®Google Scholar
• Yang M, Li FG, Xie XS, et al. CagA, a major virulence factor of Helicobacter pylori, promotes the production and underglycosylation of IgA1 in DAKIKI cells. Biochem Biophys Res Commun. 2014;444(2):276–281. doi: 10.1016/j.bbrc.2014.01.050.
   PubMed Web of Science ®Google Scholar
• Lin SY, Lin CL, Liu JH, et al. Association between Helicobacter pylori infection and the subsequent risk of end-stage renal disease: a nationwide population-based cohort study. Int J Clin Pract. 2015;69(5):604–610. doi: 10.1111/ijcp.12602.
   PubMed Web of Science ®Google Scholar
• Smith AC, Molyneux K, Feehally J, et al. O-glycosylation of serum IgA1 antibodies against mucosal and systemic antigens in IgA nephropathy. J Am Soc Nephrol. 2006;17(12):3520–3528. doi: 10.1681/ASN.2006060658.
   PubMed Web of Science ®Google Scholar
• Suzuki H, Kiryluk K, Novak J, et al. The pathophysiology of IgA nephropathy. J Am Soc Nephrol. 2011;22(10):1795–1803. doi: 10.1681/ASN.2011050464.
   PubMed Web of Science ®Google Scholar
• Ko GH, Park HB, Shin MK, et al. Monoclonal antibodies against Helicobacter pylori cross-react with human tissue. Helicobacter. 1997;2(4):210–215. doi: 10.1111/j.1523-5378.1997.tb00090.x.
   PubMed Web of Science ®Google Scholar
• Caraman PL, Azoulay E, Kessler M, et al. Mucosal infections and allergy in IgA nephropathy. A retrospective study. Association des Néphrologues de l’Est de la France. Contrib Nephrol. 1993;104:24–30.
   Google Scholar
• Béné MC, Ligny BHd, Kessler M, et al. Tonsils in IgA nephropathy. Contrib Nephrol. 1993;104:153–161.
   PubMedGoogle Scholar
• Park JS, Song JH, Yang WS, et al. Cytomegalovirus is not specifically associated with immunoglobulin A nephropathy. J Am Soc Nephrol. 1994;4(8):1623–1626. doi: 10.1681/ASN.V481623.
   PubMed Web of Science ®Google Scholar
• Suzuki S, Nakatomi Y, Sato H, et al. Haemophilus parainfluenzae antigen and antibody in renal biopsy samples and serum of patients with IgA nephropathy. Lancet. 1994;343(8888):12–16. doi: 10.1016/S0140-6736(94)90875-3.
   PubMed Web of Science ®Google Scholar
• Sharmin S, Shimizu Y, Hagiwara M, et al. Staphylococcus aureus antigens induce IgA-type glomerulonephritis in Balb/c mice. J Nephrol. 2004;17(4):504–511.
   PubMed Web of Science ®Google Scholar
• Iwama H, Horikoshi S, Shirato I, et al. Epstein-Barr virus detection in kidney biopsy specimens ­correlates with glomerular mesangial injury. Am J Kidney Dis. 1998;32(5):785–793. doi: 10.1016/S0272-6386(98)70134-9.
   PubMed Web of Science ®Google Scholar
• Tomino Y, Yagame M, Omata F, et al. A case of IgA nephropathy associated with adeno- and herpes simplex viruses. Nephron. 1987;47(4):258–261. doi: 10.1159/000184520.
   PubMed Web of Science ®Google Scholar
• Nagashima R, Maeda K, Yuda F, et al. Helicobacter pylori antigen in the glomeruli of patients with membranous nephropathy. Virchows Arch. 1997;431(4):235–239. doi: 10.1007/s004280050094.
   PubMed Web of Science ®Google Scholar
• Zhu Z, Yang Y, Han X, et al. Causality of Helicobacter pylori infection on eosinophilic esophagitis and potential pathogenesis: a Mendelian randomization study. Front Immunol. 2024;15:1365604. doi: 10.3389/fimmu.2024.1365604.
   PubMed Web of Science ®Google Scholar
• Huang J, Liu Y, Xu D, et al. Causal associations between Helicobacter pylori infection and pregnancy and neonatal outcomes: a two-sample Mendelian randomization study. Front Cell Infect Microbiol. 2024;14:1343499. doi: 10.3389/fcimb.2024.1343499.
   PubMed Web of Science ®Google Scholar
• Yeo SC, Goh SM, Barratt J. Is immunoglobulin A nephropathy different in different ethnic populations? Nephrology. 2019;24(9):885–895. doi: 10.1111/nep.13592.
   PubMed Web of Science ®Google Scholar