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Original Articles

Toxicological Effects of Hepatotoxins (Microcystins) on Aquatic Organisms

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Pages 89-101 | Published online: 15 Sep 2010

  • Carmichael , W.W. and Falconer , I.A. 1993 . “ Diseases related to freshwater blue-green algal toxins, and control measures ” . In Algal Toxins in Seafood and Drinking Water , Edited by: Falconer , I.A. 187 – 209 . New York : Academic Press .
  • Carmichael , W.W. 1992 . Cyanobacterial secondary metabolites-the cyanotoxins . Applied Bacteriology , 72 : 445 – 459 .
  • Bell , S.G. and Codd , G.A. 1994 . Cyanobacterial toxins and human health . Reviews in Medical Microbiology , 5 : 256 – 264 .
  • Fischer , W.J. and Dietrich , D.R. 2000 . Pathological and biochemical characterization of microcystin-induced hepatopancreas and kidney damage in carp (Cyprinus carpio} . Toxicology and Applied Pharmacology , 164 : 73 – 81 .
  • Dawson , R.M. 1998 . The toxicology of microcystins . Toxicon , 16 : 953 – 962 .
  • Matthiensen , A. , Seattle , K.A. , Yunes , I.S. , Kaya , K. and Codd , G.A. 2000 . [D-Leu1] microcystin-LR, from the cyanobacterium Microcystis RST 9501 and from a Microcystis bloom in the Patos Lagoon estuary, Brazil . Phytochemistry , 55 : 383 – 387 .
  • Park , H. , Namikoshi , M. , Brittain , S.M. , Carmichael , W.W. and Murphy , T. 2001 . [D-Leu1] microcystin-LR, a new microcystin isolated from waterbloom in a Canadian prairie lake . Toxicon , 39 : 855 – 862 .
  • Runnengar , M. , Berndt , N. , Kong , S. , Lee , E.Y.C. and Zhang , L. 1995 . In vivo and in vitro binding of microcystin to protein phosphatases 1 and 2A . Biochemical and Biophysical Research Communications , 216 : 162 – 169 .
  • Tencalla , F.G. , Dietrich , D.R. and Schlatter , C. 1994 . Toxicity of Microcystis aeruginosa peptide toxin to yearling rainbow trout (Oncorhyunchus mykiss} . Aquatic Toxicology , 30 : 215 – 224 .
  • Bury , N.R. , Newlands , A.D. , Eddy , F.B. and Codd , G.A. 1998 . In vivo and in vitro intestinal transport of 3H-microcystin-LR, a cyanobacterial toxin, in rainbow trout (Oncorhynchus mykiss} . Aquatic Toxicology , 42 : 139 – 148 .
  • Vasconcelos , V. , Oliveira , S. and Teles , F.O. 2001 . Impact of a toxic and a non-toxic strain of Microcystis aeruginosa on the crayfish Procambarus clarkii . Toxicon , 39 : 1461 – 1470 .
  • Carmichael , W.W. 1994 . The toxins of cyanobacteria . Scientific American , 270 : 64 – 72 .
  • Dunn , J. 1996 . Algae kill dialysis patients in Brazil . British Medical Journal. , 312 : 1183 – 1184 .
  • Magalhäes , V.F. , Scares , R.M. and Azevedo , S.M.F. 2001 . Microcystin contamination in fish from the Jacarepagua Lagoon (Rio de Janeiro, Brasil}: ecological implication and human health risk . Toxicon , 39 : 1077 – 1085 .
  • Carbis , C.R. , Mitchell , G.F. , Anderson , J.W. and McCauley , L . 1996a . The effects of microcystins on the serum biochemistry of carp, Cyprinus carpio L., when the toxins are administered by gavage, immersion and intraperitoneal routes . Fish Diseases , 19 : 151 – 159 .
  • Carbis , C.R. , Rawlin , G.T. , Mitchell , G.F. , Anderson , J.W. and McCauley , I. 1996b . The histopathology of carp, Cyprinus carpio L., exposed to microsystins by gavage, immersion and intraperitoneal administration . Fish Diseases , 19 : 199 – 207 .
  • Guzman , R.E. and Solter , P.F. 1999 . Hepatic oxidative stress following prolonged sublethal microcystin LR exposure . Toxicology and Pathology , 27 : 582 – 588 .
  • Thompson , W.L. and Pace , J.G. 1992 . Substances that protect cultured hepatocytes from the toxic effects of microcystin-LR . Toxicology in Vitro , 6 : 579 – 587 .
  • Toi vola , D.M. and Eriksson , J.E. 1999 . Toxins affecting cell signalling and alteration of cytoskeletal structure . Toxicology in Vitro , 13 : 521 – 530 .
  • Pflugmacher , S. , Wiegand , C. , Oberemm , A. , Beattie , K.A. , Krause , E. , Codd , G.A. and Steinberg , C.E.W. 1998 . Identification of an enzymatically formed glutathione conjugate of the cyanobacterial hepatoxin microcystin-LR: the first step of detoxication . Biochimica et Biophysica Acta. , 1425 : 527 – 533 .
  • Eriksson , J.E. , Toivola , D. , Meriluoto , J.A.O. , Karaki , H. and Hartshorne , D. 1990 . Hepatocyte deformation induced by cyanobacterial toxins reflects inhibition of protein phosphatases . Biochemical and Biophysical Research Communication , 173 : 1347 – 1353 .
  • Battle , T. , Touchant , C. , Moulsdale , H.J. , Dowsett , B. and Stacey , G.N. 1997 . New cell substrates for in vitro evaluation of microcystin hepato-cytoxicity . Toxicology in Vitro , 11 : 557 – 567 .
  • Ding , W.X. , Shen , H.M. , Zhu , H.G. and Ong , C.N. 1998a . Studies on oxidative damage induced by cyanobacteria extract in primary cultured rat hepatocytes . Environmental Research , 784 : 12 – 18 .
  • Ding , W.X. , Shen , H.M. , Zhu , H.G. and Ong , C.N. 1998b . Microcystic cyanobacteria causes mitochondria! membrane potential alteration and reactive species formation in primary cultured rat hepatocytes . Environmental Health Perspectives , 106 : 409 – 413 .
  • Ding , W.X. , Shen , H.M. and Ong , C.N. 2000 . Microcystic cyanobacteria extract induces cytoskeletal disruption and intracellular glutathione alteration in hepatocytes . Environmental Health Perspectives , 108 : 605 – 609 .
  • Ding , W.X. , Shen , H.M. and Ong , C.N. 2001 . Critical role of reactive oxygen species formation in microcystin-induced cytoskeleton disruption in primary cultured hepatocytes . Journal of Toxicology and Environmental Health , 64 : 507 – 519 .
  • Storey , K.B. 1996 . Oxidative stress: animal adaptations in nature . Brazilian Journal of Medical and Biological Research , 29 : 1715 – 1733 .
  • Lankoff , A. , Banasik , A. and Nowak , M. 2002 . Protective effect of melatonin against nodularin-induced oxidative stress in mouse liver . Archives of Toxicology , 76 : 158 – 165 .
  • Kono , Y. and Fridovich , I. 1982 . Superoxide radical inhibits catalase . Journal of Biological Chemistry , 10 : 5751 – 5754 .
  • Escobar , I.A. , Rubio , M.A. and Lissi , E.A. 1996 . SOD and catalase inactivation by singlet oxygen and peroxyl radicals . Free Radical Biology and Medicine , 20 : 285 – 290 .
  • Griffith , O.W. 1999 . Biologic and pharmacologie regulation of mammalian glutathione synthesis . Free Radical Biology and Medicine , 27 : 922 – 935 .
  • Sies , H. 1999 . Glutathione and its role in cellular functions . Free Radical Biology and Medicine , 27 : 916 – 921 .
  • Takenaka , S. 2001 . Covalent glutathione to cyanobacterial hepatotoxin microcystin LR by F344 rat cytosolic and microsomal glutathione-S-transferases . Environmental Toxicology and Pharmacology , 9 : 135 – 139 .
  • Metcalf , I.S. , Beatle , K.A. , Pflugmacher , S. and Codd , G.A. 2000 . Immuno-crossreactivity and toxicity assessment of conjugation products of the cyanobacterial toxin, microcystin-LR . FEBS Microbiology Letters , 189 : 155 – 158 .
  • Vinagre , T.M. , Alciati , I.C. , Yunes , J.S. , Richards , I. , Bianchini , A. and Monserrat , I.M. 2002 . Effects of extracts from the cyanobacterium Microcystis aeruginosa on ion-regulation and gill Na+, K + -ATPase and K + dependent phosphatase activities of the estuarine crab Chasmagnathus granulata (Decapoda, Grapsidae} . Physiological and Biochemical Zoology , 75 : 51 – 58 .
  • Best , J.H. , Pflugmacher , S. , Wiegand , C. , Eddy , F.B. , Metcalf , J.S. and Codd , G.A. 2002 . Effects of enteric bacterial and cyanobacterial lipopolysaccharides, and of microcystin-LR, on glutathione-S-transferase activities in zebra fish (Danio rerio} . Aquatic Toxicology , 60 : 223 – 231 .
  • Freedman , J.H. , Ciriolo , M.R. and Peisach , J. 1989 . The role of glutathione in copper metabolism and toxicity . Journal of Biological Chemistry , 264 : 5598 – 5605 .
  • Gaeta , V. , Canelo , E. , Lagos , N. and Zambrano , F. 1994 . Inhibitory effects of Microcystis aeruginosa toxin on ion pumps of the gill of freshwater fish . Toxicon , 32 : 121 – 127 .
  • Bury , N.R. , Flik , G. , Eddy , F.B. and Codd , G.A. 1996 . The effects of cyanobacteria and the cyanobacterial toxin microcystin-LR on Ca2 + transport and Na + /K + ATPase in tilapia gills . Journal of Experimental Biology , 199 : 1319 – 1326 .
  • Zambrano , F. and Canelo , E. 1996 . Effects of microcystin-LR on the partial reactions of the Na + -K+ pump or the gill of carp (Cyprinus carpio Linneo} . Toxicon , 34 : 451 – 458 .
  • Bury , N.R. , Codd , G.A. , Wendelaar Bonga , S.E. and Flik , G. 1998 . Fatty acids from the cyanobacterium Microcystis aeruginosa with potent inhibitory effects on fish gill Na + , K + ATPase activity . Journal of Experimental Biology , 201 : 81 – 89 .
  • Albers , R.W. and Koval , GJ. 1972 . Sodium-potassium-activated adenosinetriphosphatase. VII. Concurrent inhibition of Na + -K + -adenosine triphosphatase and activation of K + nitrophenylphosphatase activities . Journal of Biological Chemistry , 247 : 3088 – 3092 .
  • Wright , S.H. 1991 . “ The interface of animal and aqueous environment: strategies and constraints on the maintenance of solute balance ” . In Biochemistry and Molecular Biology of Fishes , Edited by: Hochachka , P.W. and Mommsen , T.P. 16S – 180 . Amsterdam : Eisevier .
  • Péqueux , A. 1995 . Osmotic regulation in crustaceans . Journal of Crustacean Biology , 15 : 1 – 60 .
  • Boldyrev , A.A. and Bulygina , E.R. 1997 . Na/K- ATPase and oxidative stress . Annals of New York Academy of Science , 834 : 666 – 668 .
  • Rauchova , H. , Drahota , Z. and Koudelova , J. 1999 . The role of membrane fluidity changes and thiobarbituric acid-reactives substances production in the inhibition of cerebral cortex NA +, K + ATPase activity . Physiologial Research , 48 : 73 – 78 .
  • Castilho , P.C. , Martins , I.A. and Bianchini , A. 2001 . Gill Na + , K +-ATPase and osmoregulation in the estuarine crab, Chasmagnathus granulata Dana, 1851 (Decapoda, Grapsidae} . Journal of Experimental Marine Biology and Ecology , 256 : 215 – 227 .
  • Morohashi , M. , Tsuchiya , K. , Mita , T. and Kawamura , M. 1991 . Identification of (Na, K} ATPase inhibitor in brine shrimp, Anemia salina, as long-chain fatty acids . Journal of Comparative Physiology , 161 B : 69 – 72 .
  • Ikawa , M. , Haney , J.H. and Sasner , J.I. 1996 . Inhibition of Chlorella growth by the lipids of cyanobacterium Microcystis aeruginosa . Hydrobiologia , 331 : 167 – 170 .
  • Ikawa , M. , Sasner , J.J. and Haney , J.F. 1997 . Inhibition of Chlorella growth by degradation and related products of linoleic and linolenic acids and the possible significance of polyunsaturated fatty acids in phytoplankton ecology . Hydrobiologia , 356 : 143 – 148 .
  • Thomas , C.E. and Reed , DJ. 1990 . Radical-induced inactivation of kidney Na + , K + ATPase: sensitivity to membrane lipid peroxidation and the protective effect of vitamin E . Archives of Biochemistry and Biophysics , 281 : 96 – 105 .
  • Rohn , T.T. , Hinds , T.R. and Vincenzi , F.F. 1993 . Ion transport ATPases as targets for free radical damage. Protection by an aminosteroid of the Ca2 + pump ATPase and Na + /K + pump ATPase of human red blood cell membranes . Biochemistry and Pharmacology , 46 : 525 – 534 .
  • Hitschke , K. , Bühler , R. , Apell , H.-J. and Stark , G. 1994 . Inactivation of the NA, K-ATPase by radiation-induced free radicals. Evidence for a radical-chain mechanism . FEBS Letters , 353 : 297 – 300 .
  • Jamme , I. , Petit , E. , Divoux , D. , Gerbi , A. , Maixent , J.-M. and Nouvelot , A. 1995 . Modulation of mouse cerebral Na +, K + -ATPase activity by oxygen free radicals . Neuro Report , 7 : 333 – 337 .
  • Keppler , D. 1999 . Export pumps for glutathione S-conjugates . Free Radical Biology and Medicine , 27 : 985 – 991 .
  • Lecurer , V. , Courtois , A. , Payen , L. , Verhnet , L. , Guillouzo , A. and Fardel , O. 2000 . Expression and regulation of hepatic drug and bile acid transporters . Toxicology , 153 : 203 – 219 .
  • Borst , P. , Evers , R. , Kool , M. and Wijnholds , J. 1999 . The multidrug resistance protein family . Biochimica et Biophysica Acta , 461 : 347 – 357 .
  • Bard , S.M. 2000 . Multixenobiotic resistance as a cellular defense mechanism in aquatic organism . Aquatic Toxicology , 48 : 357 – 389 .
  • Köhler , A. , Lauritzen , B. , Iansen , D. , Bottcher , P. , Teguliwa , L. , Krune , G. and Broeg , K. 1998 . Detection of P-glycoprotein mediated MDR/MXR in Carcinus maenas hepatopancreas by immuno-gold-silver labeling . Marine Environmental Research , 46 : 411 – 414 .
  • Sahin , A. , Tencalla , F.G , Dietrich , D.R. and Naegeli , H. 1996 . Biliary excretion of biochemically active cyanobacteria (blue-green algae} hepatotoxins in fish . Toxicology , 106 : 123 – 130 .
  • Kurelec , B. 1995 . Inhibition of multixenobiotic resistance in aquatic organisms: ecotoxic consequences . Science of the Total Environment , 171 : 197 – 204 .
  • Smital , T. and Kurelec , B. 1998 . The activity of mutixenobiotic resistance mechanism determined by rhodamine B-efflux method as a biomarker of exposure . Marine Environmental Research , 46 : 443 – 447 .
  • Smital , T. , Sauerborn , R. , Pivcevic , B. , Krca , S. and Kurelec , B. 2000 . Interspecies differences in P-glycoprotein mediated activity of multixenobiotic resistance mechanism in several marine and freshwater invertebrates . Comparative Biochemistry and Physiology , 1260 : 175 – 186 .
  • Yunes , I.S. , Salomon , P.S. , Matthiensen , A. , Beattie , K.A. , Raggett , S.L. and Codd , G.A. 1996 . Toxic blooms of cyanobacteria in the Patos Lagon Estuary, southern Brazil . Journal of Aquatic Ecosystem Health , 5 : 223 – 229 .
  • Dawson , J.F. and Holmes , C.F.B. 1999 . Molecular mechanisms underlying inhibition of protein phosphatases by marine toxins . Frontiers in Bioscience , 4 : 646 – 658 .
  • Xu , L. , Lam , P.K.S. , Chen , J. , Zhang , Y. and Harada , K. 2000 . Comparative study on in vitro inhibition of grass carp (Ctenopharyngodon ideallus} and mouse protein phosphatases by microcystins . Environmental Toxicology , 15 : 71 – 75 .

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