Neuropsychological Functioning Among Chronic Khat Users in Jazan Region, Saudi Arabia

REFERENCES

• Feyissa AM, Kelly JP. A review of the neuropharmacological properties of khat. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32:1147–1166.
   PubMed Web of Science ®Google Scholar
• Hoffman R, Al’Absi M. Khat use and neurobehavioral functions: suggestions for future studies. J Ethnopharmacol. 2010;132:554–563.
   PubMed Web of Science ®Google Scholar
• Ageely H. Health and socio-economic hazards associated with khat consumption. J Fam Community Med 2008;15:3–11.
   PubMedGoogle Scholar
• Cox G, Rampes H. Adverse effects of khat: a review. Adv Psychiatr Treat. 2003;9:456–463.
   Google Scholar
• Althani IM. Development a Saudi solution for khat problem. In: AlMarzoki H, Abu Khatwa AN, eds. Khat. Jeddah: Mutbouat Publications; 1988:241–257.
   Google Scholar
• Kite GC, Ismail M, Simmonds MS, Houghton PJ. Use of doubly protonated molecules in the analysis of cathedulins in crude extracts of khat (Catha edulis) by liquid chromatography/serial mass spectrometry. Rapid Commun Mass Spectrom. 2003;17:1553–1564.
   PubMed Web of Science ®Google Scholar
• Geisshusler S, Brenneisen R. The content of psychoactive phenylpropyl and phenylpentenyl khatamines in Catha edulis Forsk. of different origin. J Ethnopharmacol. 1987;19:269–277.
   PubMed Web of Science ®Google Scholar
• Toennes SW, Harder S, Schramm M, Niess C, Kauert GF. Pharmacokinetics of cathinone, cathine and norephedrine after the chewing of khat leaves. Br J Clin Pharmacol. 2003;56:125–130.
   PubMed Web of Science ®Google Scholar
• Al-Hebshi NN, Skaug N. Khat (Catha edulis)—an updated review. Addict Biol. 2005;10:299–307.
   PubMed Web of Science ®Google Scholar
• Odenwald M, Neuner F, Schauer M, et al. Khat use as risk factor for psychotic disorders: a cross-sectional and case-control study in Somalia. BMC Med. 2005;3:5.
   PubMed Web of Science ®Google Scholar
• Hassan NA, Gunaid AA, El-Khally FM, Murray-Lyon IM. The effect of chewing Khat leaves on human mood. Saudi Med J. 2002;23:850–853.
   PubMed Web of Science ®Google Scholar
• Saleh M, Mekkawy H, el-Komy F. Acute effects of a khat extract on the rat electroencephalogram. J Ethnopharmacol. 1988;23:291–298.
   PubMed Web of Science ®Google Scholar
• Banjaw MY, Miczek K, Schmidt WJ. Repeated Catha edulis oral administration enhances the baseline aggressive behavior in isolated rats. J Neural Transm. 2006;113:543–556.
   PubMed Web of Science ®Google Scholar
• Banjaw MY, Schmidt WJ. Behavioural sensitisation following repeated intermittent oral administration of Catha edulis in rats. Behav Brain Res. 2005;156:181–189.
   PubMed Web of Science ®Google Scholar
• Al-Motarreb A, Baker K, Broadley KJ. Khat: pharmacological and medical aspects and its social use in Yemen. Phytother Res. 2002;16:403–413.
   PubMed Web of Science ®Google Scholar
• Colzato LS, Ruiz MJ, van den Wildenberg WP, Bajo MT, Hommel B. Long-term effects of chronic khat use: impaired inhibitory control. Front Psychol. 2010;1:219.
   PubMedGoogle Scholar
• Colzato LS, Ruiz MJ, van den Wildenberg WP, Hommel B. Khat use is associated with impaired working memory and cognitive flexibility. PLoS ONE. 2011;6:e20602.
   PubMed Web of Science ®Google Scholar
• Colzato LS, Ruiz MJ, van den Wildenberg WP, Hommel B. Khat use is associated with increased response conflict in humans. Hum Psychopharmacol. 2012;27:315–321.
   PubMed Web of Science ®Google Scholar
• Scott JC, Woods SP, Matt GE, et al. Neurocognitive effects of methamphetamine: a critical review and meta-analysis. Neuropsychol Rev. 2007;17:275–297.
   PubMed Web of Science ®Google Scholar
• Alem A, Shibre T. Khat induced psychosis and its medico-legal implication: a case report. Ethiop Med J. 1997;35:137–139.
   PubMedGoogle Scholar
• Cohen J. Statistical Power Analysis for the Behavioral Sciences. 2nd ed. Hillsdale, NJ: Lawrence Earlbaum Associates; 1988.
   Google Scholar
• Erdfelder E, Faul F, Buchner A. GPOWER: a general power analysis program. Behav Res Methods 1996;28:1–11.
   Web of Science ®Google Scholar
• Mahoney JJ 3rd, Jackson BJ, Kalechstein AD, De la Garza R 2nd, Newton TF. Acute, low-dose methamphetamine administration improves attention/information processing speed and working memory in methamphetamine-dependent individuals displaying poorer cognitive performance at baseline. Prog Neuropsychopharmacol Biol Psychiatry. 2011;35:459–465.
   PubMed Web of Science ®Google Scholar
• Uftring SJ, Wachtel SR, Chu D, McCandless C, Levin DN, de Wit H. An fMRI study of the effect of amphetamine on brain activity. Neuropsychopharmacology. 2001;25:925–935.
   PubMed Web of Science ®Google Scholar
• Wardle MC, Treadway MT, Mayo LM, Zald DH, de Wit H. Amping up effort: effects of d-amphetamine on human effort-based decision-making. J Neurosci. 2011;31:16597–16602.
   PubMed Web of Science ®Google Scholar
• Sostek AJ, Buchsbaum MS, Rapoport JL. Effects of amphetamine on vigilance performance in normal and hyperactive children. J Abnorm Child Psychol. 1980;8:491–500.
   PubMed Web of Science ®Google Scholar
• Gonzalez R, Rippeth JD, Carey CL, et al. Neurocognitive performance of methamphetamine users discordant for history of marijuana exposure. Drug Alcohol Depend. 2004;76:181–190.
   PubMed Web of Science ®Google Scholar
• Rippeth JD, Heaton RK, Carey CL, et al. Methamphetamine dependence increases risk of neuropsychological impairment in HIV infected persons. J Int Neuropsychol Soc. 2004;10:1–14.
   PubMed Web of Science ®Google Scholar
• Woods SP, Rippeth JD, Conover E, et al. Deficient strategic control of verbal encoding and retrieval in individuals with methamphetamine dependence. Neuropsychology. 2005;19:35–43.
   PubMed Web of Science ®Google Scholar
• Al-Zahrani MA, Elsayed YA. The impacts of substance abuse and dependence on neuropsychological functions in a sample of patients from Saudi Arabia. Behav Brain Funct. 2009;5:48–58.
   PubMed Web of Science ®Google Scholar
• Kalechstein AD, Newton TF, Green M. Methamphetamine dependence is associated with neurocognitive impairment in the initial phases of abstinence. J Neuropsychiatry Clin Neurosci. 2003;15:215–220.
   PubMed Web of Science ®Google Scholar
• Simon SL, Domier C, Carnell J, Brethen P, Rawson R, Ling W. Cognitive impairment in individuals currently using methamphetamine. Am J Addict. 2000;9:222–231.
   PubMed Web of Science ®Google Scholar
• Salo R, Nordahl TE, Moore C, et al. A dissociation in attentional control: evidence from methamphetamine dependence. Biol Psychiatry. 2005;57:310–313.
   PubMed Web of Science ®Google Scholar
• McKetin R, Mattick RP. Attention and memory in illicit amphetamine users. Drug Alcohol Depend. 1997;48:235–242.
   PubMed Web of Science ®Google Scholar
• Rendell PG, Mazur M, Henry JD. Prospective memory impairment in former users of methamphetamine. Psychopharmacology (Berl). 2009;203:609–616.
   PubMed Web of Science ®Google Scholar
• Johanson CE, Frey KA, Lundahl LH, et al. Cognitive function and nigrostriatal markers in abstinent methamphetamine abusers. Psychopharmacology (Berl). 2006;185:327–338.
   PubMed Web of Science ®Google Scholar
• Cherner M, Suarez P, Casey C, et al. Methamphetamine use parameters do not predict neuropsychological impairment in currently abstinent dependent adults. Drug Alcohol Depend. 2010;106:154–163.
   PubMed Web of Science ®Google Scholar
• Iudicello JE, Woods SP, Vigil O, et al. Longer term improvement in neurocognitive functioning and affective distress among methamphetamine users who achieve stable abstinence. J Clin Exp Neuropsychol. 2010;32:704–718.
   PubMed Web of Science ®Google Scholar
• Chang L, Ernst T, Speck O, et al. Perfusion MRI and computerized cognitive test abnormalities in abstinent methamphetamine users. Psychiatry Res. 2002;114:65–79.
   PubMed Web of Science ®Google Scholar
• London ED, Berman SM, Voytek B, et al. Cerebral metabolic dysfunction and impaired vigilance in recently abstinent methamphetamine abusers. Biol Psychiatry. 2005;58:770–778.
   PubMed Web of Science ®Google Scholar
• Rohlman DS, Gimenes LS, Eckerman DA, Kang SK, Farahat FM, Anger WK. Development of the Behavioral Assessment and Research System (BARS) to detect and characterize neurotoxicity in humans. NeuroToxicology. 2003;25:523–532.
   Web of Science ®Google Scholar
• Anger WK, Letz R, Chrislip DW, et al. Neurobehavioral test methods for environmental health studies of adults. Neurotoxicol Teratol. 1994;16:489–497.
   PubMed Web of Science ®Google Scholar
• Anger WK, Rohlman DS, Sizemore OJ, Kovera CA, Gibertini M, Ger J. Human behavioral assessment in neurotoxicology: producing appropriate test performance with written and shaping instructions. Neurotoxicol Teratol. 1996;18:371–379.
   PubMed Web of Science ®Google Scholar
• Rohlman DS, Sizemore OJ, Anger WK, Kovera CA. Computerized neurobehavioral testing: techniques for improving test instructions. Neurotoxicol Teratol. 1996;18:407–412.
   PubMed Web of Science ®Google Scholar
• Rohlman DS, Ismail AA, Olson JR, Hendy OM, Abdel Rasoul GM. Occupational pesticide exposure and neurobehavioral deficits in an adolescent population. Paper presented at 50th meeting of the Society of Toxicology; Washington, DC; March 6, 2011.
   Google Scholar
• Ismail AA, Rohlman DS. The test-retest reliability of the Behavioral Assessment and Research System in Arabic Speaking Adults. Paper presented at 66th Annual Meeting of the Oregon Academy of Science; Portland, OR; February 23, 2008.
   Google Scholar
• Holm S. A simple sequentially rejective Bonferroni test procedure. Scand J Stat. 1979;6:65–70.
   Web of Science ®Google Scholar
• Anger WK, Sizemore OJ, Grossmann SJ, Glasser JA, Letz R, Bowler R. Human neurobehavioral research methods: impact of subject variables. Environ Res. 1997;73:18–41.
   PubMed Web of Science ®Google Scholar
• Ersche KD, Clark L, London M, Robbins TW, Sahakian BJ. Profile of executive and memory function associated with amphetamine and opiate dependence. Neuropsychopharmacology. 2006;31:1036–1047.
   PubMed Web of Science ®Google Scholar
• Hill RD, Nilsson LG, Nyberg L, Backman L. Cigarette smoking and cognitive performance in healthy Swedish adults. Age Ageing. 2003;32:548–550.
   PubMed Web of Science ®Google Scholar
• Durazzo TC, Meyerhoff DJ, Nixon SJ. A comprehensive assessment of neurocognition in middle-aged chronic cigarette smokers. Drug Alcohol Depend. 2012;122:105–111.
   PubMed Web of Science ®Google Scholar
• Corley J, Gow AJ, Starr JM, Deary IJ. Smoking, childhood IQ, and cognitive function in old age. J Psychosom Res. 2012;73: 132–138.
   PubMed Web of Science ®Google Scholar
• Fried PA, Watkinson B, Gray R. Neurocognitive consequences of cigarette smoking in young adults—a comparison with pre-drug performance. NeuroToxicol Teratol. 2006;28:517–525.
   PubMed Web of Science ®Google Scholar
• Dome P, Lazary J, Kalapos MP, Rihmer Z. Smoking, nicotine and neuropsychiatric disorders. Neurosci Biobehav Rev. 2010; 34:295–342.
   PubMed Web of Science ®Google Scholar
• Whalley LJ, Fox HC, Deary IJ, Starr JM. Childhood IQ, smoking, and cognitive change from age 11 to 64 years. Addict Behav. 2005;30:77–88.
   PubMed Web of Science ®Google Scholar
• Wang CC, Lu TH, Liao WC, et al. Cigarette smoking and cognitive impairment: a 10-year cohort study in Taiwan. Arch Gerontol Geriatr. 2010;51:143–148.
   PubMed Web of Science ®Google Scholar
• Volkow ND, Chang L, Wang GJ, et al. Loss of dopamine transporters in methamphetamine abusers recovers with protracted abstinence. J Neurosci. 2001;21:9414–9418.
   PubMed Web of Science ®Google Scholar
• Ellison G. Neural degeneration following chronic stimulant abuse reveals a weak link in brain, fasciculus retroflexus, implying the loss of forebrain control circuitry. Eur Neuropsychopharmacol. 2002;12:287–297.
   PubMed Web of Science ®Google Scholar
• Kalix P, Glennon RA. Further evidence for an amphetamine-like mechanism of action of the alkaloid cathinone. Biochem Pharmacol. 1986;35:3015–3019.
   PubMed Web of Science ®Google Scholar
• Wagner GC, Preston K, Ricaurte GA, Schuster CR, Seiden LS. Neurochemical similarities between d,l-cathinone and d-amphetamine. Drug Alcohol Depend. 1982;9:279–284.
   PubMed Web of Science ®Google Scholar
• Kimani ST, Nyongesa AW. Effects of single daily khat (Catha edulis) extract on spatial learning and memory in CBA mice. Behav Brain Res. 16 2008;195:192–197.
   PubMed Web of Science ®Google Scholar
• Kimani ST, Patel NB, Kioy PG. Effect of single and daily khat (Catha edulis) extract on locomotor behaviour in CBA mice. Sci Res Essays. 2008;3:187–196.
   Web of Science ®Google Scholar
• Daba D, Hymete A, Bekhit AA, Mohamed AM, Bekhit Ael D. Multi residue analysis of pesticides in wheat and khat collected from different regions of Ethiopia. Bull Environ Contam Toxicol. 2011;86:336–341.
   PubMed Web of Science ®Google Scholar