Gender differences in association of prescription opioid use and mortality: A propensity-matched analysis from the REasons for Geographic And Racial Differences in Stroke (REGARDS) prospective cohort

References

• Sawyer P, Bodner EV, Ritchie CS, Allman RM. Pain and pain medication use in community-dwelling older adults. Am J Geriat Pharmacother. 2006;4(4):316–324.
   PubMedGoogle Scholar
• Przekop P, Haviland MG, Oda K, Morton KR. Prevalence and correlates of pain interference in older adults: why treating the whole body and mind is necessary. J Bodywork Movement Ther. 2015;19(2):217–225.
   PubMed Web of Science ®Google Scholar
• Laslett LL, Quinn SJ, Winzenberg TM, Sanderson K, Cicuttini F, Jones G. A prospective study of the impact of musculoskeletal pain and radiographic osteoarthritis on health related quality of life in community dwelling older people. BMC Musculoskelet Disord. 2012;13(1):168.
   PubMedGoogle Scholar
• Wright EA, Katz JN, Abrams S, Solomon DH, Losina E. Trends in prescription of opioids from 2003-2009 in persons with knee osteoarthritis. Arthritis Care Res. 2014;66(10):1489–1495.
   PubMed Web of Science ®Google Scholar
• Manchikanti L, Singh A. Therapeutic opioids: a ten-year perspective on the complexities and complications of the escalating use, abuse, and nonmedical use of opioids. Pain Physician. 2008;11(2):S63–S88.
   PubMed Web of Science ®Google Scholar
• Manchikanti L, Fellows B, Ailinani H, Pampati V. Therapeutic use, abuse, and nonmedical use of opioids: a ten-year perspective. Pain Physician. 2010;13(5):401–435.
   PubMed Web of Science ®Google Scholar
• Schwetz TA, Calder T, Rosenthal E, Kattakuzhy S, Fauci AS. Opioids and infectious diseases: a converging public health crisis. J Infect Dis. 2019;220(3):346–349.
   PubMed Web of Science ®Google Scholar
• Dart RC, Surratt HL, Cicero TJ, et al. Trends in opioid analgesic abuse and mortality in the United States. N Engl J Med. 2015;372(3):241–248.
   PubMed Web of Science ®Google Scholar
• Guy GP, Jr., Zhang K, Bohm MK, et al. Vital signs: changes in opioid prescribing in the United States, 2006-2015. MMWR Morb Mortal Wkly Rep. 2017;66(26):697–704.
   PubMed Web of Science ®Google Scholar
• Dowell D, Haegerich TM, Chou R. CDC guideline for prescribing opioids for chronic pain–United States, 2016. JAMA 2016;315(15):1624–1645.
   PubMed Web of Science ®Google Scholar
• Parsells Kelly J, Cook SF, Kaufman DW, Anderson T, Rosenberg L, Mitchell AA. Prevalence and characteristics of opioid use in the US adult population. Pain 2008;138(3):507–513.
   PubMed Web of Science ®Google Scholar
• Centers for Disease Control and Prevention. Adult use of prescription opioid pain medications, Utah, 2008. MMWR Morbidity Mortality Weekly Report 2010;59(06):4.
   Google Scholar
• Bohnert AS, Valenstein M, Bair MJ, et al. Association between opioid prescribing patterns and opioid overdose-related deaths. JAMA 2011;305(13):1315–1321.
   PubMed Web of Science ®Google Scholar
• McCabe SE, West BT, Boyd CJ. Medical use, medical misuse, and nonmedical use of prescription opioids: results from a longitudinal study. Pain 2013;154(5):708–713.
   PubMed Web of Science ®Google Scholar
• Visconti AJ, Santos GM, Lemos NP, Burke C, Coffin PO. Opioid overdose deaths in the city and county of San Francisco: prevalence, distribution, and disparities. J Urban Health. 2015;92(4):758.
   PubMed Web of Science ®Google Scholar
• Cerda M, Ransome Y, Keyes KM, et al. Prescription opioid mortality trends in New York City, 1990-2006: examining the emergence of an epidemic. Drug Alcohol Depend. 2013;132(1–2):53–62.
   PubMed Web of Science ®Google Scholar
• Reid MC, Bennett DA, Chen WG, et al. Improving the pharmacologic management of pain in older adults: identifying the research gaps and methods to address them. Pain Med. 2011;12(9):1336–1357.
   PubMed Web of Science ®Google Scholar
• Spitz A, Moore AA, Papaleontiou M, Granieri E, Turner BJ, Reid MC. Primary care providers’ perspective on prescribing opioids to older adults with chronic non-cancer pain: a qualitative study. BMC Geriatr. 2011;11(1):35.
   PubMedGoogle Scholar
• Jamison RN, Sheehan KA, Scanlan E, Matthews M, Ross EL. Beliefs and attitudes about opioid prescribing and chronic pain management: survey of primary care providers. J Opioid Manag. 2014;10(6):375–382.
   PubMedGoogle Scholar
• Liberman JS, Samuels LR, Goggins K, et al. Opioid prescriptions at hospital discharge are associated with more postdischarge healthcare utilization. JAHA. 2019;8(3):e010664–e010664.
   Google Scholar
• Ray WA, Chung CP, Murray KT, Hall K, Stein CM. Prescription of long-acting opioids and mortality in patients with chronic noncancer pain. JAMA 2016;315(22):2415–2423.
   PubMed Web of Science ®Google Scholar
• Abnett D, Jones N, White S, Hansen J, Park N. Wallace & Gromit: Plots in Space. London, UK: Titan; 2007.
   Google Scholar
• Ekholm O, Kurita GP, Hjsted J, Juel K, Sjgren P. Chronic pain, opioid prescriptions, and mortality in Denmark: a population-based cohort study. Pain 2014;155(12):2486–2490.
   PubMed Web of Science ®Google Scholar
• Solomon DH, Rassen JA, Glynn RJ. The comparative safety of opioids for nonmalignant pain in older adults. Arch Intern Med. 2010;170(22):1979–1986.
   PubMed Web of Science ®Google Scholar
• Solomon DH, Rassen JA, Glynn RJ, Lee J, Levin R, Schneeweiss S. The comparative safety of analgesics in older adults with arthritis. Arch Intern Med. 2010;170(22):1968–1976.
   PubMedGoogle Scholar
• Li L, Setoguchi S, Cabral H, Jick S. Opioid use for noncancer pain and risk of myocardial infarction amongst adults. J Intern Med. 2013;273(5):511–526.
   PubMed Web of Science ®Google Scholar
• Khodneva Y, Muntner P, Kertesz S, Kissela B, Safford MM. Prescription opioid use and risk of coronary heart disease, stroke, and cardiovascular death among adults from a prospective cohort (REGARDS Study). Pain Med. 2016;17(3):444–455.
   PubMed Web of Science ®Google Scholar
• Von Korff M, Kolodny A, Deyo RA, Chou R. Long-term opioid therapy reconsidered. Ann Intern Med. 2011;155(5):325–328.
   PubMed Web of Science ®Google Scholar
• Sullivan MD, Ballantyne JC. What are we treating with long-term opioid therapy? Arch Intern Med. 2012;172(5):433–434.
   PubMedGoogle Scholar
• Howard VJ, Cushman M, Pulley L, et al. The reasons for geographic and racial differences in stroke study: objectives and design. Neuroepidemiology 2005;25(3):135–143.
   PubMed Web of Science ®Google Scholar
• Safford MM, Brown TM, Muntner PM, et al. Association of race and sex with risk of incident acute coronary heart disease events. JAMA 2012;308(17):1768–1774.
   PubMed Web of Science ®Google Scholar
• Barkin RL, Barkin SJ, Barkin DS. Propoxyphene (dextropropoxyphene): a critical review of a weak opioid analgesic that should remain in antiquity. Am J Therap. 2006;13(6):534–542.
   PubMedGoogle Scholar
• Stuart EA. Matching methods for causal inference: a review and a look forward. Statist Sci. 2010;25(1):1–21.
   PubMed Web of Science ®Google Scholar
• Sokolow M, Lyon TP. The ventricular complex in left ventricular hypertrophy as obtained by unipolar precordial and limb leads. Am Heart J. 1949;37(2):161–186.
   PubMed Web of Science ®Google Scholar
• Radloff LS, Rae DS. Susceptibility and precipitating factors in depression: sex differences and similarities. J Abnorm Psychol. 1979;88(2):174–181.
   PubMed Web of Science ®Google Scholar
• Stewart AL, Napoles-Springer A. Health-related quality-of-life assessments in diverse population groups in the United States. Med Care. 2000;38(9):102–124.
   Web of Science ®Google Scholar
• Soliman EZ, Howard G, Cushman M, et al. Prolongation of QTc and risk of stroke: the REGARDS (REasons for Geographic and Racial Differences in Stroke) study. J Am College Cardiol. 2012;59(16):1460–1467.
   PubMed Web of Science ®Google Scholar
• Morisky DE, Green LW, Levine DM. Concurrent and predictive validity of a self-reported measure of medication adherence. Med Care. 1986;24(1):67–74.
   PubMed Web of Science ®Google Scholar
• Redmond N, Richman J, Gamboa CM, et al. Perceived stress is associated with incident coronary heart disease and all-cause mortality in low- but not high-income participants in the Reasons for Geographic And Racial Differences in Stroke Study. JAHA. 2013;2(6):e000447.
   Google Scholar
• Rubin DB, Schenker N. Multiple imputation in health-care databases: an overview and some applications. Statist Med. 1991;10(4):585–598.
   PubMed Web of Science ®Google Scholar
• Mitra R, Reiter JP. A comparison of two methods of estimating propensity scores after multiple imputation. Stat Meth Med Res. 2012;25(1):188–204.
   PubMedGoogle Scholar
• Eriksen J, Sjogren P, Bruera E, Ekholm O, Rasmussen NK. Critical issues on opioids in chronic non-cancer pain: an epidemiological study. Pain 2006;125(1):172–179.
   PubMed Web of Science ®Google Scholar
• Svendsen K, Fredheim OM, Romundstad P, Borchgrevink PC, Skurtveit S. Persistent opioid use and socio-economic factors: a population-based study in Norway. Acta Anaessiol Scand. 2014;58(4):437–445.
   PubMed Web of Science ®Google Scholar
• Dobscha SK, Morasco BJ, Duckart JP, Macey T, Deyo RA. Correlates of prescription opioid initiation and long-term opioid use in veterans with persistent pain. Clin J Pain. 2013;29(2):102–108.
   PubMed Web of Science ®Google Scholar
• Fredheim OM, Mahic M, Skurtveit S, Dale O, Romundstad P, Borchgrevink PC. Chronic pain and use of opioids: a population-based pharmacoepidemiological study from the Norwegian prescription database and the Nord-Trondelag health study. Pain 2014;155(7):1213–1221.
   PubMed Web of Science ®Google Scholar
• Ashworth J, Green DJ, Dunn KM, Jordan KP. Opioid use among low back pain patients in primary care: is opioid prescription associated with disability at 6-month follow-up? Pain 2013;154(7):1038–1044.
   PubMed Web of Science ®Google Scholar
• Mellbye A, Karlstad O, Skurtveit S, Borchgrevink PC, Fredheim OM. Co-morbidity in persistent opioid users with chronic non-malignant pain in Norway. EJP. 2014;18(8):1083–1093.
   PubMed Web of Science ®Google Scholar
• Sjogren P, Gronbaek M, Peuckmann V, Ekholm O. A population-based cohort study on chronic pain: the role of opioids. Clin J Pain. 2010;26(9):763–769.
   PubMed Web of Science ®Google Scholar
• Weisberg DF, Gordon KS, Barry DT, et al. Long-term prescription of opioids and/or benzodiazepines and mortality among HIV-infected and uninfected patients. J Acquired Immune Def Synd. 2015;69(2):223–233.
   PubMed Web of Science ®Google Scholar
• Rose AJ, McBain R, Schuler MS, et al. Effect of age on opioid prescribing, overdose, and mortality in Massachusetts, 2011 to 2015. J Am Geriatr Soc. 2019;67(1):128–132.
   PubMed Web of Science ®Google Scholar
• Miller M, Barber CW, Leatherman S, et al. Prescription opioid duration of action and the risk of unintentional overdose among patients receiving opioid therapy. JAMA Intern Med. 2015;175(4):608–615.
   PubMed Web of Science ®Google Scholar
• Park TW, Saitz R, Ganoczy D, Ilgen MA, Bohnert AS. Benzodiazepine prescribing patterns and deaths from drug overdose among US veterans receiving opioid analgesics: case-cohort study. BMJ 2015;350(9):h2698.
   PubMedGoogle Scholar
• Qureshi WT, O’Neal WT, Khodneva Y, et al. Association between opioid use and atrial fibrillation: the reasons for Geographic and Racial Differences in Stroke (REGARDS) Study. JAMA Intern Med. 2015;175(6):1058–1060.
   PubMed Web of Science ®Google Scholar
• Winton JC, Twilla JD. Sudden cardiac arrest in a patient on chronic methadone after the addition of azithromycin. Am J Med Sci. 2013;345(2):160–162.
   PubMed Web of Science ®Google Scholar
• Fanoe S, Jensen GB, Sjogren P, Korsgaard MP, Grunnet M. Oxycodone is associated with dose-dependent QTc prolongation in patients and low-affinity inhibiting of hERG activity in vitro. Br J Clin Pharmacol. 2009;67(2):172–179.
   PubMed Web of Science ®Google Scholar
• van den Beuken-van Everdingen MH, Geurts JW, Patijn J. Prolonged QT interval by methadone: relevance for daily practice? A prospective study in patients with cancer and noncancer pain. J Opioid Manag. 2013;9(4):263–267.
   PubMedGoogle Scholar
• Khodneva Y, Muntner P, Kertesz S, Safford MM. Prescription opioid use and risk of cardiovascular disease among older adults from a community sample. Drug & Alcohol Depend. 2014;140:e103.
   Google Scholar
• Sarton E, Olofsen E, Romberg R, et al. Sex differences in morphine analgesia: an experimental study in healthy volunteers. Anessiology 2000;93(5):1245–1254.
   PubMed Web of Science ®Google Scholar
• Planelles B, Margarit C, Inda MD, et al. Gender based differences, pharmacogenetics and adverse events in chronic pain management. Pharmacogenomics J. 2019. doi:10.1038/s41397-019-0118-9
   PubMed Web of Science ®Google Scholar
• Sadhasivam S, Chidambaran V, Olbrecht VA, et al. Opioid-related adverse effects in children undergoing surgery: unequal burden on younger girls with higher doses of opioids. Pain Med. 2015;16(5):985–997.
   PubMed Web of Science ®Google Scholar