A Review of the Evidence of Health Claims for Biotherapeutic Agents

References

• Elmer GW, McFarland LV, Surawicz CM, eds. Biotherapeu-tic agents and infectious diseases. Totowa, NJ: Humana Press, 1999.
   Google Scholar
• Fuller R (ed). Probiotics 2. Applications and practical as-pects. London: Chapman & Hall, 1997.
   Google Scholar
• Sanders ME. Development of consumer probiotics for the US Market. Brit J Nutr 1998; 80: S213–8.
   Web of Science ®Google Scholar
• Jensen B. Dr. Jensen's guide to better bowel care. Garden City Park, NY: Avery Publishing Group, 1999: 36–38.
   Google Scholar
• Rolfe RD. Colonization resistance. In: Mackie RI, White BA, Isaacson RE, eds. Gastrointestinal Microbiology. Vol-ume 2. New York: Chapman & Hall, 1997: 501–36.
   Google Scholar
• Guerrant RL, Steiner TS, Lima AAM, Bobak DA. How intestinal bacteria cause disease. J Infect Dis 1999; 179: S331–7.
   PubMed Web of Science ®Google Scholar
• Clausen MR, Bonnen H, Tvede M, Mortensen PB. Colonic fermentation to short-chain fatty acids is decreased in antibi-otic-associated diarrhea. Gastroenterology 1991; 101: 1497–504.
   PubMed Web of Science ®Google Scholar
• DuPont HL: Prevention of diarrhea by the probiotic, Lacto-bacillus GG [editorial]. J Pediatr 1999; 134: 1–2.
   Web of Science ®Google Scholar
• Oberhelman RA, Gilman RH, Sheen P, Taylor DN, Black RE, Cabrera L, Lescano AG, Meza R, Madico G. A placebo-controlled trial of Lactobacillus GG to prevent di-arrhea in undernourished Peruvian children. J Pediatr 1999; 134: 15–20.
   Google Scholar
• Vaisanen ML, Leskinen M, Siitonen A, Kanervo A, Harila-Saari A, Mottonen M, Kokkonen J, Rantala H, Saxelin M, Uhari M, Jousimies-Somer H. Occurrence of diarrhea in children receiving oral antibiotics with or without probiotic supplementation with Lactobacillus GG. Microbiology Ecol-ogy in Health and Disease 1998; 10: 199–200.
   Google Scholar
• Roffe C. Biotherapy for antibiotic-associated and other di-arrhoeas. J Infect 1996; 32: 1–10.
   Web of Science ®Google Scholar
• Romond MB, Ais A, Guillemot F, Bounouader R, Cortot A, Romond C. Cell-free whey from milk fermented with Bifidobacterium breve C50 used to modify the colonic mi-croflora of healthy subjects. J Dairy Sci 1998; 81: 1229–35.
   PubMed Web of Science ®Google Scholar
• Buydens P, Debeuckelaere S. Efficacy of SF68 in the treat-ment of acute diarrhea. A placebo-controlled trial. Scand J Gastroenterol 1996; 31: 887–91.
   PubMed Web of Science ®Google Scholar
• McFarland LV. Biotherapeutic agents for Clostridium diffi-cile-associated disease. In: Elmer GW, McFarland LV, Surawicz CM, eds. Biotherapeutic agents and infectious diseases. Totowa, NJ: Humana Press, 1999: 159–93.
   Google Scholar
• McFarland LV, Surawicz CM, Rubin M, Fekety R, Elmer GW, Greenberg RN. Recurrent Clostridium difficile disease: epidemiology and clinical characteristics. Infect Control Hosp Epidemiol 1999; 20: 43–50.
   PubMed Web of Science ®Google Scholar
• Elmer GW, Surawicz CM, McFarland LV. Biotherapeutic agents. A neglected modality for the treatment and preven-tion of selected intestinal and vaginal infections. JAMA 1996; 275: 870–6.
   Google Scholar
• McFarland LV. Microecologic approaches for traveler's di-arrhea, antibiotic-associated diarrhea, and acute pediatric diarrhea. Curr Gastroenterol Rep 1999; I: 301–7.
   Google Scholar
• Salminen S, Bouley C, Boutron-Ruault M-C, Cummings JH, Franck A, Gibson GR, Isolauri E, Moreau M-C, Roberfroid M, Rowland I. Functional food science and gastrointestinal physiology and function. Br J Nutr 1998; 80: S147–71.
   Google Scholar
• Pochapin M. The effect of probiotics on Clostridium difficile diarrhea. Am J Gastroenterol 2000; 95: S11–3.
   PubMed Web of Science ®Google Scholar
• Tannock GW (ed). Probiotics: A critical review. Norfolk, England: Horizon Scientific Press, 1999.
   Google Scholar
• Adam J, Barret C, Barret-Bellet A, Benedetti E, Calendini A, Darchen P, Galibert JM, Guerci P, Guiot G, Haechler M, Junqua R, Le Matelot J, Legrand JP, Mallez B, Massonneau A, Mestas JJ, Michelet FX, Papel B, Petit P, Pfeiffer G, Pidoux A, Portalis H, Prado F, Rameau J, Valence P. [Controlled double-blind clinical trials of Ultra-Levure: mul-ticentre study by 25 physicians in 388 cases]. Gazette Med-icale de France 1977; 84: 2072–8.
   Google Scholar
• Surawicz CM, Elmer GW, Speelman P, McFarland LV, Chinn J, van Belle G. Prevention of antibiotic-associated diarrhea by Saccharomyces boulardii: a prospective study. Gastroenterology 1989; 96: 981–8.
   Google Scholar
• McFarland LV, Surawicz CM, Greenberg RN, Elmer GW, Moyer KA, Melcher SA, Bowen KE, Cox JL. Prevention of fl-lactam-associated diarrhea by Saccharomyces boulardii compared to placebo. Am J Gastroenterol 1995; 90: 439–48.
   PubMed Web of Science ®Google Scholar
• Lewis SJ, Potts LF, Barry RE. The lack of therapeutic effect of Saccharomyces boulardii in the prevention of antibiotic-re-lated diarrhoea in elderly patients. J Infect 1998; 36: 171–4.
   Google Scholar
• Elmer GW, McFarland LV. Comment on 'The lack of therapeutic effect of Saccharomyces boulardii in the preven-tion of antibiotic-associated diarrhoea in elderly patients'. J Infect 1998; 37: 307–8.
   Web of Science ®Google Scholar
• McFarland LV. Epidemiology, risk factors and treatments for antibiotic-associated diarrhea. Dig Dis 1998; 16: 292–307.
   PubMed Web of Science ®Google Scholar
• McFarland LV, Surawicz CM, Greenberg RN, Fekety R, Elmer GW, Moyer KA, Melcher SA, Bowen KE, Cox JL, Noorani Z, Harrington G, Rubin M, Greenwald D. A randomized placebo-controlled trial of Saccharomyces bou-lardii in combination with standard antibiotics for Clostrid-ium difficile disease. JAMA 1994; 271: 1913–8.
   Google Scholar
• McFarland LV, Surawicz CM, Elmer GW, Greenberg RN, Fekety R, Rubin M. A new combination treatment for recurrent Clostridium difficile infections: Saccharomyces bou-lardii and high dose vancomycin. Microbial Ecology in Health and Disease 1998; 10: 194.
   Google Scholar
• Kollaritsch H, Hoist H, Grobara P, Wiedermann G. Pro-phylaxe der reisediarrhoe mit Saccharomyces boulardii. Fortschr Med 1993; 111: 153–6.
   Google Scholar
• Witsell DL, Garrett G, Yarbrough WG, Dorrestein SP, Drake AF, Weissler MC. Effect of Lactobacillus acidophilus on antibiotic-associated gastrointestinal morbidity: a prospective randomized trial. J Otolarynogol 1995; 24: 231–3.
   Google Scholar
• Gotz V, Romankiewicz JA, Moss J, Murray HW. Prophy-laxis against ampicillin-associated diarrhea with a Lacto-bacillus preparation. Am J Hosp Pharm 1979; 36: 754–7.
   PubMedGoogle Scholar
• Tankanow RM, Ross MB, Ertel U, Dickinson DG, Mc-Cormick LS, Garfinkel JF. A double-blind, placebo-con-trolled study of the efficacy of Lactinex in the prophylaxis of amoxicillin-induced diarrhea. DICP 1990; 24: 382–4.
   Google Scholar
• Shornikova A-V, Casas IA, Isolauri E, Mykkanen H, Vesikari T. Lactobacillus reuteri as a therapeutic agent in acute diarrhea in young children. J Pediatr Gastroenterol Nutr 1997; 24: 399–404.
   Google Scholar
• Guandalini S, Pensabene L, Zikri MA, Dias JA, Casali LG, Hoekstra H, Kolacek S, Massar K, Micetic-Turk D, Pa-padopoulou A, Salazar de Sousa J, Sandhu B, Szajewska H, Weizman Z. Lactobacillus GG administered in oral rehydra-tion solution to children with acute diarrhea: a multicenter European trial. J Pediatr Gastroenterol Nutr 2000; 30: 54–60.
   Google Scholar
• Orrhage K, Brismar B, Nord CE. Effects of supplements of Bifidobacterium longum and Lactobacillus acidophilus on the intestinal microbiota during administration of clindamycin. Microbial Ecology in Health and Disease 1994; 7: 17–25.
   Google Scholar
• Shomikova A-V, Isolauri E, Burkanova L, Lukovnikova S, Vesikari T. A trial in the Karelian Republic of oral rehydra-tion and Lactobacillus GG for treatment of acute diarrhoea. Acta Paediatr 1997; 86: 460–5.
   Google Scholar
• Majamaa H, Isolauri E, Saxelin M, Vesikari T. Lactic acid bacteria in the treatment of acute rotavirus gastroenteritis. J Pediatr Gastroenterol Nutr 1995; 20: 333–8.
   PubMed Web of Science ®Google Scholar
• Pochapin MB, Oltikar A, Pringle-Smith R, Schreiber C. A prospective randomized placebo-controlled trial of Lacto-bacillus GG in combination with standard antibiotics for the treatment of Clostridium difficile infection. Am J Gastroen-terol 1998; 93: 1697.
   Google Scholar
• Wunderlich PF, Braun L, Fumagalli I, D'Apuzzo V, Heim F, Karly M, Lodi R, Politta G, Vonbank F, Zeltner L. Double-blind report on the efficacy of lactic acid-producing Enterococcus SF68 in the prevention of antibiotic-associated diarrhoea and in the treatment of acute diarrhoea. J Int Med Res 1989; 17: 333–8.
   Google Scholar
• Tvede M, Rask-Madsen J. Bacteriotherapy for chronic re-lapsing Clostridium difficile diarrhoea in six patients. Lancet 1989; I: 1156–60.
   Google Scholar
• Naidu AS, Bidlack WR, Clemens RA. Probiotic spectra of lactic acid bacteria (LAB). Crit Rev Food Sci Nutr 1999; 38: 13–126.
   Web of Science ®Google Scholar
• Reddy BS. Prevention of colon cancer by pre- and probi-otics: evidence from laboratory studies. Br J Nutr 1998; 80: S219–23.
   PubMed Web of Science ®Google Scholar
• Moore WE, Moore LH. Intestinal floras of populations that have a high risk of colon cancer. Appl Environ Microbiol 1995; 61: 3202–7.
   PubMed Web of Science ®Google Scholar
• Zhang XB, Ohta Y. Binding of mutagens by fractions of the cell wall skeleton of lactic acid bacteria on mutagens. J Dairy Sci 1991; 74: 1477–81.
   PubMed Web of Science ®Google Scholar
• Sanders ME. Effect of consumption of lactic cultures on human health. Adv Food Nutr Res 1993; 37: 67–130.
   PubMedGoogle Scholar
• Lankaputhra WE, Shah NP. Antimutagenic properties of probiotic bacteria and of organic acids. Mutat Res 1998; 397: 169–82.
   PubMed Web of Science ®Google Scholar
• Gorbach SL, Goldin BR. The intestinal microflora and the colon cancer connection. Rev Infect Dis 1990; 12: S252–9.
   PubMedGoogle Scholar
• McBain AJ, Macfarlane GT. Ecological and physiological studies on large intestinal bacteria in relation to production of hydrolytic and reductive enzymes involved in formation of genotoxic metabolites. J Med Microbiol 1998; 47: 407–16.
   PubMed Web of Science ®Google Scholar
• Goldin BR. Intestinal microflora: metabolism of drugs and carcinogens. Ann Med 1990; 22: 43–8.
   PubMed Web of Science ®Google Scholar
• Rowland IR, Rumney CJ, Coutts JT, Lievense LC. Effect of Bifidobacterium longum and inulin on gut bacterial metabolism and carcinogen-induced aberrant crypt foci in rats. Carcinogenesis 1998; 19: 281–5.
   PubMed Web of Science ®Google Scholar
• McConnell MA, Tannock GW. Lactobacilli and azoreduc-tase activity in the murine cecum. Appl Environ Microbiol 1991; 57: 3664–5.
   PubMed Web of Science ®Google Scholar
• Goldin BR, Gorbach SL. The effect of oral administration on Lactobacillus and antibiotics on intestinal bacterial activ-ity and chemical induction of large bowel tumors. Dev Indust Microbiol 1984; 25: 139–50.
   Google Scholar
• Gibson PR, Moeller I, Kagelari O, Folino M, Young GP. Contrasting effects of butyrate on the expression of pheno-typic markers of differentation in neoplastic and non-neo-plastic colonic epithelial cells in vitro. J Gastroenterol Hepatol 1992; 7: 165–72.
   Google Scholar
• Kato I, Kobayashi S, Yokokura T, Mutai M. Antitumor activity of Lactobacillus casei in mice. Gann 1981; 72: 517–23.
   PubMedGoogle Scholar
• Sekine K, Toida T, Saito M, Kuboyama M, Kawashima T, Hashimoto Y. A new morphologically characterized cell wall preparation (whole peptidoglycan) from Bfidobacterium in-fantis with a higher efficacy on the regression of an estab-lished tumor in mice. Cancer Res 1985; 45: 1300–7.
   PubMed Web of Science ®Google Scholar
• Kohwi T, Imai K, Tamura A, Hashimoto Y. Antitumor effect of Bifidobacterium infantis in mice. Gunn 1978; 69: 613–8.
   PubMedGoogle Scholar
• Shackelford LA, Rao DR, Chawan CB, Pulusani SR. Effect of feeding fermented milk on the incidence of chemically induced colon tumors in rats. Nutr Cancer 1983; 5: 159–64.
   PubMedGoogle Scholar
• Goldin BR, Gorbach SL. Effect of Lactobacillus acidophilus dietary supplements on 1,2-dimethylhydrazine in dihy-drochloride-induced intestinal cancer in rats. J Natl Cancer Inst 1980; 64: 263–5.
   PubMed Web of Science ®Google Scholar
• Van't Veer P, Kok FJ, Brants HA, Ockhuizen T, Sturmans F, Hermus RJ. Dietary fat and the risk of breast cancer. Int J Epidemiol 1990; 19: 12–8.
   Google Scholar
• Okawa T, Kita M, Arai T, Iida K, Dokiya T, Takegawa Y, Hirokawa Y, Yamazaki K, Hashimoto S. Phase II random-ized clinical trial of LC9018 concurrently used with radiation in the treatment of carcinoma of the uterine cervix. Its effect on tumor reduction and histology. Cancer 1989; 64: 1769–76.
   Google Scholar
• Okawa T, Niibe H, Arai T, Sekiba K, Noda K, Takeuchi S, Hashimoto S, Ogawa N. Effect of LC9018 combined with radiation therapy on carcinoma of the uterine cervix. A phase III, multicenter, randomized, controlled study. Cancer 1993; 72: 1949–54.
   Google Scholar
• Aso Y, Akazan H. Prophylactic effect of a Lactobacillus casei preparation on the recurrence of superficial bladder cancer. BLP study group. Uro Int 1992; 49: 125–9.
   Web of Science ®Google Scholar
• Aso Y, Akaza H, Kotake T, Tsukamoto T, Imai K, Naito S. Preventive effect of a Lactobacillus casei preparation on the recurrence of superficial bladder cancer in a double-blind trial. The BLP study group. Eur Urol 1995; 27: 104–9.
   PubMed Web of Science ®Google Scholar
• Danielson AD, Peo ERJ, Shahani KM, Lewis AJ, Whalen PJ, Amer MA. Anticholesterolemic property of Lactobacillus acidophilus yogurt fed to mature boars. J Animal Sci 1989; 67: 966–74.
   PubMed Web of Science ®Google Scholar
• Gilliland SE, Nelson CR, Maxwell C. Assimilation of cholesterol by Lactobacillus acidophilus. Appl Environ Mi-crobiol 1985; 49: 377–81.
   Google Scholar
• Zacconi C, Bottazzi V, Rebecchi A, Bosi E, Sarra PG, Tagliaferri L. Serum cholesterol levels in axenic mice colo-nized with Enterococcus faecium and Lactobacillus acidophilus. Microbiologica 1992; 15: 413–7.
   PubMedGoogle Scholar
• Oda T, Hashiba H. Effects of skim milk and its fermented product by Lactobacillus acidophilus on plasma and liver lipid levels in diet-induced hypertriglyceridemic rats. J Nutr Sci Vitaminol (Tokyo) 1994; 40: 617–21.
   Web of Science ®Google Scholar
• Harrison VC, Peat G. Serum cholesterol and bowel flora in the newborn. Am J Clin Nutr 1975; 28: 1351–5.
   PubMed Web of Science ®Google Scholar
• Mohan JC, Arora R, Khalilullah M. Short-term hypolipi-demic effects of oral Lactobacillus sporo genes therapy in patients with primary dyslipidemias. Indian Heart J 1990; 42: 361–4.
   Google Scholar
• Lin SY, Ayres JW, Winkler WJR, Sandine WE. Lactobacil-lus effects on cholesterol: in vitro and in vivo results. J Dairy Sci 1989; 72: 2885–99.
   PubMed Web of Science ®Google Scholar
• Taylor GRJ, Williams CM. Effects of probiotics and prebi-otics on blood lipids. Br J Nutr 1998; 80: S225–30.
   PubMed Web of Science ®Google Scholar
• Saltzman JR, Russell RM, Golner B, Barakat S, Dallal GE, Boldin BR. A randomized trial of Lactobacillus acidophilus BG2F04 to treat lactose intolerance. Am J Clin Nutr 1999; 69: 140–6.
   PubMed Web of Science ®Google Scholar
• Shermak MA, Saavedra JM, Jackson TL, Huang SS, Bayless TM, Perman JA. Effect of yogurt on symptoms and kinetics of hydrogen production in lactose-malabsorbing children. Am J Clin Nutr 1995; 62: 1003–6.
   PubMed Web of Science ®Google Scholar
• Majamaa H, Isolauri E. Probiotics: a novel approach in the management of food allergy. J Allergy Clin Immunol 1997; 99: 179–85.
   PubMed Web of Science ®Google Scholar
• Briet F, Pochart P, Marteau P, Flourie B, Arrigoni E, Rambaud JC. Improved clinical tolerance to chronic lactose ingestion in subjects with lactose intolerance: a placebo effect? Gut 1997; 41: 632–5.
   PubMed Web of Science ®Google Scholar
• Hove H, Nordgaard-Anderson I, Mortensen PB. Effect of lactic acid bacteria on the intestinal production of lactate and short-chain fatty acids, and the absorption of lactose. Am J Clin Nutr 1994; 59: 74–9.
   Web of Science ®Google Scholar
• Martini MC, Lerebours EC, Lin W-J, Harlander SK, Berrada NM, Antoine JM, Savaiano DA. Strains and spe-cies of lactice acid bacteria in fermented milks (yogurts): effect on in vivo lactose digestion. Am J Clin Nutr 1991; 54: 1041–6.
   Google Scholar
• Salminen S, Isolauri E, Onnela T. Gut flora in normal and disordered states. Chemotherapy 1995; 41: 5–15.
   Google Scholar
• Buts J-P, Bemasconi P, Vaerman J-P, Dive C. Stimulation of secretory IgA and secretory component of immunoglobu-lins in small intestine of rats treated with Saccharomyces boulardii. Dig Dis Sci 1990; 35: 251–6.
   Google Scholar
• Qamar A, Warny M, Michetti P, Pothoulakis C, LaMont JT, Kelly CP. Saccharomyces boulardii stimulates an intesti-nal IgA immune response to Clostridium difficile toxin A in mice. Gastroenterology 1999; 116: A894.
   Web of Science ®Google Scholar
• Rodrigues ACP, Fretez SHGG, Neumann E, Cara DC, Vieira EC, Nicoli JR, Vieira LQ. Saccharomyces boulardii stimulates the host phagocytic system and type 1 cytokine production. Microbiology Ecology in Health and Disease 1999; 11: 124.
   Google Scholar
• Fukushima Y, Kawata Y, Hara H, Terada A, Mitsuoka T. Effect of a probiotic formula on intestinal immunoglobulin A production in healthy children. Int J Food Microbiol 1998; 42: 39–44.
   Google Scholar
• Kaila M, Isolauri E, Soppi E, Virtanen E, LaMe S, Arvilommi H. Enhancement of the circulating antibody se-creting cell response in human diarrhea by a human Lacto-bacillus strain. Pediatr Res 1992; 32: 141–4.
   PubMed Web of Science ®Google Scholar
• Isolauri E, Joensuu J, Suomalainen H, Luomala M, Vesikari T. Improved immunogenicity of oral D x RRV reassortment rotavirus vaccine by Lactobacillus casei GG. Vaccine 1995; 13: 310–2.
   Google Scholar
• De Simone C, Ciardi A, Grassi A, Lambert Gardini S, Tzantzoglou S, Trinchieri V, Moretti S, Jirillo E. Effect of Bifidobacterium bifidum and Lactobacillus acidophilus on gut mucosa and peripheral blood B lymphocytes. Immunophar-macol Immunotoxicol 1992; 14: 331–40.
   Google Scholar
• Marteau P, Vaerman J-P, Dehennin J-P, Bord S, Brassart D, Pochart P, Desjeux J-F, Rambaud J-C. Effects of intrajeju-nal perfusion and chronic ingestion of Lactobacillus johnsonii strain La 1 on serum concentrations and jejunal secretions of immunoglobulins and serum proteins in healthy humans. Gastroenterol Clin Biol 1997; 21: 293–8.
   Google Scholar
• Sachar DB. How do you treat refractory pouchitis and when do you decide to remove the pouch? Inflammatory Bowel Diseases 1998; 4: 165–6.
   Google Scholar
• Uribarri J, Oh MS, Carroll HJ. D-Lactic acidosis: a review of clinical presentation, biochemical features, and patho-physiologic mechanisms. Medicine 1998; 77: 73–82.
   Google Scholar
• Bongaerts GP, Tolboom JJ, Naber AH, Sperl WJ, Severij-nen RS, Bakkeren JA, Willems JL. Role of bacteria in the pathogenesis of short bowel syndrome-associated D-lactic acidemia. Microb Pathog 1997; 22: 285–93.
   Google Scholar
• Caldarini MI, Pons S, D'Agostino D, DePaula JA, Greco G, Negri G, Ascione A, Bustos D. Abnormal fecal flora in a patient with short bowel syndrome. An in vitro study on effect of pH on D-lactic acid production. Dig Dis Sci 1996; 41: 1649–52.
   Google Scholar
• Caplan MS, Miller-Catchpole R, Kaup S, Russell T, Licker-man M, Amer M, Xiao Y, Thomson R Jr. Bifidobacterial supplementation reduces the incidence of necrotizing enter-colitis in a neonatal rat model. Gastroenterology 1999; 117: 577–83.
   PubMed Web of Science ®Google Scholar
• Berg R, Bernasconi P, Fowler D, Gautreaux M. Inhibition of Candida albicans translocation from the gastrointestinal tract of mice by oral administrate of Saccharomyces bou-lardii. J Infect Dis 1993; 168: 1314–8.
   PubMed Web of Science ®Google Scholar
• Peret Filho LA, Penna FJ, Bambirra EA, Nicoli JR. Dose effect of oral Saccharomyces boulardii treatments on morbid-ity and mortality in immunosuppressed mice. J Med Micro-biol 1998; 47: 111–6.
   PubMed Web of Science ®Google Scholar
• Umesaki Y, Setoyama H, Matsumoto S, Okada Y. Expan-sion of alpha-beta T-cell receptor-bearing intestinal intraep-ithelial lymphocytes after microbial colonization in germ-free mice and its independence from thymus. Immunology 1993; 79: 32–7.
   PubMed Web of Science ®Google Scholar
• Bovee-Oudenhoven IM, Termont DS, Heidt PJ, Van der meer R. Increasing the intestinal resistance of rats to the invasive pathogen Salmonella enteritidis: additive effects of dietary lactulose and calcium. Gut 1997; 40: 497–504.
   Google Scholar
• Tuomola EM, Crittenden RG, Kirjavainen PV, Ouwehand AC, Morris LF, Peltonen KD, Playne MJ, Salminen SJ. Adhesion of clinical Lactobacillus isolates to human intesti-nal mucosal models. Microbial Ecology in Health and Dis-ease 1998; 10: 194.
   Google Scholar
• Naaber P, Mikelsaar R-H, Salminen S, Mikelsaar M. Bacte-rial translocation, intestinal microflora and morphological changes of intestinal mucosa in experimental models of Clostridium difficile infection. J Med Microbiol 1998; 47: 591–8.
   Google Scholar
• Puapermpoonsiri S, Watanabe K, Kato N, Lumbiganon P, Ueno K. Vaginal microflora associated with bacterial vagi-nosis in pregnant Japanese and Thai women. Microbial Ecology in Health and Disease 1998; 10: 193–4.
   Google Scholar
• Hillier SL. The role of naturally occurring and exogenously supplied lactobacilli in the human vagina. Microbial Ecology in Health and Disease 1998; 10: 193.
   Google Scholar
• Sobel JD. Biotherapeutic agents as therapy for vaginitis. In: Elmer GW, McFarland LV, Surawicz CM, eds. Biotherapeu-tic agents and infectious diseases. Totowa, NJ: Humana Press, 1999: 221–44.
   Google Scholar
• Smith HS, Hughes JP, Nooton TM, Roberts P, Scholes D, Stergachis A, Stapleton A, Stamm WE. Antecedent antimi-crobial use increases the risk of uncomplicated cystitis in young women. Clin Infect Dis 1997; 25: 63–8.
   Web of Science ®Google Scholar
• Winberg J, Herthelius-Elman M, Mollby R, Nord CE. Pathogenesis of urinary tract infection-experimental stud-ies of vaginal resistance to colonization. Pediatr Nephrol 1993; 5: 509–14.
   Google Scholar
• Reid G, Smeianov V, Bruce AW. Biotherapeutic agents to prevent cystitis in women. In: Elmer GW, McFarland LV, Surawicz CM. Biotherapeutic agents and infectious diseases. Totowa, NJ: Human Press, 1999; 245–61.
   Google Scholar
• Sidhu H, Enatska L, Ogden S, Williams WN, Allison MJ, Peck AB. Evaluating children in the Ukraine for coloniza-tion with the intestinal bacterium Oxalobacter formigenes, using a polymerase chain reaction-based detection system. Mol Diagn 1997; 2: 89–97.
   Google Scholar
• Sidhu H, Holmes RP, Allison MJ, Peck AB. Direct quantifi-cation of the enteric bacterium Oxalobacter formigenes in human fecal samples by quantitative competitive-template PCR. J Clin Microbiol 1999; 37: 1503–9.
   Web of Science ®Google Scholar
• Sidhu H, Hoppe B, Hesse A, Tenbrock K, Bromme S, Rietschel E, Peck AB. Absence of Oxalobacter formigenes in cystic fibrosis patients: a risk factor for hyperoxaluria. Lancet 1998; 352: 1026–9.
   Google Scholar
• Listgarten MA. Structure of the microbial flora associated with periodontal health and disease in man. A light and electron microscopic study. J Periodontol 1976; 47: 1–18.
   Google Scholar
• Perrons CJ, Donoghue HD. Colonization resistance of defined bacterial plaques to Streptococcus mutans implanta-tion on teeth in a model mouth. J Dent Res 1990; 69: 483–8.
   Web of Science ®Google Scholar
• Morozova LV, Pozharitskaia MM, Melnichuk GM. [The therapeutic efficacy of probiotics for the correction of mi-crofloral imbalance in periodontitis]. Stomatologiia Mosk 1996; Spec No: 68–9.
   Google Scholar
• Morinushi T, Lopatin DE, Van Poperin N. The relationship between gingivitis and the serum antibodies to the micro-biota associated with periodontal disease in children with Down's syndrome. J Periodontol 1997; 68: 626–31.
   Google Scholar
• Ekstrand J, Bjorkman L, Edlund C, SandborghEnglund G. Toxicological aspects on the release and systemic uptake of mercury from dental amalgam. European Journal of Oral Sciences 1998; 106: 678–86.
   PubMed Web of Science ®Google Scholar
• Holst-Jensen S, Pfeiffer-Jensen M, Monsrud M, Tarp U, Buus A, Hessov I, Thorling E, StengaardPedersen K. Treat-ment of rheumatoid arthritis with a peptide diet. A random-ized, controlled trial. Scand J Rheumatol 1998; 27: 329–36.
   Web of Science ®Google Scholar
• Kato I, Endo-Tanaka K, Yokohura T. Suppressive effects of the oral administration of Lactobacillus casei on type II collagen-induced arthritis in DBA/1 mice. Life Sci 1998; 63: 635–44.
   PubMed Web of Science ®Google Scholar
• Peltonen R, Nenonen M, Helve T, Hanninen O, Toivanen P, Eerola E. Faecal microbial flora and disease activity in rheumatoid arthritis during a vegan diet. Br J Rheumatol 1997; 36: 64–8.
   PubMedGoogle Scholar
• Pron B, Merckx J, Touzet P, Ferroni A, Poyart C, Berche P, Gaillard J. Chronic septic arthritis and osteomyelitis in a prosthetic knee joint due to Clostridium difficile. Eur J Clin Microbial Infect Dis 1995; 14: 599–601.
   Google Scholar
• Cron RQ, Gordon PV. Reactive arthritis to Clostridium difficile in a child. West J Med 1997; 166: 419–21.
   PubMedGoogle Scholar
• Hilton E, Kolakowski P, Singer C, Smith M. Efficacy of Lactobacillus GG as a diarrheal preventive in travelers. J Travel Med 1997; 4: 41–3.
   PubMedGoogle Scholar
• Goldin BR, Gorbach SL. The effect of milk and lactobacil-lus feeding on human intestinal bacterial enzyme activity. Am J Clin Nutr 1984; 39: 756–61.
   PubMed Web of Science ®Google Scholar
• Goldin BR, Gorbach SL, Saxelin M, Barakat S, Gualtieri L, Salminen S. Survival of Lactobacillus species (strain GG) in human gastrointestinal tract. Dig Dis Sci 1992; 37: 121–8.
   PubMed Web of Science ®Google Scholar
• Marteau P, Pochart P, Flourie B, Pellier P, Santos L, Desjeux J-F, Rambaud J-C. Effect of chronic ingestion of a fermented dairy product containing Lactobacillus acidophilus and Bifidobacterium bifidum on metabolic activities on the colonic flora in humans. Am J Clin Nutr 1990; 52: 685–8.
   Google Scholar
• Goldin BR, Gorbach SL. Alterations of the intestinal mi-croflora by diet, oral antibiotics, and Lactobacillus: De-creased production of free amines from aromatic nitro compounds, azo dyes, and glucuronides. J Natl Cancer Inst 1984; 73: 689–95.
   PubMed Web of Science ®Google Scholar
• Ling WH, Korpela R, Mykkanen H, Salminen S, Hanninen O. Lactobacillus strain GG supplementation decreases colonic hydrolytic and reductive enzyme activities in healthy female adults. J Nutr 1994; 124: 18–23.
   Google Scholar
• Spanhaak S, Havenaar R, Schaafsma G. The effect of consumption of milk fermented by Lactobacillus casei strain Shirota on the intestinal microflora and immune parameters in humans. Eur J Clin Nutr 1998; 52: 899–907.
   Google Scholar